mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.
Science Signaling
Baffi, Timothy R TR; Lordén, Gema G; Wozniak, Jacob M JM; Feichtner, Andreas A; Yeung, Wayland W; Kornev, Alexandr P AP; King, Charles C CC; Del Rio, Jason C JC; Limaye, Ameya J AJ; Bogomolovas, Julius J; Gould, Christine M CM; Chen, Ju J; Kennedy, Eileen J EJ; Kannan, Natarajan N; Gonzalez, David J DJ; Stefan, Eduard E; Taylor, Susan S SS; Newton, Alexandra C AC
Loss of melusin is a novel, neuronal NO synthase/FoxO3-independent master switch of unloading-induced muscle atrophy.
Journal Of Cachexia, Sarcopenia And Muscle
Vitadello, Maurizio M; Sorge, Matteo M; Percivalle, Elena E; Germinario, Elena E; Danieli-Betto, Daniela D; Turco, Emilia E; Tarone, Guido G; Brancaccio, Mara M; Gorza, Luisa L
CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms.
Frontiers In Endocrinology
Parra-Mercado, G Karina GK; Fuentes-Gonzalez, Alma M AM; Hernandez-Aranda, Judith J; Diaz-Coranguez, Monica M; Dautzenberg, Frank M FM; Catt, Kevin J KJ; Hauger, Richard L RL; Olivares-Reyes, J Alberto JA
MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression.
Nature Communications
Jiang, Yao Y; Zhang, Yanqiong Y; Leung, Janet Y JY; Fan, Cheng C; Popov, Konstantin I KI; Su, Siyuan S; Qian, Jiayi J; Wang, Xiaodong X; Holtzhausen, Alisha A; Ubil, Eric E; Xiang, Yang Y; Davis, Ian I; Dokholyan, Nikolay V NV; Wu, Gang G; Perou, Charles M CM; Kim, William Y WY; Earp, H Shelton HS; Liu, Pengda P
c-Src activation promotes nasopharyngeal carcinoma metastasis by inducing the epithelial-mesenchymal transition via PI3K/Akt signaling pathway: a new and promising target for NPC.
Oncotarget
Ke, Liangru L; Xiang, Yanqun Y; Guo, Xiang X; Lu, Jinping J; Xia, Weixiong W; Yu, Yahui Y; Peng, Yongjian Y; Wang, Li L; Wang, Gang G; Ye, Yanfang Y; Yang, Jing J; Liang, Hu H; Kang, Tiebang T; Lv, Xing X
Kaempferol Suppresses Transforming Growth Factor-β1-Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179.
Neoplasia (New York, N.Y.)
Jo, Eunji E; Park, Seong Ji SJ; Choi, Yu Sun YS; Jeon, Woo-Kwang WK; Kim, Byung-Chul BC
Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.
The Biochemical Journal
Chan, Tung O TO; Zhang, Jin J; Tiegs, Brian C BC; Blumhof, Brian B; Yan, Linda L; Keny, Nikhil N; Penny, Morgan M; Li, Xue X; Pascal, John M JM; Armen, Roger S RS; Rodeck, Ulrich U; Penn, Raymond B RB
Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt phosphorylation.
The Journal Of Biological Chemistry
Secondo, Agnese A; Esposito, Alba A; Sirabella, Rossana R; Boscia, Francesca F; Pannaccione, Anna A; Molinaro, Pasquale P; Cantile, Maria M; Ciccone, Roselia R; Sisalli, Maria Josè MJ; Scorziello, Antonella A; Di Renzo, Gianfranco G; Annunziato, Lucio L
Transcriptional and posttranslational regulation of insulin-like growth factor binding protein-3 by Akt3.
Carcinogenesis
Jin, Quanri Q; Lee, Hyo-Jong HJ; Min, Hye-Young HY; Smith, John Kendal JK; Hwang, Su Jung SJ; Whang, Young Mi YM; Kim, Woo-Young WY; Kim, Yeul Hong YH; Lee, Ho-Young HY
Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na(+)/K(+)-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats.
MEF2 is a converging hub for histone deacetylase 4 and phosphatidylinositol 3-kinase/Akt-induced transformation.
Molecular And Cellular Biology
Di Giorgio, Eros E; Clocchiatti, Andrea A; Piccinin, Sara S; Sgorbissa, Andrea A; Viviani, Giulia G; Peruzzo, Paolo P; Romeo, Salvatore S; Rossi, Sabrina S; Dei Tos, Angelo Paolo AP; Maestro, Roberta R; Brancolini, Claudio C
Integration of apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/protein kinase B-IκB kinase cascade.
Molecular And Cellular Biology
Puckett, Mary C MC; Goldman, Erinn H EH; Cockrell, Lisa M LM; Huang, Bei B; Kasinski, Andrea L AL; Du, Yuhong Y; Wang, Cun-Yu CY; Lin, Anning A; Ichijo, Hidenori H; Khuri, Fadlo F; Fu, Haian H
Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.
Plos One
McNamara, Colleen R CR; Ahuja, Ruchita R; Osafo-Addo, Awo D AD; Barrows, Douglas D; Kettenbach, Arminja A; Skidan, Igor I; Teng, Xin X; Cuny, Gregory D GD; Gerber, Scott S; Degterev, Alexei A
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.
Science (New York, N.Y.)
Wang, Richard C RC; Wei, Yongjie Y; An, Zhenyi Z; Zou, Zhongju Z; Xiao, Guanghua G; Bhagat, Govind G; White, Michael M; Reichelt, Julia J; Levine, Beth B
IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
The Journal Of Biological Chemistry
Guo, Jian-Ping JP; Coppola, Domenico D; Cheng, Jin Q JQ
Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2.
The Journal Of Biological Chemistry
Warfel, Noel A NA; Niederst, Matt M; Newton, Alexandra C AC
Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.
Endocrinology
Leen, Jason L S JL; Izzo, Angelo A; Upadhyay, Chandani C; Rowland, Katherine J KJ; Dubé, Philip E PE; Gu, Steven S; Heximer, Scott P SP; Rhodes, Christopher J CJ; Storm, Daniel R DR; Lund, P Kay PK; Brubaker, Patricia L PL
Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4.
The Journal Of Biological Chemistry
Li, Peifeng P; Jayarama, Shankar S; Ganesh, Lakshmy L; Mordi, David D; Carr, Ryan R; Kanteti, Prasad P; Hay, Nissim N; Prabhakar, Bellur S BS
Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation.
Endocrinology
Mandal, Chandi C CC; Ghosh Choudhury, Goutam G; Ghosh-Choudhury, Nandini N
Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication.
Journal Of Virology
Soares, Jamária A P JA; Leite, Flávia G G FG; Andrade, Luciana G LG; Torres, Alice A AA; De Sousa, Lirlândia P LP; Barcelos, Lucíola S LS; Teixeira, Mauro M MM; Ferreira, Paulo C P PC; Kroon, Erna G EG; Souto-Padrón, Thaís T; Bonjardim, Cláudio A CA
Phosphatidylinositol 3-kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study of Akt mutations.
The Journal Of Biological Chemistry
Rodríguez-Escudero, Isabel I; Andrés-Pons, Amparo A; Pulido, Rafael R; Molina, María M; Cid, Víctor J VJ