Variant ID: 3-178936091-G-A

NM_006218.2(PIK3CA):c.1633G>A;(p.Glu545Lys)

This variant was identified in 1517 publications




Publications:


Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy Targets.

Biomed Research International
C Chen, S Liu, R Qu, B Li
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32733937
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Status of 10 targeted genes of non-small cell lung cancer in eastern China: A study of 884 patients based on NGS in a single institution.

Thoracic Cancer
D Li, L Ding, W Ran, Y Huang, G Li, C Wang, Y Xiao, X Wang, D Lin, X Xing
Publication Date: 2020-07-30

Variant appearance in text: PIK3CA: E545K
PMID: 32729257
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Distinct Molecular Landscape of Epstein-Barr Virus Associated Pulmonary Lymphoepithelioma-Like Carcinoma Revealed by Genomic Sequencing.

Cancers
SL Chau, JH Tong, C Chow, JS Kwan, RW Lung, LY Chung, EK Tin, SS Wong, AH Cheung, RW Lau, CS Ng, TS Mok, KW Lo, KF To
Publication Date: 2020-07-27

Variant appearance in text: PIK3CA: E545K
PMID: 32726920
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Efficient mutation screening for cervical cancers from circulating tumor DNA in blood.

Bmc Cancer
SY Lee, DK Chae, SH Lee, Y Lim, J An, CH Chae, BC Kim, J Bhak, D Bolser, DH Cho
Publication Date: 2020-07-27

Variant appearance in text: PIK3CA: E545K
PMID: 32718341
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Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer.

Cancers
L Seeneevassen, J Giraud, S Molina-Castro, E Sifré, C Tiffon, C Beauvoit, C Staedel, F Mégraud, P Lehours, OCB Martin, H Boeuf, P Dubus, C Varon
Publication Date: 2020-07-22

Variant appearance in text: PIK3CA: 1633G>A; Glu545Lys
PMID: 32707998
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Selective inhibition of PI3K110α as a novel therapeutic strategy for cetuximab‑resistant oral squamous cell carcinoma.

Oncology Reports
H Tsuchihashi, T Naruse, S Yanamoto, K Okuyama, K Furukawa, K Omori, M Umeda
Publication Date: 2020-09

Variant appearance in text: PIK3CA: E545K
PMID: 32705230
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Preclinical characterization of CPL302-253, a selective inhibitor of PI3Kδ, as the candidate for the inhalatory treatment and prevention of Asthma.

Plos One
P Gunerka, K Gala, M Banach, J Dominowski, J Hucz-Kalitowska, K Mulewski, A Hajnal, EG Mikus, D Smuga, M Zagozda, K Dubiel, J Pieczykolan, BM Zygmunt, M Wieczorek
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32702053
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Characterization of Driver Mutations in Anaplastic Thyroid Carcinoma Identifies RAS and PIK3CA Mutations as Negative Survival Predictors.

Cancers
WA Lai, CY Liu, SY Lin, CC Chen, JF Hang
Publication Date: 2020-07-20

Variant appearance in text: PIK3CA: E545K
PMID: 32698386
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Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: a case report with complex morphological and molecular analysis.

Diagnostic Pathology
P Dundr, M Gregová, K Němejcová, M Bártů, N Hájková, J Hojný, I Stružinská, D Fischerová
Publication Date: 2020-07-21

Variant appearance in text: PIK3CA: E545K
PMID: 32693840
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ctDNA analysis reveals different molecular patterns upon disease progression in patients treated with osimertinib.

Translational Lung Cancer Research
A Romero, R Serna-Blasco, C Alfaro, E Sánchez-Herrero, M Barquín, MC Turpin, S Chico, S Sanz-Moreno, A Rodrigez-Festa, R Laza-Briviesca, A Cruz-Bermudez, V Calvo, A Royuela, M Provencio
Publication Date: 2020-06

Variant appearance in text: PIK3CA: E545K
PMID: 32676317
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Genomic characterization of Chinese ovarian clear cell carcinoma identifies driver genes by whole exome sequencing.

Neoplasia (New York, N.Y.)
Q Yang, C Zhang, Y Ren, H Yi, T Luo, F Xing, X Bai, L Cui, L Zhu, J Ouyang, P Jiang, W Fan, J Qiu, F Wang, X Xing, Z Zhang, X Zhang, R Zhang
Publication Date: 2020-07-07

Variant appearance in text: PIK3CA: E545K
PMID: 32650224
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Histomolecular characterization of intracranial meningiomas developed in patients exposed to high-dose cyproterone acetate: an antiandrogen treatment.

Neuro-Oncology Advances
S Portet, R Naoufal, G Tachon, A Simonneau, A Chalant, A Naar, S Milin, B Bataille, L Karayan-Tapon
Publication Date: 2019

Variant appearance in text: PIK3CA: E545K
PMID: 32642646
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Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer.

Journal Of Thoracic Disease
B Gini, N Thomas, CM Blakely
Publication Date: 2020-05

Variant appearance in text: PIK3CA: E545K
PMID: 32642201
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Proliferative Classification of Intracranially Injected HER2-positive Breast Cancer Cell Lines.

Cancers
Y Kuroiwa, J Nakayama, C Adachi, T Inoue, S Watanabe, K Semba
Publication Date: 2020-07-06

Variant appearance in text: PIK3CA: E545K
PMID: 32640677
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A Systematic Review of the Prevalence and Diagnostic Workup of PIK3CA Mutations in HR+/HER2- Metastatic Breast Cancer.

International Journal Of Breast Cancer
EJ Anderson, LE Mollon, JL Dean, TL Warholak, A Aizer, EA Platt, DH Tang, LE Davis
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32637176
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Immunohistochemistry-Based Taxonomical Classification of Bladder Cancer Predicts Response to Neoadjuvant Chemotherapy.

Cancers
A Font, M Domènech, R Benítez, M Rava, M Marqués, JL Ramírez, S Pineda, S Domínguez-Rodríguez, JL Gago, J Badal, C Carrato, H López, A Quer, D Castellano, N Malats, FX Real
Publication Date: 2020-07-03

Variant appearance in text: PIK3CA: E545K
PMID: 32635360
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Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform.

Nature Communications
ML Kutys, WJ Polacheck, MK Welch, KA Gagnon, T Koorman, S Kim, L Li, AI McClatchey, CS Chen
Publication Date: 2020-07-06

Variant appearance in text: PIK3CA: E545K
PMID: 32632100
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Clinical Perspective and Translational Oncology of Liquid Biopsy.

Diagnostics (Basel, Switzerland)
D Fernández-Lázaro, JLG Hernández, AC García, ACD Castillo, MV Hueso, JJ Cruz-Hernández
Publication Date: 2020-06-30

Variant appearance in text: PIK3CA: E545K
PMID: 32629823
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Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board.

Practical Laboratory Medicine
EB Bernhardt, MD Chamberlin, IP Gorlov, FB de Abreu, KJ Bloch, JD Peterson, GJ Tsongalis, K Shirai, KH Dragnev, TW Miller, LJ Tafe
Publication Date: 2020-08

Variant appearance in text: PIK3CA: E545K
PMID: 32613070
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Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies.

Cancers
M Mossenta, D Busato, M Dal Bo, G Toffoli
Publication Date: 2020-06-23

Variant appearance in text: PIK3CA: E545K
PMID: 32585931
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Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma.

Frontiers In Oncology
J Chen, L Zhou, J Gao, T Lu, J Wang, H Wu, Z Liang
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32582557
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Small cell transformation of non-small cell lung cancer on immune checkpoint inhibitors: uncommon or under-recognized?

Journal For Immunotherapy Of Cancer
K Sehgal, A Varkaris, H Viray, PA VanderLaan, D Rangachari, DB Costa
Publication Date: 2020-06

Variant appearance in text: PIK3CA: E545K
PMID: 32581048
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Optimization of a WGA-Free Molecular Tagging-Based NGS Protocol for CTCs Mutational Profiling.

International Journal Of Molecular Sciences
G De Luca, B Cardinali, L Del Mastro, S Lastraioli, F Carli, M Ferrarini, GA Calin, A Garuti, C Mazzitelli, S Zupo, M Dono
Publication Date: 2020-06-19

Variant appearance in text: PIK3CA: 1633G>A; Glu545Lys
PMID: 32575430
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Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma.

Scientific Reports
AC de Carvalho, S Perdomo, W Dos Santos, GC Fernandes, LM de Jesus, RS Carvalho, C Scapulatempo-Neto, GC de Almeida, BP Sorroche, LMRB Arantes, ME Melendez, P De Marchi, N Hayes, RM Reis, AL Carvalho
Publication Date: 2020-06-19

Variant appearance in text: PIK3CA: E545K
PMID: 32561788
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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.

Cell
N Koundouros, E Karali, A Tripp, A Valle, P Inglese, NJS Perry, DJ Magee, S Anjomani Virmouni, GA Elder, AL Tyson, ML Dória, A van Weverwijk, RF Soares, CM Isacke, JK Nicholson, RC Glen, Z Takats, G Poulogiannis
Publication Date: 2020-06-18

Variant appearance in text: PIK3CA: E545K
PMID: 32559461
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Mucinous borderline ovarian tumors with BRAFV600E mutation may have low risk for progression to invasive carcinomas.

Archives Of Gynecology And Obstetrics
K Ohnishi, K Nakayama, M Ishikawa, T Ishibashi, H Yamashita, K Nakamura, T Minamoto, K Iida, S Razia, N Ishikawa, S Kyo
Publication Date: 2020-06-16

Variant appearance in text: PIK3CA: E545K
PMID: 32556513
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Advances in the Detection Technologies and Clinical Applications of Circulating Tumor DNA in Metastatic Breast Cancer.

Cancer Management And Research
H Liao, H Li
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32547192
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Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach.

Cancer Informatics
V D'Afonseca, AD Arencibia, A Echeverría-Vega, L Cerpa, JP Cayún, NM Varela, M Salazar, LA Quiñones
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32546937
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Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors.

Communications Biology
P Savage, A Pacis, H Kuasne, L Liu, D Lai, A Wan, M Dankner, C Martinez, V Muñoz-Ramos, V Pilon, A Monast, H Zhao, M Souleimanova, MG Annis, A Aguilar-Mahecha, J Lafleur, NR Bertos, J Asselah, N Bouganim, K Petrecca, PM Siegel, A Omeroglu, SP Shah, S Aparicio, M Basik, S Meterissian, M Park
Publication Date: 2020-06-16

Variant appearance in text: PI3K: E545K
PMID: 32546838
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Comparative genomics of high grade neuroendocrine carcinoma of the cervix.

Plos One
RT Hillman, R Cardnell, J Fujimoto, WC Lee, J Zhang, LA Byers, P Ramalingam, M Leitao, E Swisher, PA Futreal, M Frumovitz
Publication Date: 2020

Variant appearance in text: PIK3CA: 1633G>A
PMID: 32544169
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PIK3CA Mutational Analysis of Parathyroid Adenomas.

Jbmr Plus
A Riccardi, C Lemos, R Ramos, J Bellizzi, K Parham, TC Brown, R Korah, T Carling, J Costa-Guda, A Arnold
Publication Date: 2020-06

Variant appearance in text: PIK3CA: E545K
PMID: 32537547
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Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.

Nature Communications
I Martinez-Corral, Y Zhang, M Petkova, H Ortsäter, S Sjöberg, SD Castillo, P Brouillard, L Libbrecht, D Saur, M Graupera, K Alitalo, L Boon, M Vikkula, T Mäkinen
Publication Date: 2020-06-08

Variant appearance in text: PI3K: E545K
PMID: 32513927
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Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment.

Molecules (Basel, Switzerland)
M Zoetemelk, GM Ramzy, M Rausch, P Nowak-Sliwinska
Publication Date: 2020-06-04

Variant appearance in text: PIK3CA: E545K
PMID: 32512790
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Heterogeneous genomic aberrations in esophageal squamous cell carcinoma: a review.

American Journal Of Translational Research
R Li, P Li, W Xing, H Qiu
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32509161
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Clinical significance of PI3K/Akt/mTOR signaling in gastric carcinoma.

International Journal Of Clinical And Experimental Pathology
EJ Jung, JH Suh, WH Kim, HS Kim
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32509071
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Multidisciplinary therapy strategy of precision medicine in clinical practice.

Clinical And Translational Medicine
M Qian, Q Li, M Zhang, X Xu, Q Shen, H Chen, X Wang, T Liu, Y Cheng
Publication Date: 2020-01

Variant appearance in text: PIK3CA: E545K
PMID: 32508051
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FGFR aberrations increase the risk of brain metastases and predict poor prognosis in metastatic breast cancer patients.

Therapeutic Advances In Medical Oncology
N Xie, C Tian, H Wu, X Yang, L Liu, J Li, H Xiao, J Gao, J Lu, X Hu, M Cao, Z Shui, Y Tang, X Wang, J Yang, ZY Hu, Q Ouyang
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32499836
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Clinical and molecular characteristics of Chinese non-small cell lung cancer patients with ERBB2 transmembrane domain mutations.

Molecular Oncology
Y Fan, J Qiu, R Yu, R Cao, X Chen, Q Ou, X Wu, YW Shao, M Nagasaka, J Zhang, SI Ou
Publication Date: 2020-06-01

Variant appearance in text: PIK3CA: E545K
PMID: 32478891
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Detection of ctDNA with Personalized Molecular Barcode NGS and Its Clinical Significance in Patients with Early Breast Cancer.

Translational Oncology
T Yoshinami, N Kagara, D Motooka, S Nakamura, T Miyake, T Tanei, Y Naoi, M Shimoda, K Shimazu, SJ Kim, S Noguchi
Publication Date: 2020-05-27

Variant appearance in text: PIK3CA: E545K
PMID: 32473569
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The Predictive Role of PIK3CA Mutation Status on PI3K Inhibitors in HR+ Breast Cancer Therapy: A Systematic Review and Meta-Analysis.

Biomed Research International
M Wang, J Li, J Huang, M Luo
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32461963
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The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review.

Frontiers In Oncology
R Lombardo, F Tosi, A Nocerino, K Bencardino, V Gambi, R Ricotta, F Spina, S Siena, A Sartore-Bianchi
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32457826
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Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan.

Translational Oncology
H Taniguchi, K Uehara, G Nakayama, H Nakayama, T Aiba, N Hattori, M Kataoka, Y Nakano, Y Kawase, O Okochi, H Matsuoka, S Utsunomiya, E Sakamoto, Y Mori, S Umeda, T Shikano, K Komori, M Tajika, S Kadowaki, K Muro, Y Yatabe
Publication Date: 2020-05-16

Variant appearance in text: PIK3CA: E545K
PMID: 32428838
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Comprehensive Characterization of the Mutational Landscape in Localized Anal Squamous Cell Carcinoma.

Translational Oncology
L Trilla-Fuertes, I Ghanem, J Maurel, L G-Pastrián, M Mendiola, C Peña, R López-Vacas, G Prado-Vázquez, E López-Camacho, A Zapater-Moros, V Heredia, M Cuatrecasas, P García-Alfonso, J Capdevila, C Conill, R García-Carbonero, KE Heath, R Ramos-Ruiz, C Llorens, Á Campos-Barros, A Gámez-Pozo, J Feliu, JÁF Vara
Publication Date: 2020-05-15

Variant appearance in text: rs104886003
PMID: 32422573
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Clinicopathological Characteristics of PIK3CA Mutation and Amplification in Korean Patients with Breast Cancers.

International Journal Of Medical Sciences
MH Lee, JH Cho, SY Kwon, SJ Jung, JH Lee
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32410843
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Frequency and spectrum of PIK3CA somatic mutations in breast cancer.

Breast Cancer Research : Bcr
O Martínez-Sáez, N Chic, T Pascual, B Adamo, M Vidal, B González-Farré, E Sanfeliu, F Schettini, B Conte, F Brasó-Maristany, A Rodríguez, D Martínez, P Galván, AB Rodríguez, A Martinez, M Muñoz, A Prat
Publication Date: 2020-05-13

Variant appearance in text: PIK3CA: E545K
PMID: 32404150
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Evaluation of PD-L1 expression on circulating tumor cells (CTCs) in patients with advanced urothelial carcinoma (UC).

Oncoimmunology
S Bergmann, A Coym, L Ott, A Soave, M Rink, M Janning, M Stoupiec, C Coith, S Peine, G von Amsberg, K Pantel, S Riethdorf
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32391189
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Liquid biopsy-based tumor profiling for metastatic colorectal cancer patients with ultra-deep targeted sequencing.

Plos One
JK Kang, S Heo, HP Kim, SH Song, H Yun, SW Han, GH Kang, D Bang, TY Kim
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32379795
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Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants.

Cells
AA Ghodsinia, JMT Lego, RL Garcia
Publication Date: 2020-04-30

Variant appearance in text: PIK3CA: E545K
PMID: 32365913
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Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition.

Cancers
S Boku, M Watanabe, M Sukeno, T Yaoi, K Hirota, M Iizuka-Ohashi, K Itoh, T Sakai
Publication Date: 2020-04-30

Variant appearance in text: PIK3CA: E545K
PMID: 32365457
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Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.

Angiogenesis
TD Le Cras, J Goines, N Lakes, P Pastura, AM Hammill, DM Adams, E Boscolo
Publication Date: 2020-04-30

Variant appearance in text: PIK3CA: E545K
PMID: 32350708
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Safety and efficacy of sirolimus combined with endocrine therapy in patients with advanced hormone receptor-positive breast cancer and the exploration of biomarkers.

Breast (Edinburgh, Scotland)
Z Yi, B Liu, X Sun, G Rong, W Wang, H Li, X Guan, L Li, J Zhai, C Li, H Qian, F Ma, B Xu
Publication Date: 2020-04-16

Variant appearance in text: PIK3CA: E545K
PMID: 32335491
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Role of PI3K/AKT pathway in cancer: the framework of malignant behavior.

Molecular Biology Reports
N Jiang, Q Dai, X Su, J Fu, X Feng, J Peng
Publication Date: 2020-04-24

Variant appearance in text: PIK3CA: E545K
PMID: 32333246
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Allelic heterogeneity of Proteus syndrome.

Cold Spring Harbor Molecular Case Studies
A Buser, MJ Lindhurst, HC Kondolf, MR Yourick, KM Keppler-Noreuil, JC Sapp, LG Biesecker
Publication Date: 2020-04-23

Variant appearance in text: PIK3CA: 1633G>A; Glu545Lys
PMID: 32327430
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Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patients.

Journal Of Advanced Research
A Nassar, M Abouelhoda, O Mansour, SA Loutfy, MM Hafez, M Gomaa, A Bahnassy, AS El-Din Youssef, MM Lotfy, H Ismail, OS Ahmed, AA Abou-Bakr, AN Zekri
Publication Date: 2020-07

Variant appearance in text: PIK3CA: 1633G>A
PMID: 32322420
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[Acquired Drug Resistance Mechanism of Osimertinib in the Targeted Therapy of Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Z Zhao, Y Ni, L Li, T Xin
Publication Date: 2020-04-20

Variant appearance in text: PIK3CA: E545K
PMID: 32316715
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Use of an Integrated Pan-Cancer Oncology Enrichment Next-Generation Sequencing Assay to Measure Tumour Mutational Burden and Detect Clinically Actionable Variants.

Molecular Diagnosis & Therapy
V Pestinger, M Smith, T Sillo, JM Findlay, JF Laes, G Martin, G Middleton, P Taniere, AD Beggs
Publication Date: 2020-04-18

Variant appearance in text: PIK3CA: E545K
PMID: 32306292
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Ovarian mucinous tumors with mural nodules: immunohistochemical and molecular analysis of 3 cases.

Diagnostic Pathology
Y Shao, Q Liu, H Shi, B Lu
Publication Date: 2020-04-14

Variant appearance in text: PIK3CA: E545K
PMID: 32290854
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Comparison of commercially available whole-genome sequencing kits for variant detection in circulating cell-free DNA.

Scientific Reports
F Mauger, C Horgues, M Pierre-Jean, N Oussada, L Mesrob, JF Deleuze
Publication Date: 2020-04-10

Variant appearance in text: PIK3CA: E545K
PMID: 32277101
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Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors.

Journal Of Gastric Cancer
J Park, HM Yoo, HJ Sul, S Shin, SW Lee, JG Kim
Publication Date: 2020-03

Variant appearance in text: PIK3CA: 1633G>A
PMID: 32269842
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Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients.

Oncology Letters
X Ruan, Y Sun, W Wang, J Ye, D Zhang, Z Gong, M Yang
Publication Date: 2020-05

Variant appearance in text: PIK3CA: E545K
PMID: 32269623
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Somatic Mutations in HER2 and Implications for Current Treatment Paradigms in HER2-Positive Breast Cancer.

Journal Of Oncology
M Gaibar, L Beltrán, A Romero-Lorca, A Fernández-Santander, A Novillo
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32256585
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Everolimus versus alpelisib in advanced hormone receptor-positive HER2-negative breast cancer: targeting different nodes of the PI3K/AKT/mTORC1 pathway with different clinical implications.

Breast Cancer Research : Bcr
C Vernieri, F Corti, F Nichetti, F Ligorio, S Manglaviti, E Zattarin, CG Rea, G Capri, GV Bianchi, F de Braud
Publication Date: 2020-04-06

Variant appearance in text: PI3K: E545K
PMID: 32252811
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The art of obtaining a high yield of cell-free DNA from urine.

Plos One
E Augustus, K Van Casteren, L Sorber, P van Dam, G Roeyen, M Peeters, A Vorsters, A Wouters, J Raskin, C Rolfo, K Zwaenepoel, P Pauwels
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32251424
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Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses.

Cells
G Laetitia, S Sven, J Fabrice
Publication Date: 2020-03-30

Variant appearance in text: PIK3CA: Glu545Lys
PMID: 32235612
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Harmonization of Next-Generation Sequencing Procedure in Italian Laboratories: A Multi-Institutional Evaluation of the SiRe® Panel.

Frontiers In Oncology
U Malapelle, F Pepe, P Pisapia, R Sgariglia, M Nacchio, C De Luca, R Lacalamita, S Tommasi, R Pinto, G Palomba, G Palmieri, D Vacirca, M Barberis, I Bottillo, P Grammatico, LR Grillo, V Costa, R Smeraglio, D Bruzzese, G Troncone
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32219061
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Comparison of Somatic Mutation Profiles Between Formalin-Fixed Paraffin Embedded Tissues and Plasma Cell-Free DNA from Ovarian Cancer Patients Before and After Surgery.

Bioresearch Open Access
M Jagelkova, K Zelinova, Z Laucekova, M Bobrovska, Z Dankova, M Grendar, K Dokus
Publication Date: 2020

Variant appearance in text: PIK3CA: 1633G>A
PMID: 32219013
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Early prediction of resistance to tyrosine kinase inhibitors by plasma monitoring of EGFR mutations in NSCLC: a new algorithm for patient selection and personalized treatment.

Oncotarget
F Buttitta, L Felicioni, AD Lorito, A Cortellini, L Irtelli, D Brocco, PD Marino, D Traisci, N D'Ostilio, AD Paolo, F Malorgio, P Assalone, SD Felice, F Fabbri, G Cianci, M Tursi, A Marchetti
Publication Date: 2020-03-17

Variant appearance in text: PIK3CA: E545K
PMID: 32215186
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Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.

Medical Sciences (Basel, Switzerland)
U Testa, G Castelli, E Pelosi
Publication Date: 2020-03-23

Variant appearance in text: PI3K: E545K
PMID: 32210163
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Fragment Enrichment of Circulating Tumor DNA With Low-Frequency Mutations.

Frontiers In Genetics
X Liu, J Lang, S Li, Y Wang, L Peng, W Wang, Y Han, C Qi, L Song, S Yang, K Zhang, G Zang, H Pei, Q Lu, Y Peng, S Xi, W Wang, D Yuan, P Bing, L Zhou, G Tian
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32180799
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Clinical implications of APOBEC3A and 3B expression in patients with breast cancer.

Plos One
YS Kim, S Sun, JS Yoon, YH Ko, HS Won, JS Kim
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32176735
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A Pilot Study of Baseline Spatial Genomic Heterogeneity in Primary Gastric Cancers Using Multi-Region Endoscopic Sampling.

Frontiers In Oncology
J Chao, J Lee, K Kim, SY Kang, T Lee, KM Kim, ST Kim, SJ Klempner, H Lee
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32158697
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Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma.

Frontiers In Oncology
Q Li, H Dong, G Yang, Y Song, Y Mou, Y Ni
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32158692
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Precision cell-free DNA extraction for liquid biopsy by integrated microfluidics.

Npj Precision Oncology
H Lee, C Park, W Na, KH Park, S Shin
Publication Date: 2020

Variant appearance in text: PIK3CA: E545K
PMID: 32133418
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Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis.

Science Signaling
A Kharbanda, DM Walter, AA Gudiel, N Schek, DM Feldser, ES Witze
Publication Date: 2020-03-03

Variant appearance in text: PI3K: E545K
PMID: 32127496
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Model-based analysis of response and resistance factors of cetuximab treatment in gastric cancer cell lines.

Plos Computational Biology
E Raimúndez, S Keller, K Ebert, S Hug, FJ Theis, D Maier, B Luber, J Hasenauer
Publication Date: 2020-03-02

Variant appearance in text: PI3K: E545K
PMID: 32119655
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XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary.

Oncogene
R Tamura, K Yoshihara, H Nakaoka, N Yachida, M Yamaguchi, K Suda, T Ishiguro, K Nishino, H Ichikawa, K Homma, A Kikuchi, Y Ueda, Y Takei, H Fujiwara, T Motoyama, S Okuda, T Wakai, I Inoue, T Enomoto
Publication Date: 2020-03-02

Variant appearance in text: PIK3CA: E545K
PMID: 32115573
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Macropinocytosis confers resistance to therapies targeting cancer anabolism.

Nature Communications
V Jayashankar, AL Edinger
Publication Date: 2020-02-28

Variant appearance in text: PIK3CA: E545K
PMID: 32111826
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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
DA Hescheler, PS Plum, T Zander, A Quaas, M Korenkov, A Gassa, M Michel, CJ Bruns, H Alakus
Publication Date: 2020-02-27

Variant appearance in text: PIK3CA: E545K
PMID: 32107691
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Prevalence and prognostic role of PIK3CA E545K mutation in Iranian colorectal cancer patients.

Gastroenterology And Hepatology From Bed To Bench
R Ranjbar, S Mohammadpour, A Torshizi Esfahani, S Namazian, M Yaghob-Taleghani, K Baghaei, SA Mortazavi Tabatabaei, L Pasharavesh, E Nazemalhosseini-Mojarad
Publication Date: 2019

Variant appearance in text: PIK3CA: E545K; rs104886003
PMID: 32099598
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000263967.3 c.1633G>A p.Glu545Lys missense_variant 10/21 -
NM_006218.4 c.1633G>A p.Glu545Lys missense_variant 10/21 -