Genetic landscape of colorectal cancer patients manifesting tumor shrinkage during SARS-Cov-2 infection.
Therapeutic Advances In Medical Oncology
Ottaiano, Alessandro A; Santorsola, Mariachiara M; Circelli, Luisa L; Cascella, Marco M; Petrillo, Nadia N; Perri, Francesco F; Casillo, Marika M; Granata, Vincenza V; Ianniello, Monica M; Izzo, Francesco F; Picone, Carmine C; Correra, Marco M; Petrillo, Antonella A; Sirica, Roberto R; Misso, Gabriella G; Delrio, Paolo P; Nasti, Guglielmo G; Savarese, Giovanni G; Caraglia, Michele M
Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.
Cancer Research Communications
Ghezelayagh, Talayeh S TS; Kohrn, Brendan F BF; Fredrickson, Jeanne J; Manhardt, Enna E; Radke, Marc R MR; Katz, Ronit R; Gray, Heidi J HJ; Urban, Renata R RR; Pennington, Kathryn P KP; Liao, John B JB; Doll, Kemi M KM; Simons, Elise J EJ; Burzawa, Jennifer K JK; Goff, Barbara A BA; Speiser, Paul P; Swisher, Elizabeth M EM; Norquist, Barbara M BM; Risques, Rosa Ana RA
Publication Date: 2022-10
Variant appearance in text: PIK3CA: 3155C>A; T1052K
Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.
Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.
Nature Cancer
Westcott, Peter M K PMK; Sacks, Nathan J NJ; Schenkel, Jason M JM; Ely, Zackery A ZA; Smith, Olivia O; Hauck, Haley H; Jaeger, Alex M AM; Zhang, Daniel D; Backlund, Coralie M CM; Beytagh, Mary C MC; Patten, J J JJ; Elbashir, Ryan R; Eng, George G; Irvine, Darrell J DJ; Yilmaz, Omer H OH; Jacks, Tyler T
Publication Date: 2021-10
Variant appearance in text: PIK3CA: 3155C>A; Thr1052Lys
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125.
Gynecologic Oncology Reports
Minato, Takamichi T; Ito, Shin S; Li, Bin B; Fujimori, Haruna H; Mochizuki, Mai M; Yamaguchi, Kazunori K; Tamai, Keiichi K; Shimada, Muneaki M; Tokunaga, Hideki H; Shigeta, Shogo S; Sato, Ikuro I; Shima, Hiroshi H; Yamada, Hidekazu H; Yaegashi, Nobuo N; Yasuda, Jun J
Publication Date: 2021-11
Variant appearance in text: PIK3CA: 3155C>A; T1052K
Spatially interacting phosphorylation sites and mutations in cancer.
Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.
Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.
Embo Molecular Medicine
Tsui, Dana Wai Yi DWY; Murtaza, Muhammed M; Wong, Alvin Seng Cheong ASC; Rueda, Oscar M OM; Smith, Christopher G CG; Chandrananda, Dineika D; Soo, Ross A RA; Lim, Hong Liang HL; Goh, Boon Cher BC; Caldas, Carlos C; Forshew, Tim T; Gale, Davina D; Liu, Wei W; Morris, James J; Marass, Francesco F; Eisen, Tim T; Chin, Tan Min TM; Rosenfeld, Nitzan N
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.
The Journal Of Pathology
Temko, Daniel D; Van Gool, Inge C IC; Rayner, Emily E; Glaire, Mark M; Makino, Seiko S; Brown, Matthew M; Chegwidden, Laura L; Palles, Claire C; Depreeuw, Jeroen J; Beggs, Andrew A; Stathopoulou, Chaido C; Mason, John J; Baker, Ann-Marie AM; Williams, Marc M; Cerundolo, Vincenzo V; Rei, Margarida M; Taylor, Jenny C JC; Schuh, Anna A; Ahmed, Ahmed A; Amant, Frédéric F; Lambrechts, Diether D; Smit, Vincent Thbm VT; Bosse, Tjalling T; Graham, Trevor A TA; Church, David N DN; Tomlinson, Ian I
Publication Date: 2018-07
Variant appearance in text: PIK3CA: 3155C>A; T1052K
Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study.
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Juric, Dejan D; Rodon, Jordi J; Tabernero, Josep J; Janku, Filip F; Burris, Howard A HA; Schellens, Jan H M JHM; Middleton, Mark R MR; Berlin, Jordan J; Schuler, Martin M; Gil-Martin, Marta M; Rugo, Hope S HS; Seggewiss-Bernhardt, Ruth R; Huang, Alan A; Bootle, Douglas D; Demanse, David D; Blumenstein, Lars L; Coughlin, Christina C; Quadt, Cornelia C; Baselga, José J
Pan-urologic cancer genomic subtypes that transcend tissue of origin.
Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Publication Date: 2017-08-04
Variant appearance in text: PIK3CA: 3155C>A; T1052K
Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.
Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
FGFR2 point mutations in 466 endometrioid endometrial tumors: relationship with MSI, KRAS, PIK3CA, CTNNB1 mutations and clinicopathological features.
Plos One
Byron, Sara A SA; Gartside, Michael M; Powell, Matthew A MA; Wellens, Candice L CL; Gao, Feng F; Mutch, David G DG; Goodfellow, Paul J PJ; Pollock, Pamela M PM
Publication Date: 2012
Variant appearance in text: PIK3CA: 3155C>A; T1052K