PIK3CA c.1624G>T ;(p.E542*)

Variant ID: 3-178936082-G-T

NM_006218.2(PIK3CA):c.1624G>T;(p.E542*)

This variant was identified in 18 publications

View GRCh38 version.




Publications:


Genetic heterogeneity and tissue-specific patterns of tumors with multiple PIK3CA mutations.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Sivakumar, Smruthy S; Jin, Dexter X DX; Rathod, Ruchita R; Ross, Jeffrey J; Cantley, Lewis C LC; Scaltriti, Maurizio M; Chen, Jessica W JW; Hutchinson, Katherine E KE; Wilson, Timothy R TR; Sokol, Ethan S ES; Vasan, Neil N
Publication Date: 2023-01-03

Variant appearance in text: PIK3CA: E542X
PubMed Link: 36595567
Variant Present in the following documents:
  • Main text
  • 1125.pdf
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The diagnostic accuracy of PIK3CA mutations by circulating tumor DNA in breast cancer: an individual patient data meta-analysis.

Therapeutic Advances In Medical Oncology
Galvano, Antonio A; Castellana, Luisa L; Gristina, Valerio V; La Mantia, Maria M; Insalaco, Lavinia L; Barraco, Nadia N; Perez, Alessandro A; Cutaia, Sofia S; Calò, Valentina V; Bazan Russo, Tancredi Didier TD; Francini, Edoardo E; Incorvaia, Lorena L; Mirisola, Mario Giuseppe MG; Vieni, Salvatore S; Rolfo, Christian C; Bazan, Viviana V; Russo, Antonio A
Publication Date: 2022

Variant appearance in text: PIK3CA: E542X
PubMed Link: 36188485
Variant Present in the following documents:
  • Main text
  • 10.1177_17588359221110162.pdf
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PIK3CA Mutation is Associated with Poor Response to HER2-Targeted Therapy in Breast Cancer Patients.

Cancer Research And Treatment
Kim, Ju Won JW; Lim, Ah Reum AR; You, Ji Young JY; Lee, Jung Hyun JH; Song, Sung Eun SE; Lee, Nam Kwon NK; Jung, Seung Pil SP; Cho, Kyu Ran KR; Kim, Cheol Yong CY; Park, Kyong Hwa KH
Publication Date: 2022-09-07

Variant appearance in text: PIK3CA: E542X
PubMed Link: 36097803
Variant Present in the following documents:
  • Main text
  • crt-2022-221.pdf
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Anthracycline-Free Neoadjuvant Treatment in Patients with HER2-Positive Breast Cancer: Real-Life Use of Pertuzumab, Trastuzumab and Taxanes Association with an Exploratory Analysis of PIK3CA Mutational Status.

Cancers
Irelli, Azzurra A; Parisi, Alessandro A; D'Orazio, Carla C; Sidoni, Tina T; Rotondaro, Silvia S; Patruno, Leonardo L; Pavese, Francesco F; Bafile, Alberto A; Resta, Valter V; Pizzorno, Laura L; Ciuffetelli, Virginia V; Dal Mas, Antonella A; Calvisi, Giuseppe G; Di Sibio, Alessandra A; Marzullo, Anna A; Zelli, Veronica V; Compagnoni, Chiara C; Tessitore, Alessandra A; Alesse, Edoardo E; Ficorella, Corrado C; Cortellini, Alessio A; Cannita, Katia K
Publication Date: 2022-06-18

Variant appearance in text: PIK3CA: E542x
PubMed Link: 35740668
Variant Present in the following documents:
  • cancers-14-03003.pdf
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PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology
Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E
Publication Date: 2022-03

Variant appearance in text: PIK3CA: E542*
PubMed Link: 35357905
Variant Present in the following documents:
  • Main text
  • po-6-e2100370.pdf
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Integrating Histologic and Genomic Characteristics to Predict Tumor Mutation Burden of Early-Stage Non-Small-Cell Lung Cancer.

Frontiers In Oncology
Qiu, Yuan Y; Liu, Liping L; Yang, Haihong H; Chen, Hanzhang H; Deng, Qiuhua Q; Xiao, Dakai D; Lin, Yongping Y; Zhu, Changbin C; Li, Weiwei W; Shao, Di D; Jiang, Wenxi W; Wu, Kui K; He, Jianxing J
Publication Date: 2020

Variant appearance in text: PIK3CA: E542X
PubMed Link: 33996530
Variant Present in the following documents:
  • Main text
  • fonc-10-608989.pdf
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Phase 2 study of TAS-117, an allosteric akt inhibitor in advanced solid tumors harboring phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog gene mutations.

Investigational New Drugs
Lee, Jii Bum JB; Jung, Minkyu M; Beom, Seung Hoon SH; Kim, Gun Min GM; Kim, Hye Ryun HR; Choi, Hye Jin HJ; Sohn, Joo Hyuk JH; Ahn, Joong Bae JB; Rha, Sun Young SY; Chung, Hyun Cheol HC
Publication Date: 2021-10

Variant appearance in text: PIK3CA: E542X
PubMed Link: 33723724
Variant Present in the following documents:
  • Main text
  • 10637_2021_Article_1085.pdf
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Clinicopathological Correlates of γδ T Cell Infiltration in Triple-Negative Breast Cancer.

Cancers
Boissière-Michot, Florence F; Chabab, Ghita G; Mollevi, Caroline C; Guiu, Séverine S; Lopez-Crapez, Evelyne E; Ramos, Jeanne J; Bonnefoy, Nathalie N; Lafont, Virginie V; Jacot, William W
Publication Date: 2021-02-12

Variant appearance in text: PIK3CA: E542X
PubMed Link: 33673133
Variant Present in the following documents:
  • Main text
  • cancers-13-00765.pdf
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Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing.

Nature Communications
Lang, Guan-Tian GT; Jiang, Yi-Zhou YZ; Shi, Jin-Xiu JX; Yang, Fan F; Li, Xiao-Guang XG; Pei, Yu-Chen YC; Zhang, Chen-Hui CH; Ma, Ding D; Xiao, Yi Y; Hu, Peng-Chen PC; Wang, Hai H; Yang, Yun-Song YS; Guo, Lin-Wei LW; Lu, Xun-Xi XX; Xue, Meng-Zhu MZ; Wang, Peng P; Cao, A-Yong AY; Ling, Hong H; Wang, Zhong-Hua ZH; Yu, Ke-Da KD; Di, Gen-Hong GH; Li, Da-Qiang DQ; Wang, Yun-Jin YJ; Yu, Ying Y; Shi, Le-Ming LM; Hu, Xin X; Huang, Wei W; Shao, Zhi-Ming ZM
Publication Date: 2020-11-10

Variant appearance in text: PIK3CA: E542*
PubMed Link: 33173047
Variant Present in the following documents:
  • 41467_2020_19342_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.

Nature Communications
Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U
Publication Date: 2020-07-20

Variant appearance in text: PIK3CA: E542X
PubMed Link: 32686686
Variant Present in the following documents:
  • 41467_2020_17386_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer.

Molecular Cancer
Takeshita, Takashi T; Yamamoto, Yutaka Y; Yamamoto-Ibusuki, Mutsuko M; Tomiguchi, Mai M; Sueta, Aiko A; Murakami, Keiichi K; Iwase, Hirotaka H
Publication Date: 2018-02-26

Variant appearance in text: PIK3CA: E542x
PubMed Link: 29482551
Variant Present in the following documents:
  • Main text
View BVdb publication page



Analysis of ESR1 and PIK3CA mutations in plasma cell-free DNA from ER-positive breast cancer patients.

Oncotarget
Takeshita, Takashi T; Yamamoto, Yutaka Y; Yamamoto-Ibusuki, Mutsuko M; Tomiguchi, Mai M; Sueta, Aiko A; Murakami, Keiichi K; Omoto, Yoko Y; Iwase, Hirotaka H
Publication Date: 2017-08-08

Variant appearance in text: PIK3CA: E542x
PubMed Link: 28881720
Variant Present in the following documents:
  • Main text
  • oncotarget-08-52142.pdf
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PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer.

Scientific Reports
Mjos, Siv S; Werner, Henrica M J HMJ; Birkeland, Even E; Holst, Frederik F; Berg, Anna A; Halle, Mari K MK; Tangen, Ingvild L IL; Kusonmano, Kanthida K; Mauland, Karen K KK; Oyan, Anne M AM; Kalland, Karl-Henning KH; Lewis, Aurélia E AE; Mills, Gordon B GB; Krakstad, Camilla C; Trovik, Jone J; Salvesen, Helga B HB; Hoivik, Erling A EA
Publication Date: 2017-08-31

Variant appearance in text: PIK3CA: E542*
PubMed Link: 28860563
Variant Present in the following documents:
  • Main text
  • 41598_2017_Article_10717.pdf
  • 41598_2017_10717_MOESM1_ESM.pdf
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Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

The Lancet. Oncology
Kim, Sung-Bae SB; Dent, Rebecca R; Im, Seock-Ah SA; Espié, Marc M; Blau, Sibel S; Tan, Antoinette R AR; Isakoff, Steven J SJ; Oliveira, Mafalda M; Saura, Cristina C; Wongchenko, Matthew J MJ; Kapp, Amy V AV; Chan, Wai Y WY; Singel, Stina M SM; Maslyar, Daniel J DJ; Baselga, José J; ,
Publication Date: 2017-10

Variant appearance in text: PIK3CA: Glu542X
PubMed Link: 28800861
Variant Present in the following documents:
  • Main text
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: PIK3CA: 1624G>T
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers.

Bmc Cancer
Jacot, William W; Mollevi, Caroline C; Fina, Frédéric F; Lopez-Crapez, Evelyne E; Martin, Pierre-Marie PM; Colombo, Pierre-Emmanuel PE; Bibeau, Frédéric F; Romieu, Gilles G; Lamy, Pierre-Jean PJ
Publication Date: 2015-12-18

Variant appearance in text: PIK3CA: E542X
PubMed Link: 26680641
Variant Present in the following documents:
  • Main text
  • 12885_2015_Article_1977.pdf
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Pharmacogenomics of EGFR-targeted therapies in non-small cell lung cancer: EGFR and beyond.

Chinese Journal Of Cancer
Delaney, Christopher C; Frank, Samuel S; Huang, R Stephanie RS
Publication Date: 2015-04-08

Variant appearance in text: PIK3CA: E542X
PubMed Link: 25962919
Variant Present in the following documents:
  • Main text
  • 40880_2015_Article_7.pdf
View BVdb publication page



Panel based MALDI-TOF tumour profiling is a sensitive method for detecting mutations in clinical non small cell lung cancer tumour.

Plos One
Sherwood, James L JL; Müller, Susanne S; Orr, Maria C M MC; Ratcliffe, Marianne J MJ; Walker, Jill J
Publication Date: 2014

Variant appearance in text: PIK3CA: E542*
PubMed Link: 24956168
Variant Present in the following documents:
  • Main text
  • pone.0100566.pdf
View BVdb publication page