Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.
Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Methuosis Contributes to Jaspine-B-Induced Cell Death.
International Journal Of Molecular Sciences
Bielsa, Núria N; Casasampere, Mireia M; Abad, Jose Luis JL; Enrich, Carlos C; Delgado, Antonio A; Fabriàs, Gemma G; Lizcano, Jose M JM; Casas, Josefina J
The Impact of Comprehensive Genomic Profiling (CGP) on the Decision-Making Process in the Treatment of ALK-Rearranged Advanced Non-Small Cell Lung Cancer (aNSCLC) After Failure of 2nd/3rd-Generation ALK Tyrosine Kinase Inhibitors (TKIs).
Frontiers In Oncology
Raphael, Ari A; Onn, Amir A; Holtzman, Liran L; Dudnik, Julia J; Urban, Damien D; Kian, Waleed W; Cohen, Aharon Y AY; Moskovitz, Mor M; Zer, Alona A; Bar, Jair J; Rabinovich, Natalie Maimon NM; Grynberg, Shirly S; Oedegaard, Cecilie C; Agbarya, Abed A; Peled, Nir N; Shochat, Tzippy T; Dudnik, Elizabeth E
Cobimetinib Plus Gemcitabine: An Active Combination in KRAS G12R-Mutated Pancreatic Ductal Adenocarcinoma Patients in Previously Treated and Failed Multiple Chemotherapies.
Journal Of Pancreatic Cancer
Ardalan, Bach B; Azqueta, Jose J; Sleeman, Danny D
Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease.
Jco Precision Oncology
Page, Karen K; Martinson, Luke J LJ; Fernandez-Garcia, Daniel D; Hills, Allison A; Gleason, Kelly L T KLT; Gray, Molly C MC; Rushton, Amelia J AJ; Nteliopoulos, Georgios G; Hastings, Robert K RK; Goddard, Kate K; Ions, Charlotte C; Parmar, Vilas V; Primrose, Lindsay L; Openshaw, Mark R MR; Guttery, David S DS; Palmieri, Carlo C; Ali, Simak S; Stebbing, Justin J; Coombes, R Charles RC; Shaw, Jacqueline A JA
Diverse 'just-right' levels of chromosomal instability and their clinical implications in neoadjuvant treated gastric cancer.
British Journal Of Cancer
Kohlruss, Meike M; Krenauer, Marie M; Grosser, Bianca B; Pfarr, Nicole N; Jesinghaus, Moritz M; Slotta-Huspenina, Julia J; Novotny, Alexander A; Hapfelmeier, Alexander A; Schmidt, Thomas T; Steiger, Katja K; Gaida, Matthias M MM; Reiche, Magdalena M; Bauer, Lukas L; Ott, Katja K; Weichert, Wilko W; Keller, Gisela G
Association of tumor mutation burden and epidermal growth factor receptor inhibitor history with survival in patients with metastatic stage III/IV non-small-cell lung cancer: A retrospective study.
Clinics (Sao Paulo, Brazil)
Lan, Yan Y; Zhou, Shuo S; Feng, Weihong W; Qiao, Ying Y; Du, Xueming X; Li, Fenge F
The Clinical Significance of RAS, PIK3CA, and PTEN Mutations in Non-Small Cell Lung Cancer Using Cell-Free DNA.
Journal Of Clinical Medicine
Chang, Won Jin WJ; Sung, Jae Sook JS; Lee, Sung Yong SY; Kang, Eun Joo EJ; Kwon, Nak-Jung NJ; Kim, Hae Mi HM; Shin, Sang Won SW; Choi, Jung Yoon JY; Choi, Yoon Ji YJ; Kim, Ju Won JW; Park, Kyong Hwa KH; Kim, Yeul Hong YH
Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.
Cancer Research And Treatment
Lee, Youngwoo Y; Lee, Soohyeon S; Sung, Jae Sook JS; Chung, Hee-Joon HJ; Lim, Ah-Reum AR; Kim, Ju Won JW; Choi, Yoon Ji YJ; Park, Kyong Hwa KH; Kim, Yeul Hong YH
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.
Nature
Han, Kyuho K; Pierce, Sarah E SE; Li, Amy A; Spees, Kaitlyn K; Anderson, Gray R GR; Seoane, Jose A JA; Lo, Yuan-Hung YH; Dubreuil, Michael M; Olivas, Micah M; Kamber, Roarke A RA; Wainberg, Michael M; Kostyrko, Kaja K; Kelly, Marcus R MR; Yousefi, Maryam M; Simpkins, Scott W SW; Yao, David D; Lee, Keonil K; Kuo, Calvin J CJ; Jackson, Peter K PK; Sweet-Cordero, Alejandro A; Kundaje, Anshul A; Gentles, Andrew J AJ; Curtis, Christina C; Winslow, Monte M MM; Bassik, Michael C MC
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.
Nature
Han, Kyuho K; Pierce, Sarah E SE; Li, Amy A; Spees, Kaitlyn K; Anderson, Grace R GR; Seoane, Jose A JA; Lo, Yuan-Hung YH; Dubreuil, Michael M; Olivas, Micah M; Kamber, Roarke A RA; Wainberg, Michael M; Kostyrko, Kaja K; Kelly, Marcus R MR; Yousefi, Maryam M; Simpkins, Scott W SW; Yao, David D; Lee, Keonil K; Kuo, Calvin J CJ; Jackson, Peter K PK; Sweet-Cordero, Alejandro A; Kundaje, Anshul A; Gentles, Andrew J AJ; Curtis, Christina C; Winslow, Monte M MM; Bassik, Michael C MC
Clinical and genetic analysis of melanomas arising in acral sites.
European Journal Of Cancer (Oxford, England : 1990)
Zaremba, Anne A; Murali, Rajmohan R; Jansen, Philipp P; Möller, Inga I; Sucker, Antje A; Paschen, Annette A; Zimmer, Lisa L; Livingstone, Elisabeth E; Brinker, Titus J TJ; Hadaschik, Eva E; Franklin, Cindy C; Roesch, Alexander A; Ugurel, Selma S; Schadendorf, Dirk D; Griewank, Klaus G KG; Cosgarea, Ioana I
High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer.
Journal Of Hematology & Oncology
Xiao, Wenwu W; Ma, Weijie W; Wei, Sixi S; Li, Qianping Q; Liu, Ruiwu R; Carney, Randy P RP; Yang, Kevin K; Lee, Joyce J; Nyugen, Alan A; Yoneda, Ken Y KY; Lam, Kit S KS; Li, Tianhong T
Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth.
Integrative omics analyses broaden treatment targets in human cancer.
Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.
The Lancet. Gastroenterology & Hepatology
Domingo, Enric E; Camps, Carme C; Kaisaki, Pamela J PJ; Parsons, Marie J MJ; Mouradov, Dmitri D; Pentony, Melissa M MM; Makino, Seiko S; Palmieri, Michelle M; Ward, Robyn L RL; Hawkins, Nicholas J NJ; Gibbs, Peter P; Askautrud, Hanne H; Oukrif, Dahmane D; Wang, Haitao H; Wood, Joe J; Tomlinson, Evie E; Bark, Yasmine Y; Kaur, Kulvinder K; Johnstone, Elaine C EC; Palles, Claire C; Church, David N DN; Novelli, Marco M; Danielsen, Havard E HE; Sherlock, Jon J; Kerr, David D; Kerr, Rachel R; Sieber, Oliver O; Taylor, Jenny C JC; Tomlinson, Ian I
Integrated Molecular Characterization of Testicular Germ Cell Tumors.
Cell Reports
Shen, Hui H; Shih, Juliann J; Hollern, Daniel P DP; Wang, Linghua L; Bowlby, Reanne R; Tickoo, Satish K SK; Thorsson, Vésteinn V; Mungall, Andrew J AJ; Newton, Yulia Y; Hegde, Apurva M AM; Armenia, Joshua J; Sánchez-Vega, Francisco F; Pluta, John J; Pyle, Louise C LC; Mehra, Rohit R; Reuter, Victor E VE; Godoy, Guilherme G; Jones, Jeffrey J; Shelley, Carl S CS; Feldman, Darren R DR; Vidal, Daniel O DO; Lessel, Davor D; Kulis, Tomislav T; Cárcano, Flavio M FM; Leraas, Kristen M KM; Lichtenberg, Tara M TM; Brooks, Denise D; Cherniack, Andrew D AD; Cho, Juok J; Heiman, David I DI; Kasaian, Katayoon K; Liu, Minwei M; Noble, Michael S MS; Xi, Liu L; Zhang, Hailei H; Zhou, Wanding W; ZenKlusen, Jean C JC; Hutter, Carolyn M CM; Felau, Ina I; Zhang, Jiashan J; Schultz, Nikolaus N; Getz, Gad G; Meyerson, Matthew M; Stuart, Joshua M JM; , ; Akbani, Rehan R; Wheeler, David A DA; Laird, Peter W PW; Nathanson, Katherine L KL; Cortessis, Victoria K VK; Hoadley, Katherine A KA
Molecular mechanism of action and potential biomarkers of growth inhibition of synergistic combination of afatinib and dasatinib against gefitinib-resistant non-small cell lung cancer cells.
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.
Nature Communications
Goodwin, Justin J; Neugent, Michael L ML; Lee, Shin Yup SY; Choe, Joshua H JH; Choi, Hyunsung H; Jenkins, Dana M R DMR; Ruthenborg, Robin J RJ; Robinson, Maddox W MW; Jeong, Ji Yun JY; Wake, Masaki M; Abe, Hajime H; Takeda, Norihiko N; Endo, Hiroko H; Inoue, Masahiro M; Xuan, Zhenyu Z; Yoo, Hyuntae H; Chen, Min M; Ahn, Jung-Mo JM; Minna, John D JD; Helke, Kristi L KL; Singh, Pankaj K PK; Shackelford, David B DB; Kim, Jung-Whan JW
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Nature Communications
Schütte, Moritz M; Risch, Thomas T; Abdavi-Azar, Nilofar N; Boehnke, Karsten K; Schumacher, Dirk D; Keil, Marlen M; Yildiriman, Reha R; Jandrasits, Christine C; Borodina, Tatiana T; Amstislavskiy, Vyacheslav V; Worth, Catherine L CL; Schweiger, Caroline C; Liebs, Sandra S; Lange, Martin M; Warnatz, Hans-Jörg HJ; Butcher, Lee M LM; Barrett, James E JE; Sultan, Marc M; Wierling, Christoph C; Golob-Schwarzl, Nicole N; Lax, Sigurd S; Uranitsch, Stefan S; Becker, Michael M; Welte, Yvonne Y; Regan, Joseph Lewis JL; Silvestrov, Maxine M; Kehler, Inge I; Fusi, Alberto A; Kessler, Thomas T; Herwig, Ralf R; Landegren, Ulf U; Wienke, Dirk D; Nilsson, Mats M; Velasco, Juan A JA; Garin-Chesa, Pilar P; Reinhard, Christoph C; Beck, Stephan S; Schäfer, Reinhold R; Regenbrecht, Christian R A CR; Henderson, David D; Lange, Bodo B; Haybaeck, Johannes J; Keilholz, Ulrich U; Hoffmann, Jens J; Lehrach, Hans H; Yaspo, Marie-Laure ML