Publications:

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PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Spangle, Jennifer M JM; Von, Thanh T; Pavlick, Dean C DC; Khotimsky, Arina A; Zhao, Jean J JJ; Roberts, Thomas M TM

Publication Date: 2020-09-29

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PubMed Link: 32929011

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The structural basis for Ras activation of PI3Kα lipid kinase.

Physical Chemistry Chemical Physics : Pccp

Zhang, Mingzhen M; Jang, Hyunbum H; Nussinov, Ruth R

Publication Date: 2019-06-05

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PubMed Link: 31135801

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FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling.

Frontiers In Immunology

Ten Broeke, Toine T; Honing, Henk H; Brandsma, Arianne M AM; Jacobino, Shamir S; Bakema, Jantine E JE; Kanters, Deon D; van der Linden, Jan A M JAM; Bracke, Madelon M; Koenderman, Leo L; Leusen, Jeanette H W JHW

Publication Date: 2018

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PubMed Link: 30766540

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• fimmu-09-03191.pdf

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A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN.

Cellular And Molecular Life Sciences : Cmls

Leitner, Michael G MG; Hobiger, Kirstin K; Mavrantoni, Angeliki A; Feuer, Anja A; Oberwinkler, Johannes J; Oliver, Dominik D; Halaszovich, Christian R CR

Publication Date: 2018-11

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PubMed Link: 29987362

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• 18_2018_Article_2867.pdf

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Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways.

Cancers

Wee, Ping P; Wang, Zhixiang Z

Publication Date: 2017-05-17

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PubMed Link: 28513565

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• cancers-09-00052.pdf

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Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model.

Bioscience Reports

Oliver, María D MD; Fernández-Acero, Teresa T; Luna, Sandra S; Rodríguez-Escudero, Isabel I; Molina, María M; Pulido, Rafael R; Cid, Víctor J VJ

Publication Date: 2017-04-30

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PubMed Link: 28143957

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Discovery and functional characterization of a neomorphic PTEN mutation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Costa, Helio A HA; Leitner, Michael G MG; Sos, Martin L ML; Mavrantoni, Angeliki A; Rychkova, Anna A; Johnson, Jeffrey R JR; Newton, Billy W BW; Yee, Muh-Ching MC; De La Vega, Francisco M FM; Ford, James M JM; Krogan, Nevan J NJ; Shokat, Kevan M KM; Oliver, Dominik D; Halaszovich, Christian R CR; Bustamante, Carlos D CD

Publication Date: 2015-11-10

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PubMed Link: 26504226

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Kaempferol Suppresses Transforming Growth Factor-β1-Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179.

Neoplasia (New York, N.Y.)

Jo, Eunji E; Park, Seong Ji SJ; Choi, Yu Sun YS; Jeon, Woo-Kwang WK; Kim, Byung-Chul BC

Publication Date: 2015-07

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PubMed Link: 26297431

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A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases.

Frontiers In Pharmacology

Mavrantoni, Angeliki A; Thallmair, Veronika V; Leitner, Michael G MG; Schreiber, Daniela N DN; Oliver, Dominik D; Halaszovich, Christian R CR

Publication Date: 2015

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PubMed Link: 25873899

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• fphar-06-00068.pdf

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Melanoma genome sequencing reveals frequent PREX2 mutations.

Nature

Berger, Michael F MF; Hodis, Eran E; Heffernan, Timothy P TP; Deribe, Yonathan Lissanu YL; Lawrence, Michael S MS; Protopopov, Alexei A; Ivanova, Elena E; Watson, Ian R IR; Nickerson, Elizabeth E; Ghosh, Papia P; Zhang, Hailei H; Zeid, Rhamy R; Ren, Xiaojia X; Cibulskis, Kristian K; Sivachenko, Andrey Y AY; Wagle, Nikhil N; Sucker, Antje A; Sougnez, Carrie C; Onofrio, Robert R; Ambrogio, Lauren L; Auclair, Daniel D; Fennell, Timothy T; Carter, Scott L SL; Drier, Yotam Y; Stojanov, Petar P; Singer, Meredith A MA; Voet, Douglas D; Jing, Rui R; Saksena, Gordon G; Barretina, Jordi J; Ramos, Alex H AH; Pugh, Trevor J TJ; Stransky, Nicolas N; Parkin, Melissa M; Winckler, Wendy W; Mahan, Scott S; Ardlie, Kristin K; Baldwin, Jennifer J; Wargo, Jennifer J; Schadendorf, Dirk D; Meyerson, Matthew M; Gabriel, Stacey B SB; Golub, Todd R TR; Wagner, Stephan N SN; Lander, Eric S ES; Getz, Gad G; Chin, Lynda L; Garraway, Levi A LA

Publication Date: 2012-05-09

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PubMed Link: 22622578

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• NIHMS362881-supplement-3.xlsx, sheet 5

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Controlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential.

The Journal Of Biological Chemistry

Lacroix, Jérôme J; Halaszovich, Christian R CR; Schreiber, Daniela N DN; Leitner, Michael G MG; Bezanilla, Francisco F; Oliver, Dominik D; Villalba-Galea, Carlos A CA

Publication Date: 2011-05-20

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PubMed Link: 21454672

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Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.

Cell Cycle (Georgetown, Tex.)

Zhao, Li L; Vogt, Peter K PK

Publication Date: 2010-02-01

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PubMed Link: 20009532

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Class I PI3K in oncogenic cellular transformation.

Oncogene

Zhao, L L; Vogt, P K PK

Publication Date: 2008-09-18

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PubMed Link: 18794883

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Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase.

Molecular And Cellular Biology

Marqués, Miriam M; Kumar, Amit A; Cortés, Isabel I; Gonzalez-García, Ana A; Hernández, Carmen C; Moreno-Ortiz, M Carmen MC; Carrera, Ana C AC

Publication Date: 2008-04

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PubMed Link: 18285463

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Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Zhao, Li L; Vogt, Peter K PK

Publication Date: 2008-02-19

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PubMed Link: 18268322

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Phosphoinositide binding to the substrate regulates susceptibility to proteolysis by calpain.

The Journal Of Biological Chemistry

Sprague, Chelsea R CR; Fraley, Tamara S TS; Jang, Hyo Sang HS; Lal, Sangeet S; Greenwood, Jeffrey A JA

Publication Date: 2008-04-04

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PubMed Link: 18258589

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Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Kang, Sohye S; Denley, Adam A; Vanhaesebroeck, Bart B; Vogt, Peter K PK

Publication Date: 2006-01-31

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PubMed Link: 16432180

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Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling.

Journal Of Virology

Morrison, Jennifer A JA; Raab-Traub, Nancy N

Publication Date: 2005-02

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PubMed Link: 15681438

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PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus.

The Embo Journal

Ahn, Jee-Yin JY; Rong, Rong R; Liu, Xuesong X; Ye, Keqiang K

Publication Date: 2004-10-13

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PubMed Link: 15385964

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PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations.

The Embo Journal

Baki, Lia L; Shioi, Junichi J; Wen, Paul P; Shao, Zhiping Z; Schwarzman, Alexander A; Gama-Sosa, Miguel M; Neve, Rachael R; Robakis, Nikolaos K NK

Publication Date: 2004-07-07

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PubMed Link: 15192701

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IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.

Molecular Biology Of The Cell

Albanese, Chris C; Wu, Kongming K; D'Amico, Mark M; Jarrett, Christy C; Joyce, David D; Hughes, Julian J; Hulit, James J; Sakamaki, Toshiyuki T; Fu, Maofu M; Ben-Ze'ev, Avri A; Bromberg, Jacqueline F JF; Lamberti, Carmela C; Verma, Udit U; Gaynor, Richard B RB; Byers, Stephen W SW; Pestell, Richard G RG

Publication Date: 2003-02

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PubMed Link: 12589056

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Akt/PKB regulates laminin and collagen IV isotypes of the basement membrane.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Li, X X; Talts, U U; Talts, J F JF; Arman, E E; Ekblom, P P; Lonai, P P

Publication Date: 2001-12-04

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PubMed Link: 11734644

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