Variant ID: 3-178952085-A-G

NM_006218.2(PIK3CA):c.3140A>G;(p.His1047Arg)

This variant was identified in 1755 publications




Publications:


Therapeutic efficacy of liposomal Grb2 antisense oligodeoxynucleotide (L-Grb2) in preclinical models of ovarian and uterine cancer.

Oncotarget
OD Lara, E Bayraktar, P Amero, S Ma, C Ivan, W Hu, Y Wang, LS Mangala, P Dutta, P Bhattacharya, AT Ashizawa, G Lopez-Berestein, C Rodriguez-Aguayo, AK Sood
Publication Date: 2020-07-21

Variant appearance in text: PIK3CA: H1047R
PMID: 32754300
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Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy Targets.

Biomed Research International
C Chen, S Liu, R Qu, B Li
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32733937
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Activating PIK3CA mutation promotes adipogenesis of adipose-derived stem cells in macrodactyly via up-regulation of E2F1.

Cell Death & Disease
B Sun, Y Jiang, H Cui, X Fang, G Han, X Dai, S Zhou, H Mao, B Wang
Publication Date: 2020-07-30

Variant appearance in text: PIK3CA: H1047R
PMID: 32732866
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Limited Practical Utility of Liquid Biopsy in the Treated Patients with Advanced Breast Cancer.

Diagnostics (Basel, Switzerland)
A Niwinska, A Bałabas, M Kulecka, A Kluska, M Piątkowska, A Paziewska, K Pyśniak, W Olszewski, M Mikula, J Ostrowski
Publication Date: 2020-07-28

Variant appearance in text: PIK3CA: His1047Arg
PMID: 32731384
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Status of 10 targeted genes of non-small cell lung cancer in eastern China: A study of 884 patients based on NGS in a single institution.

Thoracic Cancer
D Li, L Ding, W Ran, Y Huang, G Li, C Wang, Y Xiao, X Wang, D Lin, X Xing
Publication Date: 2020-07-30

Variant appearance in text: PIK3CA: H1047R
PMID: 32729257
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Development and implementation of the SUM breast cancer cell line functional genomics knowledge base.

Npj Breast Cancer
SP Ethier, ST Guest, E Garrett-Mayer, K Armeson, RC Wilson, K Duchinski, D Couch, JW Gray, C Kappler
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32715085
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Landscape of circulating tumour DNA in metastatic breast cancer.

Ebiomedicine
AA Davis, S Jacob, L Gerratana, AN Shah, F Wehbe, N Katam, Q Zhang, L Flaum, KP Siziopikou, LC Platanias, WJ Gradishar, A Behdad, M Cristofanilli
Publication Date: 2020-07-21

Variant appearance in text: PIK3CA: H1047R
PMID: 32707446
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Selective inhibition of PI3K110α as a novel therapeutic strategy for cetuximab‑resistant oral squamous cell carcinoma.

Oncology Reports
H Tsuchihashi, T Naruse, S Yanamoto, K Okuyama, K Furukawa, K Omori, M Umeda
Publication Date: 2020-09

Variant appearance in text: PIK3CA: H1047R
PMID: 32705230
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Characterization of Driver Mutations in Anaplastic Thyroid Carcinoma Identifies RAS and PIK3CA Mutations as Negative Survival Predictors.

Cancers
WA Lai, CY Liu, SY Lin, CC Chen, JF Hang
Publication Date: 2020-07-20

Variant appearance in text: PIK3CA: H1047R
PMID: 32698386
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Cross-species oncogenic signatures of breast cancer in canine mammary tumors.

Nature Communications
TM Kim, IS Yang, BJ Seung, S Lee, D Kim, YJ Ha, MK Seo, KK Kim, HS Kim, JH Cheong, JH Sur, H Nam, S Kim
Publication Date: 2020-07-17

Variant appearance in text: PIK3CA: H1047R
PMID: 32680987
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SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer.

International Journal Of Molecular Sciences
T Schaefer, R Steiner, C Lengerke
Publication Date: 2020-07-11

Variant appearance in text: PIK3CA: H1047R
PMID: 32664542
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Somatic Mutation Profiling in Premalignant Lesions of Vulvar Squamous Cell Carcinoma.

International Journal Of Molecular Sciences
S Zięba, AW Pouwer, A Kowalik, K Zalewski, N Rusetska, E Bakuła-Zalewska, J Kopczyński, JMA Pijnenborg, JA de Hullu, M Kowalewska
Publication Date: 2020-07-10

Variant appearance in text: PIK3CA: H1047R
PMID: 32664330
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Personalised mapping of tumour development in synchronous colorectal cancer patients.

Npj Genomic Medicine
V Thomas, MB Cotter, M Tosetto, YL Khaw, R Geraghty, DC Winter, EJ Ryan, K Sheahan, SJ Furney
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32655884
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Molecular Features of Metaplastic Breast Carcinoma: An Infrequent Subtype of Triple Negative Breast Carcinoma.

Cancers
S González-Martínez, B Pérez-Mies, I Carretero-Barrio, ML Palacios-Berraquero, J Perez-García, J Cortés, J Palacios
Publication Date: 2020-07-08

Variant appearance in text: PIK3CA: H1047R
PMID: 32650408
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Genomic characterization of Chinese ovarian clear cell carcinoma identifies driver genes by whole exome sequencing.

Neoplasia (New York, N.Y.)
Q Yang, C Zhang, Y Ren, H Yi, T Luo, F Xing, X Bai, L Cui, L Zhu, J Ouyang, P Jiang, W Fan, J Qiu, F Wang, X Xing, Z Zhang, X Zhang, R Zhang
Publication Date: 2020-07-07

Variant appearance in text: PIK3CA: H1047R
PMID: 32650224
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Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma.

Communications Biology
AL Peille, V Vuaroqueaux, SS Wong, J Ting, K Klinger, B Zeitouni, M Landesfeind, WH Kim, HJ Lee, SH Kong, I Wulur, S Bray, P Bronsert, N Zanella, G Donoho, HK Yang, HH Fiebig, C Reinhard, A Aggarwal
Publication Date: 2020-07-09

Variant appearance in text: PIK3CA: H1047R
PMID: 32647357
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Histomolecular characterization of intracranial meningiomas developed in patients exposed to high-dose cyproterone acetate: an antiandrogen treatment.

Neuro-Oncology Advances
S Portet, R Naoufal, G Tachon, A Simonneau, A Chalant, A Naar, S Milin, B Bataille, L Karayan-Tapon
Publication Date: 2019

Variant appearance in text: PIK3CA: H1047R
PMID: 32642646
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Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer.

Journal Of Thoracic Disease
B Gini, N Thomas, CM Blakely
Publication Date: 2020-05

Variant appearance in text: PIK3CA: H1047R
PMID: 32642201
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κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis.

Nature Communications
S Beel, L Kolloch, LH Apken, L Jürgens, A Bolle, N Sudhof, S Ghosh, E Wardelmann, M Meisterernst, K Steinestel, A Oeckinghaus
Publication Date: 2020-07-08

Variant appearance in text: PI3K: H1047R
PMID: 32641778
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Proliferative Classification of Intracranially Injected HER2-positive Breast Cancer Cell Lines.

Cancers
Y Kuroiwa, J Nakayama, C Adachi, T Inoue, S Watanabe, K Semba
Publication Date: 2020-07-06

Variant appearance in text: PIK3CA: H1047R
PMID: 32640677
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Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy.

Breast Cancer Research And Treatment
K Li, N Liao, B Chen, G Zhang, Y Wang, L Guo, G Wei, M Jia, L Wen, C Ren, L Cao, H Mok, C Li, J Lin, X Chen, Z Zhang, T Hou, M Li, J Liu, CM Balch, N Liao
Publication Date: 2020-07-07

Variant appearance in text: PIK3CA: H1047R
PMID: 32638235
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Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform.

Nature Communications
ML Kutys, WJ Polacheck, MK Welch, KA Gagnon, T Koorman, S Kim, L Li, AI McClatchey, CS Chen
Publication Date: 2020-07-06

Variant appearance in text: PIK3CA: H1047R
PMID: 32632100
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The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling.

International Journal Of Molecular Sciences
BY Shorning, MS Dass, MJ Smalley, HB Pearson
Publication Date: 2020-06-25

Variant appearance in text: PIK3CA: H1047R
PMID: 32630372
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Clinical Perspective and Translational Oncology of Liquid Biopsy.

Diagnostics (Basel, Switzerland)
D Fernández-Lázaro, JLG Hernández, AC García, ACD Castillo, MV Hueso, JJ Cruz-Hernández
Publication Date: 2020-06-30

Variant appearance in text: PIK3CA: H1047R
PMID: 32629823
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Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.

Proceedings Of The National Academy Of Sciences Of The United States Of America
IK Zervantonakis, MD Poskus, AL Scott, LM Selfors, JR Lin, DA Dillon, S Pathania, PK Sorger, GB Mills, JS Brugge
Publication Date: 2020-06-29

Variant appearance in text: PI3K: H1047R
PMID: 32601199
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A Patient-Derived Xenograft Model for Venous Malformation.

Journal Of Visualized Experiments : Jove
S Schrenk, J Goines, E Boscolo
Publication Date: 2020-06-15

Variant appearance in text: PIK3CA: H1047R
PMID: 32597867
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Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies.

Cancers
M Mossenta, D Busato, M Dal Bo, G Toffoli
Publication Date: 2020-06-23

Variant appearance in text: PIK3CA: H1047R
PMID: 32585931
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Somatic genetic aberrations in benign breast disease and the risk of subsequent breast cancer.

Npj Breast Cancer
Z Zeng, A Vo, X Li, A Shidfar, P Saldana, L Blanco, X Xuei, Y Luo, SA Khan, SE Clare
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32566745
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Whole Exome Sequencing of Multi-Regional Biopsies from Metastatic Lesions to Evaluate Actionable Truncal Mutations Using a Single-Pass Percutaneous Technique.

Cancers
V Heong, D Tay, SE Goh, B Wee, TZ Tan, R Soo, B Pang, D Lim, A Gopinathan, S Ow, CE Chee, BC Goh, SC Lee, WP Yong, A Wong, MFM Omar, R Soong, DS Tan
Publication Date: 2020-06-17

Variant appearance in text: PIK3CA: H1047R
PMID: 32560395
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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.

Cell
N Koundouros, E Karali, A Tripp, A Valle, P Inglese, NJS Perry, DJ Magee, S Anjomani Virmouni, GA Elder, AL Tyson, ML Dória, A van Weverwijk, RF Soares, CM Isacke, JK Nicholson, RC Glen, Z Takats, G Poulogiannis
Publication Date: 2020-06-18

Variant appearance in text: PIK3CA: H1047R
PMID: 32559461
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PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS.

Embo Molecular Medicine
B Nieuwenhuis, AC Barber, RS Evans, CS Pearson, J Fuchs, AR MacQueen, S van Erp, B Haenzi, LA Hulshof, A Osborne, R Conceicao, TZ Khatib, SS Deshpande, J Cave, C Ffrench-Constant, PD Smith, K Okkenhaug, BJ Eickholt, KR Martin, JW Fawcett, R Eva
Publication Date: 2020-06-17

Variant appearance in text: PIK3CA: H1047R
PMID: 32558386
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Advances in the Detection Technologies and Clinical Applications of Circulating Tumor DNA in Metastatic Breast Cancer.

Cancer Management And Research
H Liao, H Li
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32547192
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Identification of Altered Genes in Gallbladder Cancer as Potential Driver Mutations for Diagnostic and Prognostic Purposes: A Computational Approach.

Cancer Informatics
V D'Afonseca, AD Arencibia, A Echeverría-Vega, L Cerpa, JP Cayún, NM Varela, M Salazar, LA Quiñones
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32546937
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PIK3CA Mutational Analysis of Parathyroid Adenomas.

Jbmr Plus
A Riccardi, C Lemos, R Ramos, J Bellizzi, K Parham, TC Brown, R Korah, T Carling, J Costa-Guda, A Arnold
Publication Date: 2020-06

Variant appearance in text: PIK3CA: H1047R
PMID: 32537547
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Genome Engineering Evolves Brain Tumor Modeling.

Neurologia Medico-Chirurgica
T Koga, CC Chen, FB Furnari
Publication Date: 2020-06-15

Variant appearance in text: PIK3CA: H1047R
PMID: 32536682
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Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.

Nature Communications
I Martinez-Corral, Y Zhang, M Petkova, H Ortsäter, S Sjöberg, SD Castillo, P Brouillard, L Libbrecht, D Saur, M Graupera, K Alitalo, L Boon, M Vikkula, T Mäkinen
Publication Date: 2020-06-08

Variant appearance in text: PIK3CA: H1047R
PMID: 32513927
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Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment.

Molecules (Basel, Switzerland)
M Zoetemelk, GM Ramzy, M Rausch, P Nowak-Sliwinska
Publication Date: 2020-06-04

Variant appearance in text: PIK3CA: H1047R
PMID: 32512790
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Heterogeneous genomic aberrations in esophageal squamous cell carcinoma: a review.

American Journal Of Translational Research
R Li, P Li, W Xing, H Qiu
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32509161
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Clinical significance of PI3K/Akt/mTOR signaling in gastric carcinoma.

International Journal Of Clinical And Experimental Pathology
EJ Jung, JH Suh, WH Kim, HS Kim
Publication Date: 2020

Variant appearance in text: PI3K: H1047R
PMID: 32509071
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Multidisciplinary therapy strategy of precision medicine in clinical practice.

Clinical And Translational Medicine
M Qian, Q Li, M Zhang, X Xu, Q Shen, H Chen, X Wang, T Liu, Y Cheng
Publication Date: 2020-01

Variant appearance in text: PIK3CA: 3140A>G
PMID: 32508051
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Genetic aberrations and molecular biology of cardiac sarcoma.

Therapeutic Advances In Medical Oncology
M Urbini, A Astolfi, V Indio, M Nannini, C Pizzi, P Paolisso, G Tarantino, MA Pantaleo, M Saponara
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32489430
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Unresolved Complexity in the Gene Regulatory Network Underlying EMT.

Frontiers In Oncology
DP Lavin, VK Tiwari
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32477926
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Detection of ctDNA with Personalized Molecular Barcode NGS and Its Clinical Significance in Patients with Early Breast Cancer.

Translational Oncology
T Yoshinami, N Kagara, D Motooka, S Nakamura, T Miyake, T Tanei, Y Naoi, M Shimoda, K Shimazu, SJ Kim, S Noguchi
Publication Date: 2020-05-27

Variant appearance in text: PIK3CA: H1047R
PMID: 32473569
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The Predictive Role of PIK3CA Mutation Status on PI3K Inhibitors in HR+ Breast Cancer Therapy: A Systematic Review and Meta-Analysis.

Biomed Research International
M Wang, J Li, J Huang, M Luo
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32461963
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The Quest for Improving Treatment of Cancer of Unknown Primary (CUP) Through Molecularly-Driven Treatments: A Systematic Review.

Frontiers In Oncology
R Lombardo, F Tosi, A Nocerino, K Bencardino, V Gambi, R Ricotta, F Spina, S Siena, A Sartore-Bianchi
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32457826
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Inhibitors in AKTion: ATP-competitive vs allosteric.

Biochemical Society Transactions
G Lazaro, E Kostaras, I Vivanco
Publication Date: 2020-05-26

Variant appearance in text: PIK3CA: H1047R
PMID: 32453400
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DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines.

Cells
S D'Amico, EK Krasnowska, I Manni, G Toietta, S Baldari, G Piaggio, M Ranalli, A Gambacurta, C Vernieri, F Di Giacinto, F Bernassola, F de Braud, M Lucibello
Publication Date: 2020-05-19

Variant appearance in text: PI3K: H1047R
PMID: 32438775
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Azasteroid Alkylators as Dual Inhibitors of AKT and ERK Signaling for the Treatment of Ovarian Carcinoma.

Cancers
P Dalezis, E Geromichalou, A Polonifi, S Sagredou, N Nikoleousakos, M Nikolaou, V Sarli, MI Panayiotidis, DT Trafalis
Publication Date: 2020-05-16

Variant appearance in text: PIK3CA: H1047R
PMID: 32429466
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Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan.

Translational Oncology
H Taniguchi, K Uehara, G Nakayama, H Nakayama, T Aiba, N Hattori, M Kataoka, Y Nakano, Y Kawase, O Okochi, H Matsuoka, S Utsunomiya, E Sakamoto, Y Mori, S Umeda, T Shikano, K Komori, M Tajika, S Kadowaki, K Muro, Y Yatabe
Publication Date: 2020-05-16

Variant appearance in text: PIK3CA: H1047R
PMID: 32428838
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Amplification of 3q26.2, 5q14.3, 8q24.3, 8q22.3, and 14q32.33 Are Possible Common Genetic Alterations in Oral Cancer Patients.

Frontiers In Oncology
MA Ambele, A van Zyl, MS Pepper, MB van Heerden, WFP van Heerden
Publication Date: 2020

Variant appearance in text: PIK3CA: 3140A>G; H1047R
PMID: 32426287
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Proteomic Characterization of Colorectal Cancer Cells versus Normal-Derived Colon Mucosa Cells: Approaching Identification of Novel Diagnostic Protein Biomarkers in Colorectal Cancer.

International Journal Of Molecular Sciences
M Ludvigsen, L Thorlacius-Ussing, H Vorum, MP Moyer, MT Stender, O Thorlacius-Ussing, B Honoré
Publication Date: 2020-05-14

Variant appearance in text: PIK3CA: H1047R
PMID: 32422974
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Pharmacogenomic Testing to Guide Personalized Cancer Medicine Decisions in Private Oncology Practice: A Case Study.

Frontiers In Oncology
G Astras, CI Papagiannopoulos, KA Kyritsis, C Markitani, IS Vizirianakis
Publication Date: 2020

Variant appearance in text: PIK3CA: 3140A>G
PMID: 32411592
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Detection of Fusion Genes Using a Targeted RNA Sequencing Panel in Gastrointestinal and Rare Cancers.

Journal Of Oncology
SJ Lee, JY Hong, K Kim, KM Kim, SY Kang, T Lee, ST Kim, SH Park, YS Park, HY Lim, WK Kang, J Lee, JO Park
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32411236
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Clinicopathological Characteristics of PIK3CA Mutation and Amplification in Korean Patients with Breast Cancers.

International Journal Of Medical Sciences
MH Lee, JH Cho, SY Kwon, SJ Jung, JH Lee
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32410843
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MYC transcription activation mediated by OCT4 as a mechanism of resistance to 13-cisRA-mediated differentiation in neuroblastoma.

Cell Death & Disease
SJ Wei, TH Nguyen, IH Yang, DG Mook, MR Makena, D Verlekar, A Hindle, GM Martinez, S Yang, H Shimada, CP Reynolds, MH Kang
Publication Date: 2020-05-14

Variant appearance in text: PIK3CA: H1047R
PMID: 32409685
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Differential responses to kinase inhibition in FGFR2-addicted triple negative breast cancer cells: a quantitative phosphoproteomics study.

Scientific Reports
DL Cunningham, AR Sarhan, AJ Creese, KPB Larkins, H Zhao, HR Ferguson, K Brookes, AA Marusiak, HJ Cooper, JK Heath
Publication Date: 2020-05-14

Variant appearance in text: PI3K: H1047R
PMID: 32409632
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Frequency and spectrum of PIK3CA somatic mutations in breast cancer.

Breast Cancer Research : Bcr
O Martínez-Sáez, N Chic, T Pascual, B Adamo, M Vidal, B González-Farré, E Sanfeliu, F Schettini, B Conte, F Brasó-Maristany, A Rodríguez, D Martínez, P Galván, AB Rodríguez, A Martinez, M Muñoz, A Prat
Publication Date: 2020-05-13

Variant appearance in text: PIK3CA: H1047R
PMID: 32404150
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Impact and Diagnostic Gaps of Comprehensive Genomic Profiling in Real-World Clinical Practice.

Cancers
AP Singh, E Shum, L Rajdev, H Cheng, S Goel, R Perez-Soler, B Halmos
Publication Date: 2020-05-04

Variant appearance in text: PIK3CA: H1047R
PMID: 32375398
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Oncogenic driver genes and tumor microenvironment determine the type of liver cancer.

Cell Death & Disease
G Wang, Q Wang, N Liang, H Xue, T Yang, X Chen, Z Qiu, C Zeng, T Sun, W Yuan, C Liu, Z Chen, X He
Publication Date: 2020-05-04

Variant appearance in text: PIK3CA: H1047R
PMID: 32366840
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Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants.

Cells
AA Ghodsinia, JMT Lego, RL Garcia
Publication Date: 2020-04-30

Variant appearance in text: PIK3CA: H1047R
PMID: 32365913
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Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.

Angiogenesis
TD Le Cras, J Goines, N Lakes, P Pastura, AM Hammill, DM Adams, E Boscolo
Publication Date: 2020-04-30

Variant appearance in text: PIK3CA: H1047R
PMID: 32350708
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Multimodal Targeted Deep Sequencing of Circulating Tumor Cells and Matched Cell-Free DNA Provides a More Comprehensive Tool to Identify Therapeutic Targets in Metastatic Breast Cancer Patients.

Cancers
C Keup, M Storbeck, S Hauch, P Hahn, M Sprenger-Haussels, O Hoffmann, R Kimmig, S Kasimir-Bauer
Publication Date: 2020-04-27

Variant appearance in text: PIK3CA: H1047R
PMID: 32349306
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Molecular Diagnostic of Solid Tumor Using a Next Generation Sequencing Custom-Designed Multi-Gene Panel.

Diagnostics (Basel, Switzerland)
D de Biase, G Acquaviva, M Visani, V Sanza, CM Argento, A De Leo, T Maloberti, A Pession, G Tallini
Publication Date: 2020-04-23

Variant appearance in text: PIK3CA: 3140A>G; H1047R
PMID: 32340363
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Dual EGFR blockade with cetuximab and erlotinib combined with anti-VEGF antibody bevacizumab in advanced solid tumors: a phase 1 dose escalation triplet combination trial.

Experimental Hematology & Oncology
V Subbiah, EI Dumbrava, Y Jiang, KZ Thein, A Naing, DS Hong, S Fu, SA Piha-Paul, AM Tsimberidou, F Janku, F Meric-Bernstam, R Kurzrock, G Falchook
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32337094
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Safety and efficacy of sirolimus combined with endocrine therapy in patients with advanced hormone receptor-positive breast cancer and the exploration of biomarkers.

Breast (Edinburgh, Scotland)
Z Yi, B Liu, X Sun, G Rong, W Wang, H Li, X Guan, L Li, J Zhai, C Li, H Qian, F Ma, B Xu
Publication Date: 2020-04-16

Variant appearance in text: PIK3CA: H1047R
PMID: 32335491
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Role of PI3K/AKT pathway in cancer: the framework of malignant behavior.

Molecular Biology Reports
N Jiang, Q Dai, X Su, J Fu, X Feng, J Peng
Publication Date: 2020-04-24

Variant appearance in text: PIK3CA: H1047R
PMID: 32333246
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Allelic heterogeneity of Proteus syndrome.

Cold Spring Harbor Molecular Case Studies
A Buser, MJ Lindhurst, HC Kondolf, MR Yourick, KM Keppler-Noreuil, JC Sapp, LG Biesecker
Publication Date: 2020-04-23

Variant appearance in text: PIK3CA: 3140A>G; His1047Arg
PMID: 32327430
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Targeted next generation sequencing identifies somatic mutations in a cohort of Egyptian breast cancer patients.

Journal Of Advanced Research
A Nassar, M Abouelhoda, O Mansour, SA Loutfy, MM Hafez, M Gomaa, A Bahnassy, AS El-Din Youssef, MM Lotfy, H Ismail, OS Ahmed, AA Abou-Bakr, AN Zekri
Publication Date: 2020-07

Variant appearance in text: PIK3CA: 3140A>G
PMID: 32322420
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ATAC-seq normalization method can significantly affect differential accessibility analysis and interpretation.

Epigenetics & Chromatin
JJ Reske, MR Wilson, RL Chandler
Publication Date: 2020-04-22

Variant appearance in text: PIK3CA: H1047R
PMID: 32321567
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Establishment and characterization of patient-derived xenografts as paraclinical models for head and neck cancer.

Bmc Cancer
HN Kang, JH Kim, AY Park, JW Choi, SM Lim, J Kim, EJ Shin, MH Hong, KH Pyo, MR Yun, DH Kim, H Lee, SO Yoon, DH Kim, YM Park, HK Byeon, I Jung, S Paik, YW Koh, BC Cho, HR Kim
Publication Date: 2020-04-15

Variant appearance in text: PIK3CA: H1047R
PMID: 32293356
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Genetic Characterization of Molecular Targets in Korean Patients with Gastrointestinal Stromal Tumors.

Journal Of Gastric Cancer
J Park, HM Yoo, HJ Sul, S Shin, SW Lee, JG Kim
Publication Date: 2020-03

Variant appearance in text: PIK3CA: 3140A>G
PMID: 32269842
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Everolimus versus alpelisib in advanced hormone receptor-positive HER2-negative breast cancer: targeting different nodes of the PI3K/AKT/mTORC1 pathway with different clinical implications.

Breast Cancer Research : Bcr
C Vernieri, F Corti, F Nichetti, F Ligorio, S Manglaviti, E Zattarin, CG Rea, G Capri, GV Bianchi, F de Braud
Publication Date: 2020-04-06

Variant appearance in text: PIK3CA: H1047R
PMID: 32252811
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The art of obtaining a high yield of cell-free DNA from urine.

Plos One
E Augustus, K Van Casteren, L Sorber, P van Dam, G Roeyen, M Peeters, A Vorsters, A Wouters, J Raskin, C Rolfo, K Zwaenepoel, P Pauwels
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32251424
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Frequent FOXA1-Activating Mutations in Extramammary Paget's Disease.

Cancers
T Takeichi, Y Okuno, T Matsumoto, N Tsunoda, K Suzuki, K Tanahashi, M Kono, T Kikumori, Y Muro, M Akiyama
Publication Date: 2020-03-29

Variant appearance in text: PIK3CA: H1047R
PMID: 32235312
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Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma.

Plos One
G Wang, M Wu, AC Durham, E Radaelli, NJ Mason, X Xu, DB Roth
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32210430
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Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.

Medical Sciences (Basel, Switzerland)
U Testa, G Castelli, E Pelosi
Publication Date: 2020-03-23

Variant appearance in text: PIK3CA: H1047R
PMID: 32210163
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Response to Dabrafenib and Trametinib of a Patient with Metaplastic Breast Carcinoma Harboring a BRAF V600E Mutation.

Case Reports In Oncological Medicine
T Seo, E Noguchi, M Yoshida, T Mori, M Tanioka, K Sudo, A Shimomura, K Yonemori, Y Fujiwara, K Tamura
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32206360
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The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma.

Npj Breast Cancer
T Kader, K Elder, M Zethoven, T Semple, P Hill, DL Goode, N Thio, D Cheasley, SM Rowley, DJ Byrne, JM Pang, IM Miligy, AR Green, EA Rakha, SB Fox, GB Mann, IG Campbell, KL Gorringe
Publication Date: 2020

Variant appearance in text: PIK3CA: H1047R
PMID: 32195332
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Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Y Yi, D Chen, J Ao, W Zhang, J Yi, X Ren, J Fei, F Li, M Niu, H Chen, Y Luo, Z Luo, ZJ Xiao
Publication Date: 2020-03-19

Variant appearance in text: PIK3CA: H1047R
PMID: 32193335
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000263967.3 c.3140A>G p.His1047Arg missense_variant 21/21 -
NM_006218.4 c.3140A>G p.His1047Arg missense_variant 21/21 -