Preclinical characterization of CPL302-253, a selective inhibitor of PI3Kδ, as the candidate for the inhalatory treatment and prevention of Asthma.
Plos One
P Gunerka, K Gala, M Banach, J Dominowski, J Hucz-Kalitowska, K Mulewski, A Hajnal, EG Mikus, D Smuga, M Zagozda, K Dubiel, J Pieczykolan, BM Zygmunt, M Wieczorek
ctDNA analysis reveals different molecular patterns upon disease progression in patients treated with osimertinib.
Translational Lung Cancer Research
A Romero, R Serna-Blasco, C Alfaro, E Sánchez-Herrero, M Barquín, MC Turpin, S Chico, S Sanz-Moreno, A Rodrigez-Festa, R Laza-Briviesca, A Cruz-Bermudez, V Calvo, A Royuela, M Provencio
Immunohistochemistry-Based Taxonomical Classification of Bladder Cancer Predicts Response to Neoadjuvant Chemotherapy.
Cancers
A Font, M Domènech, R Benítez, M Rava, M Marqués, JL Ramírez, S Pineda, S Domínguez-Rodríguez, JL Gago, J Badal, C Carrato, H López, A Quer, D Castellano, N Malats, FX Real
Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board.
Practical Laboratory Medicine
EB Bernhardt, MD Chamberlin, IP Gorlov, FB de Abreu, KJ Bloch, JD Peterson, GJ Tsongalis, K Shirai, KH Dragnev, TW Miller, LJ Tafe
Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma.
Frontiers In Oncology
J Chen, L Zhou, J Gao, T Lu, J Wang, H Wu, Z Liang
Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma.
Scientific Reports
AC de Carvalho, S Perdomo, W Dos Santos, GC Fernandes, LM de Jesus, RS Carvalho, C Scapulatempo-Neto, GC de Almeida, BP Sorroche, LMRB Arantes, ME Melendez, P De Marchi, N Hayes, RM Reis, AL Carvalho
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Cell
N Koundouros, E Karali, A Tripp, A Valle, P Inglese, NJS Perry, DJ Magee, S Anjomani Virmouni, GA Elder, AL Tyson, ML Dória, A van Weverwijk, RF Soares, CM Isacke, JK Nicholson, RC Glen, Z Takats, G Poulogiannis
Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors.
Communications Biology
P Savage, A Pacis, H Kuasne, L Liu, D Lai, A Wan, M Dankner, C Martinez, V Muñoz-Ramos, V Pilon, A Monast, H Zhao, M Souleimanova, MG Annis, A Aguilar-Mahecha, J Lafleur, NR Bertos, J Asselah, N Bouganim, K Petrecca, PM Siegel, A Omeroglu, SP Shah, S Aparicio, M Basik, S Meterissian, M Park
Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.
Nature Communications
I Martinez-Corral, Y Zhang, M Petkova, H Ortsäter, S Sjöberg, SD Castillo, P Brouillard, L Libbrecht, D Saur, M Graupera, K Alitalo, L Boon, M Vikkula, T Mäkinen
Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan.
Translational Oncology
H Taniguchi, K Uehara, G Nakayama, H Nakayama, T Aiba, N Hattori, M Kataoka, Y Nakano, Y Kawase, O Okochi, H Matsuoka, S Utsunomiya, E Sakamoto, Y Mori, S Umeda, T Shikano, K Komori, M Tajika, S Kadowaki, K Muro, Y Yatabe
Comprehensive Characterization of the Mutational Landscape in Localized Anal Squamous Cell Carcinoma.
Translational Oncology
L Trilla-Fuertes, I Ghanem, J Maurel, L G-Pastrián, M Mendiola, C Peña, R López-Vacas, G Prado-Vázquez, E López-Camacho, A Zapater-Moros, V Heredia, M Cuatrecasas, P García-Alfonso, J Capdevila, C Conill, R García-Carbonero, KE Heath, R Ramos-Ruiz, C Llorens, Á Campos-Barros, A Gámez-Pozo, J Feliu, JÁF Vara
Frequency and spectrum of PIK3CA somatic mutations in breast cancer.
Breast Cancer Research : Bcr
O Martínez-Sáez, N Chic, T Pascual, B Adamo, M Vidal, B González-Farré, E Sanfeliu, F Schettini, B Conte, F Brasó-Maristany, A Rodríguez, D Martínez, P Galván, AB Rodríguez, A Martinez, M Muñoz, A Prat
Safety and efficacy of sirolimus combined with endocrine therapy in patients with advanced hormone receptor-positive breast cancer and the exploration of biomarkers.
Breast (Edinburgh, Scotland)
Z Yi, B Liu, X Sun, G Rong, W Wang, H Li, X Guan, L Li, J Zhai, C Li, H Qian, F Ma, B Xu
Use of an Integrated Pan-Cancer Oncology Enrichment Next-Generation Sequencing Assay to Measure Tumour Mutational Burden and Detect Clinically Actionable Variants.
Molecular Diagnosis & Therapy
V Pestinger, M Smith, T Sillo, JM Findlay, JF Laes, G Martin, G Middleton, P Taniere, AD Beggs
Everolimus versus alpelisib in advanced hormone receptor-positive HER2-negative breast cancer: targeting different nodes of the PI3K/AKT/mTORC1 pathway with different clinical implications.
Breast Cancer Research : Bcr
C Vernieri, F Corti, F Nichetti, F Ligorio, S Manglaviti, E Zattarin, CG Rea, G Capri, GV Bianchi, F de Braud
Harmonization of Next-Generation Sequencing Procedure in Italian Laboratories: A Multi-Institutional Evaluation of the SiRe® Panel.
Frontiers In Oncology
U Malapelle, F Pepe, P Pisapia, R Sgariglia, M Nacchio, C De Luca, R Lacalamita, S Tommasi, R Pinto, G Palomba, G Palmieri, D Vacirca, M Barberis, I Bottillo, P Grammatico, LR Grillo, V Costa, R Smeraglio, D Bruzzese, G Troncone
Comparison of Somatic Mutation Profiles Between Formalin-Fixed Paraffin Embedded Tissues and Plasma Cell-Free DNA from Ovarian Cancer Patients Before and After Surgery.
Bioresearch Open Access
M Jagelkova, K Zelinova, Z Laucekova, M Bobrovska, Z Dankova, M Grendar, K Dokus
Early prediction of resistance to tyrosine kinase inhibitors by plasma monitoring of EGFR mutations in NSCLC: a new algorithm for patient selection and personalized treatment.
Oncotarget
F Buttitta, L Felicioni, AD Lorito, A Cortellini, L Irtelli, D Brocco, PD Marino, D Traisci, N D'Ostilio, AD Paolo, F Malorgio, P Assalone, SD Felice, F Fabbri, G Cianci, M Tursi, A Marchetti
Fragment Enrichment of Circulating Tumor DNA With Low-Frequency Mutations.
Frontiers In Genetics
X Liu, J Lang, S Li, Y Wang, L Peng, W Wang, Y Han, C Qi, L Song, S Yang, K Zhang, G Zang, H Pei, Q Lu, Y Peng, S Xi, W Wang, D Yuan, P Bing, L Zhou, G Tian
XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary.
Oncogene
R Tamura, K Yoshihara, H Nakaoka, N Yachida, M Yamaguchi, K Suda, T Ishiguro, K Nishino, H Ichikawa, K Homma, A Kikuchi, Y Ueda, Y Takei, H Fujiwara, T Motoyama, S Okuda, T Wakai, I Inoue, T Enomoto
Prevalence and prognostic role of PIK3CA E545K mutation in Iranian colorectal cancer patients.
Gastroenterology And Hepatology From Bed To Bench
R Ranjbar, S Mohammadpour, A Torshizi Esfahani, S Namazian, M Yaghob-Taleghani, K Baghaei, SA Mortazavi Tabatabaei, L Pasharavesh, E Nazemalhosseini-Mojarad
Publication Date: 2019
Variant appearance in text: PIK3CA: E545K; rs104886003