Type 1 diabetes: genes associated with disease development.
Central-European Journal Of Immunology
Klak, Marta M; Gomółka, Magdalena M; Kowalska, Patrycja P; Cichoń, Justyna J; Ambrożkiewicz, Filip F; Serwańska-Świętek, Marta M; Berman, Andrzej A; Wszoła, Michał M
Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge" (December 4th-5th, 2019, Naples, Italy).
Journal Of Translational Medicine
Ascierto, Paolo A PA; Butterfield, Lisa H LH; Campbell, Katie K; Daniele, Bruno B; Dougan, Michael M; Emens, Leisha A LA; Formenti, Silvia S; Janku, Filip F; Khleif, Samir N SN; Kirchhoff, Tomas T; Morabito, Alessandro A; Najjar, Yana Y; Nathan, Paul P; Odunsi, Kunle K; Patnaik, Akash A; Paulos, Chrystal M CM; Reinfeld, Bradley I BI; Skinner, Heath D HD; Timmerman, John J; Puzanov, Igor I
Perspectives in melanoma: meeting report from the "Melanoma Bridge" (December 5th-7th, 2019, Naples, Italy).
Journal Of Translational Medicine
Ascierto, Paolo A PA; Puzanov, Igor I; Agarwala, Sanjiv S SS; Blank, Christian C; Carvajal, Richard D RD; Demaria, Sandra S; Dummer, Reinhard R; Ernstoff, Marc M; Ferrone, Soldano S; Fox, Bernard A BA; Gajewski, Thomas F TF; Garbe, Claus C; Hwu, Patrick P; Lo, Roger S RS; Long, Georgina V GV; Luke, Jason J JJ; Osman, Iman I; Postow, Michael A MA; Sullivan, Ryan J RJ; Taube, Janis M JM; Trinchieri, Giorgio G; Zarour, Hassane M HM; Caracò, Corrado C; Thurin, Magdalena M
Broadening our understanding of the genetics of Juvenile Idiopathic Arthritis (JIA): Interrogation of three dimensional chromatin structures and genetic regulatory elements within JIA-associated risk loci.
Plos One
Jiang, Kaiyu K; Kessler, Haeja H; Park, Yungki Y; Sudman, Marc M; Thompson, Susan D SD; Jarvis, James N JN
Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response.
Journal Of Clinical Medicine
Xiao, Qingyang Q; Nobre, André A; Piñeiro, Pilar P; Berciano-Guerrero, Miguel-Ángel MÁ; Alba, Emilio E; Cobo, Manuel M; Lauschke, Volker M VM; Barragán, Isabel I
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes.
Nature Genetics
Ramos-Rodríguez, Mireia M; Raurell-Vila, Helena H; Colli, Maikel L ML; Alvelos, Maria Inês MI; Subirana-Granés, Marc M; Juan-Mateu, Jonàs J; Norris, Richard R; Turatsinze, Jean-Valery JV; Nakayasu, Ernesto S ES; Webb-Robertson, Bobbie-Jo M BM; Inshaw, Jamie R J JRJ; Marchetti, Piero P; Piemonti, Lorenzo L; Esteller, Manel M; Todd, John A JA; Metz, Thomas O TO; Eizirik, Décio L DL; Pasquali, Lorenzo L
Extending Classification Algorithms to Case-Control Studies.
Biomedical Engineering And Computational Biology
Stanfill, Bryan B; Reehl, Sarah S; Bramer, Lisa L; Nakayasu, Ernesto S ES; Rich, Stephen S SS; Metz, Thomas O TO; Rewers, Marian M; Webb-Robertson, Bobbie-Jo BJ; ,
Autoimmune genetic risk variants as germline biomarkers of response to melanoma immune-checkpoint inhibition.
Cancer Immunology, Immunotherapy : Cii
Chat, Vylyny V; Ferguson, Robert R; Simpson, Danny D; Kazlow, Esther E; Lax, Rebecca R; Moran, Una U; Pavlick, Anna A; Frederick, Dennie D; Boland, Genevieve G; Sullivan, Ryan R; Ribas, Antoni A; Flaherty, Keith K; Osman, Iman I; Weber, Jeffrey J; Kirchhoff, Tomas T
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Scientific Reports
Perry, Daniel J DJ; Wasserfall, Clive H CH; Oram, Richard A RA; Williams, MacKenzie D MD; Posgai, Amanda A; Muir, Andrew B AB; Haller, Michael J MJ; Schatz, Desmond A DA; Wallet, Mark A MA; Mathews, Clayton E CE; Atkinson, Mark A MA; Brusko, Todd M TM
Impact of atopy on risk of glioma: a Mendelian randomisation study.
Bmc Medicine
Disney-Hogg, Linden L; Cornish, Alex J AJ; Sud, Amit A; Law, Philip J PJ; Kinnersley, Ben B; Jacobs, Daniel I DI; Ostrom, Quinn T QT; Labreche, Karim K; Eckel-Passow, Jeanette E JE; Armstrong, Georgina N GN; Claus, Elizabeth B EB; Il'yasova, Dora D; Schildkraut, Joellen J; Barnholtz-Sloan, Jill S JS; Olson, Sara H SH; Bernstein, Jonine L JL; Lai, Rose K RK; Schoemaker, Minouk J MJ; Simon, Matthias M; Hoffmann, Per P; Nöthen, Markus M MM; Jöckel, Karl-Heinz KH; Chanock, Stephen S; Rajaraman, Preetha P; Johansen, Christoffer C; Jenkins, Robert B RB; Melin, Beatrice S BS; Wrensch, Margaret R MR; Sanson, Marc M; Bondy, Melissa L ML; Houlston, Richard S RS
Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies.
Scientific Reports
Mieth, Bettina B; Kloft, Marius M; Rodríguez, Juan Antonio JA; Sonnenburg, Sören S; Vobruba, Robin R; Morcillo-Suárez, Carlos C; Farré, Xavier X; Marigorta, Urko M UM; Fehr, Ernst E; Dickhaus, Thorsten T; Blanchard, Gilles G; Schunk, Daniel D; Navarro, Arcadi A; Müller, Klaus-Robert KR
Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease.
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
Nature Genetics
Hinds, David A DA; McMahon, George G; Kiefer, Amy K AK; Do, Chuong B CB; Eriksson, Nicholas N; Evans, David M DM; St Pourcain, Beate B; Ring, Susan M SM; Mountain, Joanna L JL; Francke, Uta U; Davey-Smith, George G; Timpson, Nicholas J NJ; Tung, Joyce Y JY
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.
Journal Of Hepatology
Folseraas, Trine T; Melum, Espen E; Rausch, Philipp P; Juran, Brian D BD; Ellinghaus, Eva E; Shiryaev, Alexey A; Laerdahl, Jon K JK; Ellinghaus, David D; Schramm, Christoph C; Weismüller, Tobias J TJ; Gotthardt, Daniel Nils DN; Hov, Johannes Roksund JR; Clausen, Ole Petter OP; Weersma, Rinse K RK; Janse, Marcel M; Boberg, Kirsten Muri KM; Björnsson, Einar E; Marschall, Hanns-Ulrich HU; Cleynen, Isabelle I; Rosenstiel, Philip P; Holm, Kristian K; Teufel, Andreas A; Rust, Christian C; Gieger, Christian C; Wichmann, H-Erich HE; Bergquist, Annika A; Ryu, Euijung E; Ponsioen, Cyriel Y CY; Runz, Heiko H; Sterneck, Martina M; Vermeire, Severine S; Beuers, Ulrich U; Wijmenga, Cisca C; Schrumpf, Erik E; Manns, Michael P MP; Lazaridis, Konstantinos N KN; Schreiber, Stefan S; Baines, John F JF; Franke, Andre A; Karlsen, Tom H TH
Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.
The Journal Of Rheumatology
Deshmukh, Harshal A HA; Maiti, Amit K AK; Kim-Howard, Xana R XR; Rojas-Villarraga, Adriana A; Guthridge, Joel M JM; Anaya, Juan-Manuel JM; Nath, Swapan K SK
Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.
Arthritis And Rheumatism
Hughes, Travis T; Kim-Howard, Xana X; Kelly, Jennifer A JA; Kaufman, Kenneth M KM; Langefeld, Carl D CD; Ziegler, Julie J; Sanchez, Elena E; Kimberly, Robert P RP; Edberg, Jeffrey C JC; Ramsey-Goldman, Rosalind R; Petri, Michelle M; Reveille, John D JD; Martín, Javier J; Brown, Elizabeth E EE; Vilá, Luis M LM; Alarcón, Graciela S GS; James, Judith A JA; Gilkeson, Gary S GS; Moser, Kathy L KL; Gaffney, Patrick M PM; Merrill, Joan T JT; Vyse, Timothy J TJ; Alarcón-Riquelme, Marta E ME; , ; Nath, Swapan K SK; Harley, John B JB; Sawalha, Amr H AH
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Nature Genetics
Anderson, Carl A CA; Boucher, Gabrielle G; Lees, Charlie W CW; Franke, Andre A; D'Amato, Mauro M; Taylor, Kent D KD; Lee, James C JC; Goyette, Philippe P; Imielinski, Marcin M; Latiano, Anna A; Lagacé, Caroline C; Scott, Regan R; Amininejad, Leila L; Bumpstead, Suzannah S; Baidoo, Leonard L; Baldassano, Robert N RN; Barclay, Murray M; Bayless, Theodore M TM; Brand, Stephan S; Büning, Carsten C; Colombel, Jean-Frédéric JF; Denson, Lee A LA; De Vos, Martine M; Dubinsky, Marla M; Edwards, Cathryn C; Ellinghaus, David D; Fehrmann, Rudolf S N RS; Floyd, James A B JA; Florin, Timothy T; Franchimont, Denis D; Franke, Lude L; Georges, Michel M; Glas, Jürgen J; Glazer, Nicole L NL; Guthery, Stephen L SL; Haritunians, Talin T; Hayward, Nicholas K NK; Hugot, Jean-Pierre JP; Jobin, Gilles G; Laukens, Debby D; Lawrance, Ian I; Lémann, Marc M; Levine, Arie A; Libioulle, Cecile C; Louis, Edouard E; McGovern, Dermot P DP; Milla, Monica M; Montgomery, Grant W GW; Morley, Katherine I KI; Mowat, Craig C; Ng, Aylwin A; Newman, William W; Ophoff, Roel A RA; Papi, Laura L; Palmieri, Orazio O; Peyrin-Biroulet, Laurent L; Panés, Julián J; Phillips, Anne A; Prescott, Natalie J NJ; Proctor, Deborah D DD; Roberts, Rebecca R; Russell, Richard R; Rutgeerts, Paul P; Sanderson, Jeremy J; Sans, Miquel M; Schumm, Philip P; Seibold, Frank F; Sharma, Yashoda Y; Simms, Lisa A LA; Seielstad, Mark M; Steinhart, A Hillary AH; Targan, Stephan R SR; van den Berg, Leonard H LH; Vatn, Morten M; Verspaget, Hein H; Walters, Thomas T; Wijmenga, Cisca C; Wilson, David C DC; Westra, Harm-Jan HJ; Xavier, Ramnik J RJ; Zhao, Zhen Z ZZ; Ponsioen, Cyriel Y CY; Andersen, Vibeke V; Torkvist, Leif L; Gazouli, Maria M; Anagnou, Nicholas P NP; Karlsen, Tom H TH; Kupcinskas, Limas L; Sventoraityte, Jurgita J; Mansfield, John C JC; Kugathasan, Subra S; Silverberg, Mark S MS; Halfvarson, Jonas J; Rotter, Jerome I JI; Mathew, Christopher G CG; Griffiths, Anne M AM; Gearry, Richard R; Ahmad, Tariq T; Brant, Steven R SR; Chamaillard, Mathias M; Satsangi, Jack J; Cho, Judy H JH; Schreiber, Stefan S; Daly, Mark J MJ; Barrett, Jeffrey C JC; Parkes, Miles M; Annese, Vito V; Hakonarson, Hakon H; Radford-Smith, Graham G; Duerr, Richard H RH; Vermeire, Séverine S; Weersma, Rinse K RK; Rioux, John D JD
The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
Arthritis And Rheumatism
Thompson, Susan D SD; Sudman, Marc M; Ramos, Paula S PS; Marion, Miranda C MC; Ryan, Mary M; Tsoras, Monica M; Weiler, Tracey T; Wagner, Michael M; Keddache, Mehdi M; Haas, J Peter JP; Mueller, Cornelia C; Prahalad, Sampath S; Bohnsack, John J; Wise, Carol A CA; Punaro, Marilynn M; Zhang, Dongping D; Rosé, Carlos D CD; Comeau, Mary E ME; Divers, Jasmin J; Glass, David N DN; Langefeld, Carl D CD
Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance.
Arthritis Research & Therapy
Hollis-Moffatt, Jade E JE; Chen-Xu, Michael M; Topless, Ruth R; Dalbeth, Nicola N; Gow, Peter J PJ; Harrison, Andrew A AA; Highton, John J; Jones, Peter B B PB; Nissen, Michael M; Smith, Malcolm D MD; van Rij, Andre A; Jones, Gregory T GT; Stamp, Lisa K LK; Merriman, Tony R TR
Tindall, Elizabeth A EA; Hoang, Hoa N HN; Southey, Melissa C MC; English, Dallas R DR; Hopper, John L JL; Giles, Graham G GG; Severi, Gianluca G; Hayes, Vanessa M VM
Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.
European Journal Of Human Genetics : Ejhg
Cavanillas, María L ML; Alcina, Antonio A; Núñez, Concepción C; de las Heras, Virginia V; Fernández-Arquero, Miguel M; Bartolomé, Manuel M; de la Concha, Emilio G EG; Fernández, Oscar O; Arroyo, Rafael R; Matesanz, Fuencisla F; Urcelay, Elena E
Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.
Human Molecular Genetics
Barton, Anne A; Eyre, Steve S; Ke, Xiayi X; Hinks, Anne A; Bowes, John J; Flynn, Edward E; Martin, Paul P; , ; , ; Wilson, Anthony G AG; Morgan, Ann W AW; Emery, Paul P; Steer, Sophia S; Hocking, Lynne J LJ; Reid, David M DM; Harrison, Pille P; Wordsworth, Paul P; Thomson, Wendy W; Worthington, Jane J
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.
Gut
Festen, E A M EA; Goyette, P P; Scott, R R; Annese, V V; Zhernakova, A A; Lian, J J; Lefèbvre, C C; Brant, S R SR; Cho, J H JH; Silverberg, M S MS; Taylor, K D KD; de Jong, D J DJ; Stokkers, P C PC; Mcgovern, D D; Palmieri, O O; Achkar, J-P JP; Xavier, R J RJ; Daly, M J MJ; Duerr, R H RH; Wijmenga, C C; Weersma, R K RK; Rioux, J D JD
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
Plos Genetics
Liu, Ying Y; Helms, Cynthia C; Liao, Wilson W; Zaba, Lisa C LC; Duan, Shenghui S; Gardner, Jennifer J; Wise, Carol C; Miner, Andrew A; Malloy, M J MJ; Pullinger, Clive R CR; Kane, John P JP; Saccone, Scott S; Worthington, Jane J; Bruce, Ian I; Kwok, Pui-Yan PY; Menter, Alan A; Krueger, James J; Barton, Anne A; Saccone, Nancy L NL; Bowcock, Anne M AM
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
Nature Genetics
Todd, John A JA; Walker, Neil M NM; Cooper, Jason D JD; Smyth, Deborah J DJ; Downes, Kate K; Plagnol, Vincent V; Bailey, Rebecca R; Nejentsev, Sergey S; Field, Sarah F SF; Payne, Felicity F; Lowe, Christopher E CE; Szeszko, Jeffrey S JS; Hafler, Jason P JP; Zeitels, Lauren L; Yang, Jennie H M JH; Vella, Adrian A; Nutland, Sarah S; Stevens, Helen E HE; Schuilenburg, Helen H; Coleman, Gillian G; Maisuria, Meeta M; Meadows, William W; Smink, Luc J LJ; Healy, Barry B; Burren, Oliver S OS; Lam, Alex A C AA; Ovington, Nigel R NR; Allen, James J; Adlem, Ellen E; Leung, Hin-Tak HT; Wallace, Chris C; Howson, Joanna M M JM; Guja, Cristian C; Ionescu-Tîrgovişte, Constantin C; , ; Simmonds, Matthew J MJ; Heward, Joanne M JM; Gough, Stephen C L SC; , ; Dunger, David B DB; Wicker, Linda S LS; Clayton, David G DG