Kallikrein augments the anticoagulant function of the protein C system in thrombin generation.
Journal Of Thrombosis And Haemostasis : Jth
Wan, Jun J; Vadaq, Nadira N; Konings, Joke J; Jaeger, Martin M; Kumar, Vinod V; de Laat, Bas B; Joosten, Leo L; Netea, Mihai G MG; van der Ven, Andre J AJ; de Groot, Philip G PG; de Mast, Quirijn Q; Roest, Mark M
Whole-exome sequencing identified a novel heterozygous mutation of SALL1 and a new homozygous mutation of PTPRQ in a Chinese family with Townes-Brocks syndrome and hearing loss.
Bmc Medical Genomics
Yang, Guangxian G; Yin, Yi Y; Tan, Zhiping Z; Liu, Jian J; Deng, Xicheng X; Yang, Yifeng Y
Longitudinal Plasma Kallikrein Levels and Their Association With the Risk of Cardiovascular Disease Outcomes in Type 1 Diabetes in DCCT/EDIC.
Diabetes
Jaffa, Miran A MA; Bebu, Ionut I; Luttrell, Deirdre D; Braffett, Barbara H BH; Lachin, John M JM; Hunt, Kelly K; Lopes-Virella, Maria M; Luttrell, Louis L; Lyons, Timothy J TJ; Jaffa, Ayad A AA; ,
Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration.
Stem Cells Translational Medicine
Petrus-Reurer, Sandra S; Kumar, Pankaj P; Padrell Sánchez, Sara S; Aronsson, Monica M; André, Helder H; Bartuma, Hammurabi H; Plaza Reyes, Alvaro A; Nandrot, Emeline F EF; Kvanta, Anders A; Lanner, Fredrik F
Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes.
Communications Biology
Perrino, Peter A PA; Talbot, Lidiya L; Kirkland, Rose R; Hill, Amanda A; Rendall, Amanda R AR; Mountford, Hayley S HS; Taylor, Jenny J; , ; Buscarello, Alexzandrea N AN; Lahiri, Nayana N; Saggar, Anand A; Fitch, R Holly RH; Newbury, Dianne F DF
Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance.
Scientific Reports
Al-Khelaifi, Fatima F; Diboun, Ilhame I; Donati, Francesco F; Botrè, Francesco F; Abraham, David D; Hingorani, Aroon A; Albagha, Omar O; Georgakopoulos, Costas C; Suhre, Karsten K; Yousri, Noha A NA; Elrayess, Mohamed A MA
Cardiac Troponin T and Troponin I in the General Population.
Circulation
Welsh, Paul P; Preiss, David D; Hayward, Caroline C; Shah, Anoop S V ASV; McAllister, David D; Briggs, Andrew A; Boachie, Charles C; McConnachie, Alex A; Padmanabhan, Sandosh S; Welsh, Claire C; Woodward, Mark M; Campbell, Archie A; Porteous, David D; Mills, Nicholas L NL; Sattar, Naveed N
Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.
Cell Death & Disease
Grassi, Ludovica L; Alfonsi, Romina R; Francescangeli, Federica F; Signore, Michele M; De Angelis, Maria Laura ML; Addario, Antonio A; Costantini, Manuela M; Flex, Elisabetta E; Ciolfi, Andrea A; Pizzi, Simone S; Bruselles, Alessandro A; Pallocca, Matteo M; Simone, Giuseppe G; Haoui, Mustapha M; Falchi, Mario M; Milella, Michele M; Sentinelli, Steno S; Di Matteo, Paola P; Stellacci, Emilia E; Gallucci, Michele M; Muto, Giovanni G; Tartaglia, Marco M; De Maria, Ruggero R; Bonci, Désirée D
Arylsulphatase A Pseudodeficiency (ARSA-PD), hypertension and chronic renal disease in Aboriginal Australians.
Scientific Reports
Tang, Dave D; Fakiola, Michaela M; Syn, Genevieve G; Anderson, Denise D; Cordell, Heather J HJ; Scaman, Elizabeth S H ESH; Davis, Elizabeth E; Miles, Simon J SJ; McLeay, Toby T; Jamieson, Sarra E SE; Lassmann, Timo T; Blackwell, Jenefer M JM
Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population.
Circulation. Cardiovascular Genetics
Salo, Perttu P PP; Havulinna, Aki S AS; Tukiainen, Taru T; Raitakari, Olli O; Lehtimäki, Terho T; Kähönen, Mika M; Kettunen, Johannes J; Männikkö, Minna M; Eriksson, Johan G JG; Jula, Antti A; Blankenberg, Stefan S; Zeller, Tanja T; Salomaa, Veikko V; Kristiansson, Kati K; Perola, Markus M
Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study.
Human Molecular Genetics
de Vries, Paul S PS; Yu, Bing B; Feofanova, Elena V EV; Metcalf, Ginger A GA; Brown, Michael R MR; Zeighami, Atefeh L AL; Liu, Xiaoming X; Muzny, Donna M DM; Gibbs, Richard A RA; Boerwinkle, Eric E; Morrison, Alanna C AC
Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study.
Plos One
Simino, Jeannette J; Wang, Zhiying Z; Bressler, Jan J; Chouraki, Vincent V; Yang, Qiong Q; Younkin, Steven G SG; Seshadri, Sudha S; Fornage, Myriam M; Boerwinkle, Eric E; Mosley, Thomas H TH
Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children.
Obesity (Silver Spring, Md.)
Sabo, Aniko A; Mishra, Pamela P; Dugan-Perez, Shannon S; Voruganti, V Saroja VS; Kent, Jack W JW; Kalra, Divya D; Cole, Shelley A SA; Comuzzie, Anthony G AG; Muzny, Donna M DM; Gibbs, Richard A RA; Butte, Nancy F NF
Identification of novel loci affecting circulating chromogranins and related peptides.
Human Molecular Genetics
Benyamin, Beben B; Maihofer, Adam X AX; Schork, Andrew J AJ; Hamilton, Bruce A BA; Rao, Fangwen F; Schmid-Schönbein, Geert W GW; Zhang, Kuixing K; Mahata, Manjula M; Stridsberg, Mats M; Schork, Nicholas J NJ; Biswas, Nilima N; Hook, Vivian Y VY; Wei, Zhiyun Z; Montgomery, Grant W GW; Martin, Nicholas G NG; Nievergelt, Caroline M CM; Whitfield, John B JB; O'Connor, Daniel T DT
Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels.
Thrombosis And Haemostasis
Zhang, Weihua W; Jernerén, Fredrik F; Lehne, Benjamin C BC; Chen, Ming-Huei MH; Luben, Robert N RN; Johnston, Carole C; Elshorbagy, Amany A; Eppinga, Ruben N RN; Scott, William R WR; Adeyeye, Elizabeth E; Scott, James J; Böger, Rainer H RH; Khaw, Kay-Tee KT; van der Harst, Pim P; Wareham, Nicholas J NJ; Vasan, Ramachandran S RS; Chambers, John C JC; Refsum, Helga H; Kooner, Jaspal S JS
A genome-wide association meta-analysis on apolipoprotein A-IV concentrations.
Human Molecular Genetics
Lamina, Claudia C; Friedel, Salome S; Coassin, Stefan S; Rueedi, Rico R; Yousri, Noha A NA; Seppälä, Ilkka I; Gieger, Christian C; Schönherr, Sebastian S; Forer, Lukas L; Erhart, Gertraud G; Kollerits, Barbara B; Marques-Vidal, Pedro P; Ried, Janina J; Waeber, Gerard G; Bergmann, Sven S; Dähnhardt, Doreen D; Stöckl, Andrea A; Kiechl, Stefan S; Raitakari, Olli T OT; Kähönen, Mika M; Willeit, Johann J; Kedenko, Ludmilla L; Paulweber, Bernhard B; Peters, Annette A; Meitinger, Thomas T; Strauch, Konstantin K; , ; Lehtimäki, Terho T; Hunt, Steven C SC; Vollenweider, Peter P; Kronenberg, Florian F
Associations Between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study.
Circulation. Cardiovascular Genetics
Solomon, Terry T; Smith, Erin N EN; Matsui, Hiroko H; Braekkan, Sigrid K SK; , ; Wilsgaard, Tom T; Njølstad, Inger I; Mathiesen, Ellisiv B EB; Hansen, John-Bjarne JB; Frazer, Kelly A KA
Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system.
Bmc Medical Genetics
Biswas, Nilima N; Maihofer, Adam X AX; Mir, Saiful Anam SA; Rao, Fangwen F; Zhang, Kuixing K; Khandrika, Srikrishna S; Mahata, Manjula M; Friese, Ryan S RS; Hightower, C Makena CM; Mahata, Sushil K SK; Baker, Dewleen G DG; Nievergelt, Caroline M CM; Vaingankar, Sucheta M SM; O'Connor, Daniel T DT
Genome-wide association analysis of plasma B-type natriuretic peptide in blacks: the Jackson Heart Study.
Circulation. Cardiovascular Genetics
Musani, Solomon K SK; Fox, Ervin R ER; Kraja, Aldi A; Bidulescu, Aurelian A; Lieb, Wolfgang W; Lin, Honghuang H; Beecham, Ashley A; Chen, Ming-Huei MH; Felix, Janine F JF; Fox, Caroline S CS; Kao, W H Linda WH; Kardia, Sharon L R SL; Liu, Ching-Ti CT; Nalls, Mike A MA; Rundek, Tatjana T; Sacco, Ralph L RL; Smith, Jennifer J; Sun, Yan V YV; Wilson, Gregory G; Zhang, Zhaogong Z; Mosley, Thomas H TH; Taylor, Herman A HA; Vasan, Ramachandran S RS
Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.
Circulation. Cardiovascular Genetics
Lieb, Wolfgang W; Chen, Ming-Huei MH; Teumer, Alexander A; de Boer, Rudolf A RA; Lin, Honghuang H; Fox, Ervin R ER; Musani, Solomon K SK; Wilson, James G JG; Wang, Thomas J TJ; Völzke, Henry H; Petersen, Ann-Kristin AK; Meisinger, Christine C; Nauck, Matthias M; Schlesinger, Sabrina S; Li, Yong Y; Menard, Jöel J; Hercberg, Serge S; Wichmann, H-Erich HE; Völker, Uwe U; Rawal, Rajesh R; Bidlingmaier, Martin M; Hannemann, Anke A; Dörr, Marcus M; Rettig, Rainer R; van Gilst, Wiek H WH; van Veldhuisen, Dirk J DJ; Bakker, Stephan J L SJ; Navis, Gerjan G; Wallaschofski, Henri H; Meneton, Pierre P; van der Harst, Pim P; Reincke, Martin M; Vasan, Ramachandran S RS; , ; , ; ,