Publications:

Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma.

Diagnostic Pathology

Lee, Hong Kyu HK; Kwon, Mi Jung MJ; Ra, Yong Joon YJ; Lee, Hee Sung HS; Kim, Hyoung Soo HS; Nam, Eun Sook ES; Cho, Seong Jin SJ; Park, Hye-Rim HR; Min, Soo Kee SK; Seo, Jinwon J; Choe, Ji-Young JY; Min, Kyueng-Whan KW; Kang, So Young SY

Publication Date: 2020-10-14

Variant appearance in text: PIK3CA: D549G

PubMed Link: 33054840

Variant Present in the following documents:

• Main text
• 13000_2020_Article_1045.pdf

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: PIK3CA: D549G

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 2
• pone.0196434.s001.xlsx, sheet 1

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Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells.

The Journal Of Investigative Dermatology

Posch, Christian C; Sanlorenzo, Martina M; Vujic, Igor I; Oses-Prieto, Juan A JA; Cholewa, Brian D BD; Kim, Sarasa T ST; Ma, Jeffrey J; Lai, Kevin K; Zekhtser, Mitchell M; Esteve-Puig, Rosaura R; Green, Gary G; Chand, Shreya S; Burlingame, Alma L AL; Panzer-Grümayer, Renate R; Rappersberger, Klemens K; Ortiz-Urda, Susana S

Publication Date: 2016-10

Variant appearance in text: PI3K: D549G

PubMed Link: 27251789

Variant Present in the following documents:

• Main text

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Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Posch, Christian C; Moslehi, Homayoun H; Feeney, Luzviminda L; Green, Gary A GA; Ebaee, Anoosheh A; Feichtenschlager, Valentin V; Chong, Kim K; Peng, Lily L; Dimon, Michelle T MT; Phillips, Thomas T; Daud, Adil I AI; McCalmont, Timothy H TH; LeBoit, Philip E PE; Ortiz-Urda, Susana S

Publication Date: 2013-03-05

Variant appearance in text: PI3K: D549G

PubMed Link: 23431193

Variant Present in the following documents:

• Main text

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