Publications:

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: PIK3CA: 3127A>T; Met1043Leu

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

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Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus.

Nature Communications

Jenkins, Meredith L ML; Ranga-Prasad, Harish H; Parson, Matthew A H MAH; Harris, Noah J NJ; Rathinaswamy, Manoj K MK; Burke, John E JE

Publication Date: 2023-01-12

Variant appearance in text: PI3K: M1043L

PubMed Link: 36635288

Variant Present in the following documents:

• Main text
• 41467_2023_Article_35789.pdf
• 41467_2023_35789_MOESM1_ESM.pdf

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: rs1057519936

PubMed Link: 36561320

Variant Present in the following documents:

• Table2.xlsx, sheet 5

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

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PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology

Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E

Publication Date: 2022-03

Variant appearance in text: PI3K: M1043L

PubMed Link: 35357905

Variant Present in the following documents:

• Main text
• po-6-e2100370.pdf

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Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology

Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN

Publication Date: 2021

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 34113354

Variant Present in the following documents:

• Table_1.xlsx, sheet 21

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Differences in Somatic Mutation Profiles between Korean Gastric Cancer and Gastric Adenoma Patients.

Journal Of Clinical Medicine

Lee, Seung Woo SW; Lee, Taekyu T; Sul, Hae Jung HJ; Park, Ki Cheol KC; Park, Joonhong J

Publication Date: 2021-05-10

Variant appearance in text: PIK3CA: 3127A>T; Met1043Leu

PubMed Link: 34068652

Variant Present in the following documents:

• Main text

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Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications

Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L

Publication Date: 2021-04-19

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 33875650

Variant Present in the following documents:

• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1
• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 5
• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 6

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The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients.

Frontiers In Oncology

Fu, Xinhui X; Lin, Hanjie H; Fan, Xinjuan X; Zhu, Yaxi Y; Wang, Chao C; Chen, Zhiting Z; Tan, Xiaoli X; Huang, Jinglin J; Cai, Yacheng Y; Huang, Yan Y

Publication Date: 2021

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 33842311

Variant Present in the following documents:

• Main text
• fonc-11-595675.pdf

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: PIK3CA: 3127A>T; M1043L

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
• 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1

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Concurrent Genetic Alterations and Other Biomarkers Predict Treatment Efficacy of EGFR-TKIs in EGFR-Mutant Non-Small Cell Lung Cancer: A Review.

Frontiers In Oncology

Guo, Yijia Y; Song, Jun J; Wang, Yanru Y; Huang, Letian L; Sun, Li L; Zhao, Jianzhu J; Zhang, Shuling S; Jing, Wei W; Ma, Jietao J; Han, Chengbo C

Publication Date: 2020

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 33363040

Variant Present in the following documents:

• Main text
• fonc-10-610923.pdf

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Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports

Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O

Publication Date: 2020-10-13

Variant appearance in text: rs1057519936

PubMed Link: 33051506

Variant Present in the following documents:

• 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1

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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors.

Science (New York, N.Y.)

Vasan, Neil N; Razavi, Pedram P; Johnson, Jared L JL; Shao, Hong H; Shah, Hardik H; Antoine, Alesia A; Ladewig, Erik E; Gorelick, Alexander A; Lin, Ting-Yu TY; Toska, Eneda E; Xu, Guotai G; Kazmi, Abiha A; Chang, Matthew T MT; Taylor, Barry S BS; Dickler, Maura N MN; Jhaveri, Komal K; Chandarlapaty, Sarat S; Rabadan, Raul R; Reznik, Ed E; Smith, Melissa L ML; Sebra, Robert R; Schimmoller, Frauke F; Wilson, Timothy R TR; Friedman, Lori S LS; Cantley, Lewis C LC; Scaltriti, Maurizio M; Baselga, José J

Publication Date: 2019-11-08

Variant appearance in text: PI3K: M1043L

PubMed Link: 31699932

Variant Present in the following documents:

• Main text

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SWOG S1400B (NCT02785913), a Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study).

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer

Langer, Corey J CJ; Redman, Mary W MW; Wade, James L JL; Aggarwal, Charu C; Bradley, Jeffrey D JD; Crawford, Jeffrey J; Stella, Philip J PJ; Knapp, Mark H MH; Miao, Jieling J; Minichiello, Katherine K; Herbst, Roy S RS; Kelly, Karen K; Gandara, David R DR; Papadimitrakopoulou, Vassiliki A VA

Publication Date: 2019-10

Variant appearance in text: PI3K: M1043L

PubMed Link: 31158500

Variant Present in the following documents:

• Main text

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer.

Scientific Reports

Kaur, Pushpinder P; Porras, Tania B TB; Ring, Alexander A; Carpten, John D JD; Lang, Julie E JE

Publication Date: 2019-02-06

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 30728399

Variant Present in the following documents:

• 41598_2018_37574_MOESM1_ESM.pdf

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Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients.

Bmc Cancer

Koyama, Takahiko T; Rhrissorrakrai, Kahn K; Parida, Laxmi L

Publication Date: 2019-02-01

Variant appearance in text: PIK3CA: 3127A>T; M1043L

PubMed Link: 30709382

Variant Present in the following documents:

• 12885_2019_5313_MOESM2_ESM.xlsx, sheet 1
• 12885_2019_5313_MOESM3_ESM.xlsx, sheet 1

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An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.

Scientific Reports

Collord, Grace G; Tarpey, Patrick P; Kurbatova, Natalja N; Martincorena, Inigo I; Moran, Sebastian S; Castro, Manuel M; Nagy, Tibor T; Bignell, Graham G; Maura, Francesco F; Young, Matthew D MD; Berna, Jorge J; Tubio, Jose M C JMC; McMurran, Chris E CE; Young, Adam M H AMH; Sanders, Mathijs M; Noorani, Imran I; Price, Stephen J SJ; Watts, Colin C; Leipnitz, Elke E; Kirsch, Matthias M; Schackert, Gabriele G; Pearson, Danita D; Devadass, Abel A; Ram, Zvi Z; Collins, V Peter VP; Allinson, Kieren K; Jenkinson, Michael D MD; Zakaria, Rasheed R; Syed, Khaja K; Hanemann, C Oliver CO; Dunn, Jemma J; McDermott, Michael W MW; Kirollos, Ramez W RW; Vassiliou, George S GS; Esteller, Manel M; Behjati, Sam S; Brazma, Alvis A; Santarius, Thomas T; McDermott, Ultan U

Publication Date: 2018-09-10

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 30202034

Variant Present in the following documents:

• 41598_2018_31659_MOESM2_ESM.xlsx, sheet 30

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Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma.

Scientific Reports

Li, Chenguang C; Gao, Zhibo Z; Li, Fei F; Li, Xiangchun X; Sun, Yihua Y; Wang, Mengyun M; Li, Dan D; Wang, Rui R; Li, Fuming F; Fang, Rong R; Pan, Yunjian Y; Luo, Xiaoyang X; He, Jing J; Zheng, Liangtao L; Xia, Jufeng J; Qiu, Lixin L; He, Jun J; Ye, Ting T; Zhang, Ruoxin R; He, Minghui M; Zhu, Meiling M; Hu, Haichuan H; Shi, Tingyan T; Zhou, Xiaoyan X; Sun, Menghong M; Tian, Shilin S; Zhou, Yong Y; Wang, Qiaoxiu Q; Chen, Longyun L; Yin, Guangliang G; Lu, Jingya J; Wu, Renhua R; Guo, Guangwu G; Li, Yingrui Y; Hu, Xueda X; Li, Lin L; Asan, ; Wang, Qin Q; Yin, Ye Y; Feng, Qiang Q; Wang, Bin B; Wang, Hang H; Wang, Mingbang M; Yang, Xiaonan X; Zhang, Xiuqing X; Yang, Huanming H; Jin, Li L; Wang, Cun-Yu CY; Ji, Hongbin H; Chen, Haiquan H; Wang, Jun J; Wei, Qingyi Q

Publication Date: 2015-10-27

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 26503331

Variant Present in the following documents:

• srep14237-s4.xls, sheet 1
• srep14237-s2.xls, sheet 1

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Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

British Journal Of Cancer

Wong, S Q SQ; Fellowes, A A; Doig, K K; Ellul, J J; Bosma, T J TJ; Irwin, D D; Vedururu, R R; Tan, A Y-C AY; Weiss, J J; Chan, K S KS; Lucas, M M; Thomas, D M DM; Dobrovic, A A; Parisot, J P JP; Fox, S B SB

Publication Date: 2015-04-14

Variant appearance in text: PIK3CA: 3127A>T; Met1043Leu

PubMed Link: 25742471

Variant Present in the following documents:

• bjc201580x7.xls, sheet 1

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Clinical massively parallel next-generation sequencing analysis of 409 cancer-related genes for mutations and copy number variations in solid tumours.

British Journal Of Cancer

Singh, R R RR; Patel, K P KP; Routbort, M J MJ; Aldape, K K; Lu, X X; Manekia, J J; Abraham, R R; Reddy, N G NG; Barkoh, B A BA; Veliyathu, J J; Medeiros, L J LJ; Luthra, R R

Publication Date: 2014-11-11

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 25314059

Variant Present in the following documents:

View BVdb publication page

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Replicative DNA polymerase mutations in cancer.

Current Opinion In Genetics & Development

Heitzer, Ellen E; Tomlinson, Ian I

Publication Date: 2014-02

Variant appearance in text: PIK3CA: M1043l

PubMed Link: 24583393

Variant Present in the following documents:

• main.pdf

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PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cell lung cancer and suggest poor prognosis in EGFR/KRAS wildtype subgroup.

Plos One

Wang, Lei L; Hu, Haichuan H; Pan, Yunjian Y; Wang, Rui R; Li, Yuan Y; Shen, Lei L; Yu, Yongfu Y; Li, Hang H; Cai, Deng D; Sun, Yihua Y; Chen, Haiquan H

Publication Date: 2014

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 24533074

Variant Present in the following documents:

• Main text

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Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions.

Cancer Cell

Hao, Yujun Y; Wang, Chao C; Cao, Bo B; Hirsch, Brett M BM; Song, Jing J; Markowitz, Sanford D SD; Ewing, Rob M RM; Sedwick, David D; Liu, Lili L; Zheng, Weiping W; Wang, Zhenghe Z

Publication Date: 2013-05-13

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 23643389

Variant Present in the following documents:

• Main text

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Targetable "driver" mutations in non small cell lung cancer.

Indian Journal Of Surgical Oncology

Vijayalakshmi, R R; Krishnamurthy, Arvind A

Publication Date: 2011-09

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 22942608

Variant Present in the following documents:

• Main text

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PIK3CA mutations and copy number gains in human lung cancers.

Cancer Research

Yamamoto, Hiromasa H; Shigematsu, Hisayuki H; Nomura, Masaharu M; Lockwood, William W WW; Sato, Mitsuo M; Okumura, Naoki N; Soh, Junichi J; Suzuki, Makoto M; Wistuba, Ignacio I II; Fong, Kwun M KM; Lee, Huei H; Toyooka, Shinichi S; Date, Hiroshi H; Lam, Wan L WL; Minna, John D JD; Gazdar, Adi F AF

Publication Date: 2008-09-01

Variant appearance in text: PIK3CA: M1043L

PubMed Link: 18757405

Variant Present in the following documents:

• Main text

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Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.

Cell Cycle (Georgetown, Tex.)

Huang, Chuan-Hsiang CH; Mandelker, Diana D; Gabelli, Sandra B SB; Amzel, L Mario LM

Publication Date: 2008-05-01

Variant appearance in text: PI3K: Met1043Leu

PubMed Link: 18418043

Variant Present in the following documents:

• Main text

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