SLC15A2 c.170G>A ;(p.R57H)

Variant ID: 3-121615317-G-A

NM_021082.3(SLC15A2):c.170G>A;(p.R57H)

This variant was identified in 18 publications

View GRCh38 version.




Publications:


Biology of Peptide Transporter 2 in Mammals: New Insights into Its Function, Structure and Regulation.

Cells
Wang, Caihong C; Chu, Chu C; Ji, Xiang X; Luo, Guoliang G; Xu, Chunling C; He, Houhong H; Yao, Jianbiao J; Wu, Jian J; Hu, Jiangning J; Jin, Yuanxiang Y
Publication Date: 2022-09-14

Variant appearance in text: PEPT2: Arg57His
PubMed Link: 36139448
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology
Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J
Publication Date: 2021-09

Variant appearance in text: SLC15A2: 170G>A; R57H; rs1920305
PubMed Link: 34621706
Variant Present in the following documents:
  • tcp-29-135-s001.xls, sheet 1
View BVdb publication page



Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.

Clinical Pharmacokinetics
Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR
Publication Date: 2021-01

Variant appearance in text: SLC15A2: 170G>A; R57H; rs1920305
PubMed Link: 32607875
Variant Present in the following documents:
  • 40262_2020_913_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Transporters in the Mammary Gland-Contribution to Presence of Nutrients and Drugs into Milk.

Nutrients
García-Lino, Alba M AM; Álvarez-Fernández, Indira I; Blanco-Paniagua, Esther E; Merino, Gracia G; Álvarez, Ana I AI
Publication Date: 2019-10-05

Variant appearance in text: PEPT2: R57H
PubMed Link: 31590349
Variant Present in the following documents:
  • Main text
  • nutrients-11-02372.pdf
View BVdb publication page



Genetic variation in human drug-related genes.

Genome Medicine
Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS
Publication Date: 2017-12-22

Variant appearance in text: rs1920305
PubMed Link: 29273096
Variant Present in the following documents:
  • 13073_2017_502_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population.

Scientific Reports
Cai, Liang-Liang LL; Huang, Wen-Qing WQ; Su, Zhi-Ying ZY; Ye, Hui-Ming HM; Wang, Lian-Sheng LS; Wu, Yuan Y; Zhang, Zhong-Ying ZY; Zhang, Wei W; Tzeng, Chi-Meng CM
Publication Date: 2017-12-12

Variant appearance in text: PEPT2: R57H; rs1920305
PubMed Link: 29234073
Variant Present in the following documents:
  • Main text
  • 41598_2017_Article_17731.pdf
View BVdb publication page



iFish: predicting the pathogenicity of human nonsynonymous variants using gene-specific/family-specific attributes and classifiers.

Scientific Reports
Wang, Meng M; Wei, Liping L
Publication Date: 2016-08-16

Variant appearance in text: SLC15A2: R57H
PubMed Link: 27527004
Variant Present in the following documents:
  • srep31321-s3.xls, sheet 1
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: SLC15A2: 170G>A; R57H
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 3
View BVdb publication page



Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One
Holehouse, Alex S AS; Naegle, Kristen M KM
Publication Date: 2015

Variant appearance in text: rs1920305
PubMed Link: 26659599
Variant Present in the following documents:
  • pone.0144692.s002.xlsx, sheet 1
View BVdb publication page



Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project.

The Journal Of Molecular Diagnostics : Jmd
Pratt, Victoria M VM; Everts, Robin E RE; Aggarwal, Praful P; Beyer, Brittany N BN; Broeckel, Ulrich U; Epstein-Baak, Ruth R; Hujsak, Paul P; Kornreich, Ruth R; Liao, Jun J; Lorier, Rachel R; Scott, Stuart A SA; Smith, Chingying Huang CH; Toji, Lorraine H LH; Turner, Amy A; Kalman, Lisa V LV
Publication Date: 2016-01

Variant appearance in text: SLC15A2: R57H
PubMed Link: 26621101
Variant Present in the following documents:
  • Main text
View BVdb publication page



Population pharmacokinetic modeling of cefadroxil renal transport in wild-type and Pept2 knockout mice.

Xenobiotica; The Fate Of Foreign Compounds In Biological Systems
Xie, Yehua Y; Shen, Hong H; Hu, Yongjun Y; Feng, Meihua Rose MR; Smith, David E DE
Publication Date: 2016

Variant appearance in text: PEPT2: R57H
PubMed Link: 26372256
Variant Present in the following documents:
  • Main text
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: SLC15A2: R57H
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 3
View BVdb publication page



The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers
Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N
Publication Date: 2015

Variant appearance in text: rs1920305
PubMed Link: 25802476
Variant Present in the following documents:
  • 542543.f1.xlsx, sheet 1
View BVdb publication page



The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports
Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK
Publication Date: 2014

Variant appearance in text: rs1920305
PubMed Link: 25126521
Variant Present in the following documents:
  • mmc1.xls, sheet 1
View BVdb publication page



Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.

Molecular Aspects Of Medicine
Smith, David E DE; Clémençon, Benjamin B; Hediger, Matthias A MA
Publication Date: 2013

Variant appearance in text: SLC15A2: R57H
PubMed Link: 23506874
Variant Present in the following documents:
  • Main text
View BVdb publication page



Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling.

Pharmaceutical Research
Huh, Yeamin Y; Hynes, Scott M SM; Smith, David E DE; Feng, Meihua R MR
Publication Date: 2013-05

Variant appearance in text: PEPT2: R57H
PubMed Link: 23371515
Variant Present in the following documents:
  • Main text
View BVdb publication page



Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice.

Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism
Smith, David E DE; Hu, Yongjun Y; Shen, Hong H; Nagaraja, Tavarekere N TN; Fenstermacher, Joseph D JD; Keep, Richard F RF
Publication Date: 2011-01

Variant appearance in text: PEPT2: Arg57His
PubMed Link: 20571525
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity.

Drug Metabolism And Pharmacokinetics
Kamal, Mohamed A MA; Keep, Richard F RF; Smith, David E DE
Publication Date: 2008

Variant appearance in text: PEPT2: Arg57His
PubMed Link: 18762710
Variant Present in the following documents:
  • Main text
View BVdb publication page