Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST).
International Journal Of Molecular Sciences
Rassner, Michael M; Waldeck, Silvia S; Follo, Marie M; Jilg, Stefanie S; Philipp, Ulrike U; Jolic, Martina M; Wehrle, Julius J; Jost, Philipp J PJ; Peschel, Christian C; Illert, Anna Lena AL; Duyster, Justus J; Scherer, Florian F; von Bubnoff, Nikolas N
Synergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia.
Molecular & Cellular Proteomics : Mcp
Murray, Heather C HC; Miller, Kasey K; Brzozowski, Joshua S JS; Kahl, Richard G S RGS; Smith, Nathan D ND; Humphrey, Sean J SJ; Dun, Matthew D MD; Verrills, Nicole M NM
Escalation of radiotherapy dose in large locally advanced drug-resistant gastrointestinal stromal tumors by multi-shell simultaneous integrated boost intensity-modulated technique: a feasibility study.
Plasma Sequencing for Patients with GIST-Limitations and Opportunities in an Academic Setting.
Cancers
Falkenhorst, Johanna J; Grunewald, Susanne S; Krzeciesa, Dawid D; Herold, Thomas T; Ketzer, Julia J; Christoff, Miriam M; Hamacher, Rainer R; Kostbade, Karina K; Treckmann, Jürgen J; Köster, Johannes J; Farzaliyev, Farhad F; Fletcher, Benjamin Samulon BS; Dieckmann, Nils N; Kaths, Moritz M; Mühlenberg, Thomas T; Schildhaus, Hans-Ulrich HU; Bauer, Sebastian S
Clonal hematopoiesis is not significantly associated with COVID-19 disease severity.
Blood
Zhou, Yifan Y; Shalhoub, Ruba R; Rogers, Stephanie N SN; Yu, Shiqin S; Gu, Muxin M; Fabre, Margarete A MA; Quiros, Pedro M PM; Shin, Tae-Hoon TH; Diangson, Arch A; Deng, Wenhan W; Anand, Shubha S; Lu, Wenhua W; Cullen, Matthew M; Godfrey, Anna L AL; Preller, Jacobus J; Hadjadj, Jerome J; Jouanguy, Emmanuelle E; Cobat, Aurélie A; Abel, Laurent L; Rieux-Laucat, Frederic F; Terrier, Benjamin B; Fischer, Alain A; Novik, Lara L; Gordon, Ingelise J IJ; Strom, Larisa L; Gaudinski, Martin R MR; Lisco, Andrea A; Sereti, Irini I; Gniadek, Thomas J TJ; Biondi, Andrea A; Bonfanti, Paolo P; Imberti, Luisa L; Dalgard, Clifton L CL; Zhang, Yu Y; Dobbs, Kerry K; Su, Helen C HC; Notarangelo, Luigi D LD; Wu, Colin O CO; Openshaw, Peter J M PJM; Semple, Malcolm G MG; Mallat, Ziad Z; Baillie, Kenneth K; Dunbar, Cynthia E CE; Vassiliou, George S GS
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.
Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.
Molecular Portrait of GISTs Associated With Clinicopathological Features: A Retrospective Study With Molecular Analysis by a Custom 9-Gene Targeted Next-Generation Sequencing Panel.
Frontiers In Genetics
Qian, Haoran H; Yan, Na N; Hu, Xiaotong X; Jiang, Junchang J; Cao, Zhengzheng Z; Shen, Dan D
Circulating Tumor DNA Mutations in Progressive Gastrointestinal Stromal Tumors Identify Biomarkers of Treatment Resistance and Uncover Potential Therapeutic Strategies.
Frontiers In Oncology
Ko, Tun Kiat TK; Lee, Elizabeth E; Ng, Cedric Chuan-Young CC; Yang, Valerie Shiwen VS; Farid, Mohamad M; Teh, Bin Tean BT; Chan, Jason Yongsheng JY; Somasundaram, Nagavalli N
The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies.
The Journal Of Pathology. Clinical Research
Tessier-Cloutier, Basile B; Grewal, Jasleen K JK; Jones, Martin R MR; Pleasance, Erin E; Shen, Yaoqing Y; Cai, Ellen E; Dunham, Chris C; Hoang, Lynn L; Horst, Basil B; Huntsman, David G DG; Ionescu, Diana D; Karnezis, Anthony N AN; Lee, Anna F AF; Lee, Cheng Han CH; Lee, Tae Hoon TH; Twa, David Dw DD; Mungall, Andrew J AJ; Mungall, Karen K; Naso, Julia R JR; Ng, Tony T; Schaeffer, David F DF; Sheffield, Brandon S BS; Skinnider, Brian B; Smith, Tyler T; Williamson, Laura L; Zhong, Ellia E; Regier, Dean A DA; Laskin, Janessa J; Marra, Marco A MA; Gilks, C Blake CB; Jones, Steven Jm SJ; Yip, Stephen S
Publication Date: 2022-07
Variant appearance in text: KIT: 1961T>C; Val654Ala; rs121913523
Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma Patients.
Cancers
Schipper, Luuk J LJ; Monkhorst, Kim K; Samsom, Kris G KG; Bosch, Linda J W LJW; Snaebjornsson, Petur P; van Boven, Hester H; Roepman, Paul P; van der Kolk, Lizet E LE; van Houdt, Winan J WJ; van der Graaf, Winette T A WTA; Meijer, Gerrit A GA; Voest, Emile E EE
Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma Patients.
Cancers
Schipper, Luuk J LJ; Monkhorst, Kim K; Samsom, Kris G KG; Bosch, Linda J W LJW; Snaebjornsson, Petur P; van Boven, Hester H; Roepman, Paul P; van der Kolk, Lizet E LE; van Houdt, Winan J WJ; van der Graaf, Winette T A WTA; Meijer, Gerrit A GA; Voest, Emile E EE
Broad spectrum of regorafenib activity on mutant KIT and absence of clonal selection in gastrointestinal stromal tumor (GIST): correlative analysis from the GRID trial.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Jeffers, Michael M; Kappeler, Christian C; Kuss, Iris I; Beckmann, Georg G; Mehnert, Daniel H DH; Fredebohm, Johannes J; Teufel, Michael M
Preclinical model-based evaluation of Imatinib resistance induced by KIT mutations and its overcoming strategies in gastrointestinal stromal tumor (GIST).
American Journal Of Translational Research
Zhao, Qian Q; Zhang, Cheng C; Qi, Changsong C; Yang, Jing J; Chen, Yang Y; Ge, Sai S; Shen, Lin L; Gao, Jing J; Li, Jian J
Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis.
Clinical And Translational Gastroenterology
Cowan, Robert W RW; Pratt, Erica D ED; Kang, Jin Muk JM; Zhao, Jun J; Wilhelm, Joshua J JJ; Abdulla, Muhamad M; Qiao, Edmund M EM; Brennan, Luke P LP; Ulintz, Peter J PJ; Bellin, Melena D MD; Rhim, Andrew D AD
Publication Date: 2021-11-18
Variant appearance in text: KIT: 1961T>C; Val654Ala; rs121913523
Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy.
Cell Reports
Zhang, Yiqun Y; Chen, Fengju F; Pleasance, Erin E; Williamson, Laura L; Grisdale, Cameron J CJ; Titmuss, Emma E; Laskin, Janessa J; Jones, Steven J M SJM; Cortes-Ciriano, Isidro I; Marra, Marco A MA; Creighton, Chad J CJ
Publication Date: 2021-11-16
Variant appearance in text: KIT: 1961T>C; Val654Ala
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Bauer, Sebastian S; Heinrich, Michael C MC; George, Suzanne S; Zalcberg, John R JR; Serrano, César C; Gelderblom, Hans H; Jones, Robin L RL; Attia, Steven S; D'Amato, Gina G; Chi, Ping P; Reichardt, Peter P; Meade, Julie J; Su, Ying Y; Ruiz-Soto, Rodrigo R; Blay, Jean-Yves JY; von Mehren, Margaret M; Schöffski, Patrick P
Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor.
Cancers
Kozinova, Marya M; Joshi, Shalina S; Ye, Shuai S; Belinsky, Martin G MG; Sharipova, Dinara D; Farma, Jeffrey M JM; Reddy, Sanjay S SS; Litwin, Samuel S; Devarajan, Karthik K; Campos, Alex Rosa AR; Yu, Yi Y; Schwartz, Brian B; von Mehren, Margaret M; Rink, Lori L
Guideline-Adherent Clinical Validation of a Comprehensive 170-Gene DNA/RNA Panel for Determination of Small Variants, Copy Number Variations, Splice Variants, and Fusions on a Next-Generation Sequencing Platform in the CLIA Setting.
Frontiers In Genetics
Boyle, Theresa A TA; Mondal, Ashis K AK; Saeed-Vafa, Daryoush D; Ananth, Sudha S; Ahluwalia, Pankaj P; Kothapalli, Ravi R; Chaubey, Alka A; Roberts, Evans E; Qin, Dahui D; Magliocco, Anthony M AM; Rojiani, Amyn M AM; Kolhe, Ravindra R