The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.
The Journal Of Physiology
Song, Weihua W; Xiao, Yucheng Y; Chen, Hanying H; Ashpole, Nicole M NM; Piekarz, Andrew D AD; Ma, Peilin P; Hudmon, Andy A; Cummins, Theodore R TR; Shou, Weinian W
Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites.
The Journal Of Biological Chemistry
Ashpole, Nicole M NM; Herren, Anthony W AW; Ginsburg, Kenneth S KS; Brogan, Joseph D JD; Johnson, Derrick E DE; Cummins, Theodore R TR; Bers, Donald M DM; Hudmon, Andy A