Induced Pluripotent Stem Cell-Derived Cardiomyocytes with SCN5A R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes.
Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity.
Cell Stem Cell
McKeithan, Wesley L WL; Feyen, Dries A M DAM; Bruyneel, Arne A N AAN; Okolotowicz, Karl J KJ; Ryan, Daniel A DA; Sampson, Kevin J KJ; Potet, Franck F; Savchenko, Alex A; Gómez-Galeno, Jorge J; Vu, Michelle M; Serrano, Ricardo R; George, Alfred L AL; Kass, Robert S RS; Cashman, John R JR; Mercola, Mark M
Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease-Causing Mutation.
Journal Of The American Heart Association
Veerman, Christiaan C CC; Mengarelli, Isabella I; Lodder, Elisabeth M EM; Kosmidis, Georgios G; Bellin, Milena M; Zhang, Miao M; Dittmann, Sven S; Guan, Kaomei K; Wilde, Arthur A M AAM; Schulze-Bahr, Eric E; Greber, Boris B; Bezzina, Connie R CR; Verkerk, Arie O AO
Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia.
Heart Rhythm
Murphy, Lisa L LL; Moon-Grady, Anita J AJ; Cuneo, Bettina F BF; Wakai, Ronald T RT; Yu, Suhong S; Kunic, Jennifer D JD; Benson, D Woodrow DW; George, Alfred L AL