PIK3CA c.2119G>A ;(p.E707K)

Variant ID: 3-178938877-G-A

NM_006218.2(PIK3CA):c.2119G>A;(p.E707K)

This variant was identified in 32 publications

View GRCh38 version.




Publications:


NSD1 Mutations and Pediatric High-Grade Gliomas: A Comparative Genomic Study in Primary and Recurrent Tumors.

Diagnostics (Basel, Switzerland)
d'Amati, Antonio A; Nicolussi, Arianna A; Miele, Evelina E; Mastronuzzi, Angela A; Rossi, Sabrina S; Gianno, Francesca F; Buttarelli, Francesca Romana FR; Minasi, Simone S; Lodeserto, Pietro P; Gardiman, Marina Paola MP; Viscardi, Elisabetta E; Coppa, Anna A; Donofrio, Vittoria V; Giovannoni, Isabella I; Giangaspero, Felice F; Antonelli, Manila M
Publication Date: 2022-12-27

Variant appearance in text: PIK3CA: 2119G>A; Glu707Lys
PubMed Link: 36611369
Variant Present in the following documents:
  • Main text
  • diagnostics-13-00078.pdf
View BVdb publication page



Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics
G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A
Publication Date: 2022

Variant appearance in text: PIK3CA: E707K
PubMed Link: 36561320
Variant Present in the following documents:
  • Table3.xlsx, sheet 1
  • Table2.xlsx, sheet 5
View BVdb publication page



Gene mutations in sporadic lymphangioleiomyomatosis and genotype-phenotype correlation analysis.

Bmc Pulmonary Medicine
Huang, Jiannan J; Xu, Wenshuai W; Liu, Peng P; Liu, Yaping Y; Shen, Cheng C; Liu, Song S; Wang, Yani Y; Wang, Jun J; Zhang, Tengyue T; He, Yudi Y; Cheng, Chongsheng C; Yang, Luning L; Zhang, Weihong W; Tian, Xinlun X; Xu, Kai-Feng KF
Publication Date: 2022-09-18

Variant appearance in text: PIK3CA: 2119G>A; E707K
PubMed Link: 36117164
Variant Present in the following documents:
  • 12890_2022_2154_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



The Clonal Relationship Between the Ductal and Lobular Components of Mixed Ductal-Lobular Carcinomas Suggested a Ductal Origin in Most Tumors.

The American Journal Of Surgical Pathology
Pérez-Mies, Belén B; Caniego-Casas, Tamara T; Carretero-Barrio, Irene I; Biscuola, Michele M; López-García, María A MA; Hardisson, David D; Rosas, Marta M; López Rodríguez, María J MJ; Cristóbal, Eva E; Pizarro, David D; Rosa-Rosa, Juan M JM; Palacios, José J
Publication Date: 2022-11-01

Variant appearance in text: PIK3CA: E707K
PubMed Link: 35877198
Variant Present in the following documents:
  • pas-46-1545-s003.xlsx, sheet 1
View BVdb publication page



Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Publication Date: 2022-07-13

Variant appearance in text: PIK3CA: 2119G>A
PubMed Link: 35831314
Variant Present in the following documents:
  • 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3
View BVdb publication page



Differences in actionable genomic alterations between brain metastases and non‑brain metastases in patients with non‑small cell lung cancer.

International Journal Of Oncology
Nian, Rui R; Jiang, Huihui H; Zhao, Jiangman J; Hou, Wanle W; Zhang, Hua H; Ma, Jiangtao J; Lv, Pengbiao P; Jiang, Lisha L; Wang, Yongpan Y; Xu, Yue Y; Wu, Shouxin S; Lou, Jingwei J; Li, Wanjun W
Publication Date: 2022-09

Variant appearance in text: PIK3CA: E707K; rs3729687
PubMed Link: 35796015
Variant Present in the following documents:
  • Supplementary_Data6.xlsx, sheet 1
View BVdb publication page



Mutation profiles in circulating cell-free DNA predict acquired resistance to olaparib in high-grade serous ovarian carcinoma.

Cancer Science
Hu, Dianxing D; Guo, Ensong E; Yang, Bin B; Qin, Xu X; Fu, Yu Y; Fan, Junpeng J; Zhuang, Xucui X; Yao, Qianqian Q; Lu, Funian F; Li, Wenting W; Xiao, Rourou R; Wu, Xue X; Yang, Xiaohang X; Wang, Zizhuo Z; Liu, Chen C; You, Lixin L; Zang, Rongyu R; Zhou, Qi Q; Zhao, Weidong W; Chen, Gang G; Sun, Chaoyang C
Publication Date: 2022-08

Variant appearance in text: PIK3CA: E707K
PubMed Link: 35661486
Variant Present in the following documents:
  • Main text
  • CAS-113-2849-s005.xlsx, sheet 1
  • CAS-113-2849.pdf
  • CAS-113-2849-s010.xlsx, sheet 1
View BVdb publication page



Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.

Journal Of Hepatology
Sumazin, Pavel P; Peters, Tricia L TL; Sarabia, Stephen F SF; Kim, Hyunjae R HR; Urbicain, Martin M; Hollingsworth, Emporia Faith EF; Alvarez, Karla R KR; Perez, Cintia R CR; Pozza, Alice A; Najaf Panah, Mohammad Javad MJ; Epps, Jessica L JL; Scorsone, Kathy K; Zorman, Barry B; Katzenstein, Howard H; O'Neill, Allison F AF; Meyers, Rebecka R; Tiao, Greg G; Geller, Jim J; Ranganathan, Sarangarajan S; Rangaswami, Arun A AA; Woodfield, Sarah E SE; Goss, John A JA; Vasudevan, Sanjeev A SA; Heczey, Andras A; Roy, Angshumoy A; Fisher, Kevin E KE; Alaggio, Rita R; Patel, Kalyani R KR; Finegold, Milton J MJ; López-Terrada, Dolores H DH
Publication Date: 2022-10

Variant appearance in text: PIK3CA: 2119G>A; E707K
PubMed Link: 35577029
Variant Present in the following documents:
  • mmc5.xlsx, sheet 1
View BVdb publication page



Overview on Molecular Biomarkers for Laryngeal Cancer: Looking for New Answers to an Old Problem.

Cancers
Falco, Michela M; Tammaro, Chiara C; Takeuchi, Takashi T; Cossu, Alessia Maria AM; Scafuro, Giuseppe G; Zappavigna, Silvia S; Itro, Annalisa A; Addeo, Raffaele R; Scrima, Marianna M; Lombardi, Angela A; Ricciardiello, Filippo F; Irace, Carlo C; Caraglia, Michele M; Misso, Gabriella G
Publication Date: 2022-03-28

Variant appearance in text: PIK3CA: Glu707Lys
PubMed Link: 35406495
Variant Present in the following documents:
  • Main text
  • cancers-14-01716.pdf
View BVdb publication page



A patient with two gliomas with independent oligodendroglioma and glioblastoma biology proved by DNA-methylation profiling: a case report and review of the literature.

Brain Tumor Pathology
Kraus, Theo F J TFJ; Schwartz, Christoph C; Machegger, Lukas L; Zellinger, Barbara B; Hölzl, Dorothee D; Schlicker, Hans U HU; Pöppe, Johannes J; Ladisich, Barbara B; Spendel, Mathias M; Kral, Michael M; Sotlar, Karl K
Publication Date: 2022-04

Variant appearance in text: PIK3CA: 2119G>A; Glu707Lys
PubMed Link: 35018523
Variant Present in the following documents:
  • 10014_2021_Article_423.pdf
View BVdb publication page



Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis.

Clinical And Translational Gastroenterology
Cowan, Robert W RW; Pratt, Erica D ED; Kang, Jin Muk JM; Zhao, Jun J; Wilhelm, Joshua J JJ; Abdulla, Muhamad M; Qiao, Edmund M EM; Brennan, Luke P LP; Ulintz, Peter J PJ; Bellin, Melena D MD; Rhim, Andrew D AD
Publication Date: 2021-11-18

Variant appearance in text: PIK3CA: 2119G>A; Glu707Lys; rs3729687
PubMed Link: 34797250
Variant Present in the following documents:
  • ct9-12-e00431-s006.xlsx, sheet 1
  • ct9-12-e00431-s005.xlsx, sheet 1
View BVdb publication page



The shifting landscape of genetic alterations separating endometriosis and ovarian endometrioid carcinoma.

American Journal Of Cancer Research
Gaia-Oltean, Adriana I AI; Pop, Laura A LA; Cojocneanu, Roxana M RM; Buse, Mihail M; Zimta, Andreea A AA; Kubelac, Paul P; Irimie, Alexandru A; Coza, Ovidiu F OF; Roman, Horace H; Berindan-Neagoe, Ioana I
Publication Date: 2021

Variant appearance in text: PIK3CA: 2119G>A
PubMed Link: 33948387
Variant Present in the following documents:
  • Main text
View BVdb publication page



Bile-Based Cell-Free DNA Analysis Is a Reliable Diagnostic Tool in Pancreatobiliary Cancer.

Cancers
Driescher, Caroline C; Fuchs, Katharina K; Haeberle, Lena L; Goering, Wolfgang W; Frohn, Lisa L; Opitz, Friederike V FV; Haeussinger, Dieter D; Knoefel, Wolfram Trudo WT; Keitel, Verena V; Esposito, Irene I
Publication Date: 2020-12-25

Variant appearance in text: PIK3CA: Glu707Lys
PubMed Link: 33375555
Variant Present in the following documents:
  • cancers-13-00039-s001.pdf
View BVdb publication page



Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups.

Bmc Medical Genomics
Miller, Eirwen M EM; Patterson, Nicole E NE; Gressel, Gregory M GM; Karabakhtsian, Rouzan G RG; Bejerano-Sagie, Michal M; Ravi, Nivedita N; Maslov, Alexander A; Quispe-Tintaya, Wilber W; Wang, Tao T; Lin, Juan J; Smith, Harriet O HO; Goldberg, Gary L GL; Kuo, Dennis Y S DYS; Montagna, Cristina C
Publication Date: 2020-11-30

Variant appearance in text: PIK3CA: Glu707Lys
PubMed Link: 33256706
Variant Present in the following documents:
  • 12920_2020_824_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Comparable cancer-relevant mutation profiles in synchronous ductal carcinoma in situ and invasive breast cancer.

Cancer Reports (Hoboken, N.J.)
Bergholtz, Helga H; Kumar, Surendra S; Wärnberg, Fredrik F; Lüders, Torben T; Kristensen, Vessela V; Sørlie, Therese T
Publication Date: 2020-06

Variant appearance in text: PIK3CA: E707K
PubMed Link: 32671987
Variant Present in the following documents:
  • CNR2-3-e1248-s003.xlsx, sheet 1
View BVdb publication page



Durable benefit from immunotherapy and accompanied lupus erythematosus in pancreatic adenocarcinoma with DNA repair deficiency.

Journal For Immunotherapy Of Cancer
Pang, Xionghao X; Qian, Juanjuan J; Jin, Hua H; Zhang, Lei L; Lin, Lin L; Wang, Yuli Y; Lei, Yi Y; Zhou, Zeqiang Z; Li, Meixiang M; Zhang, Henghui H
Publication Date: 2020-07

Variant appearance in text: PIK3CA: 2119G>A; E707K
PubMed Link: 32636238
Variant Present in the following documents:
  • jitc-2019-000463supp001.pdf
View BVdb publication page



DNA sequencing of cytopathologically inconclusive EUS-FNA from solid pancreatic lesions suspicious for malignancy confirms EUS diagnosis.

Endoscopic Ultrasound
Plougmann, Julie Isabelle JI; Klausen, Pia P; Toxvaerd, Anders A; Abedi, Armita Armina AA; Kovacevic, Bojan B; Karstensen, John Gásdal JG; Poulsen, Tim Svenstrup TS; Kalaitzakis, Evangelos E; Høgdall, Estrid E; Vilmann, Peter P
Publication Date: 2020

Variant appearance in text: PIK3CA: E707K
PubMed Link: 31552911
Variant Present in the following documents:
  • Main text
  • EUS-9-37.pdf
View BVdb publication page



Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.

Nature Communications
Menden, Michael P MP; Wang, Dennis D; Mason, Mike J MJ; Szalai, Bence B; Bulusu, Krishna C KC; Guan, Yuanfang Y; Yu, Thomas T; Kang, Jaewoo J; Jeon, Minji M; Wolfinger, Russ R; Nguyen, Tin T; Zaslavskiy, Mikhail M; , ; Jang, In Sock IS; Ghazoui, Zara Z; Ahsen, Mehmet Eren ME; Vogel, Robert R; Neto, Elias Chaibub EC; Norman, Thea T; Tang, Eric K Y EKY; Garnett, Mathew J MJ; Veroli, Giovanni Y Di GYD; Fawell, Stephen S; Stolovitzky, Gustavo G; Guinney, Justin J; Dry, Jonathan R JR; Saez-Rodriguez, Julio J
Publication Date: 2019-06-17

Variant appearance in text: PIK3CA: E707K
PubMed Link: 31209238
Variant Present in the following documents:
  • 41467_2019_9799_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Resectable lung lesions malignancy assessment and cancer detection by ultra-deep sequencing of targeted gene mutations in plasma cell-free DNA.

Journal Of Medical Genetics
Peng, Muyun M; Xie, Yuancai Y; Li, Xiaohua X; Qian, Youhui Y; Tu, Xiaonian X; Yao, Xumei X; Cheng, Fangsheng F; Xu, Feiyue F; Kong, Deju D; He, Bing B; Liu, Chaoyu C; Cao, Fengjun F; Yang, Haoxian H; Yu, Fenglei F; Xu, Chuanbo C; Tian, Geng G
Publication Date: 2019-10

Variant appearance in text: PIK3CA: 2119G>A; Glu707Lys
PubMed Link: 30981987
Variant Present in the following documents:
  • jmedgenet-2018-105825supp002.xlsx, sheet 3
View BVdb publication page



Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation Sequencing.

Frontiers In Oncology
Wang, Yao Y; Yu, Mei M; Yang, Jia-Xin JX; Cao, Dong-Yan DY; Zhang, Ying Y; Zhou, Hui-Mei HM; Yuan, Zhen Z; Shen, Keng K
Publication Date: 2019

Variant appearance in text: PIK3CA: 2119G>A; E707K
PubMed Link: 30886832
Variant Present in the following documents:
  • Table_2.xls, sheet 1
  • Table_2.xls, sheet 2
View BVdb publication page



Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases.

Oncology Letters
Hájková, Nikola N; Tichá, Ivana I; Hojný, Jan J; Němejcová, Kristýna K; Bártů, Michaela M; Michálková, Romana R; Zikán, Michal M; Cibula, David D; Laco, Jan J; Geryk, Tomáš T; Méhes, Gábor G; Dundr, Pavel P
Publication Date: 2019-02

Variant appearance in text: PIK3CA: E707K
PubMed Link: 30675285
Variant Present in the following documents:
  • Main text
  • ol-17-02-2207.pdf
View BVdb publication page



DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.

Ebiomedicine
Mäki-Nevala, Satu S; Valo, Satu S; Ristimäki, Ari A; Sarhadi, Virinder V; Knuutila, Sakari S; Nyström, Minna M; Renkonen-Sinisalo, Laura L; Lepistö, Anna A; Mecklin, Jukka-Pekka JP; Peltomäki, Päivi P
Publication Date: 2019-01

Variant appearance in text: PIK3CA: Glu707Lys
PubMed Link: 30578081
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



Germline mutation in the TP53 gene in uveal melanoma.

Scientific Reports
Hajkova, Nikola N; Hojny, Jan J; Nemejcova, Kristyna K; Dundr, Pavel P; Ulrych, Jan J; Jirsova, Katerina K; Glezgova, Johana J; Ticha, Ivana I
Publication Date: 2018-05-16

Variant appearance in text: PIK3CA: 2119G>A; E707K; rs3729687
PubMed Link: 29769598
Variant Present in the following documents:
  • 41598_2018_26040_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.

Nature Communications
Chen, Li L; Yang, Liu L; Yao, Ling L; Kuang, Xia-Ying XY; Zuo, Wen-Jia WJ; Li, Shan S; Qiao, Feng F; Liu, Yi-Rong YR; Cao, Zhi-Gang ZG; Zhou, Shu-Ling SL; Zhou, Xiao-Yan XY; Yang, Wen-Tao WT; Shi, Jin-Xiu JX; Huang, Wei W; Hu, Xin X; Shao, Zhi-Ming ZM
Publication Date: 2018-04-10

Variant appearance in text: PIK3CA: E707K
PubMed Link: 29636477
Variant Present in the following documents:
  • 41467_2018_3867_MOESM1_ESM.pdf
  • 41467_2018_Article_3867.pdf
View BVdb publication page



Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil.

Scientific Reports
Ishida, Kaoru K; Ito, Chie C; Ohmori, Yukimi Y; Kume, Kohei K; Sato, Kei A KA; Koizumi, Yuka Y; Konta, Akari A; Iwaya, Takeshi T; Nukatsuka, Mamoru M; Kobunai, Takashi T; Takechi, Teiji T; Nishizuka, Satoshi S SS
Publication Date: 2017-05-23

Variant appearance in text: PI3K: E707K; rs3729687
PubMed Link: 28536445
Variant Present in the following documents:
  • Main text
  • 41598_2017_2548_MOESM1_ESM.pdf
  • 41598_2017_Article_2548.pdf
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: PI3K: 2119G>A; rs3729687
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



Genetic profiling of a rare condition: co-occurrence of albinism and multiple primary melanoma in a Caucasian family.

Oncotarget
De Summa, Simona S; Guida, Michele M; Tommasi, Stefania S; Strippoli, Sabino S; Pellegrini, Cristina C; Fargnoli, Maria Concetta MC; Pilato, Brunella B; Natalicchio, Iole I; Guida, Gabriella G; Pinto, Rosamaria R
Publication Date: 2017-05-02

Variant appearance in text: PIK3CA: Glu707Lys
PubMed Link: 27776349
Variant Present in the following documents:
  • Main text
  • oncotarget-08-29751.pdf
View BVdb publication page



Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung.

Oncotarget
Shin, Dong Hoon DH; Lee, Donghoon D; Hong, Dong Wan DW; Hong, Seung Hyun SH; Hwang, Jung-Ah JA; Lee, Byung Il BI; You, Hye Jin HJ; Lee, Geon Kook GK; Kim, In-Hoo IH; Lee, Yeon-Su YS; Han, Ji-Youn JY
Publication Date: 2016-10-25

Variant appearance in text: PIK3CA: E707K
PubMed Link: 27626312
Variant Present in the following documents:
  • oncotarget-07-69450-s002.xlsx, sheet 2
View BVdb publication page



Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity.

Oncotarget
Grünewald, Inga I; Vollbrecht, Claudia C; Meinrath, Jeannine J; Meyer, Moritz F MF; Heukamp, Lukas C LC; Drebber, Uta U; Quaas, Alexander A; Beutner, Dirk D; Hüttenbrink, Karl-Bernd KB; Wardelmann, Eva E; Hartmann, Wolfgang W; Büttner, Reinhard R; Odenthal, Margarete M; Stenner, Markus M
Publication Date: 2015-07-20

Variant appearance in text: PIK3CA: 2119G>A
PubMed Link: 26053092
Variant Present in the following documents:
  • Main text
  • oncotarget-06-18224-s001.pdf
  • oncotarget-06-18224.pdf
View BVdb publication page



Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines.

Genes & Genomics
Sosonkina, Nadiya N; Hong, Seung-Keun SK; Starenki, Dmytro D; Park, Jong-In JI
Publication Date: 2014-12

Variant appearance in text: PIK3CA: E707K
PubMed Link: 25530832
Variant Present in the following documents:
  • Main text
View BVdb publication page



Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.

Oncotarget
Weber, Genevieve L GL; Parat, Marie-Odile MO; Binder, Zev A ZA; Gallia, Gary L GL; Riggins, Gregory J GJ
Publication Date: 2011-11

Variant appearance in text: PI3K: E707K
PubMed Link: 22064833
Variant Present in the following documents:
  • Main text
  • oncotarget-02-833.pdf
View BVdb publication page