Publications:

---

Recent Advances (2015-2020) in Drug Discovery for Attenuation of Pulmonary Fibrosis and COPD.

Molecules (Basel, Switzerland)

Dorababu, Atukuri A; Maraswami, Manikantha M

Publication Date: 2023-04-24

Variant appearance in text: PI3K: T315I

PubMed Link: 37175084

Variant Present in the following documents:

• molecules-28-03674.pdf

View BVdb publication page

---

I13 overrides resistance mediated by the T315I mutation in chronic myeloid leukemia by direct BCR-ABL inhibition.

Frontiers In Pharmacology

Gao, Congying C; Zhang, Lei L; Xu, Yun Y; Ma, Xiangyu X; Chen, Peilei P; Chen, Zhe-Sheng ZS; Wei, Liuya L

Publication Date: 2023

Variant appearance in text: PI3K: T315I

PubMed Link: 37124196

Variant Present in the following documents:

• Main text
• fphar-14-1183052.pdf

View BVdb publication page

---

A combination of metformin and epigallocatechin gallate potentiates glioma chemotherapy in vivo.

Frontiers In Pharmacology

Kuduvalli, Shreyas S SS; Daisy, Precilla S PS; Vaithy, Anandraj A; Purushothaman, Mugilarasi M; Ramachandran Muralidharan, Arumugam A; Agiesh, Kumar B KB; Mezger, Markus M; Antony, Justin S JS; Subramani, Madhu M; Dubashi, Biswajit B; Biswas, Indrani I; Guruprasad, K P KP; Anitha, T S TS

Publication Date: 2023

Variant appearance in text: PI3K: T315I

PubMed Link: 37025487

Variant Present in the following documents:

• fphar-14-1096614.pdf

View BVdb publication page

---

PROTAC'ing oncoproteins: targeted protein degradation for cancer therapy.

Molecular Cancer

Kelm, Jeremy M JM; Pandey, Deepti S DS; Malin, Evan E; Kansou, Hussein H; Arora, Sahil S; Kumar, Raj R; Gavande, Navnath S NS

Publication Date: 2023-03-30

Variant appearance in text: PI3K: T315I

PubMed Link: 36991452

Variant Present in the following documents:

• Main text
• 12943_2022_Article_1707.pdf

View BVdb publication page

---

The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia.

Molecular Medicine (Cambridge, Mass.)

Bai, Tao T; Li, Mingxing M; Liu, Yuanfeng Y; Qiao, Zhentao Z; Zhang, Xusheng X; Wang, Yafeng Y; Wang, Zhiwei Z

Publication Date: 2023-03-28

Variant appearance in text: PI3K: T315I

PubMed Link: 36977984

Variant Present in the following documents:

• 10020_2023_Article_635.pdf

View BVdb publication page

---

Diagnostic value of liquid biopsy in the era of precision medicine: 10 years of clinical evidence in cancer.

Exploration Of Targeted Anti-Tumor Therapy

Caputo, Vincenza V; Ciardiello, Fortunato F; Corte, Carminia Maria Della CMD; Martini, Giulia G; Troiani, Teresa T; Napolitano, Stefania S

Publication Date: 2023

Variant appearance in text: PIK3CA: T315I

PubMed Link: 36937316

Variant Present in the following documents:

• etat-04-1002125.pdf

View BVdb publication page

---

Clinical Circulating Tumor DNA testing for Precision Oncology.

Cancer Research And Treatment

Kim, Hyunji H; Park, Kyoung Un KU

Publication Date: 2023-03-13

Variant appearance in text: PIK3CA: T315I

PubMed Link: 36915242

Variant Present in the following documents:

• crt-2022-1026.pdf

View BVdb publication page

---

Synergistic cytotoxicity effect of the combination of chitosan nanoencapsulated imatinib mesylate and quercetin in BCR-ABL positive K562 cells.

Iranian Journal Of Basic Medical Sciences

Kamyabi, Rohollah R; Jahandideh, Alireza A; Panahi, Negar N; Muhammadnejad, Samad S

Publication Date: 2023-03

Variant appearance in text: PI3K: T315I

PubMed Link: 36865043

Variant Present in the following documents:

• IJBMS-26-359.pdf

View BVdb publication page

---

Whole-exome sequencing identified recurrent and novel variants in benzene-induced leukemia.

Bmc Medical Genomics

Lin, Dafeng D; Wang, Dianpeng D; Li, Peimao P; Deng, Lihua L; Zhang, Zhimin Z; Zhang, Yanfang Y; Zhang, Ming M; Zhang, Naixing N

Publication Date: 2023-01-26

Variant appearance in text: PI3K: T315I

PubMed Link: 36703207

Variant Present in the following documents:

• Main text
• 12920_2023_Article_1442.pdf

View BVdb publication page

---

Curcumin Decreases Viability and Inhibits Proliferation of Imatinib-Sensitive and Imatinib-Resistant Chronic Myeloid Leukemia Cell Lines.

Metabolites

Bilajac, Esma E; Mahmutović, Lejla L; Glamočlija, Una U; Osmanović, Amar A; Hromić-Jahjefendić, Altijana A; Tambuwala, Murtaza M MM; Suljagić, Mirza M

Publication Date: 2022-12-30

Variant appearance in text: PI3K: T315I

PubMed Link: 36676983

Variant Present in the following documents:

• Main text
• metabolites-13-00058.pdf

View BVdb publication page

---

Identification of Thiazolo[5,4-b]pyridine Derivatives as c-KIT Inhibitors for Overcoming Imatinib Resistance.

Cancers

Nam, Yunju Y; Kim, Chan C; Han, Junghee J; Ryu, SeongShick S; Cho, Hanna H; Song, Chiman C; Kim, Nam Doo ND; Kim, Namkyoung N; Sim, Taebo T

Publication Date: 2022-12-26

Variant appearance in text: PI3K: T315I

PubMed Link: 36612139

Variant Present in the following documents:

• Main text
• cancers-15-00143.pdf

View BVdb publication page

---

Alterations in cellular metabolisms after TKI therapy for Philadelphia chromosome-positive leukemia in children: A review.

Frontiers In Oncology

Li, Chunmou C; Wen, Luping L; Dong, Junchao J; Li, Lindi L; Huang, Junbin J; Yang, Jing J; Liang, Tianqi T; Li, Tianwen T; Xia, Zhigang Z; Chen, Chun C

Publication Date: 2022

Variant appearance in text: PI3K: T315I

PubMed Link: 36561525

Variant Present in the following documents:

• Main text
• fonc-12-1072806.pdf

View BVdb publication page

---

Natural Products as Anticancer Agents: Current Status and Future Perspectives.

Molecules (Basel, Switzerland)

Naeem, Abid A; Hu, Pengyi P; Yang, Ming M; Zhang, Jing J; Liu, Yali Y; Zhu, Weifeng W; Zheng, Qin Q

Publication Date: 2022-11-30

Variant appearance in text: PI3K: t315i

PubMed Link: 36500466

Variant Present in the following documents:

• Main text
• molecules-27-08367.pdf

View BVdb publication page

---

Ponatinib modulates the metabolic profile of obese mice by inhibiting adipose tissue macrophage inflammation.

Frontiers In Pharmacology

Lin, Zhuomiao Z; Lin, Xiaochun X; Lai, Ying Y; Han, Congcong C; Fan, Xinran X; Tang, Jie J; Mo, Shiqi S; Su, Jiahui J; Liang, Sijia S; Shang, Jinyan J; Lv, Xiaofei X; Guo, Siwan S; Pang, Ruiping R; Zhou, Jiaguo J; Zhang, Tingting T; Zhang, Feiran F

Publication Date: 2022

Variant appearance in text: PI3K: T315I

PubMed Link: 36457708

Variant Present in the following documents:

• fphar-13-1040999.pdf

View BVdb publication page

---

The hedgehog pathway in hematopoiesis and hematological malignancy.

Frontiers In Oncology

Lemos, Tucker T; Merchant, Akil A

Publication Date: 2022

Variant appearance in text: PI3K: T315I

PubMed Link: 36091167

Variant Present in the following documents:

• Main text
• fonc-12-960943.pdf

View BVdb publication page

---

Targeting dual oncogenic machineries driven by TAL1 and PI3K-AKT pathways in Tcell acute lymphoblastic leukemia.

Haematologica

Lim, Fang Qi FQ; Chan, Allison Si-Yu AS; Yokomori, Rui R; Huang, Xiao Zi XZ; Theardy, Madelaine Skolastika MS; Yeoh, Allen Eng Juh AEJ; Tan, Shi Hao SH; Sanda, Takaomi T

Publication Date: 2022-09-08

Variant appearance in text: PI3K: T315I

PubMed Link: 36073513

Variant Present in the following documents:

• 2022_280761_LIM_TABLES_SUPPL.xlsx, sheet 5

View BVdb publication page

---

A New View of Activating Mutations in Cancer.

Cancer Research

Nussinov, Ruth R; Tsai, Chung-Jung CJ; Jang, Hyunbum H

Publication Date: 2022-11-15

Variant appearance in text: PI3K: T315I

PubMed Link: 36069825

Variant Present in the following documents:

• Main text
• 4114.pdf

View BVdb publication page

---

Properties of Leukemic Stem Cells in Regulating Drug Resistance in Acute and Chronic Myeloid Leukemias.

Biomedicines

Zhai, Xingjian X; Jiang, Xiaoyan X

Publication Date: 2022-07-30

Variant appearance in text: PI3K: T315I

PubMed Link: 36009388

Variant Present in the following documents:

• Main text
• biomedicines-10-01841.pdf

View BVdb publication page

---

Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies.

Biomolecules

Moshawih, Said S; Lim, Ai Fern AF; Ardianto, Chrismawan C; Goh, Khang Wen KW; Kifli, Nurolaini N; Goh, Hui Poh HP; Jarrar, Qais Q; Ming, Long Chiau LC

Publication Date: 2022-06-23

Variant appearance in text: PI3K: T315I

PubMed Link: 35883434

Variant Present in the following documents:

• biomolecules-12-00878.pdf

View BVdb publication page

---

Quercetin Inhibits KBM7R Cell Proliferation through Wnt/β-Catenin Signaling.

Evidence-Based Complementary And Alternative Medicine : Ecam

Li, Wei W; Yu, Yang Y; Cheng, Huanchen H; Liu, Shengwei S; Gong, Tiejun T; Ma, Jun J; Tang, Qinghua Q

Publication Date: 2022

Variant appearance in text: PI3K: T315I

PubMed Link: 35783534

Variant Present in the following documents:

• ECAM2022-1378976.pdf

View BVdb publication page

---

Current and Future Perspectives of Cell-Free DNA in Liquid Biopsy.

Current Issues In Molecular Biology

Liu, Shicai S; Wang, Jinke J

Publication Date: 2022-06-10

Variant appearance in text: PIK3CA: T315I

PubMed Link: 35735625

Variant Present in the following documents:

• cimb-44-00184.pdf

View BVdb publication page

---

Integrated bioinformatics and statistical approaches to explore molecular biomarkers for breast cancer diagnosis, prognosis and therapies.

Plos One

Alam, Md Shahin MS; Sultana, Adiba A; Reza, Md Selim MS; Amanullah, Md M; Kabir, Syed Rashel SR; Mollah, Md Nurul Haque MNH

Publication Date: 2022

Variant appearance in text: PI3K: T315I

PubMed Link: 35617355

Variant Present in the following documents:

• pone.0268967.pdf

View BVdb publication page

---

Metformin and Thymoquinone Synergistically Inhibit Proliferation of Imatinib-Resistant Human Leukemic Cells.

Frontiers In Pharmacology

Glamoclija, Una U; Mahmutovic, Lejla L; Bilajac, Esma E; Soljic, Violeta V; Vukojevic, Katarina K; Suljagic, Mirza M

Publication Date: 2022

Variant appearance in text: PI3K: T315I

PubMed Link: 35496297

Variant Present in the following documents:

• fphar-13-867133.pdf

View BVdb publication page

---

Double Repositioning: Veterinary Antiparasitic to Human Anticancer.

International Journal Of Molecular Sciences

Sultana, Tania T; Jan, Umair U; Lee, Jeong Ik JI

Publication Date: 2022-04-13

Variant appearance in text: PI3K: T315I

PubMed Link: 35457127

Variant Present in the following documents:

• ijms-23-04315.pdf

View BVdb publication page

---

KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response.

Cell Death & Disease

Shen, Xiaohui X; Zhang, Yuchen Y; Xu, Zhuoqing Z; Gao, Han H; Feng, Wenqing W; Li, Wenchang W; Miao, Yiming Y; Xu, Zifeng Z; Zong, Yaping Y; Zhao, Jingkun J; Lu, Aiguo A

Publication Date: 2022-04-05

Variant appearance in text: PI3K: T315I

PubMed Link: 35379798

Variant Present in the following documents:

• 41419_2022_4773_MOESM9_ESM.xlsx, sheet 1

View BVdb publication page

---

Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: PIK3CA: T315I

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12

View BVdb publication page

---

Pancreatic Cancer Organoids in the Field of Precision Medicine: A Review of Literature and Experience on Drug Sensitivity Testing with Multiple Readouts and Synergy Scoring.

Cancers

Mäkinen, Lotta L; Vähä-Koskela, Markus M; Juusola, Matilda M; Mustonen, Harri H; Wennerberg, Krister K; Hagström, Jaana J; Puolakkainen, Pauli P; Seppänen, Hanna H

Publication Date: 2022-01-21

Variant appearance in text: PI3K: T315I

PubMed Link: 35158794

Variant Present in the following documents:

• cancers-14-00525.pdf

View BVdb publication page

---

Pancreatic Cancer Organoids in the Field of Precision Medicine: A Review of Literature and Experience on Drug Sensitivity Testing with Multiple Readouts and Synergy Scoring.

Cancers

Mäkinen, Lotta L; Vähä-Koskela, Markus M; Juusola, Matilda M; Mustonen, Harri H; Wennerberg, Krister K; Hagström, Jaana J; Puolakkainen, Pauli P; Seppänen, Hanna H

Publication Date: 2022-01-21

Variant appearance in text: PI3K: T315I

PubMed Link: 35158794

Variant Present in the following documents:

• cancers-14-00525.pdf

View BVdb publication page

---

Filamin A Is Required for NK Cell Cytotoxicity at the Expense of Cytokine Production via Synaptic Filamentous Actin Modulation.

Frontiers In Immunology

Kim, Nayoung N; Yi, Eunbi E; Kwon, Soon Jae SJ; Park, Hyo Jin HJ; Kwon, Hyung-Joon HJ; Kim, Hun Sik HS

Publication Date: 2021

Variant appearance in text: PI3K: T315I

PubMed Link: 35058930

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Semi-Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationships of Brefeldin A Derivatives with Antileukemia Activity.

Marine Drugs

Lu, Xu-Xiu XX; Jiang, Yao-Yao YY; Wu, Yan-Wei YW; Chen, Guang-Ying GY; Shao, Chang-Lun CL; Gu, Yu-Cheng YC; Liu, Ming M; Wei, Mei-Yan MY

Publication Date: 2021-12-24

Variant appearance in text: PI3K: T315I

PubMed Link: 35049881

Variant Present in the following documents:

• Main text
• marinedrugs-20-00026.pdf

View BVdb publication page

---

Semi-Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationships of Brefeldin A Derivatives with Antileukemia Activity.

Marine Drugs

Lu, Xu-Xiu XX; Jiang, Yao-Yao YY; Wu, Yan-Wei YW; Chen, Guang-Ying GY; Shao, Chang-Lun CL; Gu, Yu-Cheng YC; Liu, Ming M; Wei, Mei-Yan MY

Publication Date: 2021-12-24

Variant appearance in text: PI3K: T315I

PubMed Link: 35049881

Variant Present in the following documents:

• Main text
• marinedrugs-20-00026.pdf

View BVdb publication page

---

Shedding Light on Targeting Chronic Myeloid Leukemia Stem Cells.

Journal Of Clinical Medicine

Houshmand, Mohammad M; Kazemi, Alireza A; Anjam Najmedini, Ali A; Ali, Muhammad Shahzad MS; Gaidano, Valentina V; Cignetti, Alessandro A; Fava, Carmen C; Cilloni, Daniela D; Saglio, Giuseppe G; Circosta, Paola P

Publication Date: 2021-12-11

Variant appearance in text: PI3K: T315I

PubMed Link: 34945101

Variant Present in the following documents:

• Main text

View BVdb publication page

---

N,N'-Diphenyldithiomalonodiamide: Structural Features, Acidic Properties, and In Silico Estimation of Biological Activity.

Russian Journal Of General Chemistry

Sinotsko, A E AE; Bespalov, A V AV; Pashchevskaya, N V NV; Dotsenko, V V VV; Aksenov, N A NA; Aksenova, I V IV

Publication Date: 2021

Variant appearance in text: PI3K: T315I

PubMed Link: 34934303

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?

Cellular & Molecular Biology Letters

Haronikova, Lucia L; Bonczek, Ondrej O; Zatloukalova, Pavlina P; Kokas-Zavadil, Filip F; Kucerikova, Martina M; Coates, Philip J PJ; Fahraeus, Robin R; Vojtesek, Borivoj B

Publication Date: 2021-12-15

Variant appearance in text: PI3K: T315I

PubMed Link: 34911439

Variant Present in the following documents:

• 11658_2021_Article_293.pdf

View BVdb publication page

---

Tyrosine Kinase Inhibitors-Induced Arrhythmias: From Molecular Mechanisms, Pharmacokinetics to Therapeutic Strategies.

Frontiers In Cardiovascular Medicine

Cheng, Mengfei M; Yang, Fang F; Liu, Jiahui J; Yang, Dan D; Zhang, Shuo S; Yu, Yang Y; Jiang, Shuai S; Dong, Mei M

Publication Date: 2021

Variant appearance in text: PI3K: T315I

PubMed Link: 34869670

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Leukemia Stem Cells as a Potential Target to Achieve Therapy-Free Remission in Chronic Myeloid Leukemia.

Cancers

Ito, Kyoko K; Ito, Keisuke K

Publication Date: 2021-11-20

Variant appearance in text: PI3K: T315I

PubMed Link: 34830976

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Targeted Therapy for Advanced or Metastatic Cholangiocarcinoma: Focus on the Clinical Potential of Infigratinib.

Oncotargets And Therapy

Yu, James J; Mahipal, Amit A; Kim, Richard R

Publication Date: 2021

Variant appearance in text: PI3K: T315I

PubMed Link: 34720591

Variant Present in the following documents:

• ott-14-5145.pdf

View BVdb publication page

---

Kinase Inhibition in Relapsed/Refractory Leukemia and Lymphoma Settings: Recent Prospects into Clinical Investigations.

Pharmaceutics

Machado, Caio Bezerra CB; de Pinho Pessoa, Flávia Melo Cunha FMC; da Silva, Emerson Lucena EL; da Costa Pantoja, Laudreísa L; Ribeiro, Rodrigo Monteiro RM; de Moraes Filho, Manoel Odorico MO; de Moraes, Maria Elisabete Amaral MEA; Montenegro, Raquel Carvalho RC; Burbano, Rommel Mário Rodriguez RMR; Khayat, André Salim AS; Moreira-Nunes, Caroline Aquino CA

Publication Date: 2021-10-02

Variant appearance in text: PI3K: T315I

PubMed Link: 34683897

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Ferroptosis: At the Crossroad of Gemcitabine Resistance and Tumorigenesis in Pancreatic Cancer.

International Journal Of Molecular Sciences

Yang, Jianhui J; Xu, Jin J; Zhang, Bo B; Tan, Zhen Z; Meng, Qingcai Q; Hua, Jie J; Liu, Jiang J; Wang, Wei W; Shi, Si S; Yu, Xianjun X; Liang, Chen C

Publication Date: 2021-10-10

Variant appearance in text: PI3K: T315I

PubMed Link: 34681603

Variant Present in the following documents:

• ijms-22-10944.pdf

View BVdb publication page

---

Oridonin inhibits DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia by inducing apoptosis and necroptosis.

Cell Death Discovery

Liao, Min M; Dong, Qiongye Q; Chen, Ruiqing R; Xu, Liqian L; Jiang, Yuxuan Y; Guo, Zhenxing Z; Xiao, Min M; He, Wei W; Cao, Changcai C; Hu, Ronghua R; Sun, Wanling W; Jiang, Hong H; Wang, Jianwei J

Publication Date: 2021-10-18

Variant appearance in text: PI3K: T315I

PubMed Link: 34663800

Variant Present in the following documents:

• 41420_2021_697_MOESM5_ESM.xlsx, sheet 3

View BVdb publication page

---

Ex Vivo Drug Screening Informed Targeted Therapy for Metastatic Parotid Squamous Cell Carcinoma.

Frontiers In Oncology

Nykänen, Noora N; Mäkelä, Rami R; Arjonen, Antti A; Härmä, Ville V; Lewandowski, Laura L; Snowden, Eileen E; Blaesius, Rainer R; Jantunen, Ismo I; Kuopio, Teijo T; Kononen, Juha J; Rantala, Juha K JK

Publication Date: 2021

Variant appearance in text: PI3K: T315I

PubMed Link: 34604070

Variant Present in the following documents:

• fonc-11-735820.pdf

View BVdb publication page

---

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities.

Molecules (Basel, Switzerland)

Chen, Yung-Chia YC; Chia, Yi-Chen YC; Huang, Bu-Miin BM

Publication Date: 2021-09-03

Variant appearance in text: PI3K: T315I

PubMed Link: 34500802

Variant Present in the following documents:

• Main text
• molecules-26-05369.pdf

View BVdb publication page

---

Celecoxib Analogues for Cancer Treatment: An Update on OSU-03012 and 2,5-Dimethyl-Celecoxib.

Biomolecules

Sobolewski, Cyril C; Legrand, Noémie N

Publication Date: 2021-07-16

Variant appearance in text: PI3K: T315I

PubMed Link: 34356673

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target.

Cancers

Raimundo, Liliana L; Calheiros, Juliana J; Saraiva, Lucília L

Publication Date: 2021-07-09

Variant appearance in text: PI3K: T315I

PubMed Link: 34298653

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Proteomics and Drug Repurposing in CLL towards Precision Medicine.

Cancers

Mavridou, Dimitra D; Psatha, Konstantina K; Aivaliotis, Michalis M

Publication Date: 2021-07-06

Variant appearance in text: PI3K: T315I

PubMed Link: 34298607

Variant Present in the following documents:

• cancers-13-03391.pdf

View BVdb publication page

---

Targeting Leukemic Stem Cells in Chronic Myeloid Leukemia: Is It Worth the Effort?

International Journal Of Molecular Sciences

Soverini, Simona S; De Santis, Sara S; Monaldi, Cecilia C; Bruno, Samantha S; Mancini, Manuela M

Publication Date: 2021-06-30

Variant appearance in text: PI3K: T315I

PubMed Link: 34209376

Variant Present in the following documents:

• ijms-22-07093.pdf

View BVdb publication page

---

Doxorubicin/Nucleophosmin Binding Protein-Conjugated Nanoparticle Enhances Anti-leukemia Activity in Acute Lymphoblastic Leukemia Cells in vitro and in vivo.

Frontiers In Pharmacology

Gan, Donghui D; Chen, Yuwen Y; Wu, Zhengjun Z; Luo, Liping L; Yirga, Shimuye Kalayu SK; Zhang, Na N; Ye, Fu F; Chen, Haijun H; Hu, Jianda J; Chen, Yingyu Y

Publication Date: 2021

Variant appearance in text: PI3K: T315I

PubMed Link: 34122059

Variant Present in the following documents:

• fphar-12-607755.pdf

View BVdb publication page

---

Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities.

Cells

Chen, Yongfeng Y; Li, Jing J; Zhao, Zhiqiang Z

Publication Date: 2021-05-17

Variant appearance in text: PI3K: T315I

PubMed Link: 34067520

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances.

Frontiers In Oncology

Chen, Run-Ze RZ; Yang, Fei F; Zhang, Min M; Sun, Zhi-Gang ZG; Zhang, Nan N

Publication Date: 2021

Variant appearance in text: PI3K: T315I

PubMed Link: 34026649

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Kinase drug discovery 20 years after imatinib: progress and future directions.

Nature Reviews. Drug Discovery

Cohen, Philip P; Cross, Darren D; Jänne, Pasi A PA

Publication Date: 2021-07

Variant appearance in text: PI3K: T315I

PubMed Link: 34002056

Variant Present in the following documents:

• Main text

View BVdb publication page

---

GSK-3α Inhibition in Drug-Resistant CML Cells Promotes Susceptibility to NK Cell-Mediated Lysis in an NKG2D- and NKp30-Dependent Manner.

Cancers

Kim, Nayoung N; Kim, Mi Yeon MY; Choi, Woo Seon WS; Yi, Eunbi E; Lee, Hyo Jung HJ; Kim, Hun Sik HS

Publication Date: 2021-04-09

Variant appearance in text: PI3K: T315I

PubMed Link: 33918810

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Targeting MCL-1 in cancer: current status and perspectives.

Journal Of Hematology & Oncology

Wang, Haolan H; Guo, Ming M; Wei, Hudie H; Chen, Yongheng Y

Publication Date: 2021-04-21

Variant appearance in text: PI3K: T315I

PubMed Link: 33883020

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Novel agents and regimens for hematological malignancies: recent updates from 2020 ASH annual meeting.

Journal Of Hematology & Oncology

Hou, Jing-Zhou JZ; Ye, Jing Christine JC; Pu, Jeffrey J JJ; Liu, Hongtao H; Ding, Wei W; Zheng, Hong H; Liu, Delong D

Publication Date: 2021-04-21

Variant appearance in text: PI3K: T315I

PubMed Link: 33879198

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Dual Inhibition of AKT and MEK Pathways Potentiates the Anti-Cancer Effect of Gefitinib in Triple-Negative Breast Cancer Cells.

Cancers

You, Kyu Sic KS; Yi, Yong Weon YW; Cho, Jeonghee J; Seong, Yeon-Sun YS

Publication Date: 2021-03-10

Variant appearance in text: PI3K: T315I

PubMed Link: 33801977

Variant Present in the following documents:

• Main text
• cancers-13-01205.pdf

View BVdb publication page

---

Metformin - its anti-cancer effects in hematologic malignancies.

Oncology Reviews

Podhorecka, Monika M

Publication Date: 2021-02-26

Variant appearance in text: PI3K: T315I

PubMed Link: 33747367

Variant Present in the following documents:

• Main text
• onco-15-1-514.pdf

View BVdb publication page

---

A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC).

Ebiomedicine

Low, Joo-Leng JL; Lau, Dawn Pingxi DP; Zhang, Xiaoqian X; Kwang, Xue-Lin XL; Rohatgi, Neha N; Chan, Jane Vin JV; Chong, Fui-Teen FT; Wong, Stephen Qi Rong SQR; Leong, Hui-Sun HS; Thangavelu, Matan Thangavelu MT; Rikka, Shivaji S; Skanderup, Anders Martin Jacobsen AMJ; Tan, Daniel Shao Weng DSW; Periyasamy, Giridharan G; Koh, Judice Lie Yong JLY; Iyer, N Gopalakrishna NG; DasGupta, Ramanuj R

Publication Date: 2021-02

Variant appearance in text: PI3K: T315I

PubMed Link: 33529999

Variant Present in the following documents:

• mmc2.xlsx, sheet 8

View BVdb publication page

---

BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib.

Leukemia

Estupiñán, H Yesid HY; Wang, Qing Q; Berglöf, Anna A; Schaafsma, Gerard C P GCP; Shi, Yuye Y; Zhou, Litao L; Mohammad, Dara K DK; Yu, Liang L; Vihinen, Mauno M; Zain, Rula R; Smith, C I Edvard CIE

Publication Date: 2021-05

Variant appearance in text: PIK3CA: T315I

PubMed Link: 33526860

Variant Present in the following documents:

• 41375_2021_Article_1123.pdf

View BVdb publication page

---

Dual Kinase Targeting in Leukemia.

Cancers

Mologni, Luca L; Marzaro, Giovanni G; Redaelli, Sara S; Zambon, Alfonso A

Publication Date: 2021-01-01

Variant appearance in text: PI3K: T315I

PubMed Link: 33401428

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology

Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S

Publication Date: 2020

Variant appearance in text: PIK3CA: T315I

PubMed Link: 33133066

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo.

Drug Design, Development And Therapy

Sun, Peng P; Yang, Qichang Q; Wang, Yanben Y; Peng, Jiaxuan J; Zhao, Kangxian K; Jia, Yewei Y; Zhang, Tan T; Lu, Xuanyuan X; Han, Weiqi W; Qian, Yu Y

Publication Date: 2020

Variant appearance in text: PI3K: T315I

PubMed Link: 33116407

Variant Present in the following documents:

• dddt-14-4189.pdf

View BVdb publication page

---

The role of Aurora-A in human cancers and future therapeutics.

American Journal Of Cancer Research

Lin, Xinrong X; Xiang, Xiaosong X; Hao, Liping L; Wang, Ting T; Lai, Yongting Y; Abudoureyimu, Mubalake M; Zhou, Hao H; Feng, Bing B; Chu, Xiaoyuan X; Wang, Rui R

Publication Date: 2020

Variant appearance in text: PI3K: T315I

PubMed Link: 33042612

Variant Present in the following documents:

• Main text

View BVdb publication page

---

A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia.

Bmc Pharmacology & Toxicology

Lang, Fabian F; Wunderle, Lydia L; Badura, Susanne S; Schleyer, Eberhard E; Brüggemann, Monika M; Serve, Hubert H; Schnittger, Susanne S; Gökbuget, Nicola N; Pfeifer, Heike H; Wagner, Sebastian S; Ashelford, Kevin K; Bug, Gesine G; Ottmann, Oliver G OG

Publication Date: 2020-09-29

Variant appearance in text: PI3K: T315I

PubMed Link: 32993794

Variant Present in the following documents:

• Main text
• 40360_2020_Article_446.pdf

View BVdb publication page

---