PIK3CA c.536A>T ;(p.K179M)

Variant ID: 3-178917661-A-T

NM_006218.2(PIK3CA):c.536A>T;(p.K179M)

This variant was identified in 94 publications

View GRCh38 version.




Publications:


Small-molecule Akt-activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2.

Respiratory Research
Gopallawa, Indiwari I; Kuek, Li Eon LE; Adappa, Nithin D ND; Palmer, James N JN; Lee, Robert J RJ
Publication Date: 2021-10-19

Variant appearance in text: PI3K: K179M
PubMed Link: 34666758
Variant Present in the following documents:
  • Main text
  • 12931_2021_Article_1865.pdf
  • 12931_2021_1865_MOESM1_ESM.pdf
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mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Science Signaling
Baffi, Timothy R TR; Lordén, Gema G; Wozniak, Jacob M JM; Feichtner, Andreas A; Yeung, Wayland W; Kornev, Alexandr P AP; King, Charles C CC; Del Rio, Jason C JC; Limaye, Ameya J AJ; Bogomolovas, Julius J; Gould, Christine M CM; Chen, Ju J; Kennedy, Eileen J EJ; Kannan, Natarajan N; Gonzalez, David J DJ; Stefan, Eduard E; Taylor, Susan S SS; Newton, Alexandra C AC
Publication Date: 2021-04-13

Variant appearance in text: PI3K: K179M
PubMed Link: 33850054
Variant Present in the following documents:
  • Main text
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Loss of melusin is a novel, neuronal NO synthase/FoxO3-independent master switch of unloading-induced muscle atrophy.

Journal Of Cachexia, Sarcopenia And Muscle
Vitadello, Maurizio M; Sorge, Matteo M; Percivalle, Elena E; Germinario, Elena E; Danieli-Betto, Daniela D; Turco, Emilia E; Tarone, Guido G; Brancaccio, Mara M; Gorza, Luisa L
Publication Date: 2020-06

Variant appearance in text: PI3K: K179M
PubMed Link: 32154658
Variant Present in the following documents:
  • Main text
  • JCSM-11-802.pdf
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CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms.

Frontiers In Endocrinology
Parra-Mercado, G Karina GK; Fuentes-Gonzalez, Alma M AM; Hernandez-Aranda, Judith J; Diaz-Coranguez, Monica M; Dautzenberg, Frank M FM; Catt, Kevin J KJ; Hauger, Richard L RL; Olivares-Reyes, J Alberto JA
Publication Date: 2019

Variant appearance in text: PI3K: K179M
PubMed Link: 31920979
Variant Present in the following documents:
  • Main text
  • fendo-10-00869.pdf
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Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice.

International Journal Of Molecular Sciences
Huang, Jian-Wei JW; Chen, Chao-Ju CJ; Yen, Chia-Hung CH; Chen, Yi-Ming Arthur YA; Liu, Yu-Peng YP
Publication Date: 2019-08-29

Variant appearance in text: PI3K: K179M
PubMed Link: 31470507
Variant Present in the following documents:
  • Main text
  • ijms-20-04223.pdf
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SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy.

Theranostics
Zhang, Yingjie Y; Nie, Liming L; Xu, Keqian K; Fu, Yang Y; Zhong, Juchang J; Gu, Kongzhen K; Zhang, Lingling L
Publication Date: 2019

Variant appearance in text: PI3K: K179M
PubMed Link: 31149050
Variant Present in the following documents:
  • Main text
  • thnov09p2380.pdf
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MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression.

Nature Communications
Jiang, Yao Y; Zhang, Yanqiong Y; Leung, Janet Y JY; Fan, Cheng C; Popov, Konstantin I KI; Su, Siyuan S; Qian, Jiayi J; Wang, Xiaodong X; Holtzhausen, Alisha A; Ubil, Eric E; Xiang, Yang Y; Davis, Ian I; Dokholyan, Nikolay V NV; Wu, Gang G; Perou, Charles M CM; Kim, William Y WY; Earp, H Shelton HS; Liu, Pengda P
Publication Date: 2019-04-03

Variant appearance in text: PIK3CA: K179M
PubMed Link: 30944303
Variant Present in the following documents:
  • Main text
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Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance.

Cell Reports
Zemanovic, Sara S; Ivanov, Maxim V MV; Ivanova, Lena V LV; Bhatnagar, Amogh A; Michalkiewicz, Teresa T; Teng, Ru-Jeng RJ; Kumar, Suresh S; Rathore, Rajendra R; Pritchard, Kirkwood A KA; Konduri, Girija G GG; Afolayan, Adeleye J AJ
Publication Date: 2018-11-27

Variant appearance in text: PI3K: K179M
PubMed Link: 30485823
Variant Present in the following documents:
  • Main text
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Heterologous mammalian Akt disrupts plasma membrane homeostasis by taking over TORC2 signaling in Saccharomyces cerevisiae.

Scientific Reports
Rodríguez-Escudero, Isabel I; Fernández-Acero, Teresa T; Cid, Víctor J VJ; Molina, María M
Publication Date: 2018-05-16

Variant appearance in text: PI3K: K179M
PubMed Link: 29769614
Variant Present in the following documents:
  • Main text
  • 41598_2018_Article_25717.pdf
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Helicobacter pylori CagA protein activates Akt and attenuates chemotherapeutics-induced apoptosis in gastric cancer cells.

Oncotarget
Lan, Keng-Hsueh KH; Lee, Wei-Ping WP; Wang, Yu-Shan YS; Liao, Shi-Xian SX; Lan, Keng-Hsin KH
Publication Date: 2017-12-26

Variant appearance in text: PI3K: K179M
PubMed Link: 29371922
Variant Present in the following documents:
  • Main text
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Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.

Molecular Cell
Wang, Vivien Ya-Fan VY; Li, Yidan Y; Kim, Daniel D; Zhong, Xiangyang X; Du, Qian Q; Ghassemian, Majid M; Ghosh, Gourisankar G
Publication Date: 2017-08-03

Variant appearance in text: PI3K: K179M
PubMed Link: 28689659
Variant Present in the following documents:
  • Main text
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Akt3 is responsible for the survival and proliferation of embryonic stem cells.

Biology Open
Wang, Ling L; Huang, Delun D; Jiang, Zongliang Z; Luo, Yan Y; Norris, Carol C; Zhang, Ming M; Tian, Xiuchun X; Tang, Young Y
Publication Date: 2017-06-15

Variant appearance in text: PI3K: K179M
PubMed Link: 28483982
Variant Present in the following documents:
  • Main text
  • biolopen-6-024505.pdf
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Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model.

Bioscience Reports
Oliver, María D MD; Fernández-Acero, Teresa T; Luna, Sandra S; Rodríguez-Escudero, Isabel I; Molina, María M; Pulido, Rafael R; Cid, Víctor J VJ
Publication Date: 2017-04-30

Variant appearance in text: PI3K: K179M
PubMed Link: 28143957
Variant Present in the following documents:
  • Main text
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Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts Into Brown Adipocytes.

Ebiomedicine
Wang, Chao C; Liu, Weiyi W; Nie, Yaohui Y; Qaher, Mulan M; Horton, Hannah Elizabeth HE; Yue, Feng F; Asakura, Atsushi A; Kuang, Shihuan S
Publication Date: 2017-02

Variant appearance in text: PI3K: K179M
PubMed Link: 28117277
Variant Present in the following documents:
  • Main text
  • main.pdf
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c-Src activation promotes nasopharyngeal carcinoma metastasis by inducing the epithelial-mesenchymal transition via PI3K/Akt signaling pathway: a new and promising target for NPC.

Oncotarget
Ke, Liangru L; Xiang, Yanqun Y; Guo, Xiang X; Lu, Jinping J; Xia, Weixiong W; Yu, Yahui Y; Peng, Yongjian Y; Wang, Li L; Wang, Gang G; Ye, Yanfang Y; Yang, Jing J; Liang, Hu H; Kang, Tiebang T; Lv, Xing X
Publication Date: 2016-05-10

Variant appearance in text: PI3K: K179M
PubMed Link: 27078847
Variant Present in the following documents:
  • oncotarget-07-28340-s001.pdf
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Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition.

Biomed Research International
Kim, Nayeong N; Jeong, Soyeon S; Jing, Kaipeng K; Shin, Soyeon S; Kim, Soyeon S; Heo, Jun-Young JY; Kweon, Gi-Ryang GR; Park, Seung-Kiel SK; Wu, Tong T; Park, Jong-Il JI; Lim, Kyu K
Publication Date: 2015

Variant appearance in text: PI3K: K179M
PubMed Link: 26339598
Variant Present in the following documents:
  • Main text
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Kaempferol Suppresses Transforming Growth Factor-β1-Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179.

Neoplasia (New York, N.Y.)
Jo, Eunji E; Park, Seong Ji SJ; Choi, Yu Sun YS; Jeon, Woo-Kwang WK; Kim, Byung-Chul BC
Publication Date: 2015-07

Variant appearance in text: PI3K: K179M
PubMed Link: 26297431
Variant Present in the following documents:
  • Main text
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Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.

The Biochemical Journal
Chan, Tung O TO; Zhang, Jin J; Tiegs, Brian C BC; Blumhof, Brian B; Yan, Linda L; Keny, Nikhil N; Penny, Morgan M; Li, Xue X; Pascal, John M JM; Armen, Roger S RS; Rodeck, Ulrich U; Penn, Raymond B RB
Publication Date: 2015-10-01

Variant appearance in text: PI3K: K179M
PubMed Link: 26201515
Variant Present in the following documents:
  • Main text
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Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.

The Journal Of Biological Chemistry
Li, Qiuling Q; Li, Yuewei Y; Gu, Bingnan B; Fang, Lei L; Zhou, Pengbo P; Bao, Shilai S; Huang, Lan L; Dai, Xing X
Publication Date: 2015-08-28

Variant appearance in text: PI3K: K179M
PubMed Link: 26170450
Variant Present in the following documents:
  • Main text
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PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.

Nature Communications
Yu, Jason S L JS; Ramasamy, Thamil Selvee TS; Murphy, Nick N; Holt, Marie K MK; Czapiewski, Rafal R; Wei, Shi-Khai SK; Cui, Wei W
Publication Date: 2015-05-22

Variant appearance in text: PI3K: K179M
PubMed Link: 25998442
Variant Present in the following documents:
  • Main text
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AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4.

Bmc Cell Biology
Xiao, Li L; Peng, Xiang X; Liu, Fuyou F; Tang, Chengyuan C; Hu, Chun C; Xu, Xiaoxuan X; Wang, Ming M; Luo, Ying Y; Yang, Shikun S; Song, Panai P; Xiao, Ping P; Kanwar, Yashpal S YS; Sun, Lin L
Publication Date: 2015-03-06

Variant appearance in text: PI3K: K179M
PubMed Link: 25885904
Variant Present in the following documents:
  • Main text
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p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodeling.

Biochimica Et Biophysica Acta
Goc, Anna A; Sabbineni, Harika H; Abdalla, Maha M; Somanath, Payaningal R PR
Publication Date: 2015-07

Variant appearance in text: PI3K: K179M
PubMed Link: 25843685
Variant Present in the following documents:
  • Main text
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Integrin α6β1 Expressed in ESCs Instructs the Differentiation to Endothelial Cells.

Stem Cells (Dayton, Ohio)
Toya, Sophie P SP; Wary, Kishore K KK; Mittal, Manish M; Li, Fei F; Toth, Peter T PT; Park, Changwon C; Rehman, Jalees J; Malik, Asrar B AB
Publication Date: 2015-06

Variant appearance in text: PI3K: K179M
PubMed Link: 25693840
Variant Present in the following documents:
  • Main text
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FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells.

Oncology Letters
Halacli, Sevil Oskay SO; Dogan, Ayse Lale AL
Publication Date: 2015-03

Variant appearance in text: PI3K: K179M
PubMed Link: 25663935
Variant Present in the following documents:
  • Main text
  • ol-09-03-1482.pdf
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Calcitonin Gene-Related Peptide Regulates Cardiomyocyte Survival through Regulation of Oxidative Stress by PI3K/Akt and MAPK Signaling Pathways.

Annals Of Clinical And Experimental Hypertension
Umoh, Nsini A NA; Walker, Robin K RK; Millis, Richard M RM; Al-Rubaiee, Mustafa M; Gangula, Pandu R PR; Haddad, Georges E GE
Publication Date: 2014-01

Variant appearance in text: PI3K: K179M
PubMed Link: 25478604
Variant Present in the following documents:
  • Main text
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Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt phosphorylation.

The Journal Of Biological Chemistry
Secondo, Agnese A; Esposito, Alba A; Sirabella, Rossana R; Boscia, Francesca F; Pannaccione, Anna A; Molinaro, Pasquale P; Cantile, Maria M; Ciccone, Roselia R; Sisalli, Maria Josè MJ; Scorziello, Antonella A; Di Renzo, Gianfranco G; Annunziato, Lucio L
Publication Date: 2015-01-16

Variant appearance in text: PI3K: K179M
PubMed Link: 25416782
Variant Present in the following documents:
  • Main text
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Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.

Molecular Biology Of The Cell
Zeng, Min M; van der Donk, Wilfred A WA; Chen, Jie J
Publication Date: 2014-12-01

Variant appearance in text: PI3K: K179M
PubMed Link: 25273559
Variant Present in the following documents:
  • Main text
  • 3954.pdf
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Recombinant viral capsid protein VP1 suppresses lung cancer metastasis by inhibiting COX-2/PGE2 and MIG-7.

Oncotarget
Ho, Ming-Yi MY; Hung, Shao-Wen SW; Liang, Chi-Ming CM; Liang, Shu-Mei SM
Publication Date: 2014-06-15

Variant appearance in text: PI3K: K179M
PubMed Link: 25004182
Variant Present in the following documents:
  • Main text
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Acute alcohol modulates cardiac function as PI3K/Akt regulates oxidative stress.

Alcoholism, Clinical And Experimental Research
Umoh, Nsini A NA; Walker, Robin K RK; Al-Rubaiee, Mustafa M; Jeffress, Miara A MA; Haddad, Georges E GE
Publication Date: 2014-07

Variant appearance in text: PI3K: K179M
PubMed Link: 24962888
Variant Present in the following documents:
  • Main text
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Transcriptional and posttranslational regulation of insulin-like growth factor binding protein-3 by Akt3.

Carcinogenesis
Jin, Quanri Q; Lee, Hyo-Jong HJ; Min, Hye-Young HY; Smith, John Kendal JK; Hwang, Su Jung SJ; Whang, Young Mi YM; Kim, Woo-Young WY; Kim, Yeul Hong YH; Lee, Ho-Young HY
Publication Date: 2014-10

Variant appearance in text: PI3K: K179M
PubMed Link: 24942865
Variant Present in the following documents:
  • Main text
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Fibroblasts in fibrosis: novel roles and mediators.

Frontiers In Pharmacology
Kendall, Ryan T RT; Feghali-Bostwick, Carol A CA
Publication Date: 2014

Variant appearance in text: PI3K: K179M
PubMed Link: 24904424
Variant Present in the following documents:
  • Main text
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Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway.

Oncogene
Havel, J J JJ; Li, Z Z; Cheng, D D; Peng, J J; Fu, H H
Publication Date: 2015-03-19

Variant appearance in text: PI3K: K179M
PubMed Link: 24704832
Variant Present in the following documents:
  • nihms572383.pdf
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Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na(+)/K(+)-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats.

Antioxidants & Redox Signaling
Ge, Shun-Na SN; Zhao, Man-Man MM; Wu, Dong-Dong DD; Chen, Ying Y; Wang, Yi Y; Zhu, Jian-Hua JH; Cai, Wen-Jie WJ; Zhu, Yi-Zhun YZ; Zhu, Yi-Chun YC
Publication Date: 2014-11-20

Variant appearance in text: PI3K: K179M
PubMed Link: 24684506
Variant Present in the following documents:
  • Main text
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MEF2 is a converging hub for histone deacetylase 4 and phosphatidylinositol 3-kinase/Akt-induced transformation.

Molecular And Cellular Biology
Di Giorgio, Eros E; Clocchiatti, Andrea A; Piccinin, Sara S; Sgorbissa, Andrea A; Viviani, Giulia G; Peruzzo, Paolo P; Romeo, Salvatore S; Rossi, Sabrina S; Dei Tos, Angelo Paolo AP; Maestro, Roberta R; Brancolini, Claudio C
Publication Date: 2013-11

Variant appearance in text: PI3K: K179M
PubMed Link: 24043307
Variant Present in the following documents:
  • Main text
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Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection.

Mitochondrion
Rajala, Ammaji A; Gupta, Vivek K VK; Anderson, Robert E RE; Rajala, Raju V S RV
Publication Date: 2013-11

Variant appearance in text: PI3K: K179M
PubMed Link: 23993956
Variant Present in the following documents:
  • Main text
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Akt-signal integration is involved in the differentiation of embryonal carcinoma cells.

Plos One
Chen, Bo B; Xue, Zheng Z; Yang, Guanghui G; Shi, Bingyang B; Yang, Ben B; Yan, Yuemin Y; Wang, Xue X; Han, Daishu D; Huang, Yue Y; Dong, Wenji W
Publication Date: 2013

Variant appearance in text: PI3K: K179M
PubMed Link: 23762260
Variant Present in the following documents:
  • Main text
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Critical role of a survivin/TGF-β/mTORC1 axis in IGF-I-mediated growth of prostate epithelial cells.

Plos One
Song, Kyung K; Shankar, Eswar E; Yang, Jiayi J; Bane, Kara L KL; Wahdan-Alaswad, Reema R; Danielpour, David D
Publication Date: 2013

Variant appearance in text: PI3K: K179M
PubMed Link: 23658701
Variant Present in the following documents:
  • Main text
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Integration of apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/protein kinase B-IκB kinase cascade.

Molecular And Cellular Biology
Puckett, Mary C MC; Goldman, Erinn H EH; Cockrell, Lisa M LM; Huang, Bei B; Kasinski, Andrea L AL; Du, Yuhong Y; Wang, Cun-Yu CY; Lin, Anning A; Ichijo, Hidenori H; Khuri, Fadlo F; Fu, Haian H
Publication Date: 2013-06

Variant appearance in text: PI3K: K179M
PubMed Link: 23530055
Variant Present in the following documents:
  • Main text
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Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.

Plos One
McNamara, Colleen R CR; Ahuja, Ruchita R; Osafo-Addo, Awo D AD; Barrows, Douglas D; Kettenbach, Arminja A; Skidan, Igor I; Teng, Xin X; Cuny, Gregory D GD; Gerber, Scott S; Degterev, Alexei A
Publication Date: 2013

Variant appearance in text: PI3K: K179M
PubMed Link: 23469174
Variant Present in the following documents:
  • Main text
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CDK inhibitor p57 (Kip2) is downregulated by Akt during HER2-mediated tumorigenicity.

Cell Cycle (Georgetown, Tex.)
Zhao, Ruiying R; Yang, Heng-Yin HY; Shin, Jihyun J; Phan, Liem L; Fang, Lekun L; Che, Ting-Fang TF; Su, Chun-Hui CH; Yeung, Sai-Ching J SC; Lee, Mong-Hong MH
Publication Date: 2013-03-15

Variant appearance in text: PI3K: K179M
PubMed Link: 23421998
Variant Present in the following documents:
  • Main text
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Angiogenin in Parkinson disease models: role of Akt phosphorylation and evaluation of AAV-mediated angiogenin expression in MPTP treated mice.

Plos One
Steidinger, Trent U TU; Slone, Sunny R SR; Ding, Huiping H; Standaert, David G DG; Yacoubian, Talene A TA
Publication Date: 2013

Variant appearance in text: PI3K: K179M
PubMed Link: 23409128
Variant Present in the following documents:
  • Main text
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Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.

Science (New York, N.Y.)
Wang, Richard C RC; Wei, Yongjie Y; An, Zhenyi Z; Zou, Zhongju Z; Xiao, Guanghua G; Bhagat, Govind G; White, Michael M; Reichelt, Julia J; Levine, Beth B
Publication Date: 2012-11-16

Variant appearance in text: PI3K: K179M
PubMed Link: 23112296
Variant Present in the following documents:
  • Main text
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HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53.

Cell Cycle (Georgetown, Tex.)
Xue, Yuwen Y; Chen, Jian J; Choi, Hyun-Ho HH; Phan, Liem L; Chou, Ping-Chieh PC; Zhao, Ruiying R; Yang, Huiling H; Santiago, Janice J; Liu, Mo M; Yeung, Giselle E GE; Yeung, Sai-Ching J SC; Lee, Mong-Hong MH
Publication Date: 2012-11-15

Variant appearance in text: PI3K: K179M
PubMed Link: 23095642
Variant Present in the following documents:
  • Main text
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PI3K p110α isoform-dependent Rho GTPase Rac1 activation mediates H2S-promoted endothelial cell migration via actin cytoskeleton reorganization.

Plos One
Zhang, Li-Jia LJ; Tao, Bei-Bei BB; Wang, Ming-Jie MJ; Jin, Hui-Ming HM; Zhu, Yi-Chun YC
Publication Date: 2012

Variant appearance in text: PI3K: K179M
PubMed Link: 22970259
Variant Present in the following documents:
  • Main text
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Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart.

Frontiers In Pharmacology
Klement, Giannoula L GL; Goukassian, David D; Hlatky, Lynn L; Carrozza, Joseph J; Morgan, James P JP; Yan, Xinhua X
Publication Date: 2012

Variant appearance in text: PI3K: K179M
PubMed Link: 22754526
Variant Present in the following documents:
  • Main text
  • fphar-03-00113.pdf
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Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases.

Cancer Research
Hiraga, Toru T; Myoui, Akira A; Hashimoto, Nobuyuki N; Sasaki, Akira A; Hata, Kenji K; Morita, Yoshihiro Y; Yoshikawa, Hideki H; Rosen, Clifford J CJ; Mundy, Gregory R GR; Yoneda, Toshiyuki T
Publication Date: 2012-08-15

Variant appearance in text: PI3K: K179M
PubMed Link: 22738911
Variant Present in the following documents:
  • Main text
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miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression.

Carcinogenesis
Mandal, Chandi Charan CC; Ghosh-Choudhury, Triparna T; Dey, Nirmalya N; Choudhury, Goutam Ghosh GG; Ghosh-Choudhury, Nandini N
Publication Date: 2012-10

Variant appearance in text: PIK3CA: K179M
PubMed Link: 22678116
Variant Present in the following documents:
  • Main text
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Pten coordinates retinal neurogenesis by regulating Notch signalling.

The Embo Journal
Jo, Hong Seok HS; Kang, Kyung Hwa KH; Joe, Cheol O CO; Kim, Jin Woo JW
Publication Date: 2012-02-15

Variant appearance in text: PI3K: K179M
PubMed Link: 22258620
Variant Present in the following documents:
  • Main text
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IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.

The Journal Of Biological Chemistry
Guo, Jian-Ping JP; Coppola, Domenico D; Cheng, Jin Q JQ
Publication Date: 2011-10-28

Variant appearance in text: PI3K: K179M
PubMed Link: 21908616
Variant Present in the following documents:
  • Main text
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Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2.

The Journal Of Biological Chemistry
Warfel, Noel A NA; Niederst, Matt M; Newton, Alexandra C AC
Publication Date: 2011-11-11

Variant appearance in text: PI3K: K179M
PubMed Link: 21908613
Variant Present in the following documents:
  • Main text
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Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate.

The Journal Of Biological Chemistry
Gan, Xiaoqing X; Wang, Jiyong J; Su, Bing B; Wu, Dianqing D
Publication Date: 2011-04-01

Variant appearance in text: PI3K: K179M
PubMed Link: 21310961
Variant Present in the following documents:
  • Main text
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Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway.

The Journal Of Biological Chemistry
Lin, Chien-Huang CH; Cheng, Hui-Wen HW; Ma, Hon-Ping HP; Wu, Chih-Hsiung CH; Hong, Chuang-Ye CY; Chen, Bing-Chang BC
Publication Date: 2011-03-25

Variant appearance in text: PI3K: K179M
PubMed Link: 21266580
Variant Present in the following documents:
  • Main text
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δ-Opioid receptors stimulate GLUT1-mediated glucose uptake through Src- and IGF-1 receptor-dependent activation of PI3-kinase signalling in CHO cells.

British Journal Of Pharmacology
Olianas, Maria C MC; Dedoni, Simona S; Onali, Pierluigi P
Publication Date: 2011-06

Variant appearance in text: PI3K: K179M
PubMed Link: 21250979
Variant Present in the following documents:
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Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.

Endocrinology
Leen, Jason L S JL; Izzo, Angelo A; Upadhyay, Chandani C; Rowland, Katherine J KJ; Dubé, Philip E PE; Gu, Steven S; Heximer, Scott P SP; Rhodes, Christopher J CJ; Storm, Daniel R DR; Lund, P Kay PK; Brubaker, Patricia L PL
Publication Date: 2011-02

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PubMed Link: 21159855
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Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signaling.

Cancer Research
Wahdan-Alaswad, Reema S RS; Song, Kyung K; Krebs, Tracy L TL; Shola, Dorjee T N DT; Gomez, Jose A JA; Matsuyama, Shigemi S; Danielpour, David D
Publication Date: 2010-11-15

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PubMed Link: 21062988
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Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4.

The Journal Of Biological Chemistry
Li, Peifeng P; Jayarama, Shankar S; Ganesh, Lakshmy L; Mordi, David D; Carr, Ryan R; Kanteti, Prasad P; Hay, Nissim N; Prabhakar, Bellur S BS
Publication Date: 2010-07-16

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PubMed Link: 20484047
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Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells.

Bmc Cancer
Xu, Zekuan Z; Zhang, Yi Y; Jiang, Jiakai J; Yang, Yang Y; Shi, Ruihua R; Hao, Bo B; Zhang, Zhihong Z; Huang, Zuhu Z; Kim, Jin W JW; Zhang, Guoxin G
Publication Date: 2010-04-27

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PubMed Link: 20423485
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DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells.

Science Signaling
Rajagopalan, Sumati S; Moyle, Mark W MW; Joosten, Irma I; Long, Eric O EO
Publication Date: 2010-02-23

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PubMed Link: 20179272
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Pharmacological manipulation of the akt signaling pathway regulates myxoma virus replication and tropism in human cancer cells.

Journal Of Virology
Werden, Steven J SJ; McFadden, Grant G
Publication Date: 2010-04

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PubMed Link: 20106927
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Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation.

Endocrinology
Mandal, Chandi C CC; Ghosh Choudhury, Goutam G; Ghosh-Choudhury, Nandini N
Publication Date: 2009-11

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PubMed Link: 19819979
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PI3K/Akt signalling-mediated protein surface expression sensed by 14-3-3 interacting motif.

The Febs Journal
Chung, Jean-Ju JJ; Okamoto, Yukari Y; Coblitz, Brian B; Li, Min M; Qiu, Yun Y; Shikano, Sojin S
Publication Date: 2009-10

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PubMed Link: 19691494
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Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae.

Journal Of Immunology (Baltimore, Md. : 1950)
Hajishengallis, George G; Wang, Min M; Liang, Shuang S
Publication Date: 2009-06-01

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PubMed Link: 19454663
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Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication.

Journal Of Virology
Soares, Jamária A P JA; Leite, Flávia G G FG; Andrade, Luciana G LG; Torres, Alice A AA; De Sousa, Lirlândia P LP; Barcelos, Lucíola S LS; Teixeira, Mauro M MM; Ferreira, Paulo C P PC; Kroon, Erna G EG; Souto-Padrón, Thaís T; Bonjardim, Cláudio A CA
Publication Date: 2009-07

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PubMed Link: 19386722
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Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability.

The Journal Of Cell Biology
Catalucci, Daniele D; Zhang, Deng-Hong DH; DeSantiago, Jaime J; Aimond, Franck F; Barbara, Guillaume G; Chemin, Jean J; Bonci, Désiré D; Picht, Eckard E; Rusconi, Francesca F; Dalton, Nancy D ND; Peterson, Kirk L KL; Richard, Sylvain S; Bers, Donald M DM; Brown, Joan Heller JH; Condorelli, Gianluigi G
Publication Date: 2009-03-23

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PubMed Link: 19307602
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Phosphatidylinositol 3-kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study of Akt mutations.

The Journal Of Biological Chemistry
Rodríguez-Escudero, Isabel I; Andrés-Pons, Amparo A; Pulido, Rafael R; Molina, María M; Cid, Víctor J VJ
Publication Date: 2009-05-15

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PubMed Link: 19307184
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Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization.

Cell Death And Differentiation
Gama, V V; Gomez, J A JA; Mayo, L D LD; Jackson, M W MW; Danielpour, D D; Song, K K; Haas, A L AL; Laughlin, M J MJ; Matsuyama, S S
Publication Date: 2009-05

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PubMed Link: 19247369
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