Publications:

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Efficacy and safety of nilotinib as frontline treatment in elderly (> 65 years) chronic myeloid leukemia patients outside clinical trials.

Annals Of Hematology

Luciano, Luigia L; Latagliata, Roberto R; Gugliotta, Gabriele G; Annunziata, Mario M; Tiribelli, Mario M; Martino, Bruno B; Sica, Antonello A; Esposito, Maria Rosaria MR; Bocchia, Monica M; Galimberti, Sara S; Sorà, Federica F; Albano, Francesco F; Palmieri, Raffaele R; Pregno, Patrizia P; Dragani, Matteo M; Iovine, Maria M; Sica, Simona S; Iurlo, Alessandra A; Castagnetti, Fausto F; Rosti, Gianantonio G; Breccia, Massimo M

Publication Date: 2023-04-20

Variant appearance in text: CP: E255K

PubMed Link: 37079069

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• Main text
• 277_2023_Article_5159.pdf

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Long-term outcomes of third-line therapy with tyrosine kinase inhibitors in chronic phase chronic myeloid leukemia: A real-life experience.

Frontiers In Oncology

Chitanava, Tamara T; Matvienko, Iuliia I; Shuvaev, Vasily V; Voloshin, Sergey S; Martynkevich, Irina I; Vlasova, Yulia Y; Efremova, Elizaveta E; Mileeva, Ekaterina E; Pirkhalo, Anna A; Makarova, Taiana T; Vlasik, Roman R; Karyagina, Elena E; Il Ina, Natalia N; Medvedeva, Nadezhda N; Dorofeeva, Natalia N; Shneider, Tatiana T; Siordiya, Nadia N; Kulemina, Olga O; Sbityakova, Evgenia E; Lazorko, Natalia N; Alexeeva, Julia J; Motorin, Dmitrii D; Morozova, Elena E; Lomaia, Elza E

Publication Date: 2023

Variant appearance in text: CP: E255K

PubMed Link: 37007128

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• Main text
• fonc-13-1138683.pdf

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Asciminib monotherapy in patients with CML-CP without BCR::ABL1 T315I mutations treated with at least two prior TKIs: 4-year phase 1 safety and efficacy results.

Leukemia

Mauro, Michael J MJ; Hughes, Timothy P TP; Kim, Dong-Wook DW; Rea, Delphine D; Cortes, Jorge E JE; Hochhaus, Andreas A; Sasaki, Koji K; Breccia, Massimo M; Talpaz, Moshe M; Ottmann, Oliver O; Minami, Hironobu H; Goh, Yeow Tee YT; DeAngelo, Daniel J DJ; Heinrich, Michael C MC; Gómez-García de Soria, Valle V; le Coutre, Philipp P; Mahon, Francois-Xavier FX; Janssen, Jeroen J W M JJWM; Deininger, Michael M; Shanmuganathan, Naranie N; Geyer, Mark B MB; Cacciatore, Silvia S; Polydoros, Fotis F; Agrawal, Nithya N; Hoch, Matthias M; Lang, Fabian F

Publication Date: 2023-03-22

Variant appearance in text: CP: E255K

PubMed Link: 36949155

Variant Present in the following documents:

• 41375_2023_1860_MOESM1_ESM.pdf

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Whole-exome sequencing identified recurrent and novel variants in benzene-induced leukemia.

Bmc Medical Genomics

Lin, Dafeng D; Wang, Dianpeng D; Li, Peimao P; Deng, Lihua L; Zhang, Zhimin Z; Zhang, Yanfang Y; Zhang, Ming M; Zhang, Naixing N

Publication Date: 2023-01-26

Variant appearance in text: CP: E255K

PubMed Link: 36703207

Variant Present in the following documents:

• Main text
• 12920_2023_Article_1442.pdf

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Downregulation of Stearoyl-CoA Desaturase 1 (SCD-1) Promotes Resistance to Imatinib in Chronic Myeloid Leukemia.

Mediterranean Journal Of Hematology And Infectious Diseases

Altinok Gunes, Buket B; Hekmatshoar, Yalda Y; Ozkan, Tulin T; Bozkurt, Sureyya S; Erdogan Aydos, O Sena OS; Buyukasik, Yahya Y; Aladag, Elifcan E; Sunguroglu, Asuman A

Publication Date: 2023

Variant appearance in text: CP: E255K

PubMed Link: 36660357

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• Main text
• mjhid-15-1-e2023008.pdf

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Long-Term Molecular Remission after Treatment with Imatinib in a Chronic Myeloid Leukemia Patient with Extreme Thrombocytosis Harboring Rare e14a3 (b3a3) BCR::ABL1 Transcript: A Case Report.

Current Oncology (Toronto, Ont.)

Zhang, Xupai X; Sun, Haoping H; Su, Yi Y; Yi, Hai H

Publication Date: 2022-10-28

Variant appearance in text: CP: E255K

PubMed Link: 36354705

Variant Present in the following documents:

• curroncol-29-00645.pdf

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Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial.

Journal Of Hematology & Oncology

Jiang, Qian Q; Li, Zongru Z; Qin, Yazhen Y; Li, Weiming W; Xu, Na N; Liu, Bingcheng B; Zhang, Yanli Y; Meng, Li L; Zhu, Huanling H; Du, Xin X; Chen, Suning S; Liang, Yang Y; Hu, Yu Y; Liu, Xiaoli X; Song, Yongping Y; Men, Lichuang L; Chen, Zi Z; Niu, Qian Q; Wang, Hengbang H; Lu, Ming M; Yang, Dajun D; Zhai, Yifan Y; Huang, Xiaojun X

Publication Date: 2022-08-18

Variant appearance in text: CP: E255K

PubMed Link: 35982483

Variant Present in the following documents:

• Main text
• 13045_2022_Article_1334.pdf

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Onset of blast crisis in chronic myeloid leukemia patients in treatment-free remission.

Haematologica

Dulucq, Stephanie S; Hayette, Sandrine S; Cayuela, Jean-Michel JM; Bauduer, Frédéric F; Chabane, Kaddour K; Chevallier, Patrice P; Cony-Makhoul, Pascale P; Flandrin-Gresta, Pascale P; Jeune, Caroline Le CL; Bris, Yannick Le YL; Legros, Laurence L; Maisonneuve, Hervé H; Roy, Lydia L; Mahon, Francois-Xavier FX; Sloma, Ivan I; Rea, Delphine D; Nicolini, Franck Emmanuel FE

Publication Date: 2022-12-01

Variant appearance in text: CP: E255K

PubMed Link: 35924576

Variant Present in the following documents:

• Main text
• 1072944.pdf

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Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA.

Scientific Reports

Sánchez, Ricardo R; Dorado, Sara S; Ruíz-Heredia, Yanira Y; Martín-Muñoz, Alejandro A; Rosa-Rosa, Juan Manuel JM; Ribera, Jordi J; García, Olga O; Jimenez-Ubieto, Ana A; Carreño-Tarragona, Gonzalo G; Linares, María M; Rufián, Laura L; Juárez, Alexandra A; Carrillo, Jaime J; Espino, María José MJ; Cáceres, Mercedes M; Expósito, Sara S; Cuevas, Beatriz B; Vanegas, Raúl R; Casado, Luis Felipe LF; Torrent, Anna A; Zamora, Lurdes L; Mercadal, Santiago S; Coll, Rosa R; Cervera, Marta M; Morgades, Mireia M; Hernández-Rivas, José Ángel JÁ; Bravo, Pilar P; Serí, Cristina C; Anguita, Eduardo E; Barragán, Eva E; Sargas, Claudia C; Ferrer-Marín, Francisca F; Sánchez-Calero, Jorge J; Sevilla, Julián J; Ruíz, Elena E; Villalón, Lucía L; Del Mar Herráez, María M; Riaza, Rosalía R; Magro, Elena E; Steegman, Juan Luis JL; Wang, Chongwu C; de Toledo, Paula P; García-Gutiérrez, Valentín V; Ayala, Rosa R; Ribera, Josep-Maria JM; Barrio, Santiago S; Martínez-López, Joaquín J

Publication Date: 2022-07-29

Variant appearance in text: CP: E255K

PubMed Link: 35906470

Variant Present in the following documents:

• 41598_2022_17271_MOESM3_ESM.xlsx, sheet 1

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KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response.

Cell Death & Disease

Shen, Xiaohui X; Zhang, Yuchen Y; Xu, Zhuoqing Z; Gao, Han H; Feng, Wenqing W; Li, Wenchang W; Miao, Yiming Y; Xu, Zifeng Z; Zong, Yaping Y; Zhao, Jingkun J; Lu, Aiguo A

Publication Date: 2022-04-05

Variant appearance in text: CP: E255K

PubMed Link: 35379798

Variant Present in the following documents:

• 41419_2022_4773_MOESM9_ESM.xlsx, sheet 1

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Contribution of BCR-ABL molecular variants and leukemic stem cells in response and resistance to tyrosine kinase inhibitors: a review.

F1000Research

Al Hamad, Mohammad M

Publication Date: 2021

Variant appearance in text: CP: E255K

PubMed Link: 35284066

Variant Present in the following documents:

• Main text
• f1000research-10-120985.pdf

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Potential Approaches Versus Approved or Developing Chronic Myeloid Leukemia Therapy.

Frontiers In Oncology

Andretta, Emanuela E; Costa, Caterina C; Longobardi, Consiglia C; Damiano, Sara S; Giordano, Antonio A; Pagnini, Francesco F; Montagnaro, Serena S; Quintiliani, Massimiliano M; Lauritano, Chiara C; Ciarcia, Roberto R

Publication Date: 2021

Variant appearance in text: CP: E255K

PubMed Link: 34993151

Variant Present in the following documents:

• Main text
• fonc-11-801779.pdf

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Somatic Mutations in Oncogenes Are in Chronic Myeloid Leukemia Acquired De Novo via Deregulated Base-Excision Repair and Alternative Non-Homologous End Joining.

Frontiers In Oncology

Curik, Nikola N; Polivkova, Vaclava V; Burda, Pavel P; Koblihova, Jitka J; Laznicka, Adam A; Kalina, Tomas T; Kanderova, Veronika V; Brezinova, Jana J; Ransdorfova, Sarka S; Karasova, Dominika D; Rejlova, Katerina K; Bakardjieva, Marina M; Kuzilkova, Daniela D; Kundrat, David D; Linhartova, Jana J; Klamova, Hana H; Salek, Cyril C; Klener, Pavel P; Hrusak, Ondrej O; Machova Polakova, Katerina K

Publication Date: 2021

Variant appearance in text: CP: E255K

PubMed Link: 34616685

Variant Present in the following documents:

• Main text

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[Analysis of clinical features and prognosis of patients with chronic myelogenous leukemia harboring additional chromosomal abnormalities in Ph-positive cells].

Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi

Dong, X Y XY; Li, Y L YL; Wu, C Y CY; Shang, B J BJ; Zhang, L L; Cheng, W W; Zhu, Z M ZM

Publication Date: 2021-08-14

Variant appearance in text: CP: E255K

PubMed Link: 34547872

Variant Present in the following documents:

• Main text
• cjh-42-08-660.pdf

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Imatinib Efficacy, Safety and Resistance in Iranian Patients with Chronic Myeloid Leukemia: A Review of Literature.

International Journal Of Hematology-Oncology And Stem Cell Research

Amouei, Asiyeh A; Daeian, Nesa N; Khezrnia, Seyedeh Sana SS; Mansouri, Ava A; Hadjibabaie, Molouk M

Publication Date: 2021-04-01

Variant appearance in text: CP: E255K

PubMed Link: 34466210

Variant Present in the following documents:

• Main text
• IJHOSCR-15-114.pdf

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Spectrum of BCR-ABL Mutations and Treatment Outcomes in Ethiopian Imatinib-Resistant Patients With Chronic Myeloid Leukemia.

Jco Global Oncology

Tadesse, Fisihatsion F; Asres, Getahun G; Abubeker, Abdulaziz A; Gebremedhin, Amha A; Radich, Jerald J

Publication Date: 2021-07

Variant appearance in text: CP: E255K

PubMed Link: 34292760

Variant Present in the following documents:

• go-7-go.21.00058.pdf

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Understanding and Monitoring Chronic Myeloid Leukemia Blast Crisis: How to Better Manage Patients.

Cancer Management And Research

Wang, Lulu L; Li, Li L; Chen, Rongrong R; Huang, Xianbo X; Ye, Xiujin X

Publication Date: 2021

Variant appearance in text: CP: E255K

PubMed Link: 34188552

Variant Present in the following documents:

• Main text

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Discovery and Protein Modeling Studies of Novel Compound Mutations Causing Resistance to Multiple Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia.

Asian Pacific Journal Of Cancer Prevention : Apjcp

Iqbal, Zafar Z; Absar, Muhammad M; Mahmood, Amer A; Aleem, Aamer A; Iqbal, Mudassar M; Jameel, Abid A; Akhtar, Tanveer T; Karim, Sajjad S; Rasool, Mahmood M; Mirza, Zeenat Z; Khalid, Muhammad M; Akram, Afia Muhammad AM; Sabar, Muhammad Farooq MF; Khalid, Ahmad M AM; Aljarrah, Khalid K; Iqbal, Janhangir J; Khalid, Muhammad M; Shah, Ijaz H IH; Alanazi, Nawaf N

Publication Date: 2020-12-01

Variant appearance in text: CP: E255K

PubMed Link: 33369447

Variant Present in the following documents:

• Main text
• APJCP-21-3517.pdf

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Prevalence and types of inconsistencies in clinical pharmacogenetic recommendations among major U.S. sources.

Npj Genomic Medicine

Shugg, Tyler T; Pasternak, Amy L AL; London, Bianca B; Luzum, Jasmine A JA

Publication Date: 2020

Variant appearance in text: CP: E255K

PubMed Link: 33145028

Variant Present in the following documents:

• 41525_2020_156_MOESM2_ESM.xlsx, sheet 2
• 41525_2020_156_MOESM2_ESM.xlsx, sheet 3
• 41525_2020_156_MOESM2_ESM.xlsx, sheet 1

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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology

Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S

Publication Date: 2020

Variant appearance in text: CP: E255K

PubMed Link: 33133066

Variant Present in the following documents:

• fimmu-11-524968.pdf

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Role of Stem-Cell Transplantation in Leukemia Treatment.

Stem Cells And Cloning : Advances And Applications

Dessie, Gashaw G; Derbew Molla, Meseret M; Shibabaw, Tewodros T; Ayelign, Birhanu B

Publication Date: 2020

Variant appearance in text: CP: E255K

PubMed Link: 32982314

Variant Present in the following documents:

• Main text
• sccaa-13-67.pdf

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PVR and ICAM-1 on Blast Crisis CML Stem and Progenitor Cells with TKI Resistance Confer Susceptibility to NK Cells.

Cancers

Kim, Nayoung N; Kim, Mi-Yeon MY; Cho, Young-Uk YU; Chen, WenYong W; Lee, Kyoo-Hyung KH; Kim, Hun Sik HS

Publication Date: 2020-07-16

Variant appearance in text: CP: E255K

PubMed Link: 32708713

Variant Present in the following documents:

• Main text

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Bcr-Abl Tyrosine Kinase Inhibitors in the Treatment of Pediatric CML.

International Journal Of Molecular Sciences

Carofiglio, Francesca F; Lopalco, Antonio A; Lopedota, Angela A; Cutrignelli, Annalisa A; Nicolotti, Orazio O; Denora, Nunzio N; Stefanachi, Angela A; Leonetti, Francesco F

Publication Date: 2020-06-23

Variant appearance in text: CP: E255K

PubMed Link: 32586039

Variant Present in the following documents:

• Main text
• ijms-21-04469.pdf

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T-cell blast crisis of chronic myelogenous leukemia presented with coexisting p210 and p190 BCR-ABL transcripts and t(10;11)(q11;p15).

Journal Of Clinical Laboratory Analysis

Xia, Ting T; Yang, Yuchao Y; Li, Guoxia G; Chang, Jianmei J; Li, Jianlan J; Ren, Fanggang F; Ren, Weixiao W; Wang, Hongwei H; Xu, Zhifang Z

Publication Date: 2020-06

Variant appearance in text: CP: E255K

PubMed Link: 32052899

Variant Present in the following documents:

• Main text
• JCLA-34-e23241.pdf

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CDK4/CDK6 inhibition as a novel strategy to suppress the growth and survival of BCR-ABL1T315I+ clones in TKI-resistant CML.

Ebiomedicine

Schneeweiss-Gleixner, Mathias M; Byrgazov, Konstantin K; Stefanzl, Gabriele G; Berger, Daniela D; Eisenwort, Gregor G; Lucini, Chantal Blanche CB; Herndlhofer, Susanne S; Preuner, Sandra S; Obrova, Klara K; Pusic, Petra P; Witzeneder, Nadine N; Greiner, Georg G; Hoermann, Gregor G; Sperr, Wolfgang R WR; Lion, Thomas T; Deininger, Michael M; Valent, Peter P; Gleixner, Karoline V KV

Publication Date: 2019-12

Variant appearance in text: CP: E255K

PubMed Link: 31761618

Variant Present in the following documents:

• Main text

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Towards a Personalized Treatment of Patients with Chronic Myeloid Leukemia.

Current Hematologic Malignancy Reports

Rabian, Florence F; Lengline, Etienne E; Rea, Delphine D

Publication Date: 2019-12

Variant appearance in text: CP: E255K

PubMed Link: 31760572

Variant Present in the following documents:

• Main text
• 11899_2019_Article_546.pdf

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WHO 2016 Definition of Chronic Myeloid Leukemia and Tyrosine Kinase Inhibitors

Turkish Journal Of Haematology : Official Journal Of Turkish Society Of Haematology

Haznedaroğlu, İbrahim C. İC; Kuzu, Işınsu I; İlhan, Osman O

Publication Date: 2020-02-20

Variant appearance in text: CP: E255K

PubMed Link: 31612694

Variant Present in the following documents:

• TJH-37-42.pdf

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Phase 2 study of nilotinib in pediatric patients with Philadelphia chromosome-positive chronic myeloid leukemia.

Blood

Hijiya, Nobuko N; Maschan, Alexey A; Rizzari, Carmelo C; Shimada, Hiroyuki H; Dufour, Carlo C; Goto, Hiroaki H; Kang, Hyoung Jin HJ; Guinipero, Terri T; Karakas, Zeynep Z; Bautista, Francisco F; Ducassou, Stéphane S; Yoo, Keon Hee KH; Zwaan, Christian Michel CM; Millot, Frédéric F; Aimone, Paola P; Allepuz, Alex A; Quenet, Sara S; Hourcade-Potelleret, Florence F; Hertle, Sabine S; Sosothikul, Darintr D

Publication Date: 2019-12-05

Variant appearance in text: CP: E255K

PubMed Link: 31511239

Variant Present in the following documents:

• Main text

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Incidence and outcome of BCR-ABL mutated chronic myeloid leukemia patients who failed to tyrosine kinase inhibitors.

Cancer Medicine

Etienne, Gabriel G; Dulucq, Stéphanie S; Huguet, Françoise F; Schmitt, Anna A; Lascaux, Axelle A; Hayette, Sandrine S; Fort, Marie-Pierre MP; Sujobert, Pierre P; Bijou, Fontanet F; Morisset, Stéphane S; Tavitian, Suzanne S; Bidet, Audrey A; Turcq, Beatrice B; Robbesyn, Fanny F; Chollet, Claudine C; Belloc, Francis F; Durrieu, Françoise F; Mahon, François-Xavier FX; Nicolini, Franck E FE

Publication Date: 2019-09

Variant appearance in text: CP: E255K

PubMed Link: 31350815

Variant Present in the following documents:

• Main text
• CAM4-8-5173.pdf

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[Clinical characteristics of chronic myeloid leukemia with T315I mutation and the efficacy of ponatinib].

Nan Fang Yi Ke Da Xue Xue Bao = Journal Of Southern Medical University

Chen, Chen C; Xu, Na N; Jiang, Xuejie X; Wu, Waner W; Zhou, Xuan X; Liu, Liang L; Huang, Jixian J; Yin, Changxin C; Cao, Rui R; Liao, Libin L; Xu, Dan D; Zhang, Yuming Y; Liu, Qifa Q; Liu, Xiaoli X

Publication Date: 2019-03-30

Variant appearance in text: CP: E255K

PubMed Link: 31068313

Variant Present in the following documents:

• Main text

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A kinase profile-adapted drug combination elicits synergistic cooperative effects on leukemic cells carrying BCR-ABL1T315I in Ph+ CML.

Leukemia Research

Gleixner, Karoline V KV; Sadovnik, Irina I; Schneeweiss, Mathias M; Eisenwort, Gregor G; Byrgazov, Konstantin K; Stefanzl, Gabriele G; Berger, Daniela D; Herrmann, Harald H; Hadzijusufovic, Emir E; Lion, Thomas T; Valent, Peter P

Publication Date: 2019-03

Variant appearance in text: CP: E255K

PubMed Link: 30711891

Variant Present in the following documents:

• Main text

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Prevalence of BCR-ABL T315I Mutation in Malaysian Patients with Imatinib-Resistant Chronic Myeloid Leukemia

Asian Pacific Journal Of Cancer Prevention : Apjcp

Mat Yusoff, Yuslina Y; Abu Seman, Zahidah Z; Othman, Norodiyah N; Kamaluddin, Nor Rizan NR; Esa, Ezalia E; Zulkiply, Nor Amalina NA; Abdullah, Julia J; Zakaria, Zubaidah Z

Publication Date: 2018-12-25

Variant appearance in text: CP: E255K

PubMed Link: 30583336

Variant Present in the following documents:

• Main text
• APJCP-19-3317.pdf

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Long-term efficacy and safety of dasatinib in patients with chronic myeloid leukemia in accelerated phase who are resistant to or intolerant of imatinib.

Blood Cancer Journal

Ottmann, Oliver O; Saglio, Giuseppe G; Apperley, Jane F JF; Arthur, Christopher C; Bullorsky, Eduardo E; Charbonnier, Aude A; Dipersio, John F JF; Kantarjian, Hagop H; Khoury, Hanna Jean HJ; Kim, Dong-Wook DW; Healey, Diane D; Strauss, Lewis L; Cortes, Jorge E JE

Publication Date: 2018-09-03

Variant appearance in text: CP: E255K

PubMed Link: 30190469

Variant Present in the following documents:

• Main text
• 41408_2018_Article_122.pdf

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Safety and efficacy of second-line bosutinib for chronic phase chronic myeloid leukemia over a five-year period: final results of a phase I/II study.

Haematologica

Gambacorti-Passerini, Carlo C; Cortes, Jorge E JE; Lipton, Jeff H JH; Kantarjian, Hagop M HM; Kim, Dong-Wook DW; Schafhausen, Philippe P; Crescenzo, Rocco R; Bardy-Bouxin, Nathalie N; Shapiro, Mark M; Noonan, Kay K; Leip, Eric E; DeAnnuntis, Liza L; Brümmendorf, Tim H TH; Khoury, H Jean HJ

Publication Date: 2018-08

Variant appearance in text: CP: E255K

PubMed Link: 29773593

Variant Present in the following documents:

• 2017.171249.GAMBACORTI-PASSERINI_SUPPL.pdf

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Excellent outcomes of 2G-TKI therapy after imatinib failure in chronic phase CML patients.

Oncotarget

Tiribelli, Mario M; Bonifacio, Massimiliano M; Binotto, Gianni G; Iurlo, Alessandra A; Cibien, Francesca F; Maino, Elena E; Guella, Anna A; Festini, Gianluca G; Minotto, Claudia C; De Biasi, Ercole E; De Marchi, Federico F; Scaffidi, Luigi L; Frison, Luca L; Bucelli, Cristina C; Medeot, Marta M; Calistri, Elisabetta E; Sancetta, Rosaria R; Stulle, Manuela M; Orofino, Nicola N; Krampera, Mauro M; Gherlinzoni, Filippo F; Semenzato, Gianpietro G; Pizzolo, Giovanni G; Ambrosetti, Achille A; Fanin, Renato R

Publication Date: 2018-03-06

Variant appearance in text: CP: E255K

PubMed Link: 29581839

Variant Present in the following documents:

• Main text

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Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant.

Cell Death & Disease

Jin, Bei B; Wang, Chengyan C; Shen, Yingying Y; Pan, Jingxuan J

Publication Date: 2018-01-22

Variant appearance in text: CP: E255K

PubMed Link: 29358661

Variant Present in the following documents:

• Main text
• 41419_2017_Article_75.pdf

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Life after ponatinib failure: outcomes of chronic and accelerated phase CML patients who discontinued ponatinib in the salvage setting.

Leukemia & Lymphoma

Boddu, Prajwal P; Shah, Abdul Rashid AR; Borthakur, Gautam G; Verstovsek, Srdan S; Garcia-Manero, Guillermo G; Daver, Naval N; Kadia, Tapan T; Ravandi, Farhad F; Jain, Nitin N; Alhuraiji, Ahmad A; Burger, Jan J; Kornblau, Steven S; Pierce, Sherry S; Dellasala, Sara S; Jabbour, Elias E; Kantarjian, Hagop H; Cortes, Jorge J

Publication Date: 2018-06

Variant appearance in text: CP: E255K

PubMed Link: 28972430

Variant Present in the following documents:

• Main text

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Cephalotaxus Alkaloids.

The Alkaloids. Chemistry And Biology

Pérard-Viret, Joëlle J; Quteishat, Laith L; Alsalim, Rana R; Royer, Jacques J; Dumas, Françoise F

Publication Date: 2017

Variant appearance in text: CP: E255K

PubMed Link: 28838429

Variant Present in the following documents:

• Main text

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Prognostic factors and survival outcomes in patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era: Cohort study of 477 patients.

Cancer

Jain, Preetesh P; Kantarjian, Hagop M HM; Ghorab, Ahmad A; Sasaki, Koji K; Jabbour, Elias J EJ; Nogueras Gonzalez, Graciela G; Kanagal-Shamanna, Rashmi R; Issa, Ghayas C GC; Garcia-Manero, Guillermo G; Kc, Devendra D; Dellasala, Sara S; Pierce, Sherry S; Konopleva, Marina M; Wierda, William G WG; Verstovsek, Srdan S; Daver, Naval G NG; Kadia, Tapan M TM; Borthakur, Gautam G; O'Brien, Susan S; Estrov, Zeev Z; Ravandi, Farhad F; Cortes, Jorge E JE

Publication Date: 2017-11-15

Variant appearance in text: CP: E255K

PubMed Link: 28743165

Variant Present in the following documents:

• Main text

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Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia.

Haematologica

Gleixner, Karoline V KV; Schneeweiss, Mathias M; Eisenwort, Gregor G; Berger, Daniela D; Herrmann, Harald H; Blatt, Katharina K; Greiner, Georg G; Byrgazov, Konstantin K; Hoermann, Gregor G; Konopleva, Marina M; Waliul, Islam I; Cumaraswamy, Abbarna A AA; Gunning, Patrick T PT; Maeda, Hiroshi H; Moriggl, Richard R; Deininger, Michael M; Lion, Thomas T; Andreeff, Michael M; Valent, Peter P

Publication Date: 2017-09

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PubMed Link: 28596283

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Phase II trial of homoharringtonine with imatinib in chronic, accelerated, and blast phase chronic myeloid leukemia.

Leukemia & Lymphoma

Maiti, Abhishek A; Cortes, Jorge J; Ferrajoli, Alessandra A; Estrov, Zeev Z; Borthakur, Gautam G; Garcia-Manero, Guillermo G; Jabbour, Elias E; Ravandi, Farhad F; O'Brien, Susan S; Kantarjian, Hagop H

Publication Date: 2017-09

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PubMed Link: 28278723

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Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors.

Oncotarget

Pietarinen, Paavo O PO; Eide, Christopher A CA; Ayuda-Durán, Pilar P; Potdar, Swapnil S; Kuusanmäki, Heikki H; Andersson, Emma I EI; Mpindi, John P JP; Pemovska, Tea T; Kontro, Mika M; Heckman, Caroline A CA; Kallioniemi, Olli O; Wennerberg, Krister K; Hjorth-Hansen, Henrik H; Druker, Brian J BJ; Enserink, Jorrit M JM; Tyner, Jeffrey W JW; Mustjoki, Satu S; Porkka, Kimmo K

Publication Date: 2017-04-04

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PubMed Link: 28186983

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Phase 1 dose-finding study of rebastinib (DCC-2036) in patients with relapsed chronic myeloid leukemia and acute myeloid leukemia.

Haematologica

Cortes, Jorge J; Talpaz, Moshe M; Smith, Hedy P HP; Snyder, David S DS; Khoury, Jean J; Bhalla, Kapil N KN; Pinilla-Ibarz, Javier J; Larson, Richard R; Mitchell, David D; Wise, Scott C SC; Rutkoski, Thomas J TJ; Smith, Bryan D BD; Flynn, Daniel L DL; Kantarjian, Hagop M HM; Rosen, Oliver O; Van Etten, Richard A RA

Publication Date: 2017-03

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PubMed Link: 27927766

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Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia.

The Journal Of Clinical Investigation

Jin, Yanli Y; Zhou, Jingfeng J; Xu, Fang F; Jin, Bei B; Cui, Lijing L; Wang, Yun Y; Du, Xin X; Li, Juan J; Li, Peng P; Ren, Ruibao R; Pan, Jingxuan J

Publication Date: 2016-10-03

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PubMed Link: 27643437

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Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with Imatinib.

Theranostics

Jin, Yanli Y; Yao, Yiwu Y; Chen, Li L; Zhu, Xiaohui X; Jin, Bei B; Shen, Yingying Y; Li, Juan J; Du, Xin X; Lu, Yuhong Y; Jiang, Sheng S; Pan, Jingxuan J

Publication Date: 2016

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PubMed Link: 27570562

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Role of tyrosine-kinase inhibitors in myeloproliferative neoplasms: comparative lessons learned.

Oncotargets And Therapy

Pinilla-Ibarz, Javier J; Sweet, Kendra L KL; Corrales-Yepez, Gabriela M GM; Komrokji, Rami S RS

Publication Date: 2016

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PubMed Link: 27570458

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Long-term bosutinib for chronic phase chronic myeloid leukemia after failure of imatinib plus dasatinib and/or nilotinib.

American Journal Of Hematology

Cortes, Jorge E JE; Khoury, Hanna J HJ; Kantarjian, Hagop M HM; Lipton, Jeff H JH; Kim, Dong-Wook DW; Schafhausen, Philippe P; Matczak, Ewa E; Leip, Eric E; Noonan, Kay K; Brümmendorf, Tim H TH; Gambacorti-Passerini, Carlo C

Publication Date: 2016-12

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PubMed Link: 27531525

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In chronic myeloid leukemia patients on second-line tyrosine kinase inhibitor therapy, deep sequencing of BCR-ABL1 at the time of warning may allow sensitive detection of emerging drug-resistant mutants.

Bmc Cancer

Soverini, Simona S; De Benedittis, Caterina C; Castagnetti, Fausto F; Gugliotta, Gabriele G; Mancini, Manuela M; Bavaro, Luana L; Machova Polakova, Katerina K; Linhartova, Jana J; Iurlo, Alessandra A; Russo, Domenico D; Pane, Fabrizio F; Saglio, Giuseppe G; Rosti, Gianantonio G; Cavo, Michele M; Baccarani, Michele M; Martinelli, Giovanni G

Publication Date: 2016-08-02

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PubMed Link: 27485109

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