HGFAC is a ChREBP regulated hepatokine that enhances glucose and lipid homeostasis.
Jci Insight
Sargsyan, Ashot A; Doridot, Ludivine L; Hannou, Sarah Anissa SA; Tong, Wenxin W; Srinivasan, Harini H; Ivison, Rachael R; Monn, Ruby R; Kou, Henry H HH; Haldeman, Jonathan M JM; Arlotto, Michelle M; White, Phillip J PJ; Grimsrud, Paul A PA; Astapova, Inna I; Tsai, Linus T-Y LT; Herman, Mark A MA
Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study.
Diabetes
Sobrin, Lucia L; Chong, Yong He YH; Fan, Qiao Q; Gan, Alfred A; Stanwyck, Lynn K LK; Kaidonis, Georgia G; Craig, Jamie E JE; Kim, Jihye J; Liao, Wen-Ling WL; Huang, Yu-Chuen YC; Lee, Wen-Jane WJ; Hung, Yi-Jen YJ; Guo, Xiuqing X; Hai, Yang Y; Ipp, Eli E; Pollack, Samuela S; Hancock, Heather H; Price, Alkes A; Penman, Alan A; Mitchell, Paul P; Liew, Gerald G; Smith, Albert V AV; Gudnason, Vilmundur V; Tan, Gavin G; Klein, Barbara E K BEK; Kuo, Jane J; Li, Xiaohui X; Christiansen, Mark W MW; Psaty, Bruce M BM; Sandow, Kevin K; , ; Jensen, Richard A RA; Klein, Ronald R; Cotch, Mary Frances MF; Wang, Jie Jin JJ; Jia, Yucheng Y; Chen, Ching J CJ; Chen, Yii-Der Ida YI; Rotter, Jerome I JI; Tsai, Fuu-Jen FJ; Hanis, Craig L CL; Burdon, Kathryn P KP; Wong, Tien Yin TY; Cheng, Ching-Yu CY
Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study.
Scientific Reports
Christie, Shanice S; Robiou-du-Pont, Sébastien S; Anand, Sonia S SS; Morrison, Katherine M KM; McDonald, Sarah D SD; Paré, Guillaume G; Atkinson, Stephanie A SA; Teo, Koon K KK; Meyre, David D
A genome-wide association meta-analysis on apolipoprotein A-IV concentrations.
Human Molecular Genetics
Lamina, Claudia C; Friedel, Salome S; Coassin, Stefan S; Rueedi, Rico R; Yousri, Noha A NA; Seppälä, Ilkka I; Gieger, Christian C; Schönherr, Sebastian S; Forer, Lukas L; Erhart, Gertraud G; Kollerits, Barbara B; Marques-Vidal, Pedro P; Ried, Janina J; Waeber, Gerard G; Bergmann, Sven S; Dähnhardt, Doreen D; Stöckl, Andrea A; Kiechl, Stefan S; Raitakari, Olli T OT; Kähönen, Mika M; Willeit, Johann J; Kedenko, Ludmilla L; Paulweber, Bernhard B; Peters, Annette A; Meitinger, Thomas T; Strauch, Konstantin K; , ; Lehtimäki, Terho T; Hunt, Steven C SC; Vollenweider, Peter P; Kronenberg, Florian F
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.
Nature Communications
Tang, Clara S CS; Zhang, He H; Cheung, Chloe Y Y CY; Xu, Ming M; Ho, Jenny C Y JC; Zhou, Wei W; Cherny, Stacey S SS; Zhang, Yan Y; Holmen, Oddgeir O; Au, Ka-Wing KW; Yu, Haiyi H; Xu, Lin L; Jia, Jia J; Porsch, Robert M RM; Sun, Lijie L; Xu, Weixian W; Zheng, Huiping H; Wong, Lai-Yung LY; Mu, Yiming Y; Dou, Jingtao J; Fong, Carol H Y CH; Wang, Shuyu S; Hong, Xueyu X; Dong, Liguang L; Liao, Yanhua Y; Wang, Jiansong J; Lam, Levina S M LS; Su, Xi X; Yan, Hua H; Yang, Min-Lee ML; Chen, Jin J; Siu, Chung-Wah CW; Xie, Gaoqiang G; Woo, Yu-Cho YC; Wu, Yangfeng Y; Tan, Kathryn C B KC; Hveem, Kristian K; Cheung, Bernard M Y BM; Zöllner, Sebastian S; Xu, Aimin A; Eugene Chen, Y Y; Jiang, Chao Qiang CQ; Zhang, Youyi Y; Lam, Tai-Hing TH; Ganesh, Santhi K SK; Huo, Yong Y; Sham, Pak C PC; Lam, Karen S L KS; Willer, Cristen J CJ; Tse, Hung-Fat HF; Gao, Wei W
Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels.
Nature Communications
van Leeuwen, Elisabeth M EM; Karssen, Lennart C LC; Deelen, Joris J; Isaacs, Aaron A; Medina-Gomez, Carolina C; Mbarek, Hamdi H; Kanterakis, Alexandros A; Trompet, Stella S; Postmus, Iris I; Verweij, Niek N; van Enckevort, David J DJ; Huffman, Jennifer E JE; White, Charles C CC; Feitosa, Mary F MF; Bartz, Traci M TM; Manichaikul, Ani A; Joshi, Peter K PK; Peloso, Gina M GM; Deelen, Patrick P; van Dijk, Freerk F; Willemsen, Gonneke G; de Geus, Eco J EJ; Milaneschi, Yuri Y; Penninx, Brenda W J H BW; Francioli, Laurent C LC; Menelaou, Androniki A; Pulit, Sara L SL; Rivadeneira, Fernando F; Hofman, Albert A; Oostra, Ben A BA; Franco, Oscar H OH; Mateo Leach, Irene I; Beekman, Marian M; de Craen, Anton J M AJ; Uh, Hae-Won HW; Trochet, Holly H; Hocking, Lynne J LJ; Porteous, David J DJ; Sattar, Naveed N; Packard, Chris J CJ; Buckley, Brendan M BM; Brody, Jennifer A JA; Bis, Joshua C JC; Rotter, Jerome I JI; Mychaleckyj, Josyf C JC; Campbell, Harry H; Duan, Qing Q; Lange, Leslie A LA; Wilson, James F JF; Hayward, Caroline C; Polasek, Ozren O; Vitart, Veronique V; Rudan, Igor I; Wright, Alan F AF; Rich, Stephen S SS; Psaty, Bruce M BM; Borecki, Ingrid B IB; Kearney, Patricia M PM; Stott, David J DJ; Adrienne Cupples, L L; , ; Jukema, J Wouter JW; van der Harst, Pim P; Sijbrands, Eric J EJ; Hottenga, Jouke-Jan JJ; Uitterlinden, Andre G AG; Swertz, Morris A MA; van Ommen, Gert-Jan B GJ; de Bakker, Paul I W PI; Eline Slagboom, P P; Boomsma, Dorret I DI; Wijmenga, Cisca C; van Duijn, Cornelia M CM
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
Nature Communications
Benyamin, Beben B; Esko, Tonu T; Ried, Janina S JS; Radhakrishnan, Aparna A; Vermeulen, Sita H SH; Traglia, Michela M; Gögele, Martin M; Anderson, Denise D; Broer, Linda L; Podmore, Clara C; Luan, Jian'an J; Kutalik, Zoltan Z; Sanna, Serena S; van der Meer, Peter P; Tanaka, Toshiko T; Wang, Fudi F; Westra, Harm-Jan HJ; Franke, Lude L; Mihailov, Evelin E; Milani, Lili L; Hälldin, Jonas J; Häldin, Jonas J; Winkelmann, Juliane J; Meitinger, Thomas T; Thiery, Joachim J; Peters, Annette A; Waldenberger, Melanie M; Rendon, Augusto A; Jolley, Jennifer J; Sambrook, Jennifer J; Kiemeney, Lambertus A LA; Sweep, Fred C FC; Sala, Cinzia F CF; Schwienbacher, Christine C; Pichler, Irene I; Hui, Jennie J; Demirkan, Ayse A; Isaacs, Aaron A; Amin, Najaf N; Steri, Maristella M; Waeber, Gérard G; Verweij, Niek N; Powell, Joseph E JE; Nyholt, Dale R DR; Heath, Andrew C AC; Madden, Pamela A F PA; Visscher, Peter M PM; Wright, Margaret J MJ; Montgomery, Grant W GW; Martin, Nicholas G NG; Hernandez, Dena D; Bandinelli, Stefania S; van der Harst, Pim P; Uda, Manuela M; Vollenweider, Peter P; Scott, Robert A RA; Langenberg, Claudia C; Wareham, Nicholas J NJ; , ; van Duijn, Cornelia C; Beilby, John J; Pramstaller, Peter P PP; Hicks, Andrew A AA; Ouwehand, Willem H WH; Oexle, Konrad K; Gieger, Christian C; Metspalu, Andres A; Camaschella, Clara C; Toniolo, Daniela D; Swinkels, Dorine W DW; Whitfield, John B JB
A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.
Nature Communications
Timpson, Nicholas J NJ; Walter, Klaudia K; Min, Josine L JL; Tachmazidou, Ioanna I; Malerba, Giovanni G; Shin, So-Youn SY; Chen, Lu L; Futema, Marta M; Southam, Lorraine L; Iotchkova, Valentina V; Cocca, Massimiliano M; Huang, Jie J; Memari, Yasin Y; McCarthy, Shane S; Danecek, Petr P; Muddyman, Dawn D; Mangino, Massimo M; Menni, Cristina C; Perry, John R B JR; Ring, Susan M SM; Gaye, Amadou A; Dedoussis, George G; Farmaki, Aliki-Eleni AE; Burton, Paul P; Talmud, Philippa J PJ; Gambaro, Giovanni G; Spector, Tim D TD; Smith, George Davey GD; Durbin, Richard R; Richards, J Brent JB; Humphries, Steve E SE; Zeggini, Eleftheria E; Soranzo, Nicole N; , ; ,
Discovery and refinement of loci associated with lipid levels.
Nature Genetics
Willer, Cristen J CJ; Schmidt, Ellen M EM; Sengupta, Sebanti S; Peloso, Gina M GM; Gustafsson, Stefan S; Kanoni, Stavroula S; Ganna, Andrea A; Chen, Jin J; Buchkovich, Martin L ML; Mora, Samia S; Beckmann, Jacques S JS; Bragg-Gresham, Jennifer L JL; Chang, Hsing-Yi HY; Demirkan, Ayşe A; Den Hertog, Heleen M HM; Do, Ron R; Donnelly, Louise A LA; Ehret, Georg B GB; Esko, Tõnu T; Feitosa, Mary F MF; Ferreira, Teresa T; Fischer, Krista K; Fontanillas, Pierre P; Fraser, Ross M RM; Freitag, Daniel F DF; Gurdasani, Deepti D; Heikkilä, Kauko K; Hyppönen, Elina E; Isaacs, Aaron A; Jackson, Anne U AU; Johansson, Åsa Å; Johnson, Toby T; Kaakinen, Marika M; Kettunen, Johannes J; Kleber, Marcus E ME; Li, Xiaohui X; Luan, Jian'an J; Lyytikäinen, Leo-Pekka LP; Magnusson, Patrik K E PKE; Mangino, Massimo M; Mihailov, Evelin E; Montasser, May E ME; Müller-Nurasyid, Martina M; Nolte, Ilja M IM; O'Connell, Jeffrey R JR; Palmer, Cameron D CD; Perola, Markus M; Petersen, Ann-Kristin AK; Sanna, Serena S; Saxena, Richa R; Service, Susan K SK; Shah, Sonia S; Shungin, Dmitry D; Sidore, Carlo C; Song, Ci C; Strawbridge, Rona J RJ; Surakka, Ida I; Tanaka, Toshiko T; Teslovich, Tanya M TM; Thorleifsson, Gudmar G; Van den Herik, Evita G EG; Voight, Benjamin F BF; Volcik, Kelly A KA; Waite, Lindsay L LL; Wong, Andrew A; Wu, Ying Y; Zhang, Weihua W; Absher, Devin D; Asiki, Gershim G; Barroso, Inês I; Been, Latonya F LF; Bolton, Jennifer L JL; Bonnycastle, Lori L LL; Brambilla, Paolo P; Burnett, Mary S MS; Cesana, Giancarlo G; Dimitriou, Maria M; Doney, Alex S F ASF; Döring, Angela A; Elliott, Paul P; Epstein, Stephen E SE; Ingi Eyjolfsson, Gudmundur G; Gigante, Bruna B; Goodarzi, Mark O MO; Grallert, Harald H; Gravito, Martha L ML; Groves, Christopher J CJ; Hallmans, Göran G; Hartikainen, Anna-Liisa AL; Hayward, Caroline C; Hernandez, Dena D; Hicks, Andrew A AA; Holm, Hilma H; Hung, Yi-Jen YJ; Illig, Thomas T; Jones, Michelle R MR; Kaleebu, Pontiano P; Kastelein, John J P JJP; Khaw, Kay-Tee KT; Kim, Eric E; Klopp, Norman N; Komulainen, Pirjo P; Kumari, Meena M; Langenberg, Claudia C; Lehtimäki, Terho T; Lin, Shih-Yi SY; Lindström, Jaana J; Loos, Ruth J F RJF; Mach, François F; McArdle, Wendy L WL; Meisinger, Christa C; Mitchell, Braxton D BD; Müller, Gabrielle G; Nagaraja, Ramaiah R; Narisu, Narisu N; Nieminen, Tuomo V M TVM; Nsubuga, Rebecca N RN; Olafsson, Isleifur I; Ong, Ken K KK; Palotie, Aarno A; Papamarkou, Theodore T; Pomilla, Cristina C; Pouta, Anneli A; Rader, Daniel J DJ; Reilly, Muredach P MP; Ridker, Paul M PM; Rivadeneira, Fernando F; Rudan, Igor I; Ruokonen, Aimo A; Samani, Nilesh N; Scharnagl, Hubert H; Seeley, Janet J; Silander, Kaisa K; Stančáková, Alena A; Stirrups, Kathleen K; Swift, Amy J AJ; Tiret, Laurence L; Uitterlinden, Andre G AG; van Pelt, L Joost LJ; Vedantam, Sailaja S; Wainwright, Nicholas N; Wijmenga, Cisca C; Wild, Sarah H SH; Willemsen, Gonneke G; Wilsgaard, Tom T; Wilson, James F JF; Young, Elizabeth H EH; Zhao, Jing Hua JH; Adair, Linda S LS; Arveiler, Dominique D; Assimes, Themistocles L TL; Bandinelli, Stefania S; Bennett, Franklyn F; Bochud, Murielle M; Boehm, Bernhard O BO; Boomsma, Dorret I DI; Borecki, Ingrid B IB; Bornstein, Stefan R SR; Bovet, Pascal P; Burnier, Michel M; Campbell, Harry H; Chakravarti, Aravinda A; Chambers, John C JC; Chen, Yii-Der Ida YI; Collins, Francis S FS; Cooper, Richard S RS; Danesh, John J; Dedoussis, George G; de Faire, Ulf U; Feranil, Alan B AB; Ferrières, Jean J; Ferrucci, Luigi L; Freimer, Nelson B NB; Gieger, Christian C; Groop, Leif C LC; Gudnason, Vilmundur V; Gyllensten, Ulf U; Hamsten, Anders A; Harris, Tamara B TB; Hingorani, Aroon A; Hirschhorn, Joel N JN; Hofman, Albert A; Hovingh, G Kees GK; Hsiung, Chao Agnes CA; Humphries, Steve E SE; Hunt, Steven C SC; Hveem, Kristian K; Iribarren, Carlos C; Järvelin, Marjo-Riitta MR; Jula, Antti A; Kähönen, Mika M; Kaprio, Jaakko J; Kesäniemi, Antero A; Kivimaki, Mika M; Kooner, Jaspal S JS; Koudstaal, Peter J PJ; Krauss, Ronald M RM; Kuh, Diana D; Kuusisto, Johanna J; Kyvik, Kirsten O KO; Laakso, Markku M; Lakka, Timo A TA; Lind, Lars L; Lindgren, Cecilia M CM; Martin, Nicholas G NG; März, Winfried W; McCarthy, Mark I MI; McKenzie, Colin A CA; Meneton, Pierre P; Metspalu, Andres A; Moilanen, Leena L; Morris, Andrew D AD; Munroe, Patricia B PB; Njølstad, Inger I; Pedersen, Nancy L NL; Power, Chris C; Pramstaller, Peter P PP; Price, Jackie F JF; Psaty, Bruce M BM; Quertermous, Thomas T; Rauramaa, Rainer R; Saleheen, Danish D; Salomaa, Veikko V; Sanghera, Dharambir K DK; Saramies, Jouko J; Schwarz, Peter E H PEH; Sheu, Wayne H-H WH; Shuldiner, Alan R AR; Siegbahn, Agneta A; Spector, Tim D TD; Stefansson, Kari K; Strachan, David P DP; Tayo, Bamidele O BO; Tremoli, Elena E; Tuomilehto, Jaakko J; Uusitupa, Matti M; van Duijn, Cornelia M CM; Vollenweider, Peter P; Wallentin, Lars L; Wareham, Nicholas J NJ; Whitfield, John B JB; Wolffenbuttel, Bruce H R BHR; Ordovas, Jose M JM; Boerwinkle, Eric E; Palmer, Colin N A CNA; Thorsteinsdottir, Unnur U; Chasman, Daniel I DI; Rotter, Jerome I JI; Franks, Paul W PW; Ripatti, Samuli S; Cupples, L Adrienne LA; Sandhu, Manjinder S MS; Rich, Stephen S SS; Boehnke, Michael M; Deloukas, Panos P; Kathiresan, Sekar S; Mohlke, Karen L KL; Ingelsson, Erik E; Abecasis, Gonçalo R GR; ,
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
Circulation
Sabater-Lleal, Maria M; Huang, Jie J; Chasman, Daniel D; Naitza, Silvia S; Dehghan, Abbas A; Johnson, Andrew D AD; Teumer, Alexander A; Reiner, Alex P AP; Folkersen, Lasse L; Basu, Saonli S; Rudnicka, Alicja R AR; Trompet, Stella S; Mälarstig, Anders A; Baumert, Jens J; Bis, Joshua C JC; Guo, Xiuqing X; Hottenga, Jouke J JJ; Shin, So-Youn SY; Lopez, Lorna M LM; Lahti, Jari J; Tanaka, Toshiko T; Yanek, Lisa R LR; Oudot-Mellakh, Tiphaine T; Wilson, James F JF; Navarro, Pau P; Huffman, Jennifer E JE; Zemunik, Tatijana T; Redline, Susan S; Mehra, Reena R; Pulanic, Drazen D; Rudan, Igor I; Wright, Alan F AF; Kolcic, Ivana I; Polasek, Ozren O; Wild, Sarah H SH; Campbell, Harry H; Curb, J David JD; Wallace, Robert R; Liu, Simin S; Eaton, Charles B CB; Becker, Diane M DM; Becker, Lewis C LC; Bandinelli, Stefania S; Räikkönen, Katri K; Widen, Elisabeth E; Palotie, Aarno A; Fornage, Myriam M; Green, David D; Gross, Myron M; Davies, Gail G; Harris, Sarah E SE; Liewald, David C DC; Starr, John M JM; Williams, Frances M K FM; Grant, Peter J PJ; Spector, Timothy D TD; Strawbridge, Rona J RJ; Silveira, Angela A; Sennblad, Bengt B; Rivadeneira, Fernando F; Uitterlinden, Andre G AG; Franco, Oscar H OH; Hofman, Albert A; van Dongen, Jenny J; Willemsen, Gonneke G; Boomsma, Dorret I DI; Yao, Jie J; Swords Jenny, Nancy N; Haritunians, Talin T; McKnight, Barbara B; Lumley, Thomas T; Taylor, Kent D KD; Rotter, Jerome I JI; Psaty, Bruce M BM; Peters, Annette A; Gieger, Christian C; Illig, Thomas T; Grotevendt, Anne A; Homuth, Georg G; Völzke, Henry H; Kocher, Thomas T; Goel, Anuj A; Franzosi, Maria Grazia MG; Seedorf, Udo U; Clarke, Robert R; Steri, Maristella M; Tarasov, Kirill V KV; Sanna, Serena S; Schlessinger, David D; Stott, David J DJ; Sattar, Naveed N; Buckley, Brendan M BM; Rumley, Ann A; Lowe, Gordon D GD; McArdle, Wendy L WL; Chen, Ming-Huei MH; Tofler, Geoffrey H GH; Song, Jaejoon J; Boerwinkle, Eric E; Folsom, Aaron R AR; Rose, Lynda M LM; Franco-Cereceda, Anders A; Teichert, Martina M; Ikram, M Arfan MA; Mosley, Thomas H TH; Bevan, Steve S; Dichgans, Martin M; Rothwell, Peter M PM; Sudlow, Cathie L M CL; Hopewell, Jemma C JC; Chambers, John C JC; Saleheen, Danish D; Kooner, Jaspal S JS; Danesh, John J; Nelson, Christopher P CP; Erdmann, Jeanette J; Reilly, Muredach P MP; Kathiresan, Sekar S; Schunkert, Heribert H; Morange, Pierre-Emmanuel PE; Ferrucci, Luigi L; Eriksson, Johan G JG; Jacobs, David D; Deary, Ian J IJ; Soranzo, Nicole N; Witteman, Jacqueline C M JC; de Geus, Eco J C EJ; Tracy, Russell P RP; Hayward, Caroline C; Koenig, Wolfgang W; Cucca, Francesco F; Jukema, J Wouter JW; Eriksson, Per P; Seshadri, Sudha S; Markus, Hugh S HS; Watkins, Hugh H; Samani, Nilesh J NJ; , ; , ; , ; , ; , ; Wallaschofski, Henri H; Smith, Nicholas L NL; Tregouet, David D; Ridker, Paul M PM; Tang, Weihong W; Strachan, David P DP; Hamsten, Anders A; O'Donnell, Christopher J CJ