Publications:

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Insulin resistance and exaggerated insulin sensitivity triggered by single-gene mutations in the insulin signaling pathway.

Diabetology International

Kushi, Ryo R; Hirota, Yushi Y; Ogawa, Wataru W

Publication Date: 2021-01

Variant appearance in text: PI3K: Arg274His

PubMed Link: 33479580

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Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses.

Frontiers In Pharmacology

Kadioglu, Onat O; Saeed, Mohamed M; Kuete, Victor V; Greten, Henry J HJ; Efferth, Thomas T

Publication Date: 2018

Variant appearance in text: PI3K: R274H

PubMed Link: 29713280

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• fphar-09-00355.pdf

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The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation.

Structure (London, England : 1993)

Lu, Shaoyong S; Deng, Rong R; Jiang, Haiming H; Song, Huili H; Li, Shuai S; Shen, Qiancheng Q; Huang, Wenkang W; Nussinov, Ruth R; Yu, Jianxiu J; Zhang, Jian J

Publication Date: 2015-09-01

Variant appearance in text: PI3K: R274H

PubMed Link: 26256536

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Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.

The Biochemical Journal

Chan, Tung O TO; Zhang, Jin J; Tiegs, Brian C BC; Blumhof, Brian B; Yan, Linda L; Keny, Nikhil N; Penny, Morgan M; Li, Xue X; Pascal, John M JM; Armen, Roger S RS; Rodeck, Ulrich U; Penn, Raymond B RB

Publication Date: 2015-10-01

Variant appearance in text: PI3K: R274H

PubMed Link: 26201515

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Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.

Nature Communications

Lim, Chun-Yan CY; Bi, Xuezhi X; Wu, Donghai D; Kim, Jae Bum JB; Gunning, Peter W PW; Hong, Wanjin W; Han, Weiping W

Publication Date: 2015-01-09

Variant appearance in text: PI3K: R274H

PubMed Link: 25575350

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• ncomms6951.pdf

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Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis.

American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology

Hu, Nan N; Dong, Maolong M; Ren, Jun J

Publication Date: 2014-05-15

Variant appearance in text: PI3K: R274H

PubMed Link: 24622975

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Insulin receptor signaling in normal and insulin-resistant states.

Cold Spring Harbor Perspectives In Biology

Boucher, Jérémie J; Kleinridders, André A; Kahn, C Ronald CR

Publication Date: 2014-01-01

Variant appearance in text: PI3K: R274H

PubMed Link: 24384568

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