PIK3CA c.725G>T ;(p.C242F)

Variant ID: 3-178919240-G-T

NM_006218.2(PIK3CA):c.725G>T;(p.C242F)

This variant was identified in 11 publications

View GRCh38 version.




Publications:


Molecular characterization of colorectal cancer related peritoneal metastatic disease.

Nature Communications
Lenos, Kristiaan J KJ; Bach, Sander S; Ferreira Moreno, Leandro L; Ten Hoorn, Sanne S; Sluiter, Nina R NR; Bootsma, Sanne S; Vieira Braga, Felipe A FA; Nijman, Lisanne E LE; van den Bosch, Tom T; Miedema, Daniel M DM; van Dijk, Erik E; Ylstra, Bauke B; Kulicke, Ruth R; Davis, Fred P FP; Stransky, Nicolas N; Smolen, Gromoslaw A GA; Coebergh van den Braak, Robert R J RRJ; IJzermans, Jan N M JNM; Martens, John W M JWM; Hallam, Sally S; Beggs, Andrew D AD; Kops, Geert J P L GJPL; Lansu, Nico N; Bastiaenen, Vivian P VP; Klaver, Charlotte E L CEL; Lecca, Maria C MC; El Makrini, Khalid K; Elbers, Clara C CC; Dings, Mark P G MPG; van Noesel, Carel J M CJM; Kranenburg, Onno O; Medema, Jan Paul JP; Koster, Jan J; Koens, Lianne L; Punt, Cornelis J A CJA; Tanis, Pieter J PJ; de Hingh, Ignace H IH; Bijlsma, Maarten F MF; Tuynman, Jurriaan B JB; Vermeulen, Louis L
Publication Date: 2022-08-04

Variant appearance in text: PIK3CA: C242F
PubMed Link: 35927254
Variant Present in the following documents:
  • 41467_2022_32198_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal Cancer.

Cancers
Pfohl, Ulrike U; Loskutov, Jürgen J; Bashir, Sanum S; Kühn, Ralf R; Herter, Patrick P; Templin, Markus M; Mamlouk, Soulafa S; Belanov, Sergei S; Linnebacher, Michael M; Bürtin, Florian F; Vetter, Marcus M; Reinhard, Christoph C; Wedeken, Lena L; Regenbrecht, Christian R A CRA
Publication Date: 2022-07-01

Variant appearance in text: PIK3CA: C242F
PubMed Link: 35805024
Variant Present in the following documents:
  • Main text
View BVdb publication page



Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.

Aging
Su, Xiaofan X; Jin, Haoxuan H; Wang, Jiaqian J; Lu, Huiping H; Gu, Tiantian T; Gao, Zhibo Z; Li, Manxiang M
Publication Date: 2022-05-25

Variant appearance in text: PIK3CA: 725G>T; C242F
PubMed Link: 35613927
Variant Present in the following documents:
  • aging-14-204101-s004.xlsx, sheet 1
View BVdb publication page



Circulating tumor DNA predicts neoadjuvant immunotherapy efficacy and recurrence-free survival in surgical non-small cell lung cancer patients.

Translational Lung Cancer Research
Yue, Dongsheng D; Liu, Weiran W; Chen, Chen C; Zhang, Tao T; Ma, Yuchen Y; Cui, Longgang L; Gu, Yajun Y; Bei, Ting T; Zhao, Xiaochen X; Zhang, Bei B; Bai, Yuezong Y; Romero, Atocha A; Xu-Welliver, Meng M; Wang, Changli C; Zhang, Zhenfa Z; Zhang, Bin B
Publication Date: 2022-02

Variant appearance in text: PIK3CA: C242F
PubMed Link: 35280315
Variant Present in the following documents:
  • tlcr-11-02-263-supplementary.pdf
View BVdb publication page



Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.

Cancer Research And Treatment
Lee, Youngwoo Y; Lee, Soohyeon S; Sung, Jae Sook JS; Chung, Hee-Joon HJ; Lim, Ah-Reum AR; Kim, Ju Won JW; Choi, Yoon Ji YJ; Park, Kyong Hwa KH; Kim, Yeul Hong YH
Publication Date: 2021-01

Variant appearance in text: PIK3CA: C242F
PubMed Link: 32810930
Variant Present in the following documents:
  • crt-2020-559-suppl3.pdf
View BVdb publication page



Mutation landscape of germline and somatic BRCA1/2 in patients with high-grade serous ovarian cancer.

Bmc Cancer
Eoh, Kyung Jin KJ; Kim, Hye Min HM; Lee, Jung-Yun JY; Kim, Sunghoon S; Kim, Sang Wun SW; Kim, Young Tae YT; Nam, Eun Ji EJ
Publication Date: 2020-03-12

Variant appearance in text: PIK3CA: 725G>T; C242F
PubMed Link: 32164585
Variant Present in the following documents:
  • 12885_2020_6693_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Nature
Abbosh, Christopher C; Birkbak, Nicolai J NJ; Wilson, Gareth A GA; Jamal-Hanjani, Mariam M; Constantin, Tudor T; Salari, Raheleh R; Le Quesne, John J; Moore, David A DA; Veeriah, Selvaraju S; Rosenthal, Rachel R; Marafioti, Teresa T; Kirkizlar, Eser E; Watkins, Thomas B K TBK; McGranahan, Nicholas N; Ward, Sophia S; Martinson, Luke L; Riley, Joan J; Fraioli, Francesco F; Al Bakir, Maise M; Grönroos, Eva E; Zambrana, Francisco F; Endozo, Raymondo R; Bi, Wenya Linda WL; Fennessy, Fiona M FM; Sponer, Nicole N; Johnson, Diana D; Laycock, Joanne J; Shafi, Seema S; Czyzewska-Khan, Justyna J; Rowan, Andrew A; Chambers, Tim T; Matthews, Nik N; Turajlic, Samra S; Hiley, Crispin C; Lee, Siow Ming SM; Forster, Martin D MD; Ahmad, Tanya T; Falzon, Mary M; Borg, Elaine E; Lawrence, David D; Hayward, Martin M; Kolvekar, Shyam S; Panagiotopoulos, Nikolaos N; Janes, Sam M SM; Thakrar, Ricky R; Ahmed, Asia A; Blackhall, Fiona F; Summers, Yvonne Y; Hafez, Dina D; Naik, Ashwini A; Ganguly, Apratim A; Kareht, Stephanie S; Shah, Rajesh R; Joseph, Leena L; Marie Quinn, Anne A; Crosbie, Phil A PA; Naidu, Babu B; Middleton, Gary G; Langman, Gerald G; Trotter, Simon S; Nicolson, Marianne M; Remmen, Hardy H; Kerr, Keith K; Chetty, Mahendran M; Gomersall, Lesley L; Fennell, Dean A DA; Nakas, Apostolos A; Rathinam, Sridhar S; Anand, Girija G; Khan, Sajid S; Russell, Peter P; Ezhil, Veni V; Ismail, Babikir B; Irvin-Sellers, Melanie M; Prakash, Vineet V; Lester, Jason F JF; Kornaszewska, Malgorzata M; Attanoos, Richard R; Adams, Haydn H; Davies, Helen H; Oukrif, Dahmane D; Akarca, Ayse U AU; Hartley, John A JA; Lowe, Helen L HL; Lock, Sara S; Iles, Natasha N; Bell, Harriet H; Ngai, Yenting Y; Elgar, Greg G; Szallasi, Zoltan Z; Schwarz, Roland F RF; Herrero, Javier J; Stewart, Aengus A; Quezada, Sergio A SA; Peggs, Karl S KS; Van Loo, Peter P; Dive, Caroline C; Lin, C Jimmy CJ; Rabinowitz, Matthew M; Aerts, Hugo J W L HJWL; Hackshaw, Allan A; Shaw, Jacqui A JA; Zimmermann, Bernhard G BG; , ; , ; Swanton, Charles C
Publication Date: 2017-04-26

Variant appearance in text: PIK3CA: C242F
PubMed Link: 28445469
Variant Present in the following documents:
  • emss-72313.pdf
View BVdb publication page



Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies.

Oncotarget
Xiu, Joanne J; Piccioni, David D; Juarez, Tiffany T; Pingle, Sandeep C SC; Hu, Jethro J; Rudnick, Jeremy J; Fink, Karen K; Spetzler, David B DB; Maney, Todd T; Ghazalpour, Anatole A; Bender, Ryan R; Gatalica, Zoran Z; Reddy, Sandeep S; Sanai, Nader N; Idbaih, Ahmed A; Glantz, Michael M; Kesari, Santosh S
Publication Date: 2016-04-19

Variant appearance in text: PIK3CA: C242F
PubMed Link: 26933808
Variant Present in the following documents:
  • oncotarget-07-21556-s001.pdf
View BVdb publication page



Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies.

Oncotarget
Tortolina, Lorenzo L; Duffy, David J DJ; Maffei, Massimo M; Castagnino, Nicoletta N; Carmody, Aimée M AM; Kolch, Walter W; Kholodenko, Boris N BN; De Ambrosi, Cristina C; Barla, Annalisa A; Biganzoli, Elia M EM; Nencioni, Alessio A; Patrone, Franco F; Ballestrero, Alberto A; Zoppoli, Gabriele G; Verri, Alessandro A; Parodi, Silvio S
Publication Date: 2015-03-10

Variant appearance in text: PI3K: c242f
PubMed Link: 25671297
Variant Present in the following documents:
  • oncotarget-06-5041-s001.pdf
View BVdb publication page



Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer.

Plos One
Burghel, George J GJ; Lin, Wei-Yu WY; Whitehouse, Helen H; Brock, Ian I; Hammond, David D; Bury, Jonathan J; Stephenson, Yvonne Y; George, Rina R; Cox, Angela A
Publication Date: 2013

Variant appearance in text: PIK3CA: 725G>T
PubMed Link: 24367615
Variant Present in the following documents:
  • pone.0083859.s005.xls, sheet 1
View BVdb publication page



Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen.

World Journal Of Gastroenterology
Yamaoka, Satoshi S; Yamamoto, Hiroyuki H; Nosho, Katsuhiko K; Taniguchi, Hiroaki H; Adachi, Yasushi Y; Sasaki, Shigeru S; Arimura, Yoshiaki Y; Imai, Kohzoh K; Shinomura, Yasuhisa Y
Publication Date: 2009-11-28

Variant appearance in text: PIK3CA: C242F
PubMed Link: 19938198
Variant Present in the following documents:
  • Main text
View BVdb publication page