Publications:

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The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51.

Plos Biology

Park, Jung Mi JM; Yang, Seung Wook SW; Zhuang, Wei W; Bera, Asim K AK; Liu, Yan Y; Gurbani, Deepak D; von Hoyningen-Huene, Sergei J SJ; Sakurada, Sadie Miki SM; Gan, Haiyun H; Pruett-Miller, Shondra M SM; Westover, Kenneth D KD; Potts, Malia B MB

Publication Date: 2021-06

Variant appearance in text: PI3K: S295A

PubMed Link: 34077419

Variant Present in the following documents:

• Main text
• pbio.3001281.pdf

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: PIK3CA: 883T>G; S295A

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

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Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes.

Elife

Ohashi, Yohei Y; Tremel, Shirley S; Masson, Glenn Robert GR; McGinney, Lauren L; Boulanger, Jerome J; Rostislavleva, Ksenia K; Johnson, Christopher M CM; Niewczas, Izabella I; Clark, Jonathan J; Williams, Roger L RL

Publication Date: 2020-06-30

Variant appearance in text: PI3K: S295A

PubMed Link: 32602837

Variant Present in the following documents:

• Main text
• elife-58281.pdf

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Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis.

Cell Systems

Gross, Sean M SM; Dane, Mark A MA; Bucher, Elmar E; Heiser, Laura M LM

Publication Date: 2019-12-18

Variant appearance in text: PI3K: S295A

PubMed Link: 31838146

Variant Present in the following documents:

• Main text

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14-3-3ζ binds to and stabilizes phospho-beclin 1S295 and induces autophagy in hepatocellular carcinoma cells.

Journal Of Cellular And Molecular Medicine

Tang, Yufu Y; Zhang, Yibing Y; Liu, Shupeng S; Sun, Zhongyi Z; Wang, Chunhui C; Li, Longfei L; Zhou, Wenping W; Cheng, Shuqun S

Publication Date: 2020-01

Variant appearance in text: PI3K: S295A

PubMed Link: 31709727

Variant Present in the following documents:

• JCMM-24-954.pdf

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Human gastric cancer modelling using organoids.

Gut

Seidlitz, Therese T; Merker, Sebastian R SR; Rothe, Alexander A; Zakrzewski, Falk F; von Neubeck, Cläre C; Grützmann, Konrad K; Sommer, Ulrich U; Schweitzer, Christine C; Schölch, Sebastian S; Uhlemann, Heike H; Gaebler, Anne-Marlene AM; Werner, Kristin K; Krause, Mechthild M; Baretton, Gustavo B GB; Welsch, Thilo T; Koo, Bon-Kyoung BK; Aust, Daniela E DE; Klink, Barbara B; Weitz, Jürgen J; Stange, Daniel E DE

Publication Date: 2019-02

Variant appearance in text: PIK3CA: Ser295Ala

PubMed Link: 29703791

Variant Present in the following documents:

• gutjnl-2017-314549supp010.xlsx, sheet 3

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Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation.

Science (New York, N.Y.)

Wang, Richard C RC; Wei, Yongjie Y; An, Zhenyi Z; Zou, Zhongju Z; Xiao, Guanghua G; Bhagat, Govind G; White, Michael M; Reichelt, Julia J; Levine, Beth B

Publication Date: 2012-11-16

Variant appearance in text: PI3K: S295A

PubMed Link: 23112296

Variant Present in the following documents:

• Main text

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