NR1I2 c.*522C>G

Variant ID: 3-119536581-C-G

NM_003889.3(NR1I2):c.*522C>G

This variant was identified in 35 publications

View GRCh38 version.




Publications:


Establishment and characterization of a new mantle cell lymphoma cell line with a NOTCH2 mutation, Arbo.

Ejhaem
Safa, Firas F; Rasmussen, Terri T; Lobelle-Rich, Patricia P; Collier, Stephanie S; Milligan, Nicholas N; Schmeig, John J; Schmid, Janet J; Wiewiorowski, Carol C; Totaro, Denise D; Brown, Theresa C TC; Satyavarapu, Ishwarya I; Badoo, Melody M; Ungerleider, Nathan N; Flemington, Erik K EK; Safah, Hana H; Saba, Nakhle S NS
Publication Date: 2022-11

Variant appearance in text: rs3732360
PubMed Link: 36467812
Variant Present in the following documents:
  • JHA2-3-1326-s001.xlsx, sheet 1
View BVdb publication page



SNPs in 3'UTR miRNA Target Sequences Associated with Individual Drug Susceptibility.

International Journal Of Molecular Sciences
Rykova, Elena E; Ershov, Nikita N; Damarov, Igor I; Merkulova, Tatiana T
Publication Date: 2022-11-08

Variant appearance in text: rs3732360
PubMed Link: 36430200
Variant Present in the following documents:
  • Main text
  • ijms-23-13725.pdf
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Combined electronic medical records and gene polymorphism characteristics to establish an anti-tuberculosis drug-induced hepatic injury (ATDH) prediction model and evaluate the prediction value.

Annals Of Translational Medicine
Zhang, Jingwei J; Zhou, Wei W; Ma, Shijie S; Kang, Yuwei Y; Yang, Wei W; Peng, Xiaodong X; Zhou, Yi Y; Deng, Fei F
Publication Date: 2022-10

Variant appearance in text: rs3732360
PubMed Link: 36388795
Variant Present in the following documents:
  • Main text
  • atm-10-20-1114.pdf
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Impact of genetic polymorphisms of drug transporters ABCB1 and ABCG2 and regulators of xenobiotic transport and metabolism PXR and CAR on clinical efficacy of dasatinib in chronic myeloid leukemia.

Frontiers In Oncology
Madejczyk, Anna Marta AM; Canzian, Federico F; Góra-Tybor, Joanna J; Campa, Daniele D; Sacha, Tomasz T; Link-Lenczowska, Dorota D; Florek, Izabela I; Prejzner, Witold W; Całbecka, M M; Rymko, M M; Dudziński, M M; Orzechowska, Magdalena Julita MJ; Jamroziak, Krzysztof K
Publication Date: 2022

Variant appearance in text: rs3732360
PubMed Link: 36212403
Variant Present in the following documents:
  • Main text
  • fonc-12-952640.pdf
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Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity.

Frontiers In Pharmacology
Zhai, Qinglian Q; van der Lee, Maaike M; van Gelder, Teun T; Swen, Jesse J JJ
Publication Date: 2022

Variant appearance in text: rs3732360
PubMed Link: 35784699
Variant Present in the following documents:
  • Main text
  • fphar-13-912618.pdf
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Genetic and RNA-related molecular markers of trastuzumab-chemotherapy-associated cardiotoxicity in HER2 positive breast cancer: a systematic review.

Bmc Cancer
Lunardi, Mattia M; Al-Habbaa, Ahmed A; Abdelshafy, Mahmoud M; Davey, Matthew G MG; Elkoumy, Ahmed A; Ganly, Sandra S; Elzomor, Hesham H; Cawley, Christian C; Sharif, Faisal F; Crowley, James J; Kerin, Michael M; Wijns, William W; Lowery, Aoife A; Soliman, Osama O
Publication Date: 2022-04-12

Variant appearance in text: rs3732360
PubMed Link: 35413811
Variant Present in the following documents:
  • Main text
  • 12885_2022_Article_9437.pdf
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Life-Threatening Docetaxel Toxicity in a Patient With Reduced-Function CYP3A Variants: A Case Report.

Frontiers In Oncology
Powell, Nicholas R NR; Shugg, Tyler T; Ly, Reynold C RC; Albany, Costantine C; Radovich, Milan M; Schneider, Bryan P BP; Skaar, Todd C TC
Publication Date: 2021

Variant appearance in text: rs3732360
PubMed Link: 35174070
Variant Present in the following documents:
  • Main text
  • fonc-11-809527.pdf
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Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance.

International Journal Of Biological Sciences
Niu, Xiaxia X; Wu, Ting T; Li, Gege G; Gu, Xinsheng X; Tian, Yanan Y; Cui, Hongmei H
Publication Date: 2022

Variant appearance in text: rs3732360
PubMed Link: 35002522
Variant Present in the following documents:
  • Main text
  • ijbsv18p0742.pdf
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Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment.

Biomolecules
Skandalaki, Aikaterini A; Sarantis, Panagiotis P; Theocharis, Stamatios S
Publication Date: 2021-08-02

Variant appearance in text: rs3732360
PubMed Link: 34439808
Variant Present in the following documents:
  • Main text
  • biomolecules-11-01142.pdf
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Single nucleotide polymorphisms and the risk of developing a second primary cancer among head and neck cancer patients: a systematic literature review and meta-analysis.

Bmc Cancer
Hoxhaj, Ilda I; Vukovic, Vladimir V; Boccia, Stefania S; Pastorino, Roberta R
Publication Date: 2021-06-02

Variant appearance in text: rs3732360
PubMed Link: 34078296
Variant Present in the following documents:
  • Main text
View BVdb publication page



NR1I2 genetic polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity: A systematic review and meta-analysis.

Pharmacology Research & Perspectives
Yang, Miaomiao M; Qiu, Yunliang Y; Jin, Yanyu Y; Liu, Wenpei W; Wang, Qingliang Q; Yi, Honggang H; Tang, Shaowen S
Publication Date: 2020-12

Variant appearance in text: rs3732360
PubMed Link: 33300686
Variant Present in the following documents:
  • Main text
  • PRP2-8-e00696.pdf
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Associations between Pregnane X Receptor and Breast Cancer Growth and Progression.

Cells
Creamer, Bradley A BA; Sloan, Shelly N B SNB; Dennis, Jennifer F JF; Rogers, Robert R; Spencer, Sidney S; McCuen, Andrew A; Persaud, Purnadeo P; Staudinger, Jeff L JL
Publication Date: 2020-10-15

Variant appearance in text: rs3732360
PubMed Link: 33076284
Variant Present in the following documents:
  • Main text
  • cells-09-02295.pdf
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Genetic 3'UTR variations and clinical factors significantly contribute to survival prediction and clinical response in breast cancer patients.

Scientific Reports
Pamuła-Piłat, Jolanta J; Tęcza, Karolina K; Kalinowska-Herok, Magdalena M; Grzybowska, Ewa E
Publication Date: 2020-03-31

Variant appearance in text: rs3732360
PubMed Link: 32235849
Variant Present in the following documents:
  • Main text
  • 41598_2020_Article_62662.pdf
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PXR: a center of transcriptional regulation in cancer.

Acta Pharmaceutica Sinica. B
Xing, Yaqi Y; Yan, Jiong J; Niu, Yongdong Y
Publication Date: 2020-02

Variant appearance in text: rs3732360
PubMed Link: 32082968
Variant Present in the following documents:
  • Main text
  • main.pdf
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MicroRNA-binding site polymorphisms and risk of colorectal cancer: A systematic review and meta-analysis.

Cancer Medicine
Gholami, Morteza M; Larijani, Bagher B; Sharifi, Farshad F; Hasani-Ranjbar, Shirin S; Taslimi, Reza R; Bastami, Milad M; Atlasi, Rasha R; Amoli, Mahsa M MM
Publication Date: 2019-12

Variant appearance in text: rs3732360
PubMed Link: 31637880
Variant Present in the following documents:
  • Main text
  • CAM4-8-7477.pdf
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Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury.

Plos One
Zhang, Jingwei J; Zhao, Zhenzhen Z; Bai, Hao H; Wang, Minjin M; Jiao, Lin L; Peng, Wu W; Wu, Tao T; Liu, Tangyuheng T; Chen, Hao H; Song, Xingbo X; Wu, Lijuan L; Hu, Xuejiao X; Wu, Qian Q; Zhou, Juan J; Song, Jiajia J; Lyv, Mengyuan M; Ying, Binwu B
Publication Date: 2019

Variant appearance in text: rs3732360
PubMed Link: 31490979
Variant Present in the following documents:
  • Main text
View BVdb publication page



Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.

Obstetrics And Gynecology
Lazorwitz, Aaron A; Aquilante, Christina L CL; Oreschak, Kris K; Sheeder, Jeanelle J; Guiahi, Maryam M; Teal, Stephanie S
Publication Date: 2019-04

Variant appearance in text: rs3732360
PubMed Link: 30870275
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Sex-Stratified Genome-Wide Association Study of Tuberculosis Using a Multi-Ethnic Genotyping Array.

Frontiers In Genetics
Schurz, Haiko H; Kinnear, Craig J CJ; Gignoux, Chris C; Wojcik, Genevieve G; van Helden, Paul D PD; Tromp, Gerard G; Henn, Brenna B; Hoal, Eileen G EG; Möller, Marlo M
Publication Date: 2018

Variant appearance in text: rs3732360
PubMed Link: 30713548
Variant Present in the following documents:
  • Main text
View BVdb publication page



Whole genome sequencing identifies high-impact variants in well-known pharmacogenomic genes.

The Pharmacogenomics Journal
Choi, Jihoon J; Tantisira, Kelan G KG; Duan, Qing Ling QL
Publication Date: 2019-04

Variant appearance in text: rs3732360
PubMed Link: 30214008
Variant Present in the following documents:
  • NIHMS1503453-supplement-3.xlsx, sheet 1
View BVdb publication page



Association between PXR polymorphisms and cancer risk: a systematic review and meta-analysis.

Bioscience Reports
Wen, Jing J; Lv, Zhi Z; Ding, Hanxi H; Fang, Xinxin X; Sun, Mingjun M
Publication Date: 2018-06-29

Variant appearance in text: rs3732360
PubMed Link: 29654162
Variant Present in the following documents:
  • Main text
  • bsr-38-bsr20171614.pdf
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Proteogenomic analysis prioritises functional single nucleotide variants in cancer samples.

Oncotarget
Ma, Shiyong S; Menon, Ranjeeta R; Poulos, Rebecca C RC; Wong, Jason W H JWH
Publication Date: 2017-11-10

Variant appearance in text: rs3732360
PubMed Link: 29221171
Variant Present in the following documents:
  • oncotarget-08-95841-s002.xlsx, sheet 4
View BVdb publication page



microRNAs Make the Call in Cancer Personalized Medicine.

Frontiers In Cell And Developmental Biology
Detassis, Simone S; Grasso, Margherita M; Del Vescovo, Valerio V; Denti, Michela A MA
Publication Date: 2017

Variant appearance in text: rs3732360
PubMed Link: 29018797
Variant Present in the following documents:
  • Main text
  • fcell-05-00086.pdf
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Germline Genetic Variants in the Wnt/β-Catenin Pathway as Predictors of Colorectal Cancer Risk.

Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Hildebrandt, Michelle A T MA; Reyes, Monica E ME; Lin, Moubin M; He, Yonggang Y; Nguyen, Son V SV; Hawk, Ernest T ET; Wu, Xifeng X
Publication Date: 2016-03

Variant appearance in text: rs3732360
PubMed Link: 26809274
Variant Present in the following documents:
  • Main text
View BVdb publication page



An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3'-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients.

Frontiers In Genetics
Swart, Marelize M; Evans, Jonathan J; Skelton, Michelle M; Castel, Sandra S; Wiesner, Lubbe L; Smith, Peter J PJ; Dandara, Collet C
Publication Date: 2015

Variant appearance in text: rs3732360
PubMed Link: 26779253
Variant Present in the following documents:
  • Main text
  • fgene-06-00356.pdf
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Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach.

Human Genomics
Karageorgos, Ioannis I; Mizzi, Clint C; Giannopoulou, Efstathia E; Pavlidis, Cristiana C; Peters, Brock A BA; Zagoriti, Zoi Z; Stenson, Peter D PD; Mitropoulos, Konstantinos K; Borg, Joseph J; Kalofonos, Haralabos P HP; Drmanac, Radoje R; Stubbs, Andrew A; van der Spek, Peter P; Cooper, David N DN; Katsila, Theodora T; Patrinos, George P GP
Publication Date: 2015-06-20

Variant appearance in text: rs3732360
PubMed Link: 26092435
Variant Present in the following documents:
  • 40246_2015_34_MOESM1_ESM.xlsx, sheet 2
View BVdb publication page



Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes.

Oncotarget
Keerthikumar, Shivakumar S; Gangoda, Lahiru L; Liem, Michael M; Fonseka, Pamali P; Atukorala, Ishara I; Ozcitti, Cemil C; Mechler, Adam A; Adda, Christopher G CG; Ang, Ching-Seng CS; Mathivanan, Suresh S
Publication Date: 2015-06-20

Variant appearance in text: rs3732360
PubMed Link: 25944692
Variant Present in the following documents:
  • oncotarget-06-15375-s005.xlsx, sheet 2
View BVdb publication page



A functional polymorphism in the 3'-UTR of PXR interacts with smoking to increase lung cancer risk in southern and eastern Chinese smoker.

International Journal Of Molecular Sciences
Zhang, Lisha L; Qiu, Fuman F; Lu, Xiaoxiao X; Li, Yinyan Y; Fang, Wenxiang W; Zhang, Lan L; Zhou, Yifeng Y; Yang, Lei L; Lu, Jiachun J
Publication Date: 2014-09-29

Variant appearance in text: rs3732360
PubMed Link: 25268617
Variant Present in the following documents:
  • Main text
  • ijms-15-17457.pdf
View BVdb publication page



Genetic variation in the 3'-UTR of CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2, and UGT2B7: potential effects on regulation by microRNA and pharmacogenomics relevance.

Frontiers In Genetics
Swart, Marelize M; Dandara, Collet C
Publication Date: 2014

Variant appearance in text: rs3732360
PubMed Link: 24926315
Variant Present in the following documents:
  • Main text
  • fgene-05-00167.pdf
View BVdb publication page



Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem.

Frontiers In Genetics
Klein, Kathrin K; Zanger, Ulrich M UM
Publication Date: 2013

Variant appearance in text: rs3732360
PubMed Link: 23444277
Variant Present in the following documents:
  • Main text
View BVdb publication page



SLC22A1-ABCB1 haplotype profiles predict imatinib pharmacokinetics in Asian patients with chronic myeloid leukemia.

Plos One
Singh, Onkar O; Chan, Jason Yongsheng JY; Lin, Keegan K; Heng, Charles Chuah Thuan CC; Chowbay, Balram B
Publication Date: 2012

Variant appearance in text: rs3732360
PubMed Link: 23272163
Variant Present in the following documents:
  • Main text
  • pone.0051771.pdf
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Donor ABCB1 variant associates with increased risk for kidney allograft failure.

Journal Of The American Society Of Nephrology : Jasn
Moore, Jason J; McKnight, Amy Jayne AJ; Döhler, Bernd B; Simmonds, Matthew J MJ; Courtney, Aisling E AE; Brand, Oliver J OJ; Briggs, David D; Ball, Simon S; Cockwell, Paul P; Patterson, Christopher C CC; Maxwell, Alexander P AP; Gough, Stephen C L SC; Opelz, Gerhard G; Borrows, Richard R
Publication Date: 2012-11

Variant appearance in text: rs3732360
PubMed Link: 23064017
Variant Present in the following documents:
  • Main text
View BVdb publication page



A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk.

International Journal Of Cancer
Campa, Daniele D; Butterbach, Katja K; Slager, Susan L SL; Skibola, Christine F CF; de Sanjosé, Silvia S; Benavente, Yolanda Y; Becker, Nikolaus N; Foretova, Lenka L; Maynadie, Marc M; Cocco, Pierluigi P; Staines, Anthony A; Kaaks, Rudolf R; Boffetta, Paolo P; Brennan, Paul P; Conde, Lucia L; Bracci, Paige M PM; Caporaso, Neil E NE; Strom, Sara S SS; Camp, Nicola J NJ; Cerhan, James R JR; , ; Canzian, Federico F; Nieters, Alexandra A
Publication Date: 2012-08-15

Variant appearance in text: rs3732360
PubMed Link: 21918980
Variant Present in the following documents:
  • Main text
View BVdb publication page



Modest but variable effect of rifampin on steady-state plasma pharmacokinetics of efavirenz in healthy African-American and Caucasian volunteers.

Antimicrobial Agents And Chemotherapy
Kwara, Awewura A; Tashima, Karen T KT; Dumond, Julie B JB; Poethke, Pamela P; Kurpewski, Jaclyn J; Kashuba, Angela D M AD; Court, Michael H MH; Greenblatt, David J DJ
Publication Date: 2011-07

Variant appearance in text: rs3732360
PubMed Link: 21518840
Variant Present in the following documents:
  • Main text
View BVdb publication page



MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.

Carcinogenesis
Zhang, Xiaofan X; Yang, Hushan H; Lee, J Jack JJ; Kim, Edward E; Lippman, Scott M SM; Khuri, Fadlo R FR; Spitz, Margaret R MR; Lotan, Reuben R; Hong, Waun K WK; Wu, Xifeng X
Publication Date: 2010-12

Variant appearance in text: rs3732360
PubMed Link: 20819778
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism.

Xenobiotica; The Fate Of Foreign Compounds In Biological Systems
Oleson, L L; von Moltke, L L LL; Greenblatt, D J DJ; Court, M H MH
Publication Date: 2010-02

Variant appearance in text: rs3732360
PubMed Link: 20082578
Variant Present in the following documents:
  • Main text
View BVdb publication page