A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density.
Cell Metabolism
Sinnott-Armstrong, Nasa N; Sousa, Isabel S IS; Laber, Samantha S; Rendina-Ruedy, Elizabeth E; Nitter Dankel, Simon E SE; Ferreira, Teresa T; Mellgren, Gunnar G; Karasik, David D; Rivas, Manuel M; Pritchard, Jonathan J; Guntur, Anyonya R AR; Cox, Roger D RD; Lindgren, Cecilia M CM; Hauner, Hans H; Sallari, Richard R; Rosen, Clifford J CJ; Hsu, Yi-Hsiang YH; Lander, Eric S ES; Kiel, Douglas P DP; Claussnitzer, Melina M
Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood.
European Journal Of Epidemiology
Zheng, Yan Y; Huang, Tao T; Wang, Tiange T; Mei, Zhendong Z; Sun, Zhonghan Z; Zhang, Tao T; Ellervik, Christina C; Chai, Jin-Fang JF; Sim, Xueling X; van Dam, Rob M RM; Tai, E-Shyong ES; Koh, Woon-Puay WP; Dorajoo, Rajkumar R; Saw, Seang-Mei SM; Sabanayagam, Charumathi C; Wong, Tien Yin TY; Gupta, Preeti P; Rossing, Peter P; Ahluwalia, Tarunveer S TS; Vinding, Rebecca K RK; Bisgaard, Hans H; Bønnelykke, Klaus K; Wang, Yujie Y; Graff, Mariaelisa M; Voortman, Trudy T; van Rooij, Frank J A FJA; Hofman, Albert A; van Heemst, Diana D; Noordam, Raymond R; Estampador, Angela C AC; Varga, Tibor V TV; Enzenbach, Cornelia C; Scholz, Markus M; Thiery, Joachim J; Burkhardt, Ralph R; Orho-Melander, Marju M; Schulz, Christina-Alexandra CA; Ericson, Ulrika U; Sonestedt, Emily E; Kubo, Michiaki M; Akiyama, Masato M; Zhou, Ang A; Kilpeläinen, Tuomas O TO; Hansen, Torben T; Kleber, Marcus E ME; Delgado, Graciela G; McCarthy, Mark M; Lemaitre, Rozenn N RN; Felix, Janine F JF; Jaddoe, Vincent W V VWV; Wu, Ying Y; Mohlke, Karen L KL; Lehtimäki, Terho T; Wang, Carol A CA; Pennell, Craig E CE; Schunkert, Heribert H; Kessler, Thorsten T; Zeng, Lingyao L; Willenborg, Christina C; Peters, Annette A; Lieb, Wolfgang W; Grote, Veit V; Rzehak, Peter P; Koletzko, Berthold B; Erdmann, Jeanette J; Munz, Matthias M; Wu, Tangchun T; He, Meian M; Yu, Caizheng C; Lecoeur, Cécile C; Froguel, Philippe P; Corella, Dolores D; Moreno, Luis A LA; Lai, Chao-Qiang CQ; Pitkänen, Niina N; Boreham, Colin A CA; Ridker, Paul M PM; Rosendaal, Frits R FR; de Mutsert, Renée R; Power, Chris C; Paternoster, Lavinia L; Sørensen, Thorkild I A TIA; Tjønneland, Anne A; Overvad, Kim K; Djousse, Luc L; Rivadeneira, Fernando F; Lee, Nanette R NR; Raitakari, Olli T OT; Kähönen, Mika M; Viikari, Jorma J; Langhendries, Jean-Paul JP; Escribano, Joaquin J; Verduci, Elvira E; Dedoussis, George G; König, Inke I; Balkau, Beverley B; Coltell, Oscar O; Dallongeville, Jean J; Meirhaeghe, Aline A; Amouyel, Philippe P; Gottrand, Frédéric F; Pahkala, Katja K; Niinikoski, Harri H; Hyppönen, Elina E; März, Winfried W; Mackey, David A DA; Gruszfeld, Dariusz D; Tucker, Katherine L KL; Fumeron, Frédéric F; Estruch, Ramon R; Ordovas, Jose M JM; Arnett, Donna K DK; Mook-Kanamori, Dennis O DO; Mozaffarian, Dariush D; Psaty, Bruce M BM; North, Kari E KE; Chasman, Daniel I DI; Qi, Lu L
Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.
Jama Network Open
, ; Huang, Tao T; Wang, Tiange T; Zheng, Yan Y; Ellervik, Christina C; Li, Xiang X; Gao, Meng M; Fang, Zhe Z; Chai, Jin-Fang JF; Ahluwalia, Tarun Veer S TVS; Wang, Yujie Y; Voortman, Trudy T; Noordam, Raymond R; Frazier-Wood, Alexis A; Scholz, Markus M; Sonestedt, Emily E; Akiyama, Masato M; Dorajoo, Rajkumar R; Zhou, Ang A; Kilpeläinen, Tuomas O TO; Kleber, Marcus E ME; Crozier, Sarah R SR; Godfrey, Keith M KM; Lemaitre, Rozenn R; Felix, Janine F JF; Shi, Yuan Y; Gupta, Preeti P; Khor, Chiea-Chuen CC; Lehtimäki, Terho T; Wang, Carol A CA; Tiesler, Carla M T CMT; Thiering, Elisabeth E; Standl, Marie M; Rzehak, Peter P; Marouli, Eirini E; He, Meian M; Lecoeur, Cécile C; Corella, Dolores D; Lai, Chao-Qiang CQ; Moreno, Luis A LA; Pitkänen, Niina N; Boreham, Colin A CA; Zhang, Tao T; Saw, Seang Mei SM; Ridker, Paul M PM; Graff, Mariaelisa M; van Rooij, Frank J A FJA; Uitterlinden, Andre G AG; Hofman, Albert A; van Heemst, Diana D; Rosendaal, Frits R FR; de Mutsert, Renée R; Burkhardt, Ralph R; Schulz, Christina-Alexandra CA; Ericson, Ulrika U; Kamatani, Yoichiro Y; Yuan, Jian-Min JM; Power, Chris C; Hansen, Torben T; Sørensen, Thorkild I A TIA; Tjønneland, Anne A; Overvad, Kim K; Delgado, Graciela G; Cooper, Cyrus C; Djousse, Luc L; Rivadeneira, Fernando F; Jameson, Karen K; Zhao, Wanting W; Liu, Jianjun J; Lee, Nanette R NR; Raitakari, Olli O; Kähönen, Mika M; Viikari, Jorma J; Grote, Veit V; Langhendries, Jean-Paul JP; Koletzko, Berthold B; Escribano, Joaquin J; Verduci, Elvira E; Dedoussis, George G; Yu, Caizheng C; Tham, Yih Chung YC; Lim, Blanche B; Lim, Sing Hui SH; Froguel, Philippe P; Balkau, Beverley B; Fink, Nadia R NR; Vinding, Rebecca K RK; Sevelsted, Astrid A; Bisgaard, Hans H; Coltell, Oscar O; Dallongeville, Jean J; Gottrand, Frédéric F; Pahkala, Katja K; Niinikoski, Harri H; Hyppönen, Elina E; Pedersen, Oluf O; März, Winfried W; Inskip, Hazel H; Jaddoe, Vincent W V VWV; Dennison, Elaine E; Wong, Tien Yin TY; Sabanayagam, Charumathi C; Tai, E-Shyong ES; Mohlke, Karen L KL; Mackey, David A DA; Gruszfeld, Dariusz D; Deloukas, Panagiotis P; Tucker, Katherine L KL; Fumeron, Frédéric F; Bønnelykke, Klaus K; Rossing, Peter P; Estruch, Ramon R; Ordovas, Jose M JM; Arnett, Donna K DK; Meirhaeghe, Aline A; Amouyel, Philippe P; Cheng, Ching-Yu CY; Sim, Xueling X; Teo, Yik Ying YY; van Dam, Rob M RM; Koh, Woon-Puay WP; Orho-Melander, Marju M; Loeffler, Markus M; Kubo, Michiaki M; Thiery, Joachim J; Mook-Kanamori, Dennis O DO; Mozaffarian, Dariush D; Psaty, Bruce M BM; Franco, Oscar H OH; Wu, Tangchun T; North, Kari E KE; Davey Smith, George G; Chavarro, Jorge E JE; Chasman, Daniel I DI; Qi, Lu L
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus.
Diabetes
Roman, Tamara S TS; Cannon, Maren E ME; Vadlamudi, Swarooparani S; Buchkovich, Martin L ML; Wolford, Brooke N BN; Welch, Ryan P RP; Morken, Mario A MA; Kwon, Grace J GJ; Varshney, Arushi A; Kursawe, Romy R; Wu, Ying Y; Jackson, Anne U AU; , ; Erdos, Michael R MR; Kuusisto, Johanna J; Laakso, Markku M; Scott, Laura J LJ; Boehnke, Michael M; Collins, Francis S FS; Parker, Stephen C J SCJ; Stitzel, Michael L ML; Mohlke, Karen L KL
ADCY5 gene expression in adipose tissue is related to obesity in men and mice.
Plos One
Knigge, Anja A; Klöting, Nora N; Schön, Michael R MR; Dietrich, Arne A; Fasshauer, Mathias M; Gärtner, Daniel D; Lohmann, Tobias T; Dreßler, Miriam M; Stumvoll, Michael M; Kovacs, Peter P; Blüher, Matthias M
The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study.
Human Molecular Genetics
Urbanek, Margrit M; Hayes, M Geoffrey MG; Armstrong, Loren L LL; Morrison, Jean J; Lowe, Lynn P LP; Badon, Sylvia E SE; Scheftner, Doug D; Pluzhnikov, Anna A; Levine, David D; Laurie, Cathy C CC; McHugh, Caitlin C; Ackerman, Christine M CM; Mirel, Daniel B DB; Doheny, Kimberly F KF; Guo, Cong C; Scholtens, Denise M DM; Dyer, Alan R AR; Metzger, Boyd E BE; Reddy, Timothy E TE; Cox, Nancy J NJ; Lowe, William L WL; ,
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Nature Genetics
Horikoshi, Momoko M; Yaghootkar, Hanieh H; Mook-Kanamori, Dennis O DO; Sovio, Ulla U; Taal, H Rob HR; Hennig, Branwen J BJ; Bradfield, Jonathan P JP; St Pourcain, Beate B; Evans, David M DM; Charoen, Pimphen P; Kaakinen, Marika M; Cousminer, Diana L DL; Lehtimäki, Terho T; Kreiner-Møller, Eskil E; Warrington, Nicole M NM; Bustamante, Mariona M; Feenstra, Bjarke B; Berry, Diane J DJ; Thiering, Elisabeth E; Pfab, Thiemo T; Barton, Sheila J SJ; Shields, Beverley M BM; Kerkhof, Marjan M; van Leeuwen, Elisabeth M EM; Fulford, Anthony J AJ; Kutalik, Zoltán Z; Zhao, Jing Hua JH; den Hoed, Marcel M; Mahajan, Anubha A; Lindi, Virpi V; Goh, Liang-Kee LK; Hottenga, Jouke-Jan JJ; Wu, Ying Y; Raitakari, Olli T OT; Harder, Marie N MN; Meirhaeghe, Aline A; Ntalla, Ioanna I; Salem, Rany M RM; Jameson, Karen A KA; Zhou, Kaixin K; Monies, Dorota M DM; Lagou, Vasiliki V; Kirin, Mirna M; Heikkinen, Jani J; Adair, Linda S LS; Alkuraya, Fowzan S FS; Al-Odaib, Ali A; Amouyel, Philippe P; Andersson, Ehm Astrid EA; Bennett, Amanda J AJ; Blakemore, Alexandra I F AI; Buxton, Jessica L JL; Dallongeville, Jean J; Das, Shikta S; de Geus, Eco J C EJ; Estivill, Xavier X; Flexeder, Claudia C; Froguel, Philippe P; Geller, Frank F; Godfrey, Keith M KM; Gottrand, Frédéric F; Groves, Christopher J CJ; Hansen, Torben T; Hirschhorn, Joel N JN; Hofman, Albert A; Hollegaard, Mads V MV; Hougaard, David M DM; Hyppönen, Elina E; Inskip, Hazel M HM; Isaacs, Aaron A; Jørgensen, Torben T; Kanaka-Gantenbein, Christina C; Kemp, John P JP; Kiess, Wieland W; Kilpeläinen, Tuomas O TO; Klopp, Norman N; Knight, Bridget A BA; Kuzawa, Christopher W CW; McMahon, George G; Newnham, John P JP; Niinikoski, Harri H; Oostra, Ben A BA; Pedersen, Louise L; Postma, Dirkje S DS; Ring, Susan M SM; Rivadeneira, Fernando F; Robertson, Neil R NR; Sebert, Sylvain S; Simell, Olli O; Slowinski, Torsten T; Tiesler, Carla M T CM; Tönjes, Anke A; Vaag, Allan A; Viikari, Jorma S JS; Vink, Jacqueline M JM; Vissing, Nadja Hawwa NH; Wareham, Nicholas J NJ; Willemsen, Gonneke G; Witte, Daniel R DR; Zhang, Haitao H; Zhao, Jianhua J; , ; Wilson, James F JF; Stumvoll, Michael M; Prentice, Andrew M AM; Meyer, Brian F BF; Pearson, Ewan R ER; Boreham, Colin A G CA; Cooper, Cyrus C; Gillman, Matthew W MW; Dedoussis, George V GV; Moreno, Luis A LA; Pedersen, Oluf O; Saarinen, Maiju M; Mohlke, Karen L KL; Boomsma, Dorret I DI; Saw, Seang-Mei SM; Lakka, Timo A TA; Körner, Antje A; Loos, Ruth J F RJ; Ong, Ken K KK; Vollenweider, Peter P; van Duijn, Cornelia M CM; Koppelman, Gerard H GH; Hattersley, Andrew T AT; Holloway, John W JW; Hocher, Berthold B; Heinrich, Joachim J; Power, Chris C; Melbye, Mads M; Guxens, Mònica M; Pennell, Craig E CE; Bønnelykke, Klaus K; Bisgaard, Hans H; Eriksson, Johan G JG; Widén, Elisabeth E; Hakonarson, Hakon H; Uitterlinden, André G AG; Pouta, Anneli A; Lawlor, Debbie A DA; Smith, George Davey GD; Frayling, Timothy M TM; McCarthy, Mark I MI; Grant, Struan F A SF; Jaddoe, Vincent W V VW; Jarvelin, Marjo-Riitta MR; Timpson, Nicholas J NJ; Prokopenko, Inga I; Freathy, Rachel M RM; ,
Variation in the maternal corticotrophin releasing hormone-binding protein (CRH-BP) gene and birth weight in Blacks, Hispanics and Whites.
Plos One
Wadhwa, Pathik D PD; Simhan, Hyagriv N HN; Entringer, Sonja S; Buss, Claudia C; Smith, Roger R; Hobel, Calvin J CJ; Farhana, Naveed N; Shimmin, Lawrence L; Hixson, James E JE; Sing, Charles F CF
The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge.
Plos One
Andersson, Ehm A EA; Harder, Marie N MN; Pilgaard, Kasper K; Pisinger, Charlotta C; Stančáková, Alena A; Kuusisto, Johanna J; Grarup, Niels N; Færch, Kristine K; Poulsen, Pernille P; Witte, Daniel R DR; Jørgensen, Torben T; Vaag, Allan A; Laakso, Markku M; Pedersen, Oluf O; Hansen, Torben T
Replication of a genome-wide association study of birth weight in preterm neonates.
The Journal Of Pediatrics
Ryckman, Kelli K KK; Feenstra, Bjarke B; Shaffer, John R JR; Bream, Elise N A EN; Geller, Frank F; Feingold, Eleanor E; Weeks, Daniel E DE; Gadow, Enrique E; Cosentino, Viviana V; Saleme, Cesar C; Simhan, Hyagriv N HN; Merrill, David D; Fong, Chin-To CT; Busch, Tamara T; Berends, Susan K SK; Comas, Belen B; Camelo, Jorge L JL; Boyd, Heather H; Laurie, Cathy C CC; Crosslin, David D; Zhang, Qi Q; Doheny, Kimberly F KF; Pugh, Elizabeth E; Melbye, Mads M; Marazita, Mary L ML; Dagle, John M JM; Murray, Jeffrey C JC
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
Nature Genetics
Freathy, Rachel M RM; Mook-Kanamori, Dennis O DO; Sovio, Ulla U; Prokopenko, Inga I; Timpson, Nicholas J NJ; Berry, Diane J DJ; Warrington, Nicole M NM; Widen, Elisabeth E; Hottenga, Jouke Jan JJ; Kaakinen, Marika M; Lange, Leslie A LA; Bradfield, Jonathan P JP; Kerkhof, Marjan M; Marsh, Julie A JA; Mägi, Reedik R; Chen, Chih-Mei CM; Lyon, Helen N HN; Kirin, Mirna M; Adair, Linda S LS; Aulchenko, Yurii S YS; Bennett, Amanda J AJ; Borja, Judith B JB; Bouatia-Naji, Nabila N; Charoen, Pimphen P; Coin, Lachlan J M LJ; Cousminer, Diana L DL; de Geus, Eco J C EJ; Deloukas, Panos P; Elliott, Paul P; Evans, David M DM; Froguel, Philippe P; , ; Glaser, Beate B; Groves, Christopher J CJ; Hartikainen, Anna-Liisa AL; Hassanali, Neelam N; Hirschhorn, Joel N JN; Hofman, Albert A; Holly, Jeff M P JM; Hyppönen, Elina E; Kanoni, Stavroula S; Knight, Bridget A BA; Laitinen, Jaana J; Lindgren, Cecilia M CM; , ; McArdle, Wendy L WL; O'Reilly, Paul F PF; Pennell, Craig E CE; Postma, Dirkje S DS; Pouta, Anneli A; Ramasamy, Adaikalavan A; Rayner, Nigel W NW; Ring, Susan M SM; Rivadeneira, Fernando F; Shields, Beverley M BM; Strachan, David P DP; Surakka, Ida I; Taanila, Anja A; Tiesler, Carla C; Uitterlinden, Andre G AG; van Duijn, Cornelia M CM; , ; Wijga, Alet H AH; Willemsen, Gonneke G; Zhang, Haitao H; Zhao, Jianhua J; Wilson, James F JF; Steegers, Eric A P EA; Hattersley, Andrew T AT; Eriksson, Johan G JG; Peltonen, Leena L; Mohlke, Karen L KL; Grant, Struan F A SF; Hakonarson, Hakon H; Koppelman, Gerard H GH; Dedoussis, George V GV; Heinrich, Joachim J; Gillman, Matthew W MW; Palmer, Lyle J LJ; Frayling, Timothy M TM; Boomsma, Dorret I DI; Davey Smith, George G; Power, Chris C; Jaddoe, Vincent W V VW; Jarvelin, Marjo-Riitta MR; , ; McCarthy, Mark I MI