PIK3CA c.346G>A ;(p.E116K)

Variant ID: 3-178916959-G-A

NM_006218.2(PIK3CA):c.346G>A;(p.E116K)

This variant was identified in 7 publications

View GRCh38 version.




Publications:


Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Publication Date: 2022-07-13

Variant appearance in text: PIK3CA: 346G>A; E116K
PubMed Link: 35831314
Variant Present in the following documents:
  • 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3
View BVdb publication page



A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research
Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H
Publication Date: 2022-01

Variant appearance in text: PIK3CA: E116K
PubMed Link: 34963661
Variant Present in the following documents:
  • supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3
View BVdb publication page



Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

The Journal Of Pathology
Temko, Daniel D; Van Gool, Inge C IC; Rayner, Emily E; Glaire, Mark M; Makino, Seiko S; Brown, Matthew M; Chegwidden, Laura L; Palles, Claire C; Depreeuw, Jeroen J; Beggs, Andrew A; Stathopoulou, Chaido C; Mason, John J; Baker, Ann-Marie AM; Williams, Marc M; Cerundolo, Vincenzo V; Rei, Margarida M; Taylor, Jenny C JC; Schuh, Anna A; Ahmed, Ahmed A; Amant, Frédéric F; Lambrechts, Diether D; Smit, Vincent Thbm VT; Bosse, Tjalling T; Graham, Trevor A TA; Church, David N DN; Tomlinson, Ian I
Publication Date: 2018-07

Variant appearance in text: PIK3CA: 346G>A; E116K
PubMed Link: 29604063
Variant Present in the following documents:
  • PATH-245-283-s022.xlsx, sheet 1
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: PI3K: 346G>A
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels.

Oncotarget
Lim, Byungho B; Mun, Jihyeob J; Kim, Jeong-Hwan JH; Kim, Chan Wook CW; Roh, Seon Ae SA; Cho, Dong-Hyung DH; Kim, Yong Sung YS; Kim, Seon-Young SY; Kim, Jin Cheon JC
Publication Date: 2015-09-08

Variant appearance in text: PIK3CA: E116K
PubMed Link: 26109429
Variant Present in the following documents:
  • oncotarget-06-22179-s002.xls, sheet 4
View BVdb publication page



Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.

Cell Cycle (Georgetown, Tex.)
Huang, Chuan-Hsiang CH; Mandelker, Diana D; Gabelli, Sandra B SB; Amzel, L Mario LM
Publication Date: 2008-05-01

Variant appearance in text: PI3K: Glu116Lys
PubMed Link: 18418043
Variant Present in the following documents:
  • Main text
View BVdb publication page



Rare cancer-specific mutations in PIK3CA show gain of function.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Gymnopoulos, Marco M; Elsliger, Marc-André MA; Vogt, Peter K PK
Publication Date: 2007-03-27

Variant appearance in text: PI3K: E116K
PubMed Link: 17376864
Variant Present in the following documents:
  • Main text
View BVdb publication page