PIK3CA c.1616C>G ;(p.P539R)

Variant ID: 3-178936074-C-G

NM_006218.2(PIK3CA):c.1616C>G;(p.P539R)

This variant was identified in 160 publications

View GRCh38 version.




Publications:


PIK3CA mutations in breast cancer: A Tunisian series.

Plos One
Ben Rekaya, Mariem M; Sassi, Farah F; Saied, Essya E; Bel Haj Kacem, Linda L; Mansouri, Nada N; Zarrouk, Sinda S; Azouz, Saifeddine S; Rammeh, Soumaya S
Publication Date: 2023

Variant appearance in text: PI3K: 1616C>G; rs121913285
PubMed Link: 37195967
Variant Present in the following documents:
  • Main text
  • pone.0285413.pdf
View BVdb publication page



A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression.

Cancer Cell
Hutten, Stefan J SJ; de Bruijn, Roebi R; Lutz, Catrin C; Badoux, Madelon M; Eijkman, Timo T; Chao, Xue X; Ciwinska, Marta M; Sheinman, Michael M; Messal, Hendrik H; Herencia-Ropero, Andrea A; Kristel, Petra P; Mulder, Lennart L; van der Waal, Rens R; Sanders, Joyce J; Almekinders, Mathilde M MM; Llop-Guevara, Alba A; Davies, Helen R HR; van Haren, Matthijs J MJ; Martin, Nathaniel I NI; Behbod, Fariba F; Nik-Zainal, Serena S; Serra, Violeta V; van Rheenen, Jacco J; Lips, Esther H EH; Wessels, Lodewyk F A LFA; , ; Wesseling, Jelle J; Scheele, Colinda L G J CLGJ; Jonkers, Jos J
Publication Date: 2023-04-24

Variant appearance in text: PIK3CA: P539R; rs121913285
PubMed Link: 37116492
Variant Present in the following documents:
  • mmc3.xlsx, sheet 1
View BVdb publication page



Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2-, PIK3CA-mutated breast cancers.

Genome Medicine
Hutchinson, Katherine E KE; Chen, Jessica W JW; Savage, Heidi M HM; Stout, Thomas J TJ; Schimmoller, Frauke F; Cortés, Javier J; Dent, Susan S; Harbeck, Nadia N; Jacot, William W; Krop, Ian I; Trabucco, Sally E SE; Sivakumar, Smruthy S; Sokol, Ethan S ES; Wilson, Timothy R TR
Publication Date: 2023-04-26

Variant appearance in text: PIK3CA: P539R
PubMed Link: 37101291
Variant Present in the following documents:
  • Main text
  • 13073_2023_1181_MOESM1_ESM.pdf
  • 13073_2023_Article_1181.pdf
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: PIK3CA: 1616C>G; Pro539Arg
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Pan-cancer clinical impact of latent drivers from double mutations.

Communications Biology
Yavuz, Bengi Ruken BR; Tsai, Chung-Jung CJ; Nussinov, Ruth R; Tuncbag, Nurcan N
Publication Date: 2023-02-20

Variant appearance in text: PIK3CA: P539R
PubMed Link: 36808143
Variant Present in the following documents:
  • 42003_2023_4519_MOESM1_ESM.pdf
  • 42003_2023_4519_MOESM3_ESM.xlsx, sheet 3
View BVdb publication page



Mutations in the MET tyrosine kinase domain and resistance to tyrosine kinase inhibitors in non-small-cell lung cancer.

Respiratory Research
Yao, Yu Y; Yang, Huaping H; Zhu, Bo B; Wang, Song S; Pang, Jiaohui J; Wu, Xiaoying X; Xu, Yang Y; Zhang, Junli J; Zhang, Jinfeng J; Ou, Qiuxiang Q; Tian, Hui H; Zhao, Zheng Z
Publication Date: 2023-01-25

Variant appearance in text: PIK3CA: P539R
PubMed Link: 36698189
Variant Present in the following documents:
  • 12931_2023_Article_2329.pdf
View BVdb publication page



Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics
G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A
Publication Date: 2022

Variant appearance in text: PIK3CA: P539R
PubMed Link: 36561320
Variant Present in the following documents:
  • Table3.xlsx, sheet 1
  • Table2.xlsx, sheet 5
View BVdb publication page



Identification of HLA class I-restricted immunogenic neoantigens in triple negative breast cancer.

Frontiers In Immunology
Aparicio, Belén B; Repáraz, David D; Ruiz, Marta M; Llopiz, Diana D; Silva, Leyre L; Vercher, Enric E; Theunissen, Patrick P; Tamayo, Ibon I; Smerdou, Cristian C; Igea, Ana A; Santisteban, Marta M; Gónzalez-Deza, Cristina C; Lasarte, Juan J JJ; Hervás-Stubbs, Sandra S; Sarobe, Pablo P
Publication Date: 2022

Variant appearance in text: PIK3CA: P539R
PubMed Link: 36405725
Variant Present in the following documents:
  • Table_1.xlsx, sheet 8
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: P539R
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics
Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q
Publication Date: 2022-11-04

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 36333792
Variant Present in the following documents:
  • 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Biology and targetability of the extended spectrum of PIK3CA mutations (PIK3CAm) detected in breast carcinoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Rugo, Hope S HS; Raskina, Kira K; Schrock, Alexa B AB; Madison, Russell W RW; Graf, Ryon P RP; Sokol, Ethan S ES; Sivakumar, Smruthy S SS; Lee, Jessica K JK; Fisher, Virginia V; Oxnard, Geoffrey R GR; Tukachinsky, Hanna H
Publication Date: 2022-11-02

Variant appearance in text: PIK3CA: P539R
PubMed Link: 36321996
Variant Present in the following documents:
  • 1056.pdf
View BVdb publication page



Heterogeneity of the cancer cell line metabolic landscape.

Molecular Systems Biology
Shorthouse, David D; Bradley, Jenna J; Critchlow, Susan E SE; Bendtsen, Claus C; Hall, Benjamin A BA
Publication Date: 2022-11

Variant appearance in text: PIK3CA: 1616C>G
PubMed Link: 36321551
Variant Present in the following documents:
  • MSB-18-e11006-s010.xlsx, sheet 1
View BVdb publication page



Ultrasensitive tumour-agnostic non-invasive detection of colorectal cancer recurrence using ctDNA methylation.

Clinical And Translational Medicine
Xiao, Yu Y; Wang, Xiaodong X; Weng, Hong H; Ding, Zhao Z; Qian, Kaiyu K; Jin, Wan W; Lu, Sen S; Ju, Lingao L; He, Zhiwen Z; Wang, Gang G; Xie, Xiaoyu X; Liu, Dongmei D; Fan, Zhou Z; Wu, Kai K; Li, Sheng S; Guo, Huanhuan H; Qian, Guofeng G; Jiang, Wei W; Leng, Yunji Y; Zhao, Junpeng J; Cao, Xinyue X; Peng, Minsheng M; Jiang, Congqing C; Li, Li L; Zhang, Yi Y; Wang, Xinghuan X
Publication Date: 2022-09

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 36103400
Variant Present in the following documents:
  • CTM2-12-e1015-s002.xlsx, sheet 1
View BVdb publication page



S6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer.

Molecular Cancer
Mo, Hongnan H; Liu, Xuefeng X; Xue, Yu Y; Chen, Hongyan H; Guo, Shichao S; Li, Zhangfu Z; Wang, Shuang S; Li, Caiming C; Han, Jiashu J; Fu, Ming M; Song, Yongmei Y; Li, Dan D; Ma, Fei F
Publication Date: 2022-08-30

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 36042494
Variant Present in the following documents:
  • 12943_2022_1642_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



A Systems Biology Approach to Investigate Kinase Signal Transduction Networks That Are Involved in Triple Negative Breast Cancer Resistance to Cisplatin.

Journal Of Personalized Medicine
Mukherjee, Nupur N; Browne, Alacoque A; Ivers, Laura L; Santra, Tapesh T; Cremona, Mattia M; Hennessy, Bryan T BT; O'Donovan, Norma N; Crown, John J; Kolch, Walter W; Fey, Dirk D; Eustace, Alex J AJ
Publication Date: 2022-08-03

Variant appearance in text: PIK3CA: P539R
PubMed Link: 36013226
Variant Present in the following documents:
  • jpm-12-01277.pdf
View BVdb publication page



Clinical Outcomes of Patients with Recurrent Microsatellite-Stable Endometrial Cancer in Early-Phase Immunotherapy Clinical Trials.

Cancers
How, Jeffrey A JA; Jazaeri, Amir A AA; Fu, Siqing S; Rodon Ahnert, Jordi J; Gong, Jing J; Stephen, Bettzy B; Ferreira Dalla Pria, Hanna H; Bhosale, Priya P; Johnson, Amber A; Yuan, Ying Y; Meric-Bernstam, Funda F; Naing, Aung A
Publication Date: 2022-07-29

Variant appearance in text: PIK3CA: 1616C>G
PubMed Link: 35954359
Variant Present in the following documents:
  • Main text
  • cancers-14-03695.pdf
View BVdb publication page



Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.

Cancer Medicine
Liu, Binliang B; Yi, Zongbi Z; Guan, Yanfang Y; Ouyang, Quchang Q; Li, Chunxiao C; Guan, Xiuwen X; Lv, Dan D; Li, Lixi L; Zhai, Jingtong J; Qian, Haili H; Xu, Binghe B; Ma, Fei F; Zeng, Yixin Y
Publication Date: 2022-07

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 35393784
Variant Present in the following documents:
  • CAM4-11-2767-s001.xlsx, sheet 1
View BVdb publication page



PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology
Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E
Publication Date: 2022-03

Variant appearance in text: PI3K: P539R
PubMed Link: 35357905
Variant Present in the following documents:
  • Main text
  • po-6-e2100370.pdf
View BVdb publication page



Diagnostic performance of automated, streamlined, daily updated exome analysis in patients with neurodevelopmental delay.

Molecular Medicine (Cambridge, Mass.)
Seo, Go Hun GH; Lee, Hane H; Lee, Jungsul J; Han, Heonjong H; Cho, You Kyung YK; Kim, Minji M; Choi, Yunha Y; Choi, Jeongmin J; Choi, In Hee IH; Rhie, Seonkyeong S; Chae, Kyu Young KY; Kim, Yoo-Mi YM; Cheon, Chong Kun CK; Kim, Su Jin SJ; Lee, Jieun J; Kang, Eungu E; Byeon, Jung Hye JH; Yu, Hee Joon HJ; Shin, Young-Lim YL; Oh, Arum A; Kim, Woo Jin WJ; Yum, Mi-Sun MS; Lee, Beom Hee BH; Eun, Baik-Lin BL
Publication Date: 2022-03-26

Variant appearance in text: PIK3CA: 1616C>G; Pro539Arg
PubMed Link: 35346031
Variant Present in the following documents:
  • 10020_2022_464_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Liquid Biopsy-based Precision Therapy in Patients with Advanced Solid Tumors: A Real-world Experience from a Community-based Oncology Practice.

The Oncologist
Choucair, Khalil K; Mattar, Bassam Ibrahim BI; Van Truong, Quoc Q; Koeneke, Travis T; Van Truong, Phu P; Dakhil, Christopher C; Cannon, Michael W MW; Page, Seth Joel SJ; Deutsch, Jeremy Michael JM; Carlson, Eric E; Moore, Dennis Frederic DF; Nabbout, Nassim H NH; Kallail, K James KJ; Dakhil, Shaker R SR; Reddy, Pavan S PS
Publication Date: 2022-03-11

Variant appearance in text: PIK3CA: P539R
PubMed Link: 35274713
Variant Present in the following documents:
View BVdb publication page



Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications
Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L
Publication Date: 2022-03-10

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 35273153
Variant Present in the following documents:
  • 41467_2022_28840_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Next-Generation Sequencing Reveals a Very Low Prevalence of Deleterious Mutations of Homologous Recombination Repair Genes and Homologous Recombination Deficiency in Ovarian Clear Cell Carcinoma.

Frontiers In Oncology
Liu, Hangqi H; Zhang, Zhiwen Z; Chen, Longyun L; Pang, Junyi J; Wu, Huanwen H; Liang, Zhiyong Z
Publication Date: 2021

Variant appearance in text: PIK3CA: 1616C>G; Pro539Arg
PubMed Link: 35096598
Variant Present in the following documents:
  • Table_2.xlsx, sheet 1
View BVdb publication page



KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.

Plos One
Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW
Publication Date: 2022

Variant appearance in text: rs121913285
PubMed Link: 35081118
Variant Present in the following documents:
  • pone.0251286.s005.xlsx, sheet 6
  • pone.0251286.s005.xlsx, sheet 8
View BVdb publication page



KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.

Plos One
Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW
Publication Date: 2022

Variant appearance in text: rs121913285
PubMed Link: 35081118
Variant Present in the following documents:
  • pone.0251286.s005.xlsx, sheet 6
  • pone.0251286.s005.xlsx, sheet 8
View BVdb publication page



Persistence of ctDNA in Patients with Breast Cancer During Neoadjuvant Treatment Is a Significant Predictor of Poor Tumor Response.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Zhou, Qing Q; Gampenrieder, Simon P SP; Frantal, Sophie S; Rinnerthaler, Gabriel G; Singer, Christian F CF; Egle, Daniel D; Pfeiler, Georg G; Bartsch, Rupert R; Wette, Viktor V; Pichler, Angelika A; Petru, Edgar E; Dubsky, Peter C PC; Bago-Horvath, Zsuzsanna Z; Fesl, Christian C; Rudas, Margaretha M; Ståhlberg, Anders A; Graf, Ricarda R; Weber, Sabrina S; Dandachi, Nadia N; Filipits, Martin M; Gnant, Michael M; Balic, Marija M; Heitzer, Ellen E
Publication Date: 2022-02-15

Variant appearance in text: PIK3CA: 1616C>G; Pro539Arg
PubMed Link: 34862246
Variant Present in the following documents:
  • ccr-21-3231_table_s2_supps2.xlsx, sheet 1
  • 697.pdf
View BVdb publication page



PI3Kinase Inhibition in Hormone Receptor-Positive Breast Cancer.

International Journal Of Molecular Sciences
Dhakal, Ajay A; Acharya, Luna L; O'Regan, Ruth R; Gandhi, Shipra S; Falkson, Carla C
Publication Date: 2021-11-02

Variant appearance in text: PIK3CA: P539R
PubMed Link: 34769309
Variant Present in the following documents:
  • Main text
  • ijms-22-11878.pdf
View BVdb publication page



Personalized First-Line Treatment of Metastatic Pancreatic Neuroendocrine Carcinoma Facilitated by Liquid Biopsy and Computational Decision Support.

Diagnostics (Basel, Switzerland)
Szkukalek, Judita J; Dóczi, Róbert R; Dirner, Anna A; Boldizsár, Ákos Á; Varga, Ágnes Á; Déri, Júlia J; Lakatos, Dóra D; Tihanyi, Dóra D; Vodicska, Barbara B; Schwáb, Richárd R; Pajkos, Gábor G; Várkondi, Edit E; Vályi-Nagy, István I; Valtinyi, Dorottya D; Nagy, Zsuzsanna Z; Peták, István I
Publication Date: 2021-10-07

Variant appearance in text: PIK3CA: P539R
PubMed Link: 34679548
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: PIK3CA: P539R
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



CXCL10 potentiates immune checkpoint blockade therapy in homologous recombination-deficient tumors.

Theranostics
Shi, Zhiwen Z; Shen, Jianfeng J; Qiu, Junjun J; Zhao, Qingguo Q; Hua, Keqin K; Wang, Hongyan H
Publication Date: 2021

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 34158843
Variant Present in the following documents:
  • thnov11p7175s3.xlsx, sheet 1
View BVdb publication page



Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology
Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN
Publication Date: 2021

Variant appearance in text: PIK3CA: P539R
PubMed Link: 34113354
Variant Present in the following documents:
  • Table_1.xlsx, sheet 31
  • Table_1.xlsx, sheet 21
  • Table_1.xlsx, sheet 3
View BVdb publication page



Comparison of two targeted ultra-deep sequencing technologies for analysis of plasma circulating tumour DNA in endocrine-therapy-resistant breast cancer patients.

Breast Cancer Research And Treatment
Nteliopoulos, Georgios G; Page, Karen K; Hills, Allison A; Howarth, Karen K; Emmett, Warren W; Green, Emma E; Martinson, Luke J LJ; Fernadez-Garcia, Daniel D; Hastings, Robert R; Guttery, David S DS; Kenny, Laura L; Stebbing, Justin J; Cleator, Susan S; Rehman, Farah F; Gleason, Kelly L T KLT; Sanela, Andrijac A; Ion, Charlotte C; Rushton, Amelia J AJ; Rosenfeld, Nitzan N; Coombes, R Charles RC; Shaw, Jacqueline A JA
Publication Date: 2021-07

Variant appearance in text: PIK3CA: P539R
PubMed Link: 34097174
Variant Present in the following documents:
  • 10549_2021_6220_MOESM2_ESM.xlsx, sheet 4
View BVdb publication page



Mutational Landscape of PI3K-AKT-mTOR Pathway in Breast Cancer: Implications for Targeted Therapeutics.

Journal Of Cancer
Xiao, Weikai W; Zhang, Guochun G; Chen, Bo B; Chen, Xiaoqing X; Wen, Lingzhu L; Lai, Jianguo J; Li, Xuerui X; Li, Min M; Liu, Hao H; Liu, Jing J; Han-Zhang, Han H; Lizaso, Analyn A; Liao, Ning N
Publication Date: 2021

Variant appearance in text: PIK3CA: P539R
PubMed Link: 34093841
Variant Present in the following documents:
  • Main text
  • jcav12p4408.pdf
View BVdb publication page



Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer.

Journal Of Hematology & Oncology
Chen, Gong G; Peng, Junjie J; Xiao, Qian Q; Wu, Hao-Xiang HX; Wu, Xiaojun X; Wang, Fulong F; Li, Liren L; Ding, Peirong P; Zhao, Qi Q; Li, Yaqi Y; Wang, Da D; Shao, Yang Y; Bao, Hua H; Pan, Zhizhong Z; Ding, Ke-Feng KF; Cai, Sanjun S; Wang, Feng F; Xu, Rui-Hua RH
Publication Date: 2021-05-17

Variant appearance in text: PIK3CA: P539R
PubMed Link: 34001194
Variant Present in the following documents:
  • 13045_2021_1089_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.

Nature Communications
Romero-Cordoba, Sandra L SL; Salido-Guadarrama, Ivan I; Rebollar-Vega, Rosa R; Bautista-Piña, Veronica V; Dominguez-Reyes, Carlos C; Tenorio-Torres, Alberto A; Villegas-Carlos, Felipe F; Fernández-López, Juan C JC; Uribe-Figueroa, Laura L; Alfaro-Ruiz, Luis L; Hidalgo-Miranda, Alfredo A
Publication Date: 2021-04-14

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33854067
Variant Present in the following documents:
  • 41467_2021_22478_MOESM8_ESM.xlsx, sheet 7
  • 41467_2021_22478_MOESM8_ESM.xlsx, sheet 9
View BVdb publication page



The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients.

Frontiers In Oncology
Fu, Xinhui X; Lin, Hanjie H; Fan, Xinjuan X; Zhu, Yaxi Y; Wang, Chao C; Chen, Zhiting Z; Tan, Xiaoli X; Huang, Jinglin J; Cai, Yacheng Y; Huang, Yan Y
Publication Date: 2021

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 33842311
Variant Present in the following documents:
  • Main text
View BVdb publication page



Resistance to Molecularly Targeted Therapies in Melanoma.

Cancers
Patel, Meet M; Eckburg, Adam A; Gantiwala, Shahina S; Hart, Zachary Z; Dein, Joshua J; Lam, Katie K; Puri, Neelu N
Publication Date: 2021-03-05

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33807778
Variant Present in the following documents:
  • Main text
  • cancers-13-01115.pdf
View BVdb publication page



Mesonephric and mesonephric-like carcinomas of the female genital tract: molecular characterization including cases with mixed histology and matched metastases.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
da Silva, Edaise M EM; Fix, Daniel J DJ; Sebastiao, Ana Paula Martins APM; Selenica, Pier P; Ferrando, Lorenzo L; Kim, Sarah H SH; Stylianou, Anthe A; Da Cruz Paula, Arnaud A; Pareja, Fresia F; Smith, Evan S ES; Zehir, Ahmet A; Konner, Jason A JA; Cadoo, Karen K; Reis-Filho, Jorge S JS; Abu-Rustum, Nadeem R NR; Mueller, Jennifer J JJ; Weigelt, Britta B; Park, Kay J KJ
Publication Date: 2021-08

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33772212
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Vitamin C sensitizes triple negative breast cancer to PI3K inhibition therapy.

Theranostics
Mustafi, Sushmita S; Camarena, Vladimir V; Qureshi, Rehana R; Sant, David W DW; Wilkes, Zachary Z; Bilbao, Daniel D; Slingerland, Joyce J; Kesmodel, Susan B SB; Wang, Gaofeng G
Publication Date: 2021

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33664847
Variant Present in the following documents:
  • Main text
  • thnov11p3552.pdf
View BVdb publication page



Gynaecological cancers and their cell lines.

Journal Of Cellular And Molecular Medicine
Skok, Kristijan K; Gradišnik, Lidija L; Maver, Uroš U; Kozar, Nejc N; Sobočan, Monika M; Takač, Iztok I; Arko, Darja D; Kavalar, Rajko R
Publication Date: 2021-04

Variant appearance in text: PIK3CA: 1616C>G; Pro539Arg
PubMed Link: 33650759
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comprehensive molecular profiling of Taiwanese breast cancers revealed potential therapeutic targets: prevalence of actionable mutations among 380 targeted sequencing analyses.

Bmc Cancer
Huang, Chi-Cheng CC; Tsai, Yi-Fang YF; Liu, Chun-Yu CY; Chao, Ta-Chung TC; Lien, Pei-Ju PJ; Lin, Yen-Shu YS; Feng, Chin-Jung CJ; Chiu, Jen-Hwey JH; Hsu, Chih-Yi CY; Tseng, Ling-Ming LM
Publication Date: 2021-02-25

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33632156
Variant Present in the following documents:
  • Main text
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Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors.

Jama Oncology
Cobain, Erin F EF; Wu, Yi-Mi YM; Vats, Pankaj P; Chugh, Rashmi R; Worden, Francis F; Smith, David C DC; Schuetze, Scott M SM; Zalupski, Mark M MM; Sahai, Vaibhav V; Alva, Ajjai A; Schott, Anne F AF; Caram, Megan E V MEV; Hayes, Daniel F DF; Stoffel, Elena M EM; Jacobs, Michelle F MF; Kumar-Sinha, Chandan C; Cao, Xuhong X; Wang, Rui R; Lucas, David D; Ning, Yu Y; Rabban, Erica E; Bell, Janice J; Camelo-Piragua, Sandra S; Udager, Aaron M AM; Cieslik, Marcin M; Lonigro, Robert J RJ; Kunju, Lakshmi P LP; Robinson, Dan R DR; Talpaz, Moshe M; Chinnaiyan, Arul M AM
Publication Date: 2021-04-01

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33630025
Variant Present in the following documents:
  • jamaoncol-e207987-s004.xlsx, sheet 2
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Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK.

Bmc Cancer
Tran, Khanh B KB; Kolekar, Sharada S; Jabed, Anower A; Jaynes, Patrick P; Shih, Jen-Hsing JH; Wang, Qian Q; Flanagan, Jack U JU; Rewcastle, Gordon W GW; Baguley, Bruce C BC; Shepherd, Peter R PR
Publication Date: 2021-02-06

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33549048
Variant Present in the following documents:
  • 12885_2021_7826_MOESM1_ESM.xlsx, sheet 1
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Copanlisib in the Treatment of Relapsed Follicular Lymphoma: Utility and Experience from the Clinic.

Cancer Management And Research
Chauhan, Ayushi F AF; Cheson, Bruce D BD
Publication Date: 2021

Variant appearance in text: PI3K: P539R
PubMed Link: 33531838
Variant Present in the following documents:
  • Main text
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Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma.

Molecular Cancer Therapeutics
Shigeta, Shogo S; Lui, Goldie Y L GYL; Shaw, Reid R; Moser, Russell R; Gurley, Kay E KE; Durenberger, Grace G; Rosati, Rachele R; Diaz, Robert L RL; Ince, Tan A TA; Swisher, Elizabeth M EM; Grandori, Carla C; Kemp, Christopher J CJ
Publication Date: 2021-04

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33509905
Variant Present in the following documents:
  • Main text
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Targetable alterations in invasive pleomorphic lobular carcinoma of the breast.

Breast Cancer Research : Bcr
Riedlinger, Gregory M GM; Joshi, Sonali S; Hirshfield, Kim M KM; Barnard, Nicola N; Ganesan, Shridar S
Publication Date: 2021-01-13

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33441174
Variant Present in the following documents:
  • Main text
  • 13058_2020_Article_1385.pdf
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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
  • 41467_2020_20162_MOESM9_ESM.xlsx, sheet 1
  • 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1
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Genotyping data of routinely processed matched primary/metastatic tumor samples.

Data In Brief
Kotoula, Vassiliki V; Chatzopoulos, Kyriakos K; Papadopoulou, Kyriaki K; Giannoulatou, Eleni E; Koliou, Georgia-Angeliki GA; Karavasilis, Vasilios V; Pazarli, Elissavet E; Pervana, Stavroula S; Kafiri, Georgia G; Tsoulfas, Georgios G; Chrisafi, Sofia S; Sgouramali, Helen H; Papakostas, Pavlos P; Pectasides, Dimitrios D; Hytiroglou, Prodromos P; Pentheroudakis, George G; Fountzilas, George G
Publication Date: 2021-02

Variant appearance in text: PIK3CA: 1616C>G; Pro539Arg; rs121913285
PubMed Link: 33365374
Variant Present in the following documents:
  • mmc1.xlsx, sheet 3
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Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine
Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS
Publication Date: 2021-01

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33314633
Variant Present in the following documents:
  • CAM4-10-53-s003.xlsx, sheet 1
  • CAM4-10-53-s002.xlsx, sheet 1
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Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.

Nature Communications
Desbois, Mélanie M; Udyavar, Akshata R AR; Ryner, Lisa L; Kozlowski, Cleopatra C; Guan, Yinghui Y; Dürrbaum, Milena M; Lu, Shan S; Fortin, Jean-Philippe JP; Koeppen, Hartmut H; Ziai, James J; Chang, Ching-Wei CW; Keerthivasan, Shilpa S; Plante, Marie M; Bourgon, Richard R; Bais, Carlos C; Hegde, Priti P; Daemen, Anneleen A; Turley, Shannon S; Wang, Yulei Y
Publication Date: 2020-11-04

Variant appearance in text: PIK3CA: Pro539Arg
PubMed Link: 33149148
Variant Present in the following documents:
  • 41467_2020_19408_MOESM8_ESM.xlsx, sheet 10
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Molecular landscape and efficacy of HER2-targeted therapy in patients with HER2-mutated metastatic breast cancer.

Npj Breast Cancer
Yi, Zongbi Z; Rong, Guohua G; Guan, Yanfang Y; Li, Jin J; Chang, Lianpeng L; Li, Hui H; Liu, Binliang B; Wang, Wenna W; Guan, Xiuwen X; Ouyang, Quchang Q; Li, Lixi L; Zhai, Jingtong J; Li, Chunxiao C; Li, Lifeng L; Xia, Xuefeng X; Yang, Ling L; Qian, Haili H; Yi, Xin X; Xu, Binghe B; Ma, Fei F
Publication Date: 2020

Variant appearance in text: PIK3CA: 1616C>G; P539R
PubMed Link: 33145402
Variant Present in the following documents:
  • 41523_2020_201_MOESM2_ESM.xlsx, sheet 1
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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology
Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S
Publication Date: 2020

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33133066
Variant Present in the following documents:
  • Table_6.xlsx, sheet 7
  • Table_6.xlsx, sheet 2
  • Table_1.xlsx, sheet 2
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Landscape of clinically actionable mutations in breast cancer 'A cohort study'.

Translational Oncology
Ghosh, Mithua M; Naik, Radheshyam R; Lingaraju, Sheela Mysore SM; Susheela, Sridhar Papaiah SP; Patil, Shekar S; Srinivasachar, Gopinath Kodaganur GK; Thungappa, Satheesh Chiradoni SC; Murugan, Krithika K; Jayappa, Srinivas Belagutty SB; Bhattacharjee, Somorat S; Rao, Nalini N; Bandimegal, Mahesh M; Krishnappa, Roopesh R; Poppareddy, Shashidhara Haragadde SH; Raghavendrachar, Krishna Chennagiri KC; Shivakumar, Yogesh Y; Nagesh, Sunitha S; Kodandapani, Ramya R; Rajan, Ashwini A; Bahadur, Urvashi U; Agrawal, Pooja P; Ramaswamy, Veena V; Nanjaiah, Tejaswini Bangalore TB; Kunigal, Sateesh S; Katragadda, Shanmukh S; Manjunath, Ashwini A; Ram, Amritanshu A; Ajaikumar, Basavalinga S BS
Publication Date: 2021-01

Variant appearance in text: PIK3CA: 1616C>G
PubMed Link: 33099186
Variant Present in the following documents:
  • Main text
  • main.pdf
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Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity.

Journal For Immunotherapy Of Cancer
Hong, Tae Hee TH; Cha, Hongui H; Shim, Joon Ho JH; Lee, Boram B; Chung, Jongsuk J; Lee, Chung C; Kim, Nayoung K D NKD; Choi, Yoon-La YL; Hwang, Soohyun S; Lee, Yoomi Y; Park, Sehhoon S; Jung, Hyun Ae HA; Kim, Ji-Yeon JY; Park, Yeon Hee YH; Sun, Jong-Mu JM; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Lee, Se-Hoon SH; Park, Woong-Yang WY
Publication Date: 2020-10

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33077514
Variant Present in the following documents:
  • jitc-2020-001199supp002.pdf
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Ultradeep targeted sequencing of circulating tumor DNA in plasma of early and advanced breast cancer.

Cancer Science
Chin, Yoon Ming YM; Takahashi, Yoko Y; Chan, Hiu Ting HT; Otaki, Masumi M; Fujishima, Makoto M; Shibayama, Tomoko T; Miki, Yoshio Y; Ueno, Takayuki T; Nakamura, Yusuke Y; Low, Siew-Kee SK
Publication Date: 2021-01

Variant appearance in text: PIK3CA: P539R
PubMed Link: 33075187
Variant Present in the following documents:
  • CAS-112-454-s002.xlsx, sheet 6
  • CAS-112-454-s002.xlsx, sheet 11
  • CAS-112-454-s002.xlsx, sheet 9
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Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs121913285
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page