Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.
The Embo Journal
Jiang, Zhe Z; Li, Huiqin H; Schroer, Stephanie A SA; Voisin, Veronique V; Ju, YoungJun Y; Pacal, Marek M; Erdmann, Natalie N; Shi, Wei W; Chung, Philip E D PED; Deng, Tao T; Chen, Nien-Jung NJ; Ciavarra, Giovanni G; Datti, Alessandro A; Mak, Tak W TW; Harrington, Lea L; Dick, Frederick A FA; Bader, Gary D GD; Bremner, Rod R; Woo, Minna M; Zacksenhaus, Eldad E
Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.
The Biochemical Journal
Zheng, Zhaohua Z; Amran, Syazwani I SI; Zhu, Jiuxiang J; Schmidt-Kittler, Oleg O; Kinzler, Kenneth W KW; Vogelstein, Bert B; Shepherd, Peter R PR; Thompson, Philip E PE; Jennings, Ian G IG