Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA.
Scientific Reports
Sánchez, Ricardo R; Dorado, Sara S; Ruíz-Heredia, Yanira Y; Martín-Muñoz, Alejandro A; Rosa-Rosa, Juan Manuel JM; Ribera, Jordi J; García, Olga O; Jimenez-Ubieto, Ana A; Carreño-Tarragona, Gonzalo G; Linares, María M; Rufián, Laura L; Juárez, Alexandra A; Carrillo, Jaime J; Espino, María José MJ; Cáceres, Mercedes M; Expósito, Sara S; Cuevas, Beatriz B; Vanegas, Raúl R; Casado, Luis Felipe LF; Torrent, Anna A; Zamora, Lurdes L; Mercadal, Santiago S; Coll, Rosa R; Cervera, Marta M; Morgades, Mireia M; Hernández-Rivas, José Ángel JÁ; Bravo, Pilar P; Serí, Cristina C; Anguita, Eduardo E; Barragán, Eva E; Sargas, Claudia C; Ferrer-Marín, Francisca F; Sánchez-Calero, Jorge J; Sevilla, Julián J; Ruíz, Elena E; Villalón, Lucía L; Del Mar Herráez, María M; Riaza, Rosalía R; Magro, Elena E; Steegman, Juan Luis JL; Wang, Chongwu C; de Toledo, Paula P; García-Gutiérrez, Valentín V; Ayala, Rosa R; Ribera, Josep-Maria JM; Barrio, Santiago S; Martínez-López, Joaquín J
Somatic Mutations in Oncogenes Are in Chronic Myeloid Leukemia Acquired De Novo via Deregulated Base-Excision Repair and Alternative Non-Homologous End Joining.
Frontiers In Oncology
Curik, Nikola N; Polivkova, Vaclava V; Burda, Pavel P; Koblihova, Jitka J; Laznicka, Adam A; Kalina, Tomas T; Kanderova, Veronika V; Brezinova, Jana J; Ransdorfova, Sarka S; Karasova, Dominika D; Rejlova, Katerina K; Bakardjieva, Marina M; Kuzilkova, Daniela D; Kundrat, David D; Linhartova, Jana J; Klamova, Hana H; Salek, Cyril C; Klener, Pavel P; Hrusak, Ondrej O; Machova Polakova, Katerina K
Discovery and Protein Modeling Studies of Novel Compound Mutations Causing Resistance to Multiple Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia.
Asian Pacific Journal Of Cancer Prevention : Apjcp
Iqbal, Zafar Z; Absar, Muhammad M; Mahmood, Amer A; Aleem, Aamer A; Iqbal, Mudassar M; Jameel, Abid A; Akhtar, Tanveer T; Karim, Sajjad S; Rasool, Mahmood M; Mirza, Zeenat Z; Khalid, Muhammad M; Akram, Afia Muhammad AM; Sabar, Muhammad Farooq MF; Khalid, Ahmad M AM; Aljarrah, Khalid K; Iqbal, Janhangir J; Khalid, Muhammad M; Shah, Ijaz H IH; Alanazi, Nawaf N
Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study.
Leukemia
Hochhaus, Andreas A; Gambacorti-Passerini, Carlo C; Abboud, Camille C; Gjertsen, Bjørn Tore BT; Brümmendorf, Tim H TH; Smith, B Douglas BD; Ernst, Thomas T; Giraldo-Castellano, Pilar P; Olsson-Strömberg, Ulla U; Saussele, Susanne S; Bardy-Bouxin, Nathalie N; Viqueira, Andrea A; Leip, Eric E; Russell-Smith, T Alexander TA; Leone, Jocelyn J; Rosti, Gianantonio G; Watts, Justin J; Giles, Francis J FJ; ,
Safety and efficacy of second-line bosutinib for chronic phase chronic myeloid leukemia over a five-year period: final results of a phase I/II study.
Haematologica
Gambacorti-Passerini, Carlo C; Cortes, Jorge E JE; Lipton, Jeff H JH; Kantarjian, Hagop M HM; Kim, Dong-Wook DW; Schafhausen, Philippe P; Crescenzo, Rocco R; Bardy-Bouxin, Nathalie N; Shapiro, Mark M; Noonan, Kay K; Leip, Eric E; DeAnnuntis, Liza L; Brümmendorf, Tim H TH; Khoury, H Jean HJ
Prognostic factors and survival outcomes in patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era: Cohort study of 477 patients.
Cancer
Jain, Preetesh P; Kantarjian, Hagop M HM; Ghorab, Ahmad A; Sasaki, Koji K; Jabbour, Elias J EJ; Nogueras Gonzalez, Graciela G; Kanagal-Shamanna, Rashmi R; Issa, Ghayas C GC; Garcia-Manero, Guillermo G; Kc, Devendra D; Dellasala, Sara S; Pierce, Sherry S; Konopleva, Marina M; Wierda, William G WG; Verstovsek, Srdan S; Daver, Naval G NG; Kadia, Tapan M TM; Borthakur, Gautam G; O'Brien, Susan S; Estrov, Zeev Z; Ravandi, Farhad F; Cortes, Jorge E JE
Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia.
Haematologica
Gleixner, Karoline V KV; Schneeweiss, Mathias M; Eisenwort, Gregor G; Berger, Daniela D; Herrmann, Harald H; Blatt, Katharina K; Greiner, Georg G; Byrgazov, Konstantin K; Hoermann, Gregor G; Konopleva, Marina M; Waliul, Islam I; Cumaraswamy, Abbarna A AA; Gunning, Patrick T PT; Maeda, Hiroshi H; Moriggl, Richard R; Deininger, Michael M; Lion, Thomas T; Andreeff, Michael M; Valent, Peter P
Resistance to imatinib in patients with chronic myelogenous leukemia and the splice variant BCR-ABL1(35INS).
Leukemia Research
Berman, Ellin E; Jhanwar, Suresh S; Hedvat, Cyrus C; Arcila, Maria E ME; Wahab, Omar Abdel- OA; Levine, Ross R; Maloy, Molly M; Ma, Wanlong W; Albitar, Maher M
Differential clinical and prognostic impact of myeloid sarcoma vs medullary myeloid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy.
Blood Cancer Journal
Chen, Z Z; Wang, W W; Cortes, J E JE; Liu, E E; Miranda, R N RN; Zhao, C C; Yuan, J J; Lu, X X; Yang, W W; Ameri, M D MD; Kantarjian, H M HM; Medeiros, L J LJ; Hu, S S
Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Sadovnik, Irina I; Hoelbl-Kovacic, Andrea A; Herrmann, Harald H; Eisenwort, Gregor G; Cerny-Reiterer, Sabine S; Warsch, Wolfgang W; Hoermann, Gregor G; Greiner, Georg G; Blatt, Katharina K; Peter, Barbara B; Stefanzl, Gabriele G; Berger, Daniela D; Bilban, Martin M; Herndlhofer, Susanne S; Sill, Heinz H; Sperr, Wolfgang R WR; Streubel, Berthold B; Mannhalter, Christine C; Holyoake, Tessa L TL; Sexl, Veronika V; Valent, Peter P
Long-term efficacy and safety of bosutinib in patients with advanced leukemia following resistance/intolerance to imatinib and other tyrosine kinase inhibitors.
American Journal Of Hematology
Gambacorti-Passerini, Carlo C; Kantarjian, Hagop M HM; Kim, Dong-Wook DW; Khoury, Hanna J HJ; Turkina, Anna G AG; Brümmendorf, Tim H TH; Matczak, Ewa E; Bardy-Bouxin, Nathalie N; Shapiro, Mark M; Turnbull, Kathleen K; Leip, Eric E; Cortes, Jorge E JE
The BCR-ABLT315I mutation compromises survival in chronic phase chronic myelogenous leukemia patients resistant to tyrosine kinase inhibitors, in a matched pair analysis.
Haematologica
Nicolini, Franck E FE; Ibrahim, Amr R AR; Soverini, Simona S; Martinelli, Giovanni G; Müller, Martin C MC; Hochhaus, Andreas A; Dufva, Inge H IH; Kim, Dong-Wook DW; Cortes, Jorge J; Mauro, Michael J MJ; Chuah, Charles C; Labussière, Hélène H; Morisset, Stéphane S; Roche-Lestienne, Catherine C; Lippert, Eric E; Hayette, Sandrine S; Peter, Senaka S; Zhou, Wei W; Maguer-Satta, Véronique V; Michallet, Mauricette M; Goldman, John J; Apperley, Jane F JF; Mahon, François-Xavier FX; Marin, David D; Etienne, Gabriel G
Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase.
Blood
Hochhaus, Andreas A; Saglio, Giuseppe G; Larson, Richard A RA; Kim, Dong-Wook DW; Etienne, Gabriel G; Rosti, Gianantonio G; De Souza, Carmino C; Kurokawa, Mineo M; Kalaycio, Matt E ME; Hoenekopp, Albert A; Fan, Xiaolin X; Shou, Yaping Y; Kantarjian, Hagop M HM; Hughes, Timothy P TP
Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: implications in the post-imatinib era.
Plos One
Iqbal, Zafar Z; Aleem, Aamer A; Iqbal, Mudassar M; Naqvi, Mubashar Iqbal MI; Gill, Ammara A; Taj, Abid Sohail AS; Qayyum, Abdul A; ur-Rehman, Najeeb N; Khalid, Ahmad Mukhtar AM; Shah, Ijaz Hussain IH; Khalid, Muhammad M; Haq, Riazul R; Khan, Mahwish M; Baig, Shahid Mahmood SM; Jamil, Abid A; Abbas, Muhammad Naeem MN; Absar, Muhammad M; Mahmood, Amer A; Rasool, Mahmood M; Akhtar, Tanveer T
BCR-ABL1 compound mutations in tyrosine kinase inhibitor-resistant CML: frequency and clonal relationships.
Blood
Khorashad, Jamshid S JS; Kelley, Todd W TW; Szankasi, Philippe P; Mason, Clinton C CC; Soverini, Simona S; Adrian, Lauren T LT; Eide, Christopher A CA; Zabriskie, Matthew S MS; Lange, Thoralf T; Estrada, Johanna C JC; Pomicter, Anthony D AD; Eiring, Anna M AM; Kraft, Ira L IL; Anderson, David J DJ; Gu, Zhimin Z; Alikian, Mary M; Reid, Alistair G AG; Foroni, Letizia L; Marin, David D; Druker, Brian J BJ; O'Hare, Thomas T; Deininger, Michael W MW
Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure.
Blood
Khoury, H Jean HJ; Cortes, Jorge E JE; Kantarjian, Hagop M HM; Gambacorti-Passerini, Carlo C; Baccarani, Michele M; Kim, Dong-Wook DW; Zaritskey, Andrey A; Countouriotis, Athena A; Besson, Nadine N; Leip, Eric E; Kelly, Virginia V; Brümmendorf, Tim H TH
Results of allogeneic hematopoietic stem cell transplantation for chronic myelogenous leukemia patients who failed tyrosine kinase inhibitors after developing BCR-ABL1 kinase domain mutations.
Blood
Jabbour, Elias E; Cortes, Jorge J; Santos, Fabio P S FP; Jones, Dan D; O'Brien, Susan S; Rondon, Gabriela G; Popat, Uday U; Giralt, Sergio S; Kebriaei, Partow P; Jones, Roy B RB; Kantarjian, Hagop H; Champlin, Richard R; de Lima, Marcos M
Epidemiologic study on survival of chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia patients with BCR-ABL T315I mutation.
Blood
Nicolini, Franck E FE; Mauro, Michael J MJ; Martinelli, Giovanni G; Kim, Dong-Wook DW; Soverini, Simona S; Müller, Martin C MC; Hochhaus, Andreas A; Cortes, Jorge J; Chuah, Charles C; Dufva, Inge H IH; Apperley, Jane F JF; Yagasaki, Fumiharu F; Pearson, Jay D JD; Peter, Senaka S; Sanz Rodriguez, Cesar C; Preudhomme, Claude C; Giles, Francis F; Goldman, John M JM; Zhou, Wei W
The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.
Cancer Cell
Klemm, Lars L; Duy, Cihangir C; Iacobucci, Ilaria I; Kuchen, Stefan S; von Levetzow, Gregor G; Feldhahn, Niklas N; Henke, Nadine N; Li, Zhiyu Z; Hoffmann, Thomas K TK; Kim, Yong-mi YM; Hofmann, Wolf-Karsten WK; Jumaa, Hassan H; Groffen, John J; Heisterkamp, Nora N; Martinelli, Giovanni G; Lieber, Michael R MR; Casellas, Rafael R; Müschen, Markus M
High-dose imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: high rates of rapid cytogenetic and molecular responses.
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Cortes, Jorge E JE; Kantarjian, Hagop M HM; Goldberg, Stuart L SL; Powell, Bayard L BL; Giles, Francis J FJ; Wetzler, Meir M; Akard, Luke L; Burke, John M JM; Kerr, Robert R; Saleh, Mansoor M; Salvado, August A; McDougall, Karen K; Albitar, Maher M; Radich, Jerald J; ,