PIK3CA c.1633G>A ;(p.E545K)

Variant ID: 3-178936091-G-A

NM_006218.2(PIK3CA):c.1633G>A;(p.E545K)

This variant was identified in 2624 publications

View GRCh38 version.




Publications:


Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness.

Breast Cancer Research : Bcr
Andersen, Lars V B LVB; Larsen, Martin J MJ; Davies, Helen H; Degasperi, Andrea A; Nielsen, Henriette Roed HR; Jensen, Louise A LA; Kroeldrup, Lone L; Gerdes, Anne-Marie AM; Lænkholm, Anne-Vibeke AV; Kruse, Torben A TA; Nik-Zainal, Serena S; Thomassen, Mads M
Publication Date: 2023-06-14

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 37316882
Variant Present in the following documents:
  • 13058_2023_1655_MOESM9_ESM.xlsx, sheet 1
View BVdb publication page



Phase 1b trial of anti-EGFR antibody JMT101 and Osimertinib in EGFR exon 20 insertion-positive non-small-cell lung cancer.

Nature Communications
Zhao, Shen S; Zhuang, Wu W; Han, Baohui B; Song, Zhengbo Z; Guo, Wei W; Luo, Feng F; Wu, Lin L; Hu, Yi Y; Wang, Huijuan H; Dong, Xiaorong X; Jiang, Da D; Wang, Mingxia M; Miao, Liyun L; Wang, Qian Q; Zhang, Junping J; Fu, Zhenming Z; Huang, Yihua Y; Xu, Chunwei C; Hu, Longyu L; Li, Lei L; Hu, Rong R; Yang, Yang Y; Li, Mengke M; Yang, Xiugao X; Zhang, Li L; Huang, Yan Y; Fang, Wenfeng W
Publication Date: 2023-06-12

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 37308490
Variant Present in the following documents:
  • 41467_2023_39139_MOESM4_ESM.xlsx, sheet 7
  • 41467_2023_39139_MOESM4_ESM.xlsx, sheet 3
View BVdb publication page



Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.

Nature Communications
González, Lorena L; Díaz, Lucía L; Pous, Joan J; Baginski, Blazej B; Duran-Corbera, Anna A; Scarpa, Margherita M; Brun-Heath, Isabelle I; Igea, Ana A; Martin-Malpartida, Pau P; Ruiz, Lidia L; Pallara, Chiara C; Esguerra, Mauricio M; Colizzi, Francesco F; Mayor-Ruiz, Cristina C; Biondi, Ricardo M RM; Soliva, Robert R; Macias, Maria J MJ; Orozco, Modesto M; Nebreda, Angel R AR
Publication Date: 2023-06-12

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37308482
Variant Present in the following documents:
  • 41467_2023_39051_MOESM3_ESM.xlsx, sheet 5
View BVdb publication page



Comprehensive genomic and immunohistochemical profiles and outcomes of immunotherapy in patients with recurrent or advanced cervical cancer.

Frontiers In Oncology
Kim, Yoo-Na YN; Lee, Kyunglim K; Park, Eunhyang E; Park, Junsik J; Lee, Yong Jae YJ; Nam, Eun Ji EJ; Kim, Sang Wun SW; Kim, Sunghoon S; Kim, Young Tae YT; Lee, Jung-Yun JY
Publication Date: 2023

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37256181
Variant Present in the following documents:
  • Main text
  • fonc-13-1156973.pdf
View BVdb publication page



Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.

Rsc Medicinal Chemistry
Willems, Henriëtte M G HMG; Edwards, Simon S; Boffey, Helen K HK; Chawner, Stephen J SJ; Green, Christopher C; Romero, Tamara T; Winpenny, David D; Skidmore, John J; Clarke, Jonathan H JH; Andrews, Stephen P SP
Publication Date: 2023-05-25

Variant appearance in text: PI3K: E545K
PubMed Link: 37252102
Variant Present in the following documents:
  • MD-014-D3MD00039G-s001.pdf
View BVdb publication page



Wnt Signaling in Brain Tumors: A Challenging Therapeutic Target.

Biology
Manfreda, Lorenzo L; Rampazzo, Elena E; Persano, Luca L
Publication Date: 2023-05-16

Variant appearance in text: PI3K: E545K
PubMed Link: 37237541
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations.

Breast Cancer Research : Bcr
Miyashita, Minoru M; Bell, Joshua S K JSK; Wenric, Stephane S; Karaesmen, Ezgi E; Rhead, Brooke B; Kase, Matthew M; Kaneva, Kristiyana K; De La Vega, Francisco M FM; Zheng, Yonglan Y; Yoshimatsu, Toshio F TF; Khramtsova, Galina G; Liu, Fang F; Zhao, Fangyuan F; Howard, Frederick M FM; Nanda, Rita R; Beaubier, Nike N; White, Kevin P KP; Huo, Dezheng D; Olopade, Olufunmilayo I OI
Publication Date: 2023-05-25

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 37231433
Variant Present in the following documents:
  • 13058_2023_1627_MOESM4_ESM.xlsx, sheet 4
  • 13058_2023_1627_MOESM4_ESM.xlsx, sheet 2
View BVdb publication page



The Swedish childhood tumor biobank: systematic collection and molecular characterization of all pediatric CNS and other solid tumors in Sweden.

Journal Of Translational Medicine
Díaz de Ståhl, Teresita T; Shamikh, Alia A; Mayrhofer, Markus M; Juhos, Szilvester S; Basmaci, Elisa E; Prochazka, Gabriela G; Garcia, Maxime M; Somarajan, Praveen Raj PR; Zielinska-Chomej, Katarzyna K; Illies, Christopher C; Øra, Ingrid I; Siesjö, Peter P; Sandström, Per-Erik PE; Stenman, Jakob J; Sabel, Magnus M; Gustavsson, Bengt B; Kogner, Per P; Pfeifer, Susan S; Ljungman, Gustaf G; Sandgren, Johanna J; Nistér, Monica M
Publication Date: 2023-05-23

Variant appearance in text: PIK3CA: Glu545Lys
PubMed Link: 37221626
Variant Present in the following documents:
  • 12967_2023_4178_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



The Role of Biomarkers in Guiding Clinical Decision-Making in Oncology.

Journal Of The Advanced Practitioner In Oncology
Moore, Donald C DC; Guinigundo, Andrew S AS
Publication Date: 2023-04

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37206905
Variant Present in the following documents:
  • Main text
  • jadpro-14-15.pdf
View BVdb publication page



ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component.

Elife
Jauhiainen, Suvi S; Ilmonen, Henna H; Vuola, Pia P; Rasinkangas, Heta H; Pulkkinen, Heidi H HH; Keränen, Sara S; Kiema, Miika M; Liikkanen, Jade J JJ; Laham Karam, Nihay N; Laidinen, Svetlana S; Beter, Mustafa M; Aavik, Einari E; Lappalainen, Kimmo K; Lohi, Jouko J; Aronniemi, Johanna J; Örd, Tiit T; Kaikkonen, Minna U MU; Salminen, Päivi P; Tukiainen, Erkki E; Ylä-Herttuala, Seppo S; Laakkonen, Johanna P JP
Publication Date: 2023-05-18

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 37199488
Variant Present in the following documents:
  • Main text
  • elife-82543.pdf
View BVdb publication page



PIK3CA mutations in breast cancer: A Tunisian series.

Plos One
Ben Rekaya, Mariem M; Sassi, Farah F; Saied, Essya E; Bel Haj Kacem, Linda L; Mansouri, Nada N; Zarrouk, Sinda S; Azouz, Saifeddine S; Rammeh, Soumaya S
Publication Date: 2023

Variant appearance in text: PI3K: 1633G>A; rs104886003
PubMed Link: 37195967
Variant Present in the following documents:
  • Main text
  • pone.0285413.pdf
View BVdb publication page



Clinical and Translational Applications of Serological and Histopathological Biomarkers in Metastatic Breast Cancer: A Comprehensive Review.

International Journal Of Molecular Sciences
Pekarek, Leonel L; Sánchez Cendra, Alicia A; Roberts Cervantes, Eduardo D ED; Sánchez Cendra, Cristina C; Fraile-Martinez, Oscar O; García-Montero, Cielo C; Diaz-Pedrero, Raul R; Torres-Carranza, Diego D; Lopez-Gonzalez, Laura L; Aguado-Henche, Soledad S; Rios-Parra, Antonio A; García-Puente, Luis M LM; García-Honduvilla, Natalio N; Bujan, Julia J; Alvarez-Mon, Melchor M; Saez, Miguel A MA; Ortega, Miguel A MA
Publication Date: 2023-05-07

Variant appearance in text: PI3K: E545K
PubMed Link: 37176102
Variant Present in the following documents:
  • Main text
  • ijms-24-08396.pdf
View BVdb publication page



EnGens: a computational framework for generation and analysis of representative protein conformational ensembles.

Biorxiv : The Preprint Server For Biology
Conev, Anja A; Rigo, Mauricio Menagatti MM; Devaurs, Didier D; Fonseca, André Faustino AF; Kalavadwala, Hussain H; de Freitas, Martiela Vaz MV; Clementi, Cecilia C; Zanatta, Geancarlo G; Antunes, Dinler Amaral DA; Kavraki, Lydia L
Publication Date: 2023-04-28

Variant appearance in text: PI3K: E545K
PubMed Link: 37163076
Variant Present in the following documents:
  • Main text
  • nihpp-2023.04.24.538094v1.pdf
View BVdb publication page



A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression.

Cancer Cell
Hutten, Stefan J SJ; de Bruijn, Roebi R; Lutz, Catrin C; Badoux, Madelon M; Eijkman, Timo T; Chao, Xue X; Ciwinska, Marta M; Sheinman, Michael M; Messal, Hendrik H; Herencia-Ropero, Andrea A; Kristel, Petra P; Mulder, Lennart L; van der Waal, Rens R; Sanders, Joyce J; Almekinders, Mathilde M MM; Llop-Guevara, Alba A; Davies, Helen R HR; van Haren, Matthijs J MJ; Martin, Nathaniel I NI; Behbod, Fariba F; Nik-Zainal, Serena S; Serra, Violeta V; van Rheenen, Jacco J; Lips, Esther H EH; Wessels, Lodewyk F A LFA; , ; Wesseling, Jelle J; Scheele, Colinda L G J CLGJ; Jonkers, Jos J
Publication Date: 2023-04-24

Variant appearance in text: PIK3CA: E545K; rs104886003
PubMed Link: 37116492
Variant Present in the following documents:
  • mmc3.xlsx, sheet 1
  • mmc3.xlsx, sheet 3
View BVdb publication page



Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2-, PIK3CA-mutated breast cancers.

Genome Medicine
Hutchinson, Katherine E KE; Chen, Jessica W JW; Savage, Heidi M HM; Stout, Thomas J TJ; Schimmoller, Frauke F; Cortés, Javier J; Dent, Susan S; Harbeck, Nadia N; Jacot, William W; Krop, Ian I; Trabucco, Sally E SE; Sivakumar, Smruthy S; Sokol, Ethan S ES; Wilson, Timothy R TR
Publication Date: 2023-04-26

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37101291
Variant Present in the following documents:
  • Main text
  • 13073_2023_1181_MOESM1_ESM.pdf
  • 13073_2023_Article_1181.pdf
View BVdb publication page



Dynamic ctDNA Mutational Complexity in Patients with Melanoma Receiving Immunotherapy.

Molecular Diagnosis & Therapy
Fitzgerald, Sandra S; Blenkiron, Cherie C; Stephens, Rosalie R; Mathy, Jon A JA; Somers-Edgar, Tiffany T; Rolfe, Gill G; Martin, Richard R; Jackson, Christopher C; Eccles, Michael M; Robb, Tamsin T; Rodger, Euan E; Lawrence, Ben B; Guilford, Parry P; Lasham, Annette A; Print, Cristin G CG
Publication Date: 2023-04-26

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 37099071
Variant Present in the following documents:
  • 40291_2023_651_MOESM1_ESM.xlsx, sheet 2
View BVdb publication page



Meta-analysis of commonly mutated genes in leptomeningeal carcinomatosis.

Peerj
Congur, Irem I; Koni, Ekin E; Onat, Onur Emre OE; Tokcaer Keskin, Zeynep Z
Publication Date: 2023

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37096065
Variant Present in the following documents:
  • Main text
  • peerj-11-15250.pdf
  • peerj-11-15250-s005.xlsx, sheet 1
View BVdb publication page



Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.

Acs Chemical Neuroscience
Ong, Han Wee HW; Liang, Yi Y; Richardson, William W; Lowry, Emily R ER; Wells, Carrow I CI; Chen, Xiangrong X; Silvestre, Margaux M; Dempster, Kelvin K; Silvaroli, Josie A JA; Smith, Jeffery L JL; Wichterle, Hynek H; Pabla, Navjot S NS; Ultanir, Sila K SK; Bullock, Alex N AN; Drewry, David H DH; Axtman, Alison D AD
Publication Date: 2023-04-21

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37084253
Variant Present in the following documents:
  • cn3c00135_si_001.pdf
View BVdb publication page



Bladder cancer organoids as a functional system to model different disease stages and therapy response.

Nature Communications
Minoli, Martina M; Cantore, Thomas T; Hanhart, Daniel D; Kiener, Mirjam M; Fedrizzi, Tarcisio T; La Manna, Federico F; Karkampouna, Sofia S; Chouvardas, Panagiotis P; Genitsch, Vera V; Rodriguez-Calero, Antonio A; Compérat, Eva E; Klima, Irena I; Gasperini, Paola P; Kiss, Bernhard B; Seiler, Roland R; Demichelis, Francesca F; Thalmann, George N GN; Kruithof-de Julio, Marianna M
Publication Date: 2023-04-18

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37072390
Variant Present in the following documents:
  • Main text
  • 41467_2023_Article_37696.pdf
View BVdb publication page



A Report of a Rare Case of Multiple Fibro adipose Venous Anomaly.

Journal Of Orthopaedic Case Reports
Kumar, L Dhruva LD; Gopurathingal, Anto A; Chinder, Pramod P; Hindiskere, Suraj S
Publication Date: 2022-06

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37065525
Variant Present in the following documents:
  • JOCR-12-19.pdf
View BVdb publication page



Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.

Nature
Abbosh, Christopher C; Frankell, Alexander M AM; Harrison, Thomas T; Kisistok, Judit J; Garnett, Aaron A; Johnson, Laura L; Veeriah, Selvaraju S; Moreau, Mike M; Chesh, Adrian A; Chaunzwa, Tafadzwa L TL; Weiss, Jakob J; Schroeder, Morgan R MR; Ward, Sophia S; Grigoriadis, Kristiana K; Shahpurwalla, Aamir A; Litchfield, Kevin K; Puttick, Clare C; Biswas, Dhruva D; Karasaki, Takahiro T; Black, James R M JRM; Martínez-Ruiz, Carlos C; Bakir, Maise Al MA; Pich, Oriol O; Watkins, Thomas B K TBK; Lim, Emilia L EL; Huebner, Ariana A; Moore, David A DA; Godin-Heymann, Nadia N; L'Hernault, Anne A; Bye, Hannah H; Odell, Aaron A; Roberts, Paula P; Gomes, Fabio F; Patel, Akshay J AJ; Manzano, Elizabeth E; Hiley, Crispin T CT; Carey, Nicolas N; Riley, Joan J; Cook, Daniel E DE; Hodgson, Darren D; Stetson, Daniel D; Barrett, J Carl JC; Kortlever, Roderik M RM; Evan, Gerard I GI; Hackshaw, Allan A; Daber, Robert D RD; Shaw, Jacqui A JA; Aerts, Hugo J W L HJWL; Licon, Abel A; Stahl, Josh J; Jamal-Hanjani, Mariam M; , ; Birkbak, Nicolai J NJ; McGranahan, Nicholas N; Swanton, Charles C
Publication Date: 2023-04-13

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37055640
Variant Present in the following documents:
  • EMS176197-supplement-Supplementary_Table_1.xlsx, sheet 18
View BVdb publication page



The evolution of non-small cell lung cancer metastases in TRACERx.

Nature
Al Bakir, Maise M; Huebner, Ariana A; Martínez-Ruiz, Carlos C; Grigoriadis, Kristiana K; Watkins, Thomas B K TBK; Pich, Oriol O; Moore, David A DA; Veeriah, Selvaraju S; Ward, Sophia S; Laycock, Joanne J; Johnson, Diana D; Rowan, Andrew A; Razaq, Maryam M; Akther, Mita M; Naceur-Lombardelli, Cristina C; Prymas, Paulina P; Toncheva, Antonia A; Hessey, Sonya S; Dietzen, Michelle M; Colliver, Emma E; Frankell, Alexander M AM; Bunkum, Abigail A; Lim, Emilia L EL; Karasaki, Takahiro T; Abbosh, Christopher C; Hiley, Crispin T CT; Hill, Mark S MS; Cook, Daniel E DE; Wilson, Gareth A GA; Salgado, Roberto R; Nye, Emma E; Stone, Richard Kevin RK; Fennell, Dean A DA; Price, Gillian G; Kerr, Keith M KM; Naidu, Babu B; Middleton, Gary G; Summers, Yvonne Y; Lindsay, Colin R CR; Blackhall, Fiona H FH; Cave, Judith J; Blyth, Kevin G KG; Nair, Arjun A; Ahmed, Asia A; Taylor, Magali N MN; Procter, Alexander James AJ; Falzon, Mary M; Lawrence, David D; Navani, Neal N; Thakrar, Ricky M RM; Janes, Sam M SM; Papadatos-Pastos, Dionysis D; Forster, Martin D MD; Lee, Siow Ming SM; Ahmad, Tanya T; Quezada, Sergio A SA; Peggs, Karl S KS; Van Loo, Peter P; Dive, Caroline C; Hackshaw, Allan A; Birkbak, Nicolai J NJ; Zaccaria, Simone S; , ; Jamal-Hanjani, Mariam M; McGranahan, Nicholas N; Swanton, Charles C
Publication Date: 2023-04-12

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37046095
Variant Present in the following documents:
  • Main text
  • 41586_2023_Article_5729.pdf
View BVdb publication page



Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors.

Signal Transduction And Targeted Therapy
Zhang, Xu X; Wang, Yuxiang Y; Zhang, Xi X; Shen, Yanyan Y; Yang, Kang K; Ma, Qingyang Q; Qiao, Yuemei Y; Shi, Jiajie J; Wang, Yi Y; Xu, Lan L; Yang, Biyu B; Ge, Gaoxiang G; Hu, Landian L; Kong, Xiangyin X; Yang, Chunhao C; Chen, Yi Y; Ding, Jian J; Meng, Linghua L
Publication Date: 2023-04-12

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37041169
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular profiling of colorectal cancer in a genetically admixed Hispanic population.

Cancer Medicine
Montes-Rodríguez, Ingrid M IM; Centeno-Girona, Hilmaris H; Rivera-Lynch, Camila C; Rivera, Noridza N; Cruz-Correa, Marcia M
Publication Date: 2023-04-11

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37039257
Variant Present in the following documents:
  • Main text
  • CAM4-12-11686.pdf
View BVdb publication page



Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Journal Of Medicinal Chemistry
Harnden, Alice C AC; Davis, Owen A OA; Box, Gary M GM; Hayes, Angela A; Johnson, Louise D LD; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Valenti, Melanie M; Cheung, Kwai-Ming J KJ; Brennan, Alfie A; Huckvale, Rosemary R; Pierrat, Olivier A OA; Talbot, Rachel R; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; de Klerk, Selby S; McAndrew, Peter Craig PC; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S
Publication Date: 2023-04-07

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37026591
Variant Present in the following documents:
  • jm3c00155_si_002.xlsx, sheet 2
View BVdb publication page



Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 4
View BVdb publication page



Molecular methods for colorectal cancer screening: Progress with next-generation sequencing evolution.

World Journal Of Gastrointestinal Oncology
Abbes, Salma S; Baldi, Simone S; Sellami, Hayet H; Amedei, Amedeo A; Keskes, Leila L
Publication Date: 2023-03-15

Variant appearance in text: PIK3CA: E545K
PubMed Link: 37009313
Variant Present in the following documents:
  • WJGO-15-425.pdf
View BVdb publication page



Anti-tumor effects of low-dose metronomic vinorelbine in combination with alpelisib in breast cancer cells.

Excli Journal
Krajnak, Slavomir S; Trier, Jannis Patrik JP; Heinzmann, Pauline Friederike PF; Anic, Katharina K; Heimes, Anne-Sophie AS; Loewe, Amelie A; Schmidt, Marcus M; Battista, Marco Johannes MJ; Hasenburg, Annette A; Brenner, Walburgis W
Publication Date: 2023

Variant appearance in text: PI3K: E545K
PubMed Link: 36998707
Variant Present in the following documents:
  • EXCLI-22-114.pdf
View BVdb publication page



Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes.

Nature Communications
Li, Lingling L; Jiang, Dongxian D; Liu, Hui H; Guo, Chunmei C; Zhao, Rui R; Zhang, Qiao Q; Xu, Chen C; Qin, Zhaoyu Z; Feng, Jinwen J; Liu, Yang Y; Wang, Haixing H; Chen, Weijie W; Zhang, Xue X; Li, Bin B; Bai, Lin L; Tian, Sha S; Tan, Subei S; Yu, Zixiang Z; Chen, Lingli L; Huang, Jie J; Zhao, Jian-Yuan JY; Hou, Yingyong Y; Ding, Chen C
Publication Date: 2023-03-29

Variant appearance in text: PIK3CA: E545K; rs104886003
PubMed Link: 36991000
Variant Present in the following documents:
  • 41467_2023_37221_MOESM5_ESM.xlsx, sheet 3
View BVdb publication page



APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential.

Journal Of Hematology & Oncology
Butler, Kelly K; Banday, A Rouf AR
Publication Date: 2023-03-28

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36978147
Variant Present in the following documents:
  • Main text
  • 13045_2023_Article_1425.pdf
View BVdb publication page



Exon-18-EGFR Mutated Transformed Small-Cell Lung Cancer: A Case Report and Literature Review.

Current Oncology (Toronto, Ont.)
Digiacomo, Nunzio N; De Pas, Tommaso T; Rossi, Giovanna G; Bossi, Paola P; Stucchi, Erika E; Conforti, Fabio F; Cocorocchio, Emilia E; Laszlo, Daniele D; Pala, Laura L; Zattarin, Emma E; Catania, Chiara C
Publication Date: 2023-03-20

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 36975478
Variant Present in the following documents:
  • Main text
  • curroncol-30-00265.pdf
View BVdb publication page



Circulating Tumor DNA Monitoring Reveals Molecular Progression before Radiologic Progression in a Real-life Cohort of Patients with Advanced Non-small Cell Lung Cancer.

Cancer Research Communications
Frank, Malene S MS; Andersen, Christina S A CSA; Ahlborn, Lise B LB; Pallisgaard, Niels N; Bodtger, Uffe U; Gehl, Julie J
Publication Date: 2022-10

Variant appearance in text: PIK3CA: 1633G>A; E545K
PubMed Link: 36969747
Variant Present in the following documents:
  • crc-22-0258-s07.pdf
  • crc-22-0258-s08.xlsx, sheet 1
  • crc-22-0258-s09.xlsx, sheet 1
View BVdb publication page



Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer.

Frontiers In Oncology
Ni, Rui R; Li, Ziwei Z; Li, Li L; Peng, Dan D; Ming, Yue Y; Li, Lin L; Liu, Yao Y
Publication Date: 2023

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36959802
Variant Present in the following documents:
  • Main text
  • fonc-13-1143798.pdf
View BVdb publication page



Targeted Phasing of 2-200 Kilobase DNA Fragments with a Short-Read Sequencer and a Single-Tube Linked-Read Library Method.

Biorxiv : The Preprint Server For Biology
Mikhaylova, Veronika V; Rzepka, Madison M; Kawamura, Tetsuya T; Xia, Yu Y; Chang, Peter L PL; Zhou, Shiguo S; Pham, Long L; Modi, Naisarg N; Yao, Likun L; Perez-Agustin, Adrian A; Pagans, Sara S; Boles, T Christian TC; Lei, Ming M; Wang, Yong Y; Garcia-Bassets, Ivan I; Chen, Zhoutao Z
Publication Date: 2023-03-06

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36945366
Variant Present in the following documents:
  • Main text
  • nihpp-2023.03.05.531179v1.pdf
View BVdb publication page



Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.

Acs Chemical Biology
Tredup, Claudia C; Ndreshkjana, Benardina B; Schneider, Natalie S NS; Tjaden, Amelie A; Kemas, Aurino M AM; Youhanna, Sonia S; Lauschke, Volker M VM; Berger, Benedict-Tilman BT; Krämer, Andreas A; Berger, Lena M LM; Röhm, Sandra S; Knapp, Stefan S; Farin, Henner F HF; Müller, Susanne S
Publication Date: 2023-03-21

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36944371
Variant Present in the following documents:
  • cb2c00877_si_002.xlsx, sheet 1
  • cb2c00877_si_004.xlsx, sheet 1
View BVdb publication page



PIK3CA and PIK3R1 tumor mutational landscape in a pan-cancer patient cohort and its association with pathway activation and treatment efficacy.

Scientific Reports
Tharin, Zoé Z; Richard, Corentin C; Derangère, Valentin V; Ilie, Alis A; Arnould, Laurent L; Ghiringhelli, François F; Boidot, Romain R; Ladoire, Sylvain S
Publication Date: 2023-03-18

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36934165
Variant Present in the following documents:
  • Main text
  • 41598_2023_Article_31593.pdf
View BVdb publication page



KRAS, NRAS, BRAF, and PIK3CA mutation rates, clinicopathological association, and their prognostic value in Iranian colorectal cancer patients.

Journal Of Clinical Laboratory Analysis
Mirzapoor Abbasabadi, Zohreh Z; Hamedi Asl, Dariush D; Rahmani, Babak B; Shahbadori, Rozhin R; Karami, Sara S; Peymani, Amir A; Taghizadeh, Sara S; Samiee Rad, Fatemeh F
Publication Date: 2023-03-17

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36930789
Variant Present in the following documents:
  • Main text
  • JCLA-37-e24868.pdf
View BVdb publication page



A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Jang, H Josh HJ; Hostetter, Galen G; MacFarlane, Alexander W AW; Madaj, Zachary Z; Ross, Eric A EA; Hinoue, Toshinori T; Kulchycki, Justin R JR; Burgos, Ryan S RS; Tafseer, Mahvish M; Alpaugh, R Katherine RK; Schwebel, Candice L CL; Kokate, Rutika R; Geynisman, Daniel M DM; Zibelman, Matthew R MR; Ghatalia, Pooja P; Nichols, Peter W PW; Chung, Woonbok W; Madzo, Jozef J; Hahn, Noah M NM; Quinn, David I DI; Issa, Jean-Pierre J JJ; Topper, Michael J MJ; Baylin, Stephen B SB; Shen, Hui H; Campbell, Kerry S KS; Jones, Peter A PA; Plimack, Elizabeth R ER
Publication Date: 2023-03-16

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36928921
Variant Present in the following documents:
  • ccr-22-3642_supplementary_tables_1_suppts1.xlsx, sheet 3
  • ccr-22-3642_supplementary_tables_1_suppts1.xlsx, sheet 4
View BVdb publication page



Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial.

Nature Medicine
Cascone, Tina T; Leung, Cheuk H CH; Weissferdt, Annikka A; Pataer, Apar A; Carter, Brett W BW; Godoy, Myrna C B MCB; Feldman, Hope H; William, William N WN; Xi, Yuanxin Y; Basu, Sreyashi S; Sun, Jing Jing JJ; Yadav, Shalini S SS; Rojas Alvarez, Frank R FR; Lee, Younghee Y; Mishra, Aditya K AK; Chen, Lili L; Pradhan, Monika M; Guo, Haiping H; Sinjab, Ansam A; Zhou, Nicolas N; Negrao, Marcelo V MV; Le, Xiuning X; Gay, Carl M CM; Tsao, Anne S AS; Byers, Lauren Averett LA; Altan, Mehmet M; Glisson, Bonnie S BS; Fossella, Frank V FV; Elamin, Yasir Y YY; Blumenschein, George G; Zhang, Jianjun J; Skoulidis, Ferdinandos F; Wu, Jia J; Mehran, Reza J RJ; Rice, David C DC; Walsh, Garrett L GL; Hofstetter, Wayne L WL; Rajaram, Ravi R; Antonoff, Mara B MB; Fujimoto, Junya J; Solis, Luisa M LM; Parra, Edwin R ER; Haymaker, Cara C; Wistuba, Ignacio I II; Swisher, Stephen G SG; Vaporciyan, Ara A AA; Lin, Heather Y HY; Wang, Jing J; Gibbons, Don L DL; Jack Lee, J J; Ajami, Nadim J NJ; Wargo, Jennifer A JA; Allison, James P JP; Sharma, Padmanee P; Kadara, Humam H; Heymach, John V JV; Sepesi, Boris B
Publication Date: 2023-03-16

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36928818
Variant Present in the following documents:
  • 41591_2022_2189_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology.

Nature Medicine
Sturm, Dominik D; Capper, David D; Andreiuolo, Felipe F; Gessi, Marco M; Kölsche, Christian C; Reinhardt, Annekathrin A; Sievers, Philipp P; Wefers, Annika K AK; Ebrahimi, Azadeh A; Suwala, Abigail K AK; Gielen, Gerrit H GH; Sill, Martin M; Schrimpf, Daniel D; Stichel, Damian D; Hovestadt, Volker V; Daenekas, Bjarne B; Rode, Agata A; Hamelmann, Stefan S; Previti, Christopher C; Jäger, Natalie N; Buchhalter, Ivo I; Blattner-Johnson, Mirjam M; Jones, Barbara C BC; Warmuth-Metz, Monika M; Bison, Brigitte B; Grund, Kerstin K; Sutter, Christian C; Hirsch, Steffen S; Dikow, Nicola N; Hasselblatt, Martin M; Schüller, Ulrich U; Gerber, Nicolas U NU; White, Christine L CL; Buntine, Molly K MK; Kinross, Kathryn K; Algar, Elizabeth M EM; Hansford, Jordan R JR; Gottardo, Nicholas G NG; Hernáiz Driever, Pablo P; Gnekow, Astrid A; Witt, Olaf O; Müller, Hermann L HL; Calaminus, Gabriele G; Fleischhack, Gudrun G; Kordes, Uwe U; Mynarek, Martin M; Rutkowski, Stefan S; Frühwald, Michael C MC; Kramm, Christof M CM; von Deimling, Andreas A; Pietsch, Torsten T; Sahm, Felix F; Pfister, Stefan M SM; Jones, David T W DTW
Publication Date: 2023-03-16

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36928815
Variant Present in the following documents:
  • 41591_2023_2255_MOESM3_ESM.xlsx, sheet 5
View BVdb publication page



Targeting the Ezrin Adaptor Protein Sensitizes Metastatic Breast Cancer Cells to Chemotherapy and Reduces Neoadjuvant Therapy-induced Metastasis.

Cancer Research Communications
Hoskin, Victoria V; Ghaffari, Abdi A; Laight, Brian J BJ; SenGupta, Sandip S; Madarnas, Yolanda Y; Nicol, Christopher J B CJB; Elliott, Bruce E BE; Varma, Sonal S; Greer, Peter A PA
Publication Date: 2022-06

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36923551
Variant Present in the following documents:
  • crc-21-0117-s01.pdf
View BVdb publication page



Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.

Cancer Research Communications
White, Jason A JA; Kaninjing, Ernest T ET; Adeniji, Kayode A KA; Jibrin, Paul P; Obafunwa, John O JO; Ogo, Chidiebere N CN; Mohammed, Faruk F; Popoola, Ademola A; Fatiregun, Omolara A OA; Oluwole, Olabode P OP; Karanam, Balasubramanyam B; Elhussin, Isra I; Ambs, Stefan S; Tang, Wei W; Davis, Melissa M; Polak, Paz P; Campbell, Moray J MJ; Brignole, Kathryn R KR; Rotimi, Solomon O SO; Dean-Colomb, Windy W; Odedina, Folake T FT; Martin, Damali N DN; Yates, Clayton C
Publication Date: 2022-09

Variant appearance in text: PIK3CA: 1633G>A; Glu545Lys; rs104886003
PubMed Link: 36922933
Variant Present in the following documents:
  • crc-22-0136-s01.xlsx, sheet 9
  • crc-22-0136-s01.xlsx, sheet 1
  • crc-22-0136-s01.xlsx, sheet 3
View BVdb publication page



Single-cell sequencing reveals that endothelial cells, EndMT cells and mural cells contribute to the pathogenesis of cavernous malformations.

Experimental & Molecular Medicine
Ren, Jian J; Xiao, Xiao X; Li, Ruofei R; Lv, Cheng C; Zhang, Yu Y; Wang, Leiming L; Hong, Tao T; Zhang, Hongqi H; Wang, Yibo Y
Publication Date: 2023-03-13

Variant appearance in text: PIK3CA: E545K
PubMed Link: 36914857
Variant Present in the following documents:
  • Main text
  • 12276_2023_Article_962.pdf
View BVdb publication page