KIT c.1250C>T ;(p.T417I)

Variant ID: 4-55589768-C-T

NM_000222.2(KIT):c.1250C>T;(p.T417I)

This variant was identified in 6 publications

View GRCh38 version.




Publications:


Identification and in silico analysis of noval alteration Arg420Gly in KIT proto oncogene among acute myeloid leukemia patients.

Scientific Reports
Akram, Afia Muhammad AM; Hassan, Mubashir M; Chaudhary, Asma A; Hayat, Sikandar S; Ali, Qurban Q; Hussain, Taha T; Zafar, Amjad A; Javed, Muhammad Arshad MA
Publication Date: 2022-11-10

Variant appearance in text: KIT: T417I
PubMed Link: 36357474
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role and significance of c-KIT receptor tyrosine kinase in cancer: A review.

Bosnian Journal Of Basic Medical Sciences
Sheikh, Emana E; Tran, Tony T; Vranic, Semir S; Levy, Arkene A; Bonfil, R Daniel RD
Publication Date: 2022-09-16

Variant appearance in text: KIT: T417I
PubMed Link: 35490363
Variant Present in the following documents:
  • BJBMS-22-683.pdf
View BVdb publication page



Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types.

Genome Medicine
Bao, Riyue R; Stapor, Daniel D; Luke, Jason J JJ
Publication Date: 2020-10-27

Variant appearance in text: KIT: T417I
PubMed Link: 33106165
Variant Present in the following documents:
  • 13073_2020_787_MOESM1_ESM.xlsx, sheet 9
View BVdb publication page



Heterogeneous prognosis among KIT mutation types in adult acute myeloid leukemia patients with t(8;21).

Blood Cancer Journal
Qin, Ya-Zhen YZ; Zhu, Hong-Hu HH; Jiang, Qian Q; Xu, Lan-Ping LP; Jiang, Hao H; Wang, Yu Y; Zhao, Xiao-Su XS; Liu, Yan-Rong YR; Zhang, Xiao-Hui XH; Liu, Kai-Yan KY; Huang, Xiao-Jun XJ
Publication Date: 2018-08-07

Variant appearance in text: KIT: T417I
PubMed Link: 30087318
Variant Present in the following documents:
  • Main text
View BVdb publication page



Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Shi, Xiarong X; Sousa, Leiliane P LP; Mandel-Bausch, Elizabeth M EM; Tome, Francisco F; Reshetnyak, Andrey V AV; Hadari, Yaron Y; Schlessinger, Joseph J; Lax, Irit I
Publication Date: 2016-08-16

Variant appearance in text: KIT: T417I
PubMed Link: 27482095
Variant Present in the following documents:
  • Main text
View BVdb publication page



The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.

Molecular Cell
Reshetnyak, Andrey V AV; Opatowsky, Yarden Y; Boggon, Titus J TJ; Folta-Stogniew, Ewa E; Tome, Francisco F; Lax, Irit I; Schlessinger, Joseph J
Publication Date: 2015-01-08

Variant appearance in text: KIT: T417I
PubMed Link: 25544564
Variant Present in the following documents:
  • Main text
View BVdb publication page