Publications:

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Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus.

Nature Communications

Jenkins, Meredith L ML; Ranga-Prasad, Harish H; Parson, Matthew A H MAH; Harris, Noah J NJ; Rathinaswamy, Manoj K MK; Burke, John E JE

Publication Date: 2023-01-12

Variant appearance in text: PI3K: M1043L

PubMed Link: 36635288

Variant Present in the following documents:

• Main text
• 41467_2023_Article_35789.pdf
• 41467_2023_35789_MOESM1_ESM.pdf

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Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan.

Cancer Science

Kage, Hidenori H; Shinozaki-Ushiku, Aya A; Ishigaki, Kazunaga K; Sato, Yusuke Y; Tanabe, Masahiko M; Tanaka, Shota S; Tanikawa, Michihiro M; Watanabe, Kousuke K; Kato, Shingo S; Akagi, Kiwamu K; Uchino, Keita K; Mitani, Kinuko K; Takahashi, Shunji S; Miura, Yuji Y; Ikeda, Sadakatsu S; Kojima, Yasushi Y; Watanabe, Kiyotaka K; Mochizuki, Hitoshi H; Yamaguchi, Hironori H; Kawazoe, Yoshimasa Y; Kashiwabara, Kosuke K; Kohsaka, Shinji S; Tatsuno, Kenji K; Ushiku, Tetsuo T; Ohe, Kazuhiko K; Yatomi, Yutaka Y; Seto, Yasuyuki Y; Aburatani, Hiroyuki H; Mano, Hiroyuki H; Miyagawa, Kiyoshi K; Oda, Katsutoshi K

Publication Date: 2023-01-05

Variant appearance in text: PIK3CA: 3127A>C; M1043L

PubMed Link: 36601953

Variant Present in the following documents:

• CAS-114-1710-s001.xlsx, sheet 1

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

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PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology

Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E

Publication Date: 2022-03

Variant appearance in text: PI3K: M1043L

PubMed Link: 35357905

Variant Present in the following documents:

• Main text
• po-6-e2100370.pdf

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Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology

Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN

Publication Date: 2021

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 34113354

Variant Present in the following documents:

• Table_1.xlsx, sheet 21

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Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications

Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L

Publication Date: 2021-04-19

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 33875650

Variant Present in the following documents:

• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1
• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 5
• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 6

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The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients.

Frontiers In Oncology

Fu, Xinhui X; Lin, Hanjie H; Fan, Xinjuan X; Zhu, Yaxi Y; Wang, Chao C; Chen, Zhiting Z; Tan, Xiaoli X; Huang, Jinglin J; Cai, Yacheng Y; Huang, Yan Y

Publication Date: 2021

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 33842311

Variant Present in the following documents:

• Main text
• fonc-11-595675.pdf

View BVdb publication page

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Concurrent Genetic Alterations and Other Biomarkers Predict Treatment Efficacy of EGFR-TKIs in EGFR-Mutant Non-Small Cell Lung Cancer: A Review.

Frontiers In Oncology

Guo, Yijia Y; Song, Jun J; Wang, Yanru Y; Huang, Letian L; Sun, Li L; Zhao, Jianzhu J; Zhang, Shuling S; Jing, Wei W; Ma, Jietao J; Han, Chengbo C

Publication Date: 2020

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 33363040

Variant Present in the following documents:

• Main text
• fonc-10-610923.pdf

View BVdb publication page

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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors.

Science (New York, N.Y.)

Vasan, Neil N; Razavi, Pedram P; Johnson, Jared L JL; Shao, Hong H; Shah, Hardik H; Antoine, Alesia A; Ladewig, Erik E; Gorelick, Alexander A; Lin, Ting-Yu TY; Toska, Eneda E; Xu, Guotai G; Kazmi, Abiha A; Chang, Matthew T MT; Taylor, Barry S BS; Dickler, Maura N MN; Jhaveri, Komal K; Chandarlapaty, Sarat S; Rabadan, Raul R; Reznik, Ed E; Smith, Melissa L ML; Sebra, Robert R; Schimmoller, Frauke F; Wilson, Timothy R TR; Friedman, Lori S LS; Cantley, Lewis C LC; Scaltriti, Maurizio M; Baselga, José J

Publication Date: 2019-11-08

Variant appearance in text: PI3K: M1043L

PubMed Link: 31699932

Variant Present in the following documents:

• Main text

View BVdb publication page

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SWOG S1400B (NCT02785913), a Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study).

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer

Langer, Corey J CJ; Redman, Mary W MW; Wade, James L JL; Aggarwal, Charu C; Bradley, Jeffrey D JD; Crawford, Jeffrey J; Stella, Philip J PJ; Knapp, Mark H MH; Miao, Jieling J; Minichiello, Katherine K; Herbst, Roy S RS; Kelly, Karen K; Gandara, David R DR; Papadimitrakopoulou, Vassiliki A VA

Publication Date: 2019-10

Variant appearance in text: PI3K: M1043L

PubMed Link: 31158500

Variant Present in the following documents:

• Main text

View BVdb publication page

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer.

Scientific Reports

Kaur, Pushpinder P; Porras, Tania B TB; Ring, Alexander A; Carpten, John D JD; Lang, Julie E JE

Publication Date: 2019-02-06

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 30728399

Variant Present in the following documents:

• 41598_2018_37574_MOESM1_ESM.pdf

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An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.

Scientific Reports

Collord, Grace G; Tarpey, Patrick P; Kurbatova, Natalja N; Martincorena, Inigo I; Moran, Sebastian S; Castro, Manuel M; Nagy, Tibor T; Bignell, Graham G; Maura, Francesco F; Young, Matthew D MD; Berna, Jorge J; Tubio, Jose M C JMC; McMurran, Chris E CE; Young, Adam M H AMH; Sanders, Mathijs M; Noorani, Imran I; Price, Stephen J SJ; Watts, Colin C; Leipnitz, Elke E; Kirsch, Matthias M; Schackert, Gabriele G; Pearson, Danita D; Devadass, Abel A; Ram, Zvi Z; Collins, V Peter VP; Allinson, Kieren K; Jenkinson, Michael D MD; Zakaria, Rasheed R; Syed, Khaja K; Hanemann, C Oliver CO; Dunn, Jemma J; McDermott, Michael W MW; Kirollos, Ramez W RW; Vassiliou, George S GS; Esteller, Manel M; Behjati, Sam S; Brazma, Alvis A; Santarius, Thomas T; McDermott, Ultan U

Publication Date: 2018-09-10

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 30202034

Variant Present in the following documents:

• 41598_2018_31659_MOESM2_ESM.xlsx, sheet 30

View BVdb publication page

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Replicative DNA polymerase mutations in cancer.

Current Opinion In Genetics & Development

Heitzer, Ellen E; Tomlinson, Ian I

Publication Date: 2014-02

Variant appearance in text: PIK3CA: M1043l

PubMed Link: 24583393

Variant Present in the following documents:

• main.pdf

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PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cell lung cancer and suggest poor prognosis in EGFR/KRAS wildtype subgroup.

Plos One

Wang, Lei L; Hu, Haichuan H; Pan, Yunjian Y; Wang, Rui R; Li, Yuan Y; Shen, Lei L; Yu, Yongfu Y; Li, Hang H; Cai, Deng D; Sun, Yihua Y; Chen, Haiquan H

Publication Date: 2014

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 24533074

Variant Present in the following documents:

• Main text

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Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions.

Cancer Cell

Hao, Yujun Y; Wang, Chao C; Cao, Bo B; Hirsch, Brett M BM; Song, Jing J; Markowitz, Sanford D SD; Ewing, Rob M RM; Sedwick, David D; Liu, Lili L; Zheng, Weiping W; Wang, Zhenghe Z

Publication Date: 2013-05-13

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 23643389

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targetable "driver" mutations in non small cell lung cancer.

Indian Journal Of Surgical Oncology

Vijayalakshmi, R R; Krishnamurthy, Arvind A

Publication Date: 2011-09

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 22942608

Variant Present in the following documents:

• Main text

View BVdb publication page

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PIK3CA mutations and copy number gains in human lung cancers.

Cancer Research

Yamamoto, Hiromasa H; Shigematsu, Hisayuki H; Nomura, Masaharu M; Lockwood, William W WW; Sato, Mitsuo M; Okumura, Naoki N; Soh, Junichi J; Suzuki, Makoto M; Wistuba, Ignacio I II; Fong, Kwun M KM; Lee, Huei H; Toyooka, Shinichi S; Date, Hiroshi H; Lam, Wan L WL; Minna, John D JD; Gazdar, Adi F AF

Publication Date: 2008-09-01

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 18757405

Variant Present in the following documents:

• Main text

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Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.

Cell Cycle (Georgetown, Tex.)

Huang, Chuan-Hsiang CH; Mandelker, Diana D; Gabelli, Sandra B SB; Amzel, L Mario LM

Publication Date: 2008-05-01

Variant appearance in text: PI3K: Met1043Leu

PubMed Link: 18418043

Variant Present in the following documents:

• Main text

View BVdb publication page

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