PIK3CA c.1363_1365del ;(p.L456del)

Variant ID: 3-178928085-TTTG-T

NM_006218.2(PIK3CA):c.1363_1365del;(p.L456del)

This variant was identified in 15 publications

View GRCh38 version.




Publications:


Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

Nature Communications
Sivakumar, Smruthy S; Jin, Dexter X DX; Tukachinsky, Hanna H; Murugesan, Karthikeyan K; McGregor, Kimberly K; Danziger, Natalie N; Pavlick, Dean D; Gjoerup, Ole O; Ross, Jeffrey S JS; Harmon, Robert R; Chung, Jon J; Decker, Brennan B; Dennis, Lucas L; Frampton, Garrett M GM; Molinero, Luciana L; Oesterreich, Steffi S; Venstrom, Jeffrey M JM; Oxnard, Geoffrey R GR; Hegde, Priti S PS; Sokol, Ethan S ES
Publication Date: 2022-12-05

Variant appearance in text: PIK3CA: L455del
PubMed Link: 36470901
Variant Present in the following documents:
  • 41467_2022_35245_MOESM4_ESM.xlsx, sheet 12
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Biology and targetability of the extended spectrum of PIK3CA mutations (PIK3CAm) detected in breast carcinoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Rugo, Hope S HS; Raskina, Kira K; Schrock, Alexa B AB; Madison, Russell W RW; Graf, Ryon P RP; Sokol, Ethan S ES; Sivakumar, Smruthy S SS; Lee, Jessica K JK; Fisher, Virginia V; Oxnard, Geoffrey R GR; Tukachinsky, Hanna H
Publication Date: 2022-11-02

Variant appearance in text: PIK3CA: L455del
PubMed Link: 36321996
Variant Present in the following documents:
  • 1056.pdf
View BVdb publication page



Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Publication Date: 2022-06-15

Variant appearance in text: PIK3CA: L455del
PubMed Link: 35705558
Variant Present in the following documents:
  • 41467_2022_30496_MOESM2_ESM.xls, sheet 1
View BVdb publication page



A Comprehensive Survey of Genomic Mutations in Breast Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.

Frontiers In Oncology
Zhou, Si S; Liu, Songming S; Zhao, Lijian L; Sun, Hai-Xi HX
Publication Date: 2022

Variant appearance in text: PIK3CA: L455del
PubMed Link: 35387130
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
View BVdb publication page



Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy.

Cell Reports
Zhang, Yiqun Y; Chen, Fengju F; Pleasance, Erin E; Williamson, Laura L; Grisdale, Cameron J CJ; Titmuss, Emma E; Laskin, Janessa J; Jones, Steven J M SJM; Cortes-Ciriano, Isidro I; Marra, Marco A MA; Creighton, Chad J CJ
Publication Date: 2021-11-16

Variant appearance in text: PIK3CA: Leu455del
PubMed Link: 34788622
Variant Present in the following documents:
  • NIHMS1757901-supplement-2.xlsx, sheet 3
View BVdb publication page



Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.

The Journal Of Clinical Investigation
Jin, Nan N; Keam, Bhumsuk B; Cho, Janice J; Lee, Michelle J MJ; Kim, Hye Ryun HR; Torosyan, Hayarpi H; Jura, Natalia N; Ng, Patrick Ks PK; Mills, Gordon B GB; Li, Hua H; Zeng, Yan Y; Barbash, Zohar Z; Tarcic, Gabi G; Kang, Hyunseok H; Bauman, Julie E JE; Kim, Mi-Ok MO; VanLandingham, Nathan K NK; Swaney, Danielle L DL; Krogan, Nevan J NJ; Johnson, Daniel E DE; Grandis, Jennifer R JR
Publication Date: 2021-11-15

Variant appearance in text: PIK3CA: L455del
PubMed Link: 34779417
Variant Present in the following documents:
  • Main text
View BVdb publication page



PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects.

International Journal Of Molecular Sciences
Mishra, Rosalin R; Patel, Hima H; Alanazi, Samar S; Kilroy, Mary Kate MK; Garrett, Joan T JT
Publication Date: 2021-03-27

Variant appearance in text: PIK3CA: L455del
PubMed Link: 33801659
Variant Present in the following documents:
  • Main text
  • ijms-22-03464.pdf
View BVdb publication page



Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine
Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS
Publication Date: 2021-01

Variant appearance in text: PIK3CA: L455del
PubMed Link: 33314633
Variant Present in the following documents:
  • CAM4-10-53-s004.xlsx, sheet 1
  • CAM4-10-53-s003.xlsx, sheet 1
  • CAM4-10-53-s002.xlsx, sheet 1
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Phase and context shape the function of composite oncogenic mutations.

Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Publication Date: 2020-06

Variant appearance in text: PIK3CA: L455del
PubMed Link: 32461694
Variant Present in the following documents:
  • NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2
View BVdb publication page



Identification of 12 cancer types through genome deep learning.

Scientific Reports
Sun, Yingshuai Y; Zhu, Sitao S; Ma, Kailong K; Liu, Weiqing W; Yue, Yao Y; Hu, Gang G; Lu, Huifang H; Chen, Wenbin W
Publication Date: 2019-11-21

Variant appearance in text: PIK3CA: L455del
PubMed Link: 31754222
Variant Present in the following documents:
  • 41598_2019_53989_MOESM4_ESM.xlsx, sheet 2
View BVdb publication page



The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells.

Cancers
Kirstein, Anna S AS; Augustin, Adrien A; Penke, Melanie M; Cea, Michele M; Körner, Antje A; Kiess, Wieland W; Garten, Antje A
Publication Date: 2019-10-17

Variant appearance in text: PI3K: Leu455del
PubMed Link: 31627436
Variant Present in the following documents:
  • Main text
  • cancers-11-01586.pdf
View BVdb publication page



Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer.

Scientific Reports
Kaur, Pushpinder P; Porras, Tania B TB; Ring, Alexander A; Carpten, John D JD; Lang, Julie E JE
Publication Date: 2019-02-06

Variant appearance in text: PIK3CA: L455del
PubMed Link: 30728399
Variant Present in the following documents:
  • 41598_2018_37574_MOESM1_ESM.pdf
View BVdb publication page



Cancer-Associated PIK3CA Mutations in Overgrowth Disorders.

Trends In Molecular Medicine
Madsen, Ralitsa R RR; Vanhaesebroeck, Bart B; Semple, Robert K RK
Publication Date: 2018-10

Variant appearance in text: PI3K: L455del
PubMed Link: 30197175
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Croessmann, Sarah S; Sheehan, Jonathan H JH; Lee, Kyung-Min KM; Sliwoski, Gregory G; He, Jie J; Nagy, Rebecca R; Riddle, David D; Mayer, Ingrid A IA; Balko, Justin M JM; Lanman, Richard R; Miller, Vincent A VA; Cantley, Lewis C LC; Meiler, Jens J; Arteaga, Carlos L CL
Publication Date: 2018-03-15

Variant appearance in text: PIK3CA: L455del
PubMed Link: 29284706
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Mayer, Ingrid A IA; Abramson, Vandana G VG; Formisano, Luigi L; Balko, Justin M JM; Estrada, Mónica V MV; Sanders, Melinda E ME; Juric, Dejan D; Solit, David D; Berger, Michael F MF; Won, Helen H HH; Li, Yisheng Y; Cantley, Lewis C LC; Winer, Eric E; Arteaga, Carlos L CL
Publication Date: 2017-01-01

Variant appearance in text: PIK3CA: L455del
PubMed Link: 27126994
Variant Present in the following documents:
  • Main text
View BVdb publication page