A stop-gain mutation in GXYLT1 promotes metastasis of colorectal cancer via the MAPK pathway.
Cell Death & Disease
Peng, Lin L; Zhao, Min M; Liu, Tianqi T; Chen, Jiangbo J; Gao, Pin P; Chen, Lei L; Xing, Pu P; Wang, Zaozao Z; Di, Jiabo J; Xu, Qiang Q; Qu, Hong H; Jiang, Beihai B; Su, Xiangqian X
Whole Exome Sequencing Study in Isolated South-Eastern Moravia (Czechia) Population Indicates Heterogenous Genetic Background for Parkinsonism Development.
Frontiers In Neuroscience
Kolarikova, Kristyna K; Vodicka, Radek R; Vrtel, Radek R; Stellmachova, Julia J; Prochazka, Martin M; Mensikova, Katerina K; Kanovsky, Petr P
Publication Date: 2022
Variant appearance in text: ADH1C: 143G>A; R48H; rs35385902
Genome-wide meta-analysis of alcohol use disorder in East Asians.
Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology
Zhou, Hang H; Kalayasiri, Rasmon R; Sun, Yan Y; Nuñez, Yaira Z YZ; Deng, Hong-Wen HW; Chen, Xiang-Ding XD; Justice, Amy C AC; Kranzler, Henry R HR; Chang, Suhua S; Lu, Lin L; Shi, Jie J; Sanichwankul, Kittipong K; Mutirangura, Apiwat A; Malison, Robert T RT; Gelernter, Joel J
Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder.
Biomolecules
Castaldelli-Maia, João M JM; Malbergier, André A; de Oliveira, Adriana B P ABP; Amaral, Ricardo A RA; Negrão, André B AB; Gonçalves, Priscila D PD; Ventriglio, Antonio A; de Berardis, Domenico D; de Antonio, Juliana J; Firigato, Isabela I; Gattás, Gilka J F GJF; de Toledo Gonçalves, Fernanda F
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.
Nature
Taliun, Daniel D; Harris, Daniel N DN; Kessler, Michael D MD; Carlson, Jedidiah J; Szpiech, Zachary A ZA; Torres, Raul R; Taliun, Sarah A Gagliano SAG; Corvelo, André A; Gogarten, Stephanie M SM; Kang, Hyun Min HM; Pitsillides, Achilleas N AN; LeFaive, Jonathon J; Lee, Seung-Been SB; Tian, Xiaowen X; Browning, Brian L BL; Das, Sayantan S; Emde, Anne-Katrin AK; Clarke, Wayne E WE; Loesch, Douglas P DP; Shetty, Amol C AC; Blackwell, Thomas W TW; Smith, Albert V AV; Wong, Quenna Q; Liu, Xiaoming X; Conomos, Matthew P MP; Bobo, Dean M DM; Aguet, François F; Albert, Christine C; Alonso, Alvaro A; Ardlie, Kristin G KG; Arking, Dan E DE; Aslibekyan, Stella S; Auer, Paul L PL; Barnard, John J; Barr, R Graham RG; Barwick, Lucas L; Becker, Lewis C LC; Beer, Rebecca L RL; Benjamin, Emelia J EJ; Bielak, Lawrence F LF; Blangero, John J; Boehnke, Michael M; Bowden, Donald W DW; Brody, Jennifer A JA; Burchard, Esteban G EG; Cade, Brian E BE; Casella, James F JF; Chalazan, Brandon B; Chasman, Daniel I DI; Chen, Yii-Der Ida YI; Cho, Michael H MH; Choi, Seung Hoan SH; Chung, Mina K MK; Clish, Clary B CB; Correa, Adolfo A; Curran, Joanne E JE; Custer, Brian B; Darbar, Dawood D; Daya, Michelle M; de Andrade, Mariza M; DeMeo, Dawn L DL; Dutcher, Susan K SK; Ellinor, Patrick T PT; Emery, Leslie S LS; Eng, Celeste C; Fatkin, Diane D; Fingerlin, Tasha T; Forer, Lukas L; Fornage, Myriam M; Franceschini, Nora N; Fuchsberger, Christian C; Fullerton, Stephanie M SM; Germer, Soren S; Gladwin, Mark T MT; Gottlieb, Daniel J DJ; Guo, Xiuqing X; Hall, Michael E ME; He, Jiang J; Heard-Costa, Nancy L NL; Heckbert, Susan R SR; Irvin, Marguerite R MR; Johnsen, Jill M JM; Johnson, Andrew D AD; Kaplan, Robert R; Kardia, Sharon L R SLR; Kelly, Tanika T; Kelly, Shannon S; Kenny, Eimear E EE; Kiel, Douglas P DP; Klemmer, Robert R; Konkle, Barbara A BA; Kooperberg, Charles C; Köttgen, Anna A; Lange, Leslie A LA; Lasky-Su, Jessica J; Levy, Daniel D; Lin, Xihong X; Lin, Keng-Han KH; Liu, Chunyu C; Loos, Ruth J F RJF; Garman, Lori L; Gerszten, Robert R; Lubitz, Steven A SA; Lunetta, Kathryn L KL; Mak, Angel C Y ACY; Manichaikul, Ani A; Manning, Alisa K AK; Mathias, Rasika A RA; McManus, David D DD; McGarvey, Stephen T ST; Meigs, James B JB; Meyers, Deborah A DA; Mikulla, Julie L JL; Minear, Mollie A MA; Mitchell, Braxton D BD; Mohanty, Sanghamitra S; Montasser, May E ME; Montgomery, Courtney C; Morrison, Alanna C AC; Murabito, Joanne M JM; Natale, Andrea A; Natarajan, Pradeep P; Nelson, Sarah C SC; North, Kari E KE; O'Connell, Jeffrey R JR; Palmer, Nicholette D ND; Pankratz, Nathan N; Peloso, Gina M GM; Peyser, Patricia A PA; Pleiness, Jacob J; Post, Wendy S WS; Psaty, Bruce M BM; Rao, D C DC; Redline, Susan S; Reiner, Alexander P AP; Roden, Dan D; Rotter, Jerome I JI; Ruczinski, Ingo I; Sarnowski, Chloé C; Schoenherr, Sebastian S; Schwartz, David A DA; Seo, Jeong-Sun JS; Seshadri, Sudha S; Sheehan, Vivien A VA; Sheu, Wayne H WH; Shoemaker, M Benjamin MB; Smith, Nicholas L NL; Smith, Jennifer A JA; Sotoodehnia, Nona N; Stilp, Adrienne M AM; Tang, Weihong W; Taylor, Kent D KD; Telen, Marilyn M; Thornton, Timothy A TA; Tracy, Russell P RP; Van Den Berg, David J DJ; Vasan, Ramachandran S RS; Viaud-Martinez, Karine A KA; Vrieze, Scott S; Weeks, Daniel E DE; Weir, Bruce S BS; Weiss, Scott T ST; Weng, Lu-Chen LC; Willer, Cristen J CJ; Zhang, Yingze Y; Zhao, Xutong X; Arnett, Donna K DK; Ashley-Koch, Allison E AE; Barnes, Kathleen C KC; Boerwinkle, Eric E; Gabriel, Stacey S; Gibbs, Richard R; Rice, Kenneth M KM; Rich, Stephen S SS; Silverman, Edwin K EK; Qasba, Pankaj P; Gan, Weiniu W; , ; Papanicolaou, George J GJ; Nickerson, Deborah A DA; Browning, Sharon R SR; Zody, Michael C MC; Zöllner, Sebastian S; Wilson, James G JG; Cupples, L Adrienne LA; Laurie, Cathy C CC; Jaquish, Cashell E CE; Hernandez, Ryan D RD; O'Connor, Timothy D TD; Abecasis, Gonçalo R GR
Homozygous Variant in ARL3 Causes Autosomal Recessive Cone Rod Dystrophy.
Investigative Ophthalmology & Visual Science
Sheikh, Shakeel A SA; Sisk, Robert A RA; Schiavon, Cara R CR; Waryah, Yar M YM; Usmani, Muhammad A MA; Steel, David H DH; Sayer, John A JA; Narsani, Ashok K AK; Hufnagel, Robert B RB; Riazuddin, Saima S; Kahn, Richard A RA; Waryah, Ali M AM; Ahmed, Zubair M ZM
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
Nature Communications
Kranzler, Henry R HR; Zhou, Hang H; Kember, Rachel L RL; Vickers Smith, Rachel R; Justice, Amy C AC; Damrauer, Scott S; Tsao, Philip S PS; Klarin, Derek D; Baras, Aris A; Reid, Jeffrey J; Overton, John J; Rader, Daniel J DJ; Cheng, Zhongshan Z; Tate, Janet P JP; Becker, William C WC; Concato, John J; Xu, Ke K; Polimanti, Renato R; Zhao, Hongyu H; Gelernter, Joel J
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.
Genes
Treutlein, Jens J; Frank, Josef J; Streit, Fabian F; Reinbold, Céline S CS; Juraeva, Dilafruz D; Degenhardt, Franziska F; Rietschel, Liz L; Witt, Stephanie H SH; Forstner, Andreas J AJ; Ridinger, Monika M; Strohmaier, Jana J; Wodarz, Norbert N; Dukal, Helene H; Foo, Jerome C JC; Hoffmann, Per P; Herms, Stefan S; Heilmann-Heimbach, Stefanie S; Soyka, Michael M; Maier, Wolfgang W; Gaebel, Wolfgang W; Dahmen, Norbert N; Scherbaum, Norbert N; Müller-Myhsok, Bertram B; Lucae, Susanne S; Ising, Marcus M; Stickel, Felix F; Berg, Thomas T; Roggenbuck, Ulla U; Jöckel, Karl-Heinz KH; Scholz, Henrike H; Zimmermann, Ulrich S US; Buch, Stephan S; Sommer, Wolfgang H WH; Spanagel, Rainer R; Brors, Benedikt B; Cichon, Sven S; Mann, Karl K; Kiefer, Falk F; Hampe, Jochen J; Rosendahl, Jonas J; Nöthen, Markus M MM; Rietschel, Marcella M
Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation × Preventive intervention.
Development And Psychopathology
Cleveland, H Harrington HH; Schlomer, Gabriel L GL; Vandenbergh, David J DJ; Wolf, Pedro S A PSA; Feinberg, Mark E ME; Greenberg, Mark T MT; Spoth, Richard L RL; Redmond, Cleve C
ADH1B: From alcoholism, natural selection, and cancer to the human phenome.
American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication Of The International Society Of Psychiatric Genetics
The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.
Disease Markers
Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
Molecular Psychiatry
Gelernter, J J; Kranzler, H R HR; Sherva, R R; Almasy, L L; Koesterer, R R; Smith, A H AH; Anton, R R; Preuss, U W UW; Ridinger, M M; Rujescu, D D; Wodarz, N N; Zill, P P; Zhao, H H; Farrer, L A LA
Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.
Frontiers In Oncology
Chuang, Shu-Chun SC; Agudo, Antonio A; Ahrens, Wolfgang W; Anantharaman, Devasena D; Benhamou, Simone S; Boccia, Stefania S; Chen, Chu C; Conway, David I DI; Fabianova, Eleonora E; Hayes, Richard B RB; Healy, Claire M CM; Holcatova, Ivana I; Kjaerheim, Kristina K; Lagiou, Pagona P; Lazarus, Philip P; Macfarlane, Tatiana V TV; Mahimkar, Manoj B MB; Mates, Dana D; Matsuo, Keitaro K; Merletti, Franco F; Metspalu, Andres A; Morgenstern, Hal H; Muscat, Joshua J; Cadoni, Gabriella G; Olshan, Andrew F AF; Purdue, Mark M; Ramroth, Heribert H; Rudnai, Peter P; Schwartz, Stephen M SM; Simonato, Lorenzo L; Smith, Elaine M EM; Sturgis, Erich M EM; Szeszenia-Dabrowska, Neonilia N; Talamini, Renato R; Thomson, Peter P; Wei, Qingyi Q; Zaridze, David D; Zhang, Zuo-Feng ZF; Znaor, Ariana A; Brennan, Paul P; Boffetta, Paolo P; Hashibe, Mia M
Alcohol consumption, genetic variants in alcohol deydrogenases, and risk of cardiovascular diseases: a prospective study and meta-analysis.
Plos One
Drogan, Dagmar D; Sheldrick, Abigail J AJ; Schütze, Madlen M; Knüppel, Sven S; Andersohn, Frank F; di Giuseppe, Romina R; Herrmann, Bianca B; Willich, Stefan N SN; Garbe, Edeltraut E; Bergmann, Manuela M MM; Boeing, Heiner H; Weikert, Cornelia C
A candidate gene association study of alcohol consumption in young women.
Alcoholism, Clinical And Experimental Research
Agrawal, Arpana A; Lynskey, Michael T MT; Todorov, Alexandre A AA; Schrage, Andrew J AJ; Littlefield, Andrew K AK; Grant, Julia D JD; Zhu, Qin Q; Nelson, Elliot C EC; Madden, Pamela A F PA; Bucholz, Kathleen K KK; Sher, Kenneth J KJ; Heath, Andrew C AC
Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations.
Alcoholism, Clinical And Experimental Research
Liu, Jixia J; Zhou, Zhifeng Z; Hodgkinson, Colin A CA; Yuan, Qiaoping Q; Shen, Pei-Hong PH; Mulligan, Connie J CJ; Wang, Alex A; Gray, Rebecca R RR; Roy, Alec A; Virkkunen, Matti M; Goldman, David D; Enoch, Mary-Anne MA
A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.
Cancer
Wei, Sheng S; Liu, Zhensheng Z; Zhao, Hui H; Niu, Jiangong J; Wang, Li-E LE; El-Naggar, Adel K AK; Sturgis, Erich M EM; Wei, Qingyi Q
Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.
Human Molecular Genetics
Macgregor, Stuart S; Lind, Penelope A PA; Bucholz, Kathleen K KK; Hansell, Narelle K NK; Madden, Pamela A F PA; Richter, Melinda M MM; Montgomery, Grant W GW; Martin, Nicholas G NG; Heath, Andrew C AC; Whitfield, John B JB
Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
American Journal Of Epidemiology
Chang, Man-Huei MH; Lindegren, Mary Lou ML; Butler, Mary A MA; Chanock, Stephen J SJ; Dowling, Nicole F NF; Gallagher, Margaret M; Moonesinghe, Ramal R; Moore, Cynthia A CA; Ned, Renée M RM; Reichler, Mary R MR; Sanders, Christopher L CL; Welch, Robert R; Yesupriya, Ajay A; Khoury, Muin J MJ; ,