Publications:

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Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance.

International Journal Of Biological Sciences

Niu, Xiaxia X; Wu, Ting T; Li, Gege G; Gu, Xinsheng X; Tian, Yanan Y; Cui, Hongmei H

Publication Date: 2022

Variant appearance in text: PXR: I403V

PubMed Link: 35002522

Variant Present in the following documents:

• Main text
• ijbsv18p0742.pdf

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Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology

Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J

Publication Date: 2021-09

Variant appearance in text: NR1I2: 1207A>G; I403V; rs72551376

PubMed Link: 34621706

Variant Present in the following documents:

• tcp-29-135-s001.xls, sheet 1

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Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.

Biochemical Pharmacology

Banerjee, Monimoy M; Chai, Sergio C SC; Wu, Jing J; Robbins, Delira D; Chen, Taosheng T

Publication Date: 2016-03-15

Variant appearance in text: PXR: I403V

PubMed Link: 26902414

Variant Present in the following documents:

• Main text

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: NR1I2: I403V

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1

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The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers

Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N

Publication Date: 2015

Variant appearance in text: rs72551376

PubMed Link: 25802476

Variant Present in the following documents:

• 542543.f1.xlsx, sheet 1

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The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports

Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK

Publication Date: 2014

Variant appearance in text: rs72551376

PubMed Link: 25126521

Variant Present in the following documents:

• mmc1.xls, sheet 1

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Role of pregnane X receptor in chemotherapeutic treatment.

Cancer Chemotherapy And Pharmacology

Zhuo, Wei W; Hu, Lei L; Lv, Jinfeng J; Wang, Hongbing H; Zhou, Honghao H; Fan, Lan L

Publication Date: 2014-08

Variant appearance in text: PXR: I403v

PubMed Link: 24889719

Variant Present in the following documents:

• Main text

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PXR variants and artemisinin use in Vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin.

Antimicrobial Agents And Chemotherapy

Piedade, Rita R; Schaeffeler, Elke E; Winter, Stefan S; Asimus, Sara S; Schwab, Matthias M; Ashton, Michael M; Burk, Oliver O; Gil, José P JP

Publication Date: 2012-04

Variant appearance in text: PXR: I403V

PubMed Link: 22252826

Variant Present in the following documents:

• Main text

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Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.

Current Pharmacogenomics And Personalized Medicine

Hernandez, J P JP; Mota, L C LC; Baldwin, W S WS

Publication Date: 2009-06-01

Variant appearance in text: PXR: I403V

PubMed Link: 20871735

Variant Present in the following documents:

• Main text

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The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

Nuclear Receptor Signaling

Zhou, Changcheng C; Verma, Suman S; Blumberg, Bruce B

Publication Date: 2009

Variant appearance in text: SXR: I403V

PubMed Link: 19240808

Variant Present in the following documents:

• Main text
• nrs07001000.pdf

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Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme.

British Journal Of Clinical Pharmacology

Wang, Xue-Ding XD; Li, Jia-Li JL; Su, Qi-Biao QB; Guan, Su S; Chen, Jie J; Du, Jun J; He, Yu-Wen YW; Zeng, Jun J; Zhang, Jin-Xin JX; Chen, Xiao X; Huang, Min M; Zhou, Shu-Feng SF

Publication Date: 2009-02

Variant appearance in text: PXR: I403V

PubMed Link: 19173680

Variant Present in the following documents:

• Main text

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