How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth.
Science Advances
Benn, Mario C MC; Pot, Simon A SA; Moeller, Jens J; Yamashita, Tadahiro T; Fonta, Charlotte M CM; Orend, Gertraud G; Kollmannsberger, Philip P; Vogel, Viola V
Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation.
Nature Communications
He, Zhengcheng Z; Ghorayeb, Ryan R; Tan, Susanna S; Chen, Ke K; Lorentzian, Amanda C AC; Bottyan, Jack J; Aalam, Syed Mohammed Musheer SMM; Pujana, Miguel Angel MA; Lange, Philipp F PF; Kannan, Nagarajan N; Eaves, Connie J CJ; Maxwell, Christopher A CA
Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.
Science Translational Medicine
Chrysostomou, Stelios S; Roy, Rajat R; Prischi, Filippo F; Thamlikitkul, Lucksamon L; Chapman, Kathryn L KL; Mufti, Uwais U; Peach, Robert R; Ding, Laifeng L; Hancock, David D; Moore, Christopher C; Molina-Arcas, Miriam M; Mauri, Francesco F; Pinato, David J DJ; Abrahams, Joel M JM; Ottaviani, Silvia S; Castellano, Leandro L; Giamas, Georgios G; Pascoe, Jennifer J; Moonamale, Devmini D; Pirrie, Sarah S; Gaunt, Claire C; Billingham, Lucinda L; Steven, Neil M NM; Cullen, Michael M; Hrouda, David D; Winkler, Mathias M; Post, John J; Cohen, Philip P; Salpeter, Seth J SJ; Bar, Vered V; Zundelevich, Adi A; Golan, Shay S; Leibovici, Dan D; Lara, Romain R; Klug, David R DR; Yaliraki, Sophia N SN; Barahona, Mauricio M; Wang, Yulan Y; Downward, Julian J; Skehel, J Mark JM; Ali, Maruf M U MMU; Seckl, Michael J MJ; Pardo, Olivier E OE
TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers.
Cancers
Regua, Angelina T AT; Aguayo, Noah R NR; Jalboush, Sara Abu SA; Doheny, Daniel L DL; Manore, Sara G SG; Zhu, Dongqin D; Wong, Grace L GL; Arrigo, Austin A; Wagner, Calvin J CJ; Yu, Yang Y; Thomas, Alexandra A; Chan, Michael D MD; Ruiz, Jimmy J; Jin, Guangxu G; Strowd, Roy R; Sun, Peiqing P; Lin, Jiayuh J; Lo, Hui-Wen HW
Marker Identification of the Grade of Dysplasia of Intraductal Papillary Mucinous Neoplasm in Pancreatic Cyst Fluid by Quantitative Proteomic Profiling.
Cancers
Do, Misol M; Kim, Hongbeom H; Shin, Dongyoon D; Park, Joonho J; Kim, Haeryoung H; Han, Youngmin Y; Jang, Jin-Young JY; Kim, Youngsoo Y
PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.
Gastroenterology
Spalinger, Marianne R MR; Sayoc-Becerra, Anica A; Santos, Alina N AN; Shawki, Ali A; Canale, Vinicius V; Krishnan, Moorthy M; Niechcial, Anna A; Obialo, Nicole N; Scharl, Michael M; Li, Jiang J; Nair, Meera G MG; McCole, Declan F DF
Computational inference of cancer-specific vulnerabilities in clinical samples.
Genome Biology
Jang, Kiwon K; Park, Min Ji MJ; Park, Jae Soon JS; Hwangbo, Haeun H; Sung, Min Kyung MK; Kim, Sinae S; Jung, Jaeyun J; Lee, Jong Won JW; Ahn, Sei-Hyun SH; Chang, Suhwan S; Choi, Jung Kyoon JK
Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms.
Science Advances
Aldonza, Mark Borris D MBD; Ku, Jayoung J; Hong, Ji-Young JY; Kim, Donghwa D; Yu, Seung Jung SJ; Lee, Min-Seok MS; Prayogo, Monica Celine MC; Tan, Stephanie S; Kim, Dayeon D; Han, Jinju J; Lee, Sang Kook SK; Im, Sung Gap SG; Ryu, Han Suk HS; Kim, Yoosik Y
An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing.
Plos Pathogens
Wong, Raymond W RW; Balachandran, Ahalya A; Cheung, Peter K PK; Cheng, Ran R; Pan, Qun Q; Stoilov, Peter P; Harrigan, P Richard PR; Blencowe, Benjamin J BJ; Branch, Donald R DR; Cochrane, Alan A
Fast-diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Marchetti, Laura L; Bonsignore, Fulvio F; Gobbo, Francesco F; Amodeo, Rosy R; Calvello, Mariantonietta M; Jacob, Ajesh A; Signore, Giovanni G; Schirripa Spagnolo, Chiara C; Porciani, David D; Mainardi, Marco M; Beltram, Fabio F; Luin, Stefano S; Cattaneo, Antonino A
Slowly Reducible Genetically Encoded Green Fluorescent Indicator for In Vivo and Ex Vivo Visualization of Hydrogen Peroxide.
International Journal Of Molecular Sciences
Subach, Oksana M OM; Kunitsyna, Tatiana A TA; Mineyeva, Olga A OA; Lazutkin, Alexander A AA; Bezryadnov, Dmitri V DV; Barykina, Natalia V NV; Piatkevich, Kiryl D KD; Ermakova, Yulia G YG; Bilan, Dmitry S DS; Belousov, Vsevolod V VV; Anokhin, Konstantin V KV; Enikolopov, Grigori N GN; Subach, Fedor V FV
A compact synthetic pathway rewires cancer signaling to therapeutic effector release.
Science (New York, N.Y.)
Chung, Hokyung K HK; Zou, Xinzhi X; Bajar, Bryce T BT; Brand, Veronica R VR; Huo, Yunwen Y; Alcudia, Javier F JF; Ferrell, James E JE; Lin, Michael Z MZ
MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression.
Nature Communications
Jiang, Yao Y; Zhang, Yanqiong Y; Leung, Janet Y JY; Fan, Cheng C; Popov, Konstantin I KI; Su, Siyuan S; Qian, Jiayi J; Wang, Xiaodong X; Holtzhausen, Alisha A; Ubil, Eric E; Xiang, Yang Y; Davis, Ian I; Dokholyan, Nikolay V NV; Wu, Gang G; Perou, Charles M CM; Kim, William Y WY; Earp, H Shelton HS; Liu, Pengda P
Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity.
Genes & Development
Zanca, Ciro C; Villa, Genaro R GR; Benitez, Jorge A JA; Thorne, Amy Haseley AH; Koga, Tomoyuki T; D'Antonio, Matteo M; Ikegami, Shiro S; Ma, Jianhui J; Boyer, Antonia D AD; Banisadr, Afsheen A; Jameson, Nathan M NM; Parisian, Alison D AD; Eliseeva, Olesja V OV; Barnabe, Gabriela F GF; Liu, Feng F; Wu, Sihan S; Yang, Huijun H; Wykosky, Jill J; Frazer, Kelly A KA; Verkhusha, Vladislav V VV; Isaguliants, Maria G MG; Weiss, William A WA; Gahman, Timothy C TC; Shiau, Andrew K AK; Chen, Clark C CC; Mischel, Paul S PS; Cavenee, Webster K WK; Furnari, Frank B FB
A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss.
Embo Molecular Medicine
Servián-Morilla, Emilia E; Takeuchi, Hideyuki H; Lee, Tom V TV; Clarimon, Jordi J; Mavillard, Fabiola F; Area-Gómez, Estela E; Rivas, Eloy E; Nieto-González, Jose L JL; Rivero, Maria C MC; Cabrera-Serrano, Macarena M; Gómez-Sánchez, Leonardo L; Martínez-López, Jose A JA; Estrada, Beatriz B; Márquez, Celedonio C; Morgado, Yolanda Y; Suárez-Calvet, Xavier X; Pita, Guillermo G; Bigot, Anne A; Gallardo, Eduard E; Fernández-Chacón, Rafael R; Hirano, Michio M; Haltiwanger, Robert S RS; Jafar-Nejad, Hamed H; Paradas, Carmen C
PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment.
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.
Science Signaling
Kusne, Yael Y; Carrera-Silva, Eugenio A EA; Perry, Anthony S AS; Rushing, Elisabeth J EJ; Mandell, Edward K EK; Dietrich, Justin D JD; Errasti, Andrea E AE; Gibbs, Daniel D; Berens, Michael E ME; Loftus, Joseph C JC; Hulme, Christopher C; Yang, Weiwei W; Lu, Zhimin Z; Aldape, Kenneth K; Sanai, Nader N; Rothlin, Carla V CV; Ghosh, Sourav S
Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.
Molecular Systems Biology
Borisov, Nikolay N; Aksamitiene, Edita E; Kiyatkin, Anatoly A; Legewie, Stefan S; Berkhout, Jan J; Maiwald, Thomas T; Kaimachnikov, Nikolai P NP; Timmer, Jens J; Hoek, Jan B JB; Kholodenko, Boris N BN