Publications:

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: C971R

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

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A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research

Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H

Publication Date: 2022-01

Variant appearance in text: PIK3CA: C971R

PubMed Link: 34963661

Variant Present in the following documents:

• supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3

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Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.

The Journal Of Clinical Investigation

Jin, Nan N; Keam, Bhumsuk B; Cho, Janice J; Lee, Michelle J MJ; Kim, Hye Ryun HR; Torosyan, Hayarpi H; Jura, Natalia N; Ng, Patrick Ks PK; Mills, Gordon B GB; Li, Hua H; Zeng, Yan Y; Barbash, Zohar Z; Tarcic, Gabi G; Kang, Hyunseok H; Bauman, Julie E JE; Kim, Mi-Ok MO; VanLandingham, Nathan K NK; Swaney, Danielle L DL; Krogan, Nevan J NJ; Johnson, Daniel E DE; Grandis, Jennifer R JR

Publication Date: 2021-11-15

Variant appearance in text: PIK3CA: C971R

PubMed Link: 34779417

Variant Present in the following documents:

• Main text

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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports

Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM

Publication Date: 2020-06-23

Variant appearance in text: PIK3CA: C971R

PubMed Link: 32579932

Variant Present in the following documents:

• mmc5.xlsx, sheet 3

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: PIK3CA: C971R

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer.

The Journal Of Experimental Medicine

Hedberg, Matthew L ML; Peyser, Noah D ND; Bauman, Julie E JE; Gooding, William E WE; Li, Hua H; Bhola, Neil E NE; Zhu, Tian Ran TR; Zeng, Yan Y; Brand, Toni M TM; Kim, Mi-Ok MO; Jordan, Richard C K RCK; VandenBerg, Scott S; Olivas, Victor V; Bivona, Trever G TG; Chiosea, Simion I SI; Wang, Lin L; Mills, Gordon B GB; Johnson, Jonas T JT; Duvvuri, Umamaheswar U; Ferris, Robert L RL; Ha, Patrick P; Johnson, Daniel E DE; Grandis, Jennifer R JR

Publication Date: 2019-02-04

Variant appearance in text: PIK3CA: C971R

PubMed Link: 30683736

Variant Present in the following documents:

• Main text
• JEM_20181936.pdf

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Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.

Viruses

Warren, Cody J CJ; Westrich, Joseph A JA; Doorslaer, Koenraad Van KV; Pyeon, Dohun D

Publication Date: 2017-08-21

Variant appearance in text: PIK3CA: C971R

PubMed Link: 28825669

Variant Present in the following documents:

• Main text

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: PIK3CA: 2911T>C; C971R

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 2

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Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology

Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B

Publication Date: 2014-10-28

Variant appearance in text: PIK3CA: C971R

PubMed Link: 25348012

Variant Present in the following documents:

• 13059_2014_484_MOESM2_ESM.xlsx, sheet 1

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Age-related mutations associated with clonal hematopoietic expansion and malignancies.

Nature Medicine

Xie, Mingchao M; Lu, Charles C; Wang, Jiayin J; McLellan, Michael D MD; Johnson, Kimberly J KJ; Wendl, Michael C MC; McMichael, Joshua F JF; Schmidt, Heather K HK; Yellapantula, Venkata V; Miller, Christopher A CA; Ozenberger, Bradley A BA; Welch, John S JS; Link, Daniel C DC; Walter, Matthew J MJ; Mardis, Elaine R ER; Dipersio, John F JF; Chen, Feng F; Wilson, Richard K RK; Ley, Timothy J TJ; Ding, Li L

Publication Date: 2014-12

Variant appearance in text: PIK3CA: C971R

PubMed Link: 25326804

Variant Present in the following documents:

• NIHMS630249-supplement-6.xlsx, sheet 1

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A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma.

Molecular Cancer Therapeutics

Mazumdar, Tuhina T; Byers, Lauren A LA; Ng, Patrick Kwok Shing PK; Mills, Gordon B GB; Peng, Shaohua S; Diao, Lixia L; Fan, You-Hong YH; Stemke-Hale, Katherine K; Heymach, John V JV; Myers, Jeffrey N JN; Glisson, Bonnie S BS; Johnson, Faye M FM

Publication Date: 2014-11

Variant appearance in text: PIK3CA: C971R

PubMed Link: 25193510

Variant Present in the following documents:

• Main text

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The determinants of head and neck cancer: Unmasking the PI3K pathway mutations.

Journal Of Carcinogenesis & Mutagenesis

Giudice, Fernanda S FS; Squarize, Cristiane H CH

Publication Date: 2013-08-02

Variant appearance in text: PIK3CA: C971R

PubMed Link: 25126449

Variant Present in the following documents:

• Main text

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Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

Cancer Discovery

Lui, Vivian W Y VW; Hedberg, Matthew L ML; Li, Hua H; Vangara, Bhavana S BS; Pendleton, Kelsey K; Zeng, Yan Y; Lu, Yiling Y; Zhang, Qiuhong Q; Du, Yu Y; Gilbert, Breean R BR; Freilino, Maria M; Sauerwein, Sam S; Peyser, Noah D ND; Xiao, Dong D; Diergaarde, Brenda B; Wang, Lin L; Chiosea, Simion S; Seethala, Raja R; Johnson, Jonas T JT; Kim, Seungwon S; Duvvuri, Umamaheswar U; Ferris, Robert L RL; Romkes, Marjorie M; Nukui, Tomoko T; Kwok-Shing Ng, Patrick P; Garraway, Levi A LA; Hammerman, Peter S PS; Mills, Gordon B GB; Grandis, Jennifer R JR

Publication Date: 2013-07

Variant appearance in text: PIK3CA: C971R

PubMed Link: 23619167

Variant Present in the following documents:

• Main text

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