Publications:

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Genetic heterogeneity and tissue-specific patterns of tumors with multiple PIK3CA mutations.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Sivakumar, Smruthy S; Jin, Dexter X DX; Rathod, Ruchita R; Ross, Jeffrey J; Cantley, Lewis C LC; Scaltriti, Maurizio M; Chen, Jessica W JW; Hutchinson, Katherine E KE; Wilson, Timothy R TR; Sokol, Ethan S ES; Vasan, Neil N

Publication Date: 2023-01-03

Variant appearance in text: PIK3CA: E545X

PubMed Link: 36595567

Variant Present in the following documents:

• Main text
• 1125.pdf

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: PIK3CA: E545*

PubMed Link: 36561320

Variant Present in the following documents:

• Table3.xlsx, sheet 1

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Abemaciclib plus fulvestrant for the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer with cystic brain metastases: A case report and literature review.

Frontiers In Oncology

Chu, Zhaohui Z

Publication Date: 2022

Variant appearance in text: PIK3CA: E545X

PubMed Link: 36531067

Variant Present in the following documents:

• Main text
• fonc-12-984454.pdf

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Analytical Performance of Next-Generation Sequencing and RT-PCR on Formalin-Fixed Paraffin-Embedded Tumor Tissues for PIK3CA Testing in HR+/HER2- Breast Cancer.

Cells

Venetis, Konstantinos K; Pepe, Francesco F; Munzone, Elisabetta E; Sajjadi, Elham E; Russo, Gianluca G; Pisapia, Pasquale P; Ivanova, Mariia M; Bonizzi, Giuseppina G; Vacirca, Davide D; Rappa, Alessandra A; Ranghiero, Alberto A; Taormina, Sergio Vincenzo SV; Viale, Giuseppe G; Troncone, Giancarlo G; Barberis, Massimo M; Guerini-Rocco, Elena E; Malapelle, Umberto U; Fusco, Nicola N

Publication Date: 2022-11-09

Variant appearance in text: PIK3CA: E545x

PubMed Link: 36428975

Variant Present in the following documents:

• cells-11-03545.pdf

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The diagnostic accuracy of PIK3CA mutations by circulating tumor DNA in breast cancer: an individual patient data meta-analysis.

Therapeutic Advances In Medical Oncology

Galvano, Antonio A; Castellana, Luisa L; Gristina, Valerio V; La Mantia, Maria M; Insalaco, Lavinia L; Barraco, Nadia N; Perez, Alessandro A; Cutaia, Sofia S; Calò, Valentina V; Bazan Russo, Tancredi Didier TD; Francini, Edoardo E; Incorvaia, Lorena L; Mirisola, Mario Giuseppe MG; Vieni, Salvatore S; Rolfo, Christian C; Bazan, Viviana V; Russo, Antonio A

Publication Date: 2022

Variant appearance in text: PIK3CA: E545X

PubMed Link: 36188485

Variant Present in the following documents:

• Main text
• 10.1177_17588359221110162.pdf

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PIK3CA Mutation is Associated with Poor Response to HER2-Targeted Therapy in Breast Cancer Patients.

Cancer Research And Treatment

Kim, Ju Won JW; Lim, Ah Reum AR; You, Ji Young JY; Lee, Jung Hyun JH; Song, Sung Eun SE; Lee, Nam Kwon NK; Jung, Seung Pil SP; Cho, Kyu Ran KR; Kim, Cheol Yong CY; Park, Kyong Hwa KH

Publication Date: 2022-09-07

Variant appearance in text: PIK3CA: E545X

PubMed Link: 36097803

Variant Present in the following documents:

• Main text
• crt-2022-221.pdf

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Anthracycline-Free Neoadjuvant Treatment in Patients with HER2-Positive Breast Cancer: Real-Life Use of Pertuzumab, Trastuzumab and Taxanes Association with an Exploratory Analysis of PIK3CA Mutational Status.

Cancers

Irelli, Azzurra A; Parisi, Alessandro A; D'Orazio, Carla C; Sidoni, Tina T; Rotondaro, Silvia S; Patruno, Leonardo L; Pavese, Francesco F; Bafile, Alberto A; Resta, Valter V; Pizzorno, Laura L; Ciuffetelli, Virginia V; Dal Mas, Antonella A; Calvisi, Giuseppe G; Di Sibio, Alessandra A; Marzullo, Anna A; Zelli, Veronica V; Compagnoni, Chiara C; Tessitore, Alessandra A; Alesse, Edoardo E; Ficorella, Corrado C; Cortellini, Alessio A; Cannita, Katia K

Publication Date: 2022-06-18

Variant appearance in text: PIK3CA: E545x

PubMed Link: 35740668

Variant Present in the following documents:

• cancers-14-03003.pdf

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Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial.

The Lancet. Oncology

Howell, Sacha J SJ; Casbard, Angela A; Carucci, Margherita M; Ingarfield, Kate K; Butler, Rachel R; Morgan, Sian S; Meissner, Magdalena M; Bale, Catherine C; Bezecny, Pavel P; Moon, Sarah S; Twelves, Chris C; Venkitaraman, Ramachandran R; Waters, Simon S; de Bruin, Elza C EC; Schiavon, Gaia G; Foxley, Andrew A; Jones, Robert H RH

Publication Date: 2022-07

Variant appearance in text: PIK3CA: E545X

PubMed Link: 35671774

Variant Present in the following documents:

• Main text
• main.pdf

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PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology

Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E

Publication Date: 2022-03

Variant appearance in text: PIK3CA: E545*

PubMed Link: 35357905

Variant Present in the following documents:

• Main text
• po-6-e2100370.pdf

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: PIK3CA: E545*

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12

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Integrating Histologic and Genomic Characteristics to Predict Tumor Mutation Burden of Early-Stage Non-Small-Cell Lung Cancer.

Frontiers In Oncology

Qiu, Yuan Y; Liu, Liping L; Yang, Haihong H; Chen, Hanzhang H; Deng, Qiuhua Q; Xiao, Dakai D; Lin, Yongping Y; Zhu, Changbin C; Li, Weiwei W; Shao, Di D; Jiang, Wenxi W; Wu, Kui K; He, Jianxing J

Publication Date: 2020

Variant appearance in text: PIK3CA: E545X

PubMed Link: 33996530

Variant Present in the following documents:

• Main text
• fonc-10-608989.pdf

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Role of Alpelisib in the Treatment of PIK3CA-Mutated Breast Cancer: Patient Selection and Clinical Perspectives.

Therapeutics And Clinical Risk Management

Chang, Dwan-Ying DY; Ma, Wei-Li WL; Lu, Yen-Shen YS

Publication Date: 2021

Variant appearance in text: PIK3CA: E545X

PubMed Link: 33707948

Variant Present in the following documents:

• Main text
• tcrm-17-193.pdf

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Clinicopathological Correlates of γδ T Cell Infiltration in Triple-Negative Breast Cancer.

Cancers

Boissière-Michot, Florence F; Chabab, Ghita G; Mollevi, Caroline C; Guiu, Séverine S; Lopez-Crapez, Evelyne E; Ramos, Jeanne J; Bonnefoy, Nathalie N; Lafont, Virginie V; Jacot, William W

Publication Date: 2021-02-12

Variant appearance in text: PIK3CA: E545X

PubMed Link: 33673133

Variant Present in the following documents:

• Main text
• cancers-13-00765.pdf

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Testing considerations for phosphatidylinositol-3-kinase catalytic subunit alpha as an emerging biomarker in advanced breast cancer.

Cancer Medicine

Toppmeyer, Deborah L DL; Press, Michael F MF

Publication Date: 2020-09

Variant appearance in text: PIK3CA: E545X

PubMed Link: 32697890

Variant Present in the following documents:

• Main text

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A Systematic Review of the Prevalence and Diagnostic Workup of PIK3CA Mutations in HR+/HER2- Metastatic Breast Cancer.

International Journal Of Breast Cancer

Anderson, Elizabeth J EJ; Mollon, Lea E LE; Dean, Joni L JL; Warholak, Terri L TL; Aizer, Ayal A; Platt, Emma A EA; Tang, Derek H DH; Davis, Lisa E LE

Publication Date: 2020

Variant appearance in text: PIK3CA: E545X

PubMed Link: 32637176

Variant Present in the following documents:

• Main text
• IJBC2020-3759179.pdf

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Phase II evaluation of copanlisib, a selective inhibitor of Pi3kca, in patients with persistent or recurrent endometrial carcinoma harboring PIK3CA hotspot mutations: An NRG Oncology study (NRG-GY008).

Gynecologic Oncology Reports

Santin, Alessandro D AD; Filiaci, Virginia V; Bellone, Stefania S; Ratner, Elena S ES; Mathews, Cara A CA; Cantuaria, Guilherme G; Gunderson, Camille C CC; Rutledge, Teresa T; Buttin, Barbara M BM; Lankes, Heather A HA; Frumovitz, Michael M; Khleif, Samir N SN; Huh, Warner K WK; Birrer, Michael J MJ

Publication Date: 2020-02

Variant appearance in text: PIK3CA: E545X

PubMed Link: 31934607

Variant Present in the following documents:

• Main text
• main.pdf

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Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor-Positive Advanced Breast Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Dickler, Maura N MN; Saura, Cristina C; Richards, Donald A DA; Krop, Ian E IE; Cervantes, Andrés A; Bedard, Philippe L PL; Patel, Manish R MR; Pusztai, Lajos L; Oliveira, Mafalda M; Cardenas, Alison K AK; Cui, Na N; Wilson, Timothy R TR; Stout, Thomas J TJ; Wei, Michael C MC; Hsu, Jerry Y JY; Baselga, José J

Publication Date: 2018-09-15

Variant appearance in text: PIK3CA: E545X

PubMed Link: 29793946

Variant Present in the following documents:

• Main text

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PIK3CA mutation, reduced AKT serine 473 phosphorylation, and increased ERα serine 167 phosphorylation are positive prognostic indicators in postmenopausal estrogen receptor-positive early breast cancer.

Oncotarget

Ishida, Naoko N; Baba, Motoi M; Hatanaka, Yutaka Y; Hagio, Kanako K; Okada, Hiromi H; Hatanaka, Kanako C KC; Togashi, Kenichi K; Matsuno, Yoshihiro Y; Yamashita, Hiroko H

Publication Date: 2018-04-03

Variant appearance in text: PIK3CA: E545X

PubMed Link: 29707142

Variant Present in the following documents:

• Main text
• oncotarget-09-17711.pdf

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Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Caumanns, Joseph J JJ; Berns, Katrien K; Wisman, G Bea A GBA; Fehrmann, Rudolf S N RSN; Tomar, Tushar T; Klip, Harry H; Meersma, Gert J GJ; Hijmans, E Marielle EM; Gennissen, Annemiek M C AMC; Duiker, Evelien W EW; Weening, Desiree D; Itamochi, Hiroaki H; Kluin, Roelof J C RJC; Reyners, Anna K L AKL; Birrer, Michael J MJ; Salvesen, Helga B HB; Vergote, Ignace I; van Nieuwenhuysen, Els E; Brenton, James J; Braicu, E Ioana EI; Kupryjanczyk, Jolanta J; Spiewankiewicz, Beata B; Mittempergher, Lorenza L; Bernards, René R; van der Zee, Ate G J AGJ; de Jong, Steven S

Publication Date: 2018-08-15

Variant appearance in text: PIK3CA: E545*

PubMed Link: 29685880

Variant Present in the following documents:

• Main text

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Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer.

Molecular Cancer

Takeshita, Takashi T; Yamamoto, Yutaka Y; Yamamoto-Ibusuki, Mutsuko M; Tomiguchi, Mai M; Sueta, Aiko A; Murakami, Keiichi K; Iwase, Hirotaka H

Publication Date: 2018-02-26

Variant appearance in text: PIK3CA: E545x

PubMed Link: 29482551

Variant Present in the following documents:

• Main text
• 12943_2018_Article_808.pdf

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PIK3CA mutations are associated with increased tumor aggressiveness and Akt activation in gastric cancer.

Oncotarget

Kim, Ji-Won JW; Lee, Hye Seung HS; Nam, Kyung Han KH; Ahn, Soyeon S; Kim, Jin Won JW; Ahn, Sang-Hoon SH; Park, Do Joong DJ; Kim, Hyung-Ho HH; Lee, Keun-Wook KW

Publication Date: 2017-10-31

Variant appearance in text: PIK3CA: E545X

PubMed Link: 29207615

Variant Present in the following documents:

• Main text
• oncotarget-08-90948.pdf
• oncotarget-08-90948-s001.pdf

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Analysis of ESR1 and PIK3CA mutations in plasma cell-free DNA from ER-positive breast cancer patients.

Oncotarget

Takeshita, Takashi T; Yamamoto, Yutaka Y; Yamamoto-Ibusuki, Mutsuko M; Tomiguchi, Mai M; Sueta, Aiko A; Murakami, Keiichi K; Omoto, Yoko Y; Iwase, Hirotaka H

Publication Date: 2017-08-08

Variant appearance in text: PIK3CA: E545x

PubMed Link: 28881720

Variant Present in the following documents:

• Main text
• oncotarget-08-52142.pdf

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Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

The Lancet. Oncology

Kim, Sung-Bae SB; Dent, Rebecca R; Im, Seock-Ah SA; Espié, Marc M; Blau, Sibel S; Tan, Antoinette R AR; Isakoff, Steven J SJ; Oliveira, Mafalda M; Saura, Cristina C; Wongchenko, Matthew J MJ; Kapp, Amy V AV; Chan, Wai Y WY; Singel, Stina M SM; Maslyar, Daniel J DJ; Baselga, José J; ,

Publication Date: 2017-10

Variant appearance in text: PIK3CA: Glu545X

PubMed Link: 28800861

Variant Present in the following documents:

• Main text

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: PI3K: 1633G>T

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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Tumor burden monitoring using cell-free tumor DNA could be limited by tumor heterogeneity in advanced breast cancer and should be evaluated together with radiographic imaging.

Bmc Cancer

García-Saenz, José Angel JA; Ayllón, Patricia P; Laig, Marion M; Acosta-Eyzaguirre, Daniel D; García-Esquinas, Marta M; Montes, Myriam M; Sanz, Julián J; Barquín, Miguel M; Moreno, Fernando F; Garcia-Barberan, Vanesa V; Díaz-Rubio, Eduardo E; Caldes, Trinidad T; Romero, Atocha A

Publication Date: 2017-03-22

Variant appearance in text: PIK3CA: E545X

PubMed Link: 28330468

Variant Present in the following documents:

• Main text
• 12885_2017_Article_3185.pdf

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High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers.

Bmc Cancer

Jacot, William W; Mollevi, Caroline C; Fina, Frédéric F; Lopez-Crapez, Evelyne E; Martin, Pierre-Marie PM; Colombo, Pierre-Emmanuel PE; Bibeau, Frédéric F; Romieu, Gilles G; Lamy, Pierre-Jean PJ

Publication Date: 2015-12-18

Variant appearance in text: PIK3CA: E545X

PubMed Link: 26680641

Variant Present in the following documents:

• Main text
• 12885_2015_Article_1977.pdf

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Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer.

Plos One

Cossu-Rocca, Paolo P; Orrù, Sandra S; Muroni, Maria Rosaria MR; Sanges, Francesca F; Sotgiu, Giovanni G; Ena, Sara S; Pira, Giovanna G; Murgia, Luciano L; Manca, Alessandra A; Uras, Maria Gabriela MG; Sarobba, Maria Giuseppina MG; Urru, Silvana S; De Miglio, Maria Rosaria MR

Publication Date: 2015

Variant appearance in text: PIK3CA: E545X

PubMed Link: 26540293

Variant Present in the following documents:

• Main text

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Pharmacogenomics of EGFR-targeted therapies in non-small cell lung cancer: EGFR and beyond.

Chinese Journal Of Cancer

Delaney, Christopher C; Frank, Samuel S; Huang, R Stephanie RS

Publication Date: 2015-04-08

Variant appearance in text: PIK3CA: E545X

PubMed Link: 25962919

Variant Present in the following documents:

• Main text
• 40880_2015_Article_7.pdf

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Next generation MUT-MAP, a high-sensitivity high-throughput microfluidics chip-based mutation analysis panel.

Plos One

Schleifman, Erica B EB; Tam, Rachel R; Patel, Rajesh R; Tsan, Alison A; Sumiyoshi, Teiko T; Fu, Ling L; Desai, Rupal R; Schoenbrunner, Nancy N; Myers, Thomas W TW; Bauer, Keith K; Smith, Edward E; Raja, Rajiv R

Publication Date: 2014

Variant appearance in text: PIK3CA: E545X

PubMed Link: 24658394

Variant Present in the following documents:

• Main text

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Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers.

Plos One

Schleifman, Erica B EB; Desai, Rupal R; Spoerke, Jill M JM; Xiao, Yuanyuan Y; Wong, Cheryl C; Abbas, Ilma I; O'Brien, Carol C; Patel, Rajesh R; Sumiyoshi, Teiko T; Fu, Ling L; Tam, Rachel N RN; Koeppen, Hartmut H; Wilson, Timothy R TR; Raja, Rajiv R; Hampton, Garret M GM; Lackner, Mark R MR

Publication Date: 2014

Variant appearance in text: PIK3CA: E545X

PubMed Link: 24520381

Variant Present in the following documents:

• Main text
• pone.0088401.pdf

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