PIK3CA c.1799A>T ;(p.E600V)

Variant ID: 3-178937411-A-T

NM_006218.2(PIK3CA):c.1799A>T;(p.E600V)

This variant was identified in 11 publications

View GRCh38 version.




Publications:


Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: E600V
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology
Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN
Publication Date: 2021

Variant appearance in text: PIK3CA: E600V
PubMed Link: 34113354
Variant Present in the following documents:
  • Table_1.xlsx, sheet 31
View BVdb publication page



Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
Publication Date: 2021-04-19

Variant appearance in text: PIK3CA: E600V
PubMed Link: 33875650
Variant Present in the following documents:
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Clinical impact of a cytological screening system using cyclin D1 immunostaining and genomic analysis for the diagnosis of thyroid nodules.

Bmc Cancer
Teshima, Masanori M; Tokita, Kazuya K; Ryo, Eijitsu E; Matsumoto, Fumihiko F; Kondo, Madoka M; Ikegami, Yota Y; Shinomiya, Hirotaka H; Otsuki, Naoki N; Hiraoka, Nobuyoshi N; Nibu, Ken-Ichi KI; Yoshimoto, Seiichi S; Mori, Taisuke T
Publication Date: 2019-03-18

Variant appearance in text: PI3K: 1799A>T
PubMed Link: 30885146
Variant Present in the following documents:
  • 12885_2019_Article_5452.pdf
View BVdb publication page



Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

The Journal Of Pathology
Temko, Daniel D; Van Gool, Inge C IC; Rayner, Emily E; Glaire, Mark M; Makino, Seiko S; Brown, Matthew M; Chegwidden, Laura L; Palles, Claire C; Depreeuw, Jeroen J; Beggs, Andrew A; Stathopoulou, Chaido C; Mason, John J; Baker, Ann-Marie AM; Williams, Marc M; Cerundolo, Vincenzo V; Rei, Margarida M; Taylor, Jenny C JC; Schuh, Anna A; Ahmed, Ahmed A; Amant, Frédéric F; Lambrechts, Diether D; Smit, Vincent Thbm VT; Bosse, Tjalling T; Graham, Trevor A TA; Church, David N DN; Tomlinson, Ian I
Publication Date: 2018-07

Variant appearance in text: PIK3CA: 1799A>T; E600V
PubMed Link: 29604063
Variant Present in the following documents:
  • PATH-245-283-s021.xlsx, sheet 1
View BVdb publication page



PIK3CA Mutations Contribute to Acquired Cetuximab Resistance in Patients with Metastatic Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Xu, Jian-Ming JM; Wang, Yan Y; Wang, You-Liang YL; Wang, Yan Y; Liu, Tao T; Ni, Ming M; Li, Man-Sheng MS; Lin, Li L; Ge, Fei-Jiao FJ; Gong, Chun C; Gu, Jun-Yan JY; Jia, Ru R; Wang, He-Fei HF; Chen, Yu-Ling YL; Liu, Rong-Rui RR; Zhao, Chuan-Hua CH; Tan, Zhao-Li ZL; Jin, Yang Y; Zhu, Yun-Ping YP; Ogino, Shuji S; Qian, Zhi-Rong ZR
Publication Date: 2017-08-15

Variant appearance in text: PIK3CA: 1799A>T
PubMed Link: 28424201
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical applicability and cost of a 46-gene panel for genomic analysis of solid tumours: Retrospective validation and prospective audit in the UK National Health Service.

Plos Medicine
Hamblin, Angela A; Wordsworth, Sarah S; Fermont, Jilles M JM; Page, Suzanne S; Kaur, Kulvinder K; Camps, Carme C; Kaisaki, Pamela P; Gupta, Avinash A; Talbot, Denis D; Middleton, Mark M; Henderson, Shirley S; Cutts, Anthony A; Vavoulis, Dimitrios V DV; Housby, Nick N; Tomlinson, Ian I; Taylor, Jenny C JC; Schuh, Anna A
Publication Date: 2017-02

Variant appearance in text: PIK3CA: 1799A>T
PubMed Link: 28196074
Variant Present in the following documents:
  • pmed.1002230.s004.xlsx, sheet 2
  • pmed.1002230.s004.xlsx, sheet 1
View BVdb publication page



Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms.

Gut
Yu, Jun J; Sadakari, Yoshihiko Y; Shindo, Koji K; Suenaga, Masaya M; Brant, Aaron A; Almario, Jose Alejandro Navarro JAN; Borges, Michael M; Barkley, Thomas T; Fesharakizadeh, Shahriar S; Ford, Madeline M; Hruban, Ralph H RH; Shin, Eun Ji EJ; Lennon, Anne Marie AM; Canto, Marcia Irene MI; Goggins, Michael M
Publication Date: 2017-09

Variant appearance in text: PIK3CA: 1799A>T
PubMed Link: 27432539
Variant Present in the following documents:
  • gutjnl-2015-311166supp002.pdf
View BVdb publication page



Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092.

Plos One
Yu, Yi Y; Savage, Ronald E RE; Eathiraj, Sudharshan S; Meade, Justin J; Wick, Michael J MJ; Hall, Terence T; Abbadessa, Giovanni G; Schwartz, Brian B
Publication Date: 2015

Variant appearance in text: PIK3CA: E600V
PubMed Link: 26469692
Variant Present in the following documents:
  • Main text
  • pone.0140479.pdf
View BVdb publication page



Novel biomarkers and therapeutic targets for optimizing the therapeutic management of melanomas.

World Journal Of Clinical Oncology
Mimeault, Murielle M; Batra, Surinder K SK
Publication Date: 2012-03-10

Variant appearance in text: PI3K: E600V
PubMed Link: 22442756
Variant Present in the following documents:
  • Main text
View BVdb publication page



EGFR related mutational status and association to clinical outcome of third-line cetuximab-irinotecan in metastatic colorectal cancer.

Bmc Cancer
Spindler, Karen-Lise G KL; Pallisgaard, Niels N; Lindebjerg, Jan J; Frifeldt, Sanne K SK; Jakobsen, Anders A
Publication Date: 2011-03-25

Variant appearance in text: PIK3CA: E600V
PubMed Link: 21439039
Variant Present in the following documents:
  • Main text
  • 1471-2407-11-107.pdf
View BVdb publication page