The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9.
Communications Biology
Bayly-Jones, Charles C; Ho, Bill H T BHT; Lau, Corinna C; Leung, Eleanor W W EWW; D'Andrea, Laura L; Lupton, Christopher J CJ; Ekkel, Susan M SM; Venugopal, Hariprasad H; Whisstock, James C JC; Mollnes, Tom E TE; Spicer, Bradley A BA; Dunstone, Michelle A MA
The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Nature Communications
Spicer, Bradley A BA; Law, Ruby H P RHP; Caradoc-Davies, Tom T TT; Ekkel, Sue M SM; Bayly-Jones, Charles C; Pang, Siew-Siew SS; Conroy, Paul J PJ; Ramm, Georg G; Radjainia, Mazdak M; Venugopal, Hariprasad H; Whisstock, James C JC; Dunstone, Michelle A MA