PIK3CA c.2235_2249del ;(p.M745_G750delinsI)

Variant ID: 3-178941916-TGGATGCTCTACAGGG-T

NM_006218.2(PIK3CA):c.2235_2249del;(p.M745_G750delinsI)

This variant was identified in 4 publications

View GRCh38 version.



Variant-Specific Resource Links:
gnomAD v2.1.1
Mutalizer Name Checker
Google
UCSC Genome Browser
ClinVar
dbSNP

Publications:

Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis.

Faseb Bioadvances
Howell, Mark C MC; Green, Ryan R; Khalil, Roukiah R; Foran, Elspeth E; Quarni, Waise W; Nair, Rajesh R; Stevens, Stanley S; Grinchuk, Aleksandr A; Hanna, Andrew A; Mohapatra, Shyam S; Mohapatra, Subhra S
Publication Date: 2020-02

Variant appearance in text: PIK3CA: 2235_2249del
PubMed Link: 32123859
Variant Present in the following documents:
  • Main text
  • FBA2-2-90.pdf
View BVdb publication page


Oncogenic driver mutations in Swiss never smoker patients with lung adenocarcinoma and correlation with clinicopathologic characteristics and outcome.

Plos One
Grosse, Claudia C; Soltermann, Alex A; Rechsteiner, Markus M; Grosse, Alexandra A
Publication Date: 2019

Variant appearance in text: PIK3CA: 2235_2249del
PubMed Link: 31386689
Variant Present in the following documents:
  • Main text
  • pone.0220691.pdf
View BVdb publication page


Genomic markers of ovarian adenocarcinoma and its relevancy to the effectiveness of chemotherapy.

Oncology Letters
Englert-Golon, Monika M; Burchardt, Bartosz B; Budny, Bartlomiej B; Dębicki, Szymon S; Majchrzycka, Blanka B; Wrotkowska, Elzbieta E; Jasiński, Piotr P; Ziemnicka, Katarzyna K; Słopień, Radosław R; Ruchała, Marek M; Sajdak, Stefan S
Publication Date: 2017-09

Variant appearance in text: PIK3CA: 2235_2249del
PubMed Link: 28927094
Variant Present in the following documents:
  • Main text
View BVdb publication page


Heterogeneity of resistance mutations detectable by nextgeneration sequencing in TKI-treated lung adenocarcinoma.

Oncotarget
Belchis, Deborah A DA; Tseng, Li-Hui LH; Gniadek, Thomas T; Haley, Lisa L; Lokhandwala, Parvez P; Illei, Peter P; Gocke, Christopher D CD; Forde, Patrick P; Brahmer, Julie J; Askin, Frederic B FB; Eshleman, James R JR; Lin, Ming-Tseh MT
Publication Date: 2016-07-19

Variant appearance in text: PIK3CA: 2235_2249del
PubMed Link: 27304188
Variant Present in the following documents:
  • oncotarget-07-45237-s001.pdf
View BVdb publication page