PIK3CA c.34G>A ;(p.G12S)

Variant ID: 3-178916647-G-A

NM_006218.2(PIK3CA):c.34G>A;(p.G12S)

This variant was identified in 90 publications

View GRCh38 version.




Publications:


Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: PIK3CA: G12S
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
View BVdb publication page



Plasma ctDNA increases tissue NGS-based detection of therapeutically targetable mutations in lung cancers.

Bmc Cancer
Xie, Jianjiang J; Yao, Weishen W; Chen, Lingxiu L; Zhu, Wenjun W; Liu, Qiang Q; Geng, Geng G; Fang, Jing J; Zhao, Yang Y; Xiao, Li L; Huang, Zhenhua Z; Zhao, Jing J
Publication Date: 2023-03-31

Variant appearance in text: PIK3CA: Gly12Ser
PubMed Link: 37004022
Variant Present in the following documents:
  • 12885_2023_Article_10674.pdf
View BVdb publication page



KRAS, NRAS, BRAF, and PIK3CA mutation rates, clinicopathological association, and their prognostic value in Iranian colorectal cancer patients.

Journal Of Clinical Laboratory Analysis
Mirzapoor Abbasabadi, Zohreh Z; Hamedi Asl, Dariush D; Rahmani, Babak B; Shahbadori, Rozhin R; Karami, Sara S; Peymani, Amir A; Taghizadeh, Sara S; Samiee Rad, Fatemeh F
Publication Date: 2023-03-17

Variant appearance in text: PIK3CA: G12S
PubMed Link: 36930789
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mutations in the MET tyrosine kinase domain and resistance to tyrosine kinase inhibitors in non-small-cell lung cancer.

Respiratory Research
Yao, Yu Y; Yang, Huaping H; Zhu, Bo B; Wang, Song S; Pang, Jiaohui J; Wu, Xiaoying X; Xu, Yang Y; Zhang, Junli J; Zhang, Jinfeng J; Ou, Qiuxiang Q; Tian, Hui H; Zhao, Zheng Z
Publication Date: 2023-01-25

Variant appearance in text: PI3K: G12S
PubMed Link: 36698189
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Durinikova, Erika E; Reilly, Nicole M NM; Buzo, Kristi K; Mariella, Elisa E; Chilà, Rosaria R; Lorenzato, Annalisa A; Dias, João M L JML; Grasso, Gaia G; Pisati, Federica F; Lamba, Simona S; Corti, Giorgio G; Degasperi, Andrea A; Cancelliere, Carlotta C; Mauri, Gianluca G; Andrei, Pietro P; Linnebacher, Michael M; Marsoni, Silvia S; Siena, Salvatore S; Sartore-Bianchi, Andrea A; Nik-Zainal, Serena S; Di Nicolantonio, Federica F; Bardelli, Alberto A; Arena, Sabrina S
Publication Date: 2022-09-01

Variant appearance in text: PIK3CA: G12S
PubMed Link: 35881546
Variant Present in the following documents:
  • EMS151756-supplement-Table_S1.xlsx, sheet 1
View BVdb publication page



Methuosis Contributes to Jaspine-B-Induced Cell Death.

International Journal Of Molecular Sciences
Bielsa, Núria N; Casasampere, Mireia M; Abad, Jose Luis JL; Enrich, Carlos C; Delgado, Antonio A; Fabriàs, Gemma G; Lizcano, Jose M JM; Casas, Josefina J
Publication Date: 2022-06-29

Variant appearance in text: PI3K: G12S
PubMed Link: 35806262
Variant Present in the following documents:
  • Main text
  • ijms-23-07257.pdf
View BVdb publication page



The Impact of Comprehensive Genomic Profiling (CGP) on the Decision-Making Process in the Treatment of ALK-Rearranged Advanced Non-Small Cell Lung Cancer (aNSCLC) After Failure of 2nd/3rd-Generation ALK Tyrosine Kinase Inhibitors (TKIs).

Frontiers In Oncology
Raphael, Ari A; Onn, Amir A; Holtzman, Liran L; Dudnik, Julia J; Urban, Damien D; Kian, Waleed W; Cohen, Aharon Y AY; Moskovitz, Mor M; Zer, Alona A; Bar, Jair J; Rabinovich, Natalie Maimon NM; Grynberg, Shirly S; Oedegaard, Cecilie C; Agbarya, Abed A; Peled, Nir N; Shochat, Tzippy T; Dudnik, Elizabeth E
Publication Date: 2022

Variant appearance in text: PIK3CA: G12S
PubMed Link: 35646707
Variant Present in the following documents:
  • Table_2.xlsx, sheet 1
View BVdb publication page



Looking at Thyroid Cancer from the Tumor-Suppressor Genes Point of View.

Cancers
Rajabi, Sadegh S; Alix-Panabières, Catherine C; Alaei, Arshia Sharbatdar AS; Abooshahab, Raziyeh R; Shakib, Heewa H; Ashrafi, Mohammad Reza MR
Publication Date: 2022-05-17

Variant appearance in text: PI3K: G12S
PubMed Link: 35626065
Variant Present in the following documents:
  • Main text
  • cancers-14-02461.pdf
View BVdb publication page



[Targeted Therapy and Mechanism of Drug Resistance in Non-small Cell Lung Cancer 
with Epidermal Growth Factor Receptor Gene Mutation].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Huang, Junxia J; Wang, Hong H
Publication Date: 2022-03-20

Variant appearance in text: PI3K: G12S
PubMed Link: 35340161
Variant Present in the following documents:
  • zgfazz-25-3-183.pdf
View BVdb publication page



Establishment and characterization of a novel highly malignant lung cancer cell line ZX2021H derived from a metastatic lymph node lesion.

Thoracic Cancer
Zu, Lingling L; Li, Xuebing X; He, Jinling J; Zhou, Ning N; Meng, Fanrong F; Li, Xiaozhou X; Xu, Song S; Zhang, Lei L
Publication Date: 2022-04

Variant appearance in text: PIK3CA: G12S
PubMed Link: 35297208
Variant Present in the following documents:
  • TCA-13-1199.pdf
View BVdb publication page



Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium.

Nature Communications
Yamaguchi, Manako M; Nakaoka, Hirofumi H; Suda, Kazuaki K; Yoshihara, Kosuke K; Ishiguro, Tatsuya T; Yachida, Nozomi N; Saito, Kyota K; Ueda, Haruka H; Sugino, Kentaro K; Mori, Yutaro Y; Yamawaki, Kaoru K; Tamura, Ryo R; Revathidevi, Sundaramoorthy S; Motoyama, Teiichi T; Tainaka, Kazuki K; Verhaak, Roel G W RGW; Inoue, Ituro I; Enomoto, Takayuki T
Publication Date: 2022-02-17

Variant appearance in text: PIK3CA: G12S
PubMed Link: 35177608
Variant Present in the following documents:
  • 41467_2022_Article_28568.pdf
View BVdb publication page



Cobimetinib Plus Gemcitabine: An Active Combination in KRAS G12R-Mutated Pancreatic Ductal Adenocarcinoma Patients in Previously Treated and Failed Multiple Chemotherapies.

Journal Of Pancreatic Cancer
Ardalan, Bach B; Azqueta, Jose J; Sleeman, Danny D
Publication Date: 2021

Variant appearance in text: PI3K: G12S
PubMed Link: 34901697
Variant Present in the following documents:
  • pancan.2021.0006.pdf
View BVdb publication page



Circulating Tumor DNA Profiling From Breast Cancer Screening Through to Metastatic Disease.

Jco Precision Oncology
Page, Karen K; Martinson, Luke J LJ; Fernandez-Garcia, Daniel D; Hills, Allison A; Gleason, Kelly L T KLT; Gray, Molly C MC; Rushton, Amelia J AJ; Nteliopoulos, Georgios G; Hastings, Robert K RK; Goddard, Kate K; Ions, Charlotte C; Parmar, Vilas V; Primrose, Lindsay L; Openshaw, Mark R MR; Guttery, David S DS; Palmieri, Carlo C; Ali, Simak S; Stebbing, Justin J; Coombes, R Charles RC; Shaw, Jacqueline A JA
Publication Date: 2021

Variant appearance in text: PIK3CA: G12S
PubMed Link: 34849446
Variant Present in the following documents:
  • po-5-po.20.00522.pdf
View BVdb publication page



Integrating real-time in vivo tumour genomes for longitudinal analysis and management of glioma recurrence.

Clinical And Translational Medicine
Sheng, Zhiyuan Z; Yu, Jinliang J; Deng, Kaiyuan K; Bu, Yage Y; Wu, Shuang S; Xu, Sensen S; Gao, Yushuai Y; Zhang, Qianqian Q; Yan, Zhaoyue Z; Bu, Chaojie C; Chen, Zhongcan Z; Gu, Jianjun J; Jia, Yan Y; Gao, Xinya X; Zemmar, Ajmal A; Sumardi, Fitri F; Hernesniemi, Juha J; Kong, Lingfei L; Liu, Gang G; Li, Ming M; Wang, Meiyun M; Li, Tianxiao T; Bu, Xingyao X
Publication Date: 2021-11

Variant appearance in text: PIK3CA: 34G>A; Gly12Ser
PubMed Link: 34841677
Variant Present in the following documents:
  • CTM2-11-e567-s004.xlsx, sheet 5
View BVdb publication page



Integrative Bioinformatics approaches to therapeutic gene target selection in various cancers for Nitroglycerin.

Scientific Reports
Chinnappan, Jayaprakash J; Ramu, Akilandeswari A; V, Vidhya Rajalakshmi VR; S, Akil Kavya AK
Publication Date: 2021-11-11

Variant appearance in text: PI3K: G12S
PubMed Link: 34764329
Variant Present in the following documents:
  • 41598_2021_Article_1508.pdf
View BVdb publication page



Tumor DNA From Tumor In Situ Fluid Reveals Mutation Landscape of Minimal Residual Disease After Glioma Surgery and Risk of Early Recurrence.

Frontiers In Oncology
Yu, Jinliang J; Sheng, Zhiyuan Z; Wu, Shuang S; Gao, Yushuai Y; Yan, Zhaoyue Z; Bu, Chaojie C; Gu, Jianjun J; Bu, Yage Y; Deng, Kaiyuan K; Xu, Sensen S; Chen, Zhongcan Z; Zhang, Qianqian Q; Zemmar, Ajmal A; Hernesniemi, Juha J; Wang, Meiyun M; Liu, Gang G; Li, Tianxiao T; Bu, Xingyao X
Publication Date: 2021

Variant appearance in text: PIK3CA: 34G>A; G12S
PubMed Link: 34712610
Variant Present in the following documents:
  • DataSheet_1.xls, sheet 5
View BVdb publication page



Diverse 'just-right' levels of chromosomal instability and their clinical implications in neoadjuvant treated gastric cancer.

British Journal Of Cancer
Kohlruss, Meike M; Krenauer, Marie M; Grosser, Bianca B; Pfarr, Nicole N; Jesinghaus, Moritz M; Slotta-Huspenina, Julia J; Novotny, Alexander A; Hapfelmeier, Alexander A; Schmidt, Thomas T; Steiger, Katja K; Gaida, Matthias M MM; Reiche, Magdalena M; Bauer, Lukas L; Ott, Katja K; Weichert, Wilko W; Keller, Gisela G
Publication Date: 2021-12

Variant appearance in text: PIK3CA: 34G>A; G12S
PubMed Link: 34671125
Variant Present in the following documents:
  • 41416_2021_1587_MOESM1_ESM.pdf
View BVdb publication page



Ras Isoforms from Lab Benches to Lives-What Are We Missing and How Far Are We?

International Journal Of Molecular Sciences
Nair, Arathi A; Kubatzky, Katharina F KF; Saha, Bhaskar B
Publication Date: 2021-06-17

Variant appearance in text: PI3K: G12S
PubMed Link: 34204435
Variant Present in the following documents:
  • Main text
  • ijms-22-06508.pdf
View BVdb publication page



Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology.

Cells
László, Loretta L; Kurilla, Anita A; Takács, Tamás T; Kudlik, Gyöngyi G; Koprivanacz, Kitti K; Buday, László L; Vas, Virag V
Publication Date: 2021-03-17

Variant appearance in text: PI3K: G12S
PubMed Link: 33802849
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of tumor mutation burden and epidermal growth factor receptor inhibitor history with survival in patients with metastatic stage III/IV non-small-cell lung cancer: A retrospective study.

Clinics (Sao Paulo, Brazil)
Lan, Yan Y; Zhou, Shuo S; Feng, Weihong W; Qiao, Ying Y; Du, Xueming X; Li, Fenge F
Publication Date: 2021

Variant appearance in text: PIK3CA: G12S
PubMed Link: 33787673
Variant Present in the following documents:
  • cln-76-2251.pdf
View BVdb publication page



Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo.

Scientific Reports
Sakamoto, Kotaro K; Masutani, Teruaki T; Hirokawa, Takatsugu T
Publication Date: 2020-12-10

Variant appearance in text: PI3K: G12S
PubMed Link: 33303890
Variant Present in the following documents:
  • Main text
  • 41598_2020_Article_78712.pdf
View BVdb publication page



KRAS and PIK3CA bi-mutations predict a poor prognosis in colorectal cancer patients: A single-site report.

Translational Oncology
Luo, Qianxin Q; Chen, Dianke D; Fan, Xinjuan X; Fu, Xinhui X; Ma, Tenghui T; Chen, Daici D
Publication Date: 2020-12

Variant appearance in text: PIK3CA: G12S
PubMed Link: 32947236
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



The Clinical Significance of RAS, PIK3CA, and PTEN Mutations in Non-Small Cell Lung Cancer Using Cell-Free DNA.

Journal Of Clinical Medicine
Chang, Won Jin WJ; Sung, Jae Sook JS; Lee, Sung Yong SY; Kang, Eun Joo EJ; Kwon, Nak-Jung NJ; Kim, Hae Mi HM; Shin, Sang Won SW; Choi, Jung Yoon JY; Choi, Yoon Ji YJ; Kim, Ju Won JW; Park, Kyong Hwa KH; Kim, Yeul Hong YH
Publication Date: 2020-08-14

Variant appearance in text: PIK3CA: G12S
PubMed Link: 32823871
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.

Cancer Research And Treatment
Lee, Youngwoo Y; Lee, Soohyeon S; Sung, Jae Sook JS; Chung, Hee-Joon HJ; Lim, Ah-Reum AR; Kim, Ju Won JW; Choi, Yoon Ji YJ; Park, Kyong Hwa KH; Kim, Yeul Hong YH
Publication Date: 2021-01

Variant appearance in text: PIK3CA: G12S
PubMed Link: 32810930
Variant Present in the following documents:
  • crt-2020-559-suppl3.pdf
View BVdb publication page



Regulators of glucose uptake in thyroid cancer cell lines.

Cell Communication And Signaling : Ccs
Heydarzadeh, Shabnam S; Moshtaghie, Ali Asghar AA; Daneshpoor, Maryam M; Hedayati, Mehdi M
Publication Date: 2020-06-03

Variant appearance in text: PI3K: Gly12Ser
PubMed Link: 32493394
Variant Present in the following documents:
  • Main text
  • 12964_2020_Article_586.pdf
View BVdb publication page



Regulators of glucose uptake in thyroid cancer cell lines.

Cell Communication And Signaling : Ccs
Heydarzadeh, Shabnam S; Moshtaghie, Ali Asghar AA; Daneshpoor, Maryam M; Hedayati, Mehdi M
Publication Date: 2020-06-03

Variant appearance in text: PI3K: Gly12Ser
PubMed Link: 32493394
Variant Present in the following documents:
  • Main text
  • 12964_2020_Article_586.pdf
View BVdb publication page



The Clinical Relevance of Frequent Germline Genetic Variants Detected by Targeted Sequencing in Patients With Rectal Adenocarcinoma (READ).

Cancer Genomics & Proteomics
Huang, Kevin Chih-Yang KC; Chiang, Shu-Fen SF; Ke, Tao-Wei TW; Chen, William Tzu-Liang WT; Chen, Tsung-Wei TW; Chao, Kun-San Clifford KC
Publication Date: 2020

Variant appearance in text: PIK3CA: G12S
PubMed Link: 32345670
Variant Present in the following documents:
  • Main text
View BVdb publication page



Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma.

Cancer Biology & Medicine
Leblanc, Olivia O; Vacher, Sophie S; Lecerf, Charlotte C; Jeannot, Emmanuelle E; Klijanienko, Jerzy J; Berger, Frédérique F; Hoffmann, Caroline C; Calugaru, Valentin V; Badois, Nathalie N; Chilles, Anne A; Lesnik, Maria M; Krhili, Samar S; Bieche, Ivan I; Le Tourneau, Christophe C; Kamal, Maud M
Publication Date: 2020-02-15

Variant appearance in text: PIK3CA: 34G>A; G12S
PubMed Link: 32296588
Variant Present in the following documents:
  • cbm-17-208-s001.pdf
View BVdb publication page



CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.

Nature
Han, Kyuho K; Pierce, Sarah E SE; Li, Amy A; Spees, Kaitlyn K; Anderson, Gray R GR; Seoane, Jose A JA; Lo, Yuan-Hung YH; Dubreuil, Michael M; Olivas, Micah M; Kamber, Roarke A RA; Wainberg, Michael M; Kostyrko, Kaja K; Kelly, Marcus R MR; Yousefi, Maryam M; Simpkins, Scott W SW; Yao, David D; Lee, Keonil K; Kuo, Calvin J CJ; Jackson, Peter K PK; Sweet-Cordero, Alejandro A; Kundaje, Anshul A; Gentles, Andrew J AJ; Curtis, Christina C; Winslow, Monte M MM; Bassik, Michael C MC
Publication Date: 2020-04

Variant appearance in text: PIK3CA: G12S
PubMed Link: 32238925
Variant Present in the following documents:
  • NIHMS1549225-supplement-Sup_Tab5.xlsx, sheet 1
View BVdb publication page



CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.

Nature
Han, Kyuho K; Pierce, Sarah E SE; Li, Amy A; Spees, Kaitlyn K; Anderson, Grace R GR; Seoane, Jose A JA; Lo, Yuan-Hung YH; Dubreuil, Michael M; Olivas, Micah M; Kamber, Roarke A RA; Wainberg, Michael M; Kostyrko, Kaja K; Kelly, Marcus R MR; Yousefi, Maryam M; Simpkins, Scott W SW; Yao, David D; Lee, Keonil K; Kuo, Calvin J CJ; Jackson, Peter K PK; Sweet-Cordero, Alejandro A; Kundaje, Anshul A; Gentles, Andrew J AJ; Curtis, Christina C; Winslow, Monte M MM; Bassik, Michael C MC
Publication Date: 2020-04

Variant appearance in text: PIK3CA: G12S
PubMed Link: 32238925
Variant Present in the following documents:
  • NIHMS1549225-supplement-Sup_Tab5.xlsx, sheet 1
View BVdb publication page



Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth.

Science Advances
Shin, Seung-Min SM; Kim, Ji-Sun JS; Park, Seong-Wook SW; Jun, Sei-Yong SY; Kweon, Hye-Jin HJ; Choi, Dong-Ki DK; Lee, Dakeun D; Cho, Yong Beom YB; Kim, Yong-Sung YS
Publication Date: 2020-01

Variant appearance in text: PIK3CA: G12S
PubMed Link: 31998840
Variant Present in the following documents:
  • aay2174_SM.pdf
View BVdb publication page



Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients.

Plos One
Papadopoulou, Eirini E; Tsoulos, Nikolaos N; Tsantikidi, Katerina K; Metaxa-Mariatou, Vasiliki V; Stamou, Pinelopi Eleftheria PE; Kladi-Skandali, Athina A; Kapeni, Evgenia E; Tsaousis, Georgios G; Pentheroudakis, George G; Petrakis, Dimitrios D; Lampropoulou, Dimitra Ioanna DI; Aravantinos, Gerasimos G; Varthalitis, Ioannis I; Kesisis, George G; Boukovinas, Ioannis I; Papakotoulas, Pavlos P; Katirtzoglou, Nikolaos N; Athanasiadis, Elias E; Stavridi, Flora F; Christodoulou, Christos C; Koumarianou, Anna A; Eralp, Yeşim Y; Nasioulas, George G
Publication Date: 2019

Variant appearance in text: PIK3CA: 34G>A; G12S
PubMed Link: 31860648
Variant Present in the following documents:
  • pone.0226853.s001.xlsx, sheet 1
View BVdb publication page



A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells.

Nature Communications
Ghezzi, Chiara C; Wong, Alicia A; Chen, Bao Ying BY; Ribalet, Bernard B; Damoiseaux, Robert R; Clark, Peter M PM
Publication Date: 2019-11-29

Variant appearance in text: PI3K: G12S
PubMed Link: 31784510
Variant Present in the following documents:
  • Main text
View BVdb publication page



Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review.

Bmc Cancer
Cheng, Yue I YI; Gan, Yun Cui YC; Liu, Dan D; Davies, Michael P A MPA; Li, Wei Min WM; Field, John K JK
Publication Date: 2019-11-08

Variant appearance in text: PIK3CA: G12S
PubMed Link: 31703574
Variant Present in the following documents:
  • Main text
  • 12885_2019_Article_6317.pdf
View BVdb publication page



Comprehensive assessment of HER2 alteration in a colorectal cancer cohort: from next-generation sequencing to clinical significance.

Cancer Management And Research
Yeh, Yu-Min YM; Lee, Chun-Hui CH; Chen, Shang-Hung SH; Lee, Chung-Ta CT; Chen, Yi-Lin YL; Lin, Bo-Wen BW; Lin, Shao-Chieh SC; Chan, Ren-Hao RH; Lee, Jenq-Chang JC; Shen, Meng-Ru MR; Lin, Peng-Chan PC
Publication Date: 2019

Variant appearance in text: PIK3CA: G12S
PubMed Link: 31692488
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical and genetic analysis of melanomas arising in acral sites.

European Journal Of Cancer (Oxford, England : 1990)
Zaremba, Anne A; Murali, Rajmohan R; Jansen, Philipp P; Möller, Inga I; Sucker, Antje A; Paschen, Annette A; Zimmer, Lisa L; Livingstone, Elisabeth E; Brinker, Titus J TJ; Hadaschik, Eva E; Franklin, Cindy C; Roesch, Alexander A; Ugurel, Selma S; Schadendorf, Dirk D; Griewank, Klaus G KG; Cosgarea, Ioana I
Publication Date: 2019-09

Variant appearance in text: PIK3CA: G12S
PubMed Link: 31419753
Variant Present in the following documents:
  • Main text
View BVdb publication page



BH3 mimetic ABT-263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation.

Cell & Bioscience
Zhan, Yihong Y; Wang, Yue Y; Qi, Miao M; Liang, Panpan P; Ma, Yu Y; Li, Ting T; Li, Hui H; Dai, Congmei C; An, Zhifeng Z; Qi, Yitao Y; Wu, Hongmei H; Shao, Huanjie H
Publication Date: 2019

Variant appearance in text: PIK3CA: G12S
PubMed Link: 31367332
Variant Present in the following documents:
  • 13578_2019_Article_322.pdf
View BVdb publication page



Systematic analysis of the intersection of disease mutations with protein modifications.

Bmc Medical Genomics
Simpson, Claire M CM; Zhang, Bin B; Hornbeck, Peter V PV; Gnad, Florian F
Publication Date: 2019-07-25

Variant appearance in text: PIK3CA: G12S
PubMed Link: 31345222
Variant Present in the following documents:
  • 12920_2019_543_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer.

Journal Of Hematology & Oncology
Xiao, Wenwu W; Ma, Weijie W; Wei, Sixi S; Li, Qianping Q; Liu, Ruiwu R; Carney, Randy P RP; Yang, Kevin K; Lee, Joyce J; Nyugen, Alan A; Yoneda, Ken Y KY; Lam, Kit S KS; Li, Tianhong T
Publication Date: 2019-06-10

Variant appearance in text: PI3K: G12S
PubMed Link: 31182116
Variant Present in the following documents:
  • Main text
View BVdb publication page



Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer.

Cancer Biology & Medicine
Wang, Yuxiang Y; Li, Xian X; Liu, Xueling X; Chen, Yi Y; Yang, Chunhao C; Tan, Cun C; Wang, Bobo B; Sun, Yiming Y; Zhang, Xi X; Gao, Yinglei Y; Ding, Jian J; Meng, Linghua L
Publication Date: 2019-02

Variant appearance in text: PI3K: G12S
PubMed Link: 31119047
Variant Present in the following documents:
  • cbm-16-1-66.pdf
View BVdb publication page



A Simple and Highly Specific MassARRAY-Based Stool DNA Assay to Prioritize Follow-up Decisions in Fecal Immunochemical Test-Positive Individuals.

Cancers
Chang, Pi-Yueh PY; Chen, Chia-Chun CC; Chiang, Jy-Ming JM; Chang, Shih-Cheng SC; Wang, Mei-Chia MC; Chen, Jinn-Shiun JS; Tsai, Wen-Sy WS; You, Jeng Fu JF; Lu, Jang-Jih JJ
Publication Date: 2019-03-25

Variant appearance in text: PIK3CA: G12S
PubMed Link: 30934598
Variant Present in the following documents:
  • cancers-11-00423.pdf
View BVdb publication page



Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation Sequencing.

Frontiers In Oncology
Wang, Yao Y; Yu, Mei M; Yang, Jia-Xin JX; Cao, Dong-Yan DY; Zhang, Ying Y; Zhou, Hui-Mei HM; Yuan, Zhen Z; Shen, Keng K
Publication Date: 2019

Variant appearance in text: PIK3CA: 34G>A; G12R
PubMed Link: 30886832
Variant Present in the following documents:
  • Table_2.xls, sheet 1
  • Table_2.xls, sheet 2
View BVdb publication page



Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth.

Cancer Biology & Therapy
Aguilar, Byron J BJ; Zhao, Yaxue Y; Zhou, Huchen H; Huo, Shouquan S; Chen, Yan-Hua YH; Lu, Qun Q
Publication Date: 2019

Variant appearance in text: PI3K: G12S
PubMed Link: 30849276
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Publication Date: 2018-07-27

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PubMed Link: 30053901
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  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 19
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Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.

The Lancet. Gastroenterology & Hepatology
Domingo, Enric E; Camps, Carme C; Kaisaki, Pamela J PJ; Parsons, Marie J MJ; Mouradov, Dmitri D; Pentony, Melissa M MM; Makino, Seiko S; Palmieri, Michelle M; Ward, Robyn L RL; Hawkins, Nicholas J NJ; Gibbs, Peter P; Askautrud, Hanne H; Oukrif, Dahmane D; Wang, Haitao H; Wood, Joe J; Tomlinson, Evie E; Bark, Yasmine Y; Kaur, Kulvinder K; Johnstone, Elaine C EC; Palles, Claire C; Church, David N DN; Novelli, Marco M; Danielsen, Havard E HE; Sherlock, Jon J; Kerr, David D; Kerr, Rachel R; Sieber, Oliver O; Taylor, Jenny C JC; Tomlinson, Ian I
Publication Date: 2018-09

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PubMed Link: 30042065
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  • mmc1.pdf
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Next‑generation sequencing‑based detection of EGFR, KRAS, BRAF, NRAS, PIK3CA, Her‑2 and TP53 mutations in patients with non‑small cell lung cancer.

Molecular Medicine Reports
Jing, Changwen C; Mao, Xuhua X; Wang, Zhuo Z; Sun, Kejing K; Ma, Rong R; Wu, Jianzhong J; Cao, Haixia H
Publication Date: 2018-08

Variant appearance in text: PIK3CA: 34G>A
PubMed Link: 29956783
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  • mmr-18-02-2191.pdf
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Integrated Molecular Characterization of Testicular Germ Cell Tumors.

Cell Reports
Shen, Hui H; Shih, Juliann J; Hollern, Daniel P DP; Wang, Linghua L; Bowlby, Reanne R; Tickoo, Satish K SK; Thorsson, Vésteinn V; Mungall, Andrew J AJ; Newton, Yulia Y; Hegde, Apurva M AM; Armenia, Joshua J; Sánchez-Vega, Francisco F; Pluta, John J; Pyle, Louise C LC; Mehra, Rohit R; Reuter, Victor E VE; Godoy, Guilherme G; Jones, Jeffrey J; Shelley, Carl S CS; Feldman, Darren R DR; Vidal, Daniel O DO; Lessel, Davor D; Kulis, Tomislav T; Cárcano, Flavio M FM; Leraas, Kristen M KM; Lichtenberg, Tara M TM; Brooks, Denise D; Cherniack, Andrew D AD; Cho, Juok J; Heiman, David I DI; Kasaian, Katayoon K; Liu, Minwei M; Noble, Michael S MS; Xi, Liu L; Zhang, Hailei H; Zhou, Wanding W; ZenKlusen, Jean C JC; Hutter, Carolyn M CM; Felau, Ina I; Zhang, Jiashan J; Schultz, Nikolaus N; Getz, Gad G; Meyerson, Matthew M; Stuart, Joshua M JM; , ; Akbani, Rehan R; Wheeler, David A DA; Laird, Peter W PW; Nathanson, Katherine L KL; Cortessis, Victoria K VK; Hoadley, Katherine A KA
Publication Date: 2018-06-12

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PubMed Link: 29898407
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  • NIHMS977848-supplement-2.xlsx, sheet 1
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Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing.

Oncotarget
Oliveira, Duarte Mendes DM; Laudanna, Carmelo C; Migliozzi, Simona S; Zoppoli, Pietro P; Santamaria, Gianluca G; Grillone, Katia K; Elia, Laura L; Mignogna, Chiara C; Biamonte, Flavia F; Sacco, Rosario R; Corcione, Francesco F; Viglietto, Giuseppe G; Malanga, Donatella D; Rizzuto, Antonia A
Publication Date: 2018-05-08

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PubMed Link: 29844865
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Molecular mechanism of action and potential biomarkers of growth inhibition of synergistic combination of afatinib and dasatinib against gefitinib-resistant non-small cell lung cancer cells.

Oncotarget
Wang, Miao M; Yuang-Chi Chang, Alex A
Publication Date: 2018-03-27

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PubMed Link: 29662665
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  • Main text
  • oncotarget-09-16533.pdf
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Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitors.

Molecular Cancer
Montor, Wagner Ricardo WR; Salas, Andrei Ronaldo Oliveira Silva Escartin AROSE; Melo, Fabiana Henriques Machado de FHM
Publication Date: 2018-02-19

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PubMed Link: 29455659
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  • Main text
  • 12943_2018_Article_792.pdf
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Direct inhibition of RAS: Quest for the Holy Grail?

Seminars In Cancer Biology
Spencer-Smith, Russell R; O'Bryan, John P JP
Publication Date: 2019-02

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PubMed Link: 29248537
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Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer.

Oncotarget
Shimada, Yoshifumi Y; Kameyama, Hitoshi H; Nagahashi, Masayuki M; Ichikawa, Hiroshi H; Muneoka, Yusuke Y; Yagi, Ryoma R; Tajima, Yosuke Y; Okamura, Takuma T; Nakano, Masato M; Sakata, Jun J; Kobayashi, Takashi T; Nogami, Hitoshi H; Maruyama, Satoshi S; Takii, Yasumasa Y; Hayashida, Tetsu T; Takaishi, Hiromasa H; Kitagawa, Yuko Y; Oki, Eiji E; Konishi, Tsuyoshi T; Ishida, Fumio F; Kudo, Shin-Ei SE; Ring, Jennifer E JE; Protopopov, Alexei A; Lyle, Stephen S; Ling, Yiwei Y; Okuda, Shujiro S; Ishikawa, Takashi T; Akazawa, Kohei K; Takabe, Kazuaki K; Wakai, Toshifumi T
Publication Date: 2017-11-07

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PubMed Link: 29212173
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  • oncotarget-08-93567-s003.xlsx, sheet 1
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Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib.

Oncotarget
Osoegawa, Atsushi A; Gills, Joell J JJ; Kawabata, Shigeru S; Dennis, Phillip A PA
Publication Date: 2017-10-20

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PubMed Link: 29152062
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  • Main text
  • oncotarget-08-87044.pdf
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Predicting ligand-dependent tumors from multi-dimensional signaling features.

Npj Systems Biology And Applications
Hass, Helge H; Masson, Kristina K; Wohlgemuth, Sibylle S; Paragas, Violette V; Allen, John E JE; Sevecka, Mark M; Pace, Emily E; Timmer, Jens J; Stelling, Joerg J; MacBeath, Gavin G; Schoeberl, Birgit B; Raue, Andreas A
Publication Date: 2017

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PubMed Link: 28944080
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Mutational frequency of KRAS, NRAS, IDH2, PIK3CA, and EGFR in North Indian gallbladder cancer patients.

Ecancermedicalscience
Sharma, Aarti A; Kumar, Ashok A; Kumari, Niraj N; Krishnani, Narendra N; Rastogi, Neeraj N
Publication Date: 2017

Variant appearance in text: PIK3CA: 34G>A
PubMed Link: 28900470
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  • can-11-757.pdf
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Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment.

International Journal Of Molecular Sciences
Bignucolo, Alessia A; De Mattia, Elena E; Cecchin, Erika E; Roncato, Rossana R; Toffoli, Giuseppe G
Publication Date: 2017-07-14

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PubMed Link: 28708103
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The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.

Nature Communications
Goodwin, Justin J; Neugent, Michael L ML; Lee, Shin Yup SY; Choe, Joshua H JH; Choi, Hyunsung H; Jenkins, Dana M R DMR; Ruthenborg, Robin J RJ; Robinson, Maddox W MW; Jeong, Ji Yun JY; Wake, Masaki M; Abe, Hajime H; Takeda, Norihiko N; Endo, Hiroko H; Inoue, Masahiro M; Xuan, Zhenyu Z; Yoo, Hyuntae H; Chen, Min M; Ahn, Jung-Mo JM; Minna, John D JD; Helke, Kristi L KL; Singh, Pankaj K PK; Shackelford, David B DB; Kim, Jung-Whan JW
Publication Date: 2017-05-26

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PubMed Link: 28548087
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  • ncomms15503-s1.pdf
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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: PI3K: 34G>A
PubMed Link: 28492226
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  • ncomms15086-s3.xlsx, sheet 1
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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Nature Communications
Schütte, Moritz M; Risch, Thomas T; Abdavi-Azar, Nilofar N; Boehnke, Karsten K; Schumacher, Dirk D; Keil, Marlen M; Yildiriman, Reha R; Jandrasits, Christine C; Borodina, Tatiana T; Amstislavskiy, Vyacheslav V; Worth, Catherine L CL; Schweiger, Caroline C; Liebs, Sandra S; Lange, Martin M; Warnatz, Hans-Jörg HJ; Butcher, Lee M LM; Barrett, James E JE; Sultan, Marc M; Wierling, Christoph C; Golob-Schwarzl, Nicole N; Lax, Sigurd S; Uranitsch, Stefan S; Becker, Michael M; Welte, Yvonne Y; Regan, Joseph Lewis JL; Silvestrov, Maxine M; Kehler, Inge I; Fusi, Alberto A; Kessler, Thomas T; Herwig, Ralf R; Landegren, Ulf U; Wienke, Dirk D; Nilsson, Mats M; Velasco, Juan A JA; Garin-Chesa, Pilar P; Reinhard, Christoph C; Beck, Stephan S; Schäfer, Reinhold R; Regenbrecht, Christian R A CR; Henderson, David D; Lange, Bodo B; Haybaeck, Johannes J; Keilholz, Ulrich U; Hoffmann, Jens J; Lehrach, Hans H; Yaspo, Marie-Laure ML
Publication Date: 2017-02-10

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PubMed Link: 28186126
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  • ncomms14262-s16.xlsx, sheet 8
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2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells.

Plos One
Sun, Linlin L; Liu, Xiuju X; Fu, Haian H; Zhou, Wei W; Zhong, Diansheng D
Publication Date: 2016

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PubMed Link: 28033353
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c-MYC responds to glucose deprivation in a cell-type-dependent manner.

Cell Death Discovery
Wu, S S; Yin, X X; Fang, X X; Zheng, J J; Li, L L; Liu, X X; Chu, L L
Publication Date: 2015

Variant appearance in text: PIK3CA: G12S
PubMed Link: 27551483
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  • cddiscovery201557.pdf
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