KIT c.1965T>G ;(p.N655K)

Variant ID: 4-55594262-T-G

NM_000222.2(KIT):c.1965T>G;(p.N655K)

This variant was identified in 32 publications

View GRCh38 version.




Publications:


Somatic mutation detection and KRAS amplification in testicular germ cell tumors.

Frontiers In Oncology
Cabral, Eduardo R M ERM; Pacanhella, Marilia F MF; Lengert, Andre V H AVH; Dos Reis, Mariana B MB; Leal, Leticia F LF; de Lima, Marcos A MA; da Silva, Aline L V ALV; Pinto, Icaro A IA; Reis, Rui M RM; Pinto, Mariana T MT; Cárcano, Flavio M FM
Publication Date: 2023

Variant appearance in text: KIT: N655K
PubMed Link: 37007070
Variant Present in the following documents:
  • Main text
  • fonc-13-1133363.pdf
View BVdb publication page



Chinese Pedigree with Hereditary Gastrointestinal Stromal Tumors: A Case Report and Literature Review.

International Journal Of Molecular Sciences
Ge, Qichao Q; Liu, Yang Y; Yang, Fan F; Sun, Guangwei G; Guo, Jintao J; Sun, Siyu S
Publication Date: 2023-01-03

Variant appearance in text: KIT: N655K
PubMed Link: 36614290
Variant Present in the following documents:
  • ijms-24-00830.pdf
View BVdb publication page



The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations.

Nature Cancer
Villani, Anita A; Davidson, Scott S; Kanwar, Nisha N; Lo, Winnie W WW; Li, Yisu Y; Cohen-Gogo, Sarah S; Fuligni, Fabio F; Edward, Lisa-Monique LM; Light, Nicholas N; Layeghifard, Mehdi M; Harripaul, Ricardo R; Waldman, Larissa L; Gallinger, Bailey B; Comitani, Federico F; Brunga, Ledia L; Hayes, Reid R; Anderson, Nathaniel D ND; Ramani, Arun K AK; Yuki, Kyoko E KE; Blay, Sasha S; Johnstone, Brittney B; Inglese, Cara C; Hammad, Rawan R; Goudie, Catherine C; Shuen, Andrew A; Wasserman, Jonathan D JD; Venier, Rosemarie E RE; Eliou, Marianne M; Lorenti, Miranda M; Ryan, Carol Ann CA; Braga, Michael M; Gloven-Brown, Meagan M; Han, Jianan J; Montero, Maria M; Spatare, Famida F; Whitlock, James A JA; Scherer, Stephen W SW; Chun, Kathy K; Somerville, Martin J MJ; Hawkins, Cynthia C; Abdelhaleem, Mohamed M; Ramaswamy, Vijay V; Somers, Gino R GR; Kyriakopoulou, Lianna L; Hitzler, Johann J; Shago, Mary M; Morgenstern, Daniel A DA; Tabori, Uri U; Meyn, Stephen S; Irwin, Meredith S MS; Malkin, David D; Shlien, Adam A
Publication Date: 2022-12-30

Variant appearance in text: KIT: 1965T>G; N655K
PubMed Link: 36585449
Variant Present in the following documents:
  • 43018_2022_474_MOESM12_ESM.xlsx, sheet 6
  • 43018_2022_474_MOESM3_ESM.xlsx, sheet 7
  • 43018_2022_474_MOESM7_ESM.xlsx, sheet 6
  • 43018_2022_474_MOESM7_ESM.xlsx, sheet 7
  • 43018_2022_474_MOESM10_ESM.xlsx, sheet 7
  • 43018_2022_474_MOESM12_ESM.xlsx, sheet 7
  • 43018_2022_474_MOESM2_ESM.xlsx, sheet 7
  • 43018_2022_474_MOESM2_ESM.xlsx, sheet 6
  • 43018_2022_474_MOESM3_ESM.xlsx, sheet 6
  • 43018_2022_474_MOESM10_ESM.xlsx, sheet 6
View BVdb publication page



[Abdominal soft tissue tumors].

Pathologie (Heidelberg, Germany)
Wardelmann, Eva E; Kuntze, Anna A; Trautmann, Marcel M; Hartmann, Wolfgang W
Publication Date: 2022-10-12

Variant appearance in text: KIT: N655K
PubMed Link: 36222918
Variant Present in the following documents:
  • 292_2022_Article_1128.pdf
View BVdb publication page



KIT-Associated Familial GIST Syndrome: Response to Tyrosine Kinase Inhibitors and Implications for Risk Management.

The Oncologist
Brodey, Alexandra A; Kounnis, Valentinos V; Hawkes, Lara L; Jones, Robin L RL; McVeigh, Terri P TP; Cojocaru, Elena E
Publication Date: 2022-08-05

Variant appearance in text: KIT: N655k
PubMed Link: 35791894
Variant Present in the following documents:
  • Main text
  • oyac120.pdf
View BVdb publication page



Target Therapies for Systemic Mastocytosis: An Update.

Pharmaceuticals (Basel, Switzerland)
Sciumè, Mariarita M; De Magistris, Claudio C; Galli, Nicole N; Ferretti, Eleonora E; Milesi, Giulia G; De Roberto, Pasquale P; Fabris, Sonia S; Grifoni, Federica Irene FI
Publication Date: 2022-06-11

Variant appearance in text: KIT: N655K
PubMed Link: 35745657
Variant Present in the following documents:
  • Main text
  • pharmaceuticals-15-00738.pdf
View BVdb publication page



Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification.

Nature Communications
Liu, Ting T; Rao, Jianan J; Hu, Wenting W; Cui, Bowen B; Cai, Jiaoyang J; Liu, Yuhan Y; Sun, Huiying H; Chen, Xiaoxiao X; Tang, Yanjing Y; Chen, Jing J; Wang, Xiang X; Wang, Han H; Qian, Wubin W; Mao, Binchen B; Guo, Sheng S; Wang, Ronghua R; Liu, Yu Y; Shen, Shuhong S
Publication Date: 2022-03-28

Variant appearance in text: KIT: N655K
PubMed Link: 35347147
Variant Present in the following documents:
  • 41467_2022_29336_MOESM8_ESM.xlsx, sheet 1
View BVdb publication page



Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research
Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL
Publication Date: 2022-05

Variant appearance in text: KIT: N655K
PubMed Link: 35229492
Variant Present in the following documents:
  • PCMR-35-369-s002.pdf
View BVdb publication page



A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research
Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H
Publication Date: 2022-01

Variant appearance in text: KIT: N655K
PubMed Link: 34963661
Variant Present in the following documents:
  • supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: KIT: N655K
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Update on Molecular Genetics of Gastrointestinal Stromal Tumors.

Diagnostics (Basel, Switzerland)
Brčić, Iva I; Argyropoulos, Alexandra A; Liegl-Atzwanger, Bernadette B
Publication Date: 2021-01-28

Variant appearance in text: KIT: N655K
PubMed Link: 33525726
Variant Present in the following documents:
  • Main text
  • diagnostics-11-00194.pdf
View BVdb publication page



A Novel Kindred with Familial Gastrointestinal Stromal Tumors Caused by a Rare KIT Germline Mutation (N655K): Clinico-Pathological Presentation and TKI Sensitivity.

Journal Of Personalized Medicine
Fornasarig, Mara M; Gasparotto, Daniela D; Foltran, Luisa L; Campigotto, Michele M; Lombardi, Sara S; Del Savio, Elisa E; Buonadonna, Angela A; Puglisi, Fabio F; Sulfaro, Sandro S; Canzonieri, Vincenzo V; Cannizzaro, Renato R; Maestro, Roberta R
Publication Date: 2020-11-17

Variant appearance in text: KIT: 1965T>G; N655K
PubMed Link: 33212994
Variant Present in the following documents:
  • Main text
  • jpm-10-00234.pdf
View BVdb publication page



Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports
Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA
Publication Date: 2020-09-21

Variant appearance in text: KIT: N655K
PubMed Link: 32958805
Variant Present in the following documents:
  • 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Phase and context shape the function of composite oncogenic mutations.

Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Publication Date: 2020-06

Variant appearance in text: KIT: N655K
PubMed Link: 32461694
Variant Present in the following documents:
  • NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2
View BVdb publication page



Genomic landscape of platinum resistant and sensitive testicular cancers.

Nature Communications
Loveday, Chey C; Litchfield, Kevin K; Proszek, Paula Z PZ; Cornish, Alex J AJ; Santo, Flavia F; Levy, Max M; Macintyre, Geoff G; Holryod, Amy A; Broderick, Peter P; Dudakia, Darshna D; Benton, Barbara B; Bakir, Maise Al MA; Hiley, Crispin C; Grist, Emily E; Swanton, Charles C; Huddart, Robert R; Powles, Tom T; Chowdhury, Simon S; Shipley, Janet J; O'Connor, Simon S; Brenton, James D JD; Reid, Alison A; de Castro, David Gonzalez DG; Houlston, Richard S RS; Turnbull, Clare C
Publication Date: 2020-05-04

Variant appearance in text: KIT: N655K
PubMed Link: 32366847
Variant Present in the following documents:
  • 41467_2020_15768_MOESM7_ESM.xlsx, sheet 2
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: KIT: N655K
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases.

Scientific Reports
Šimčíková, Daniela D; Heneberg, Petr P
Publication Date: 2019-12-09

Variant appearance in text: KIT: N655K
PubMed Link: 31819097
Variant Present in the following documents:
  • 41598_2019_54976_MOESM2_ESM.xlsx, sheet 8
View BVdb publication page



Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing.

Bmc Cancer
Lokhandwala, Parvez M PM; Tseng, Li-Hui LH; Rodriguez, Erika E; Zheng, Gang G; Pallavajjalla, Aparna A; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT
Publication Date: 2019-07-05

Variant appearance in text: KIT: N655K
PubMed Link: 31277584
Variant Present in the following documents:
  • Main text
View BVdb publication page



ATP-Competitive Inhibitors Midostaurin and Avapritinib Have Distinct Resistance Profiles in Exon 17-Mutant KIT.

Cancer Research
Apsel Winger, Beth B; Cortopassi, Wilian A WA; Garrido Ruiz, Diego D; Ding, Lucky L; Jang, Kibeom K; Leyte-Vidal, Ariel A; Zhang, Na N; Esteve-Puig, Rosaura R; Jacobson, Matthew P MP; Shah, Neil P NP
Publication Date: 2019-08-15

Variant appearance in text: KIT: N655K
PubMed Link: 31270078
Variant Present in the following documents:
  • Main text
View BVdb publication page



Lack of Response to Imatinib in Melanoma Carrying Rare KIT Mutation p.T632I.

Case Reports In Oncology
Orlova, Kristina V KV; Yanus, Grigory A GA; Aleksakhina, Svetlana N SN; Venina, Aigul R AR; Iyevleva, Aglaya G AG; Demidov, Lev V LV; Imyanitov, Evgeny N EN
Publication Date: 2019

Variant appearance in text: KIT: N655K
PubMed Link: 31043947
Variant Present in the following documents:
  • cro-0012-0109-s01.pdf
View BVdb publication page



Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer.

Nature Communications
Wagner, Alex H AH; Devarakonda, Siddhartha S; Skidmore, Zachary L ZL; Krysiak, Kilannin K; Ramu, Avinash A; Trani, Lee L; Kunisaki, Jason J; Masood, Ashiq A; Waqar, Saiama N SN; Spies, Nicholas C NC; Morgensztern, Daniel D; Waligorski, Jason J; Ponce, Jennifer J; Fulton, Robert S RS; Maggi, Leonard B LB; Weber, Jason D JD; Watson, Mark A MA; O'Conor, Christopher J CJ; Ritter, Jon H JH; Olsen, Rachelle R RR; Cheng, Haixia H; Mukhopadhyay, Anandaroop A; Can, Ismail I; Cessna, Melissa H MH; Oliver, Trudy G TG; Mardis, Elaine R ER; Wilson, Richard K RK; Griffith, Malachi M; Griffith, Obi L OL; Govindan, Ramaswamy R
Publication Date: 2018-09-17

Variant appearance in text: KIT: N655K
PubMed Link: 30224629
Variant Present in the following documents:
  • 41467_2018_6162_MOESM13_ESM.xlsx, sheet 1
View BVdb publication page



Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Publication Date: 2018-07-27

Variant appearance in text: KIT: N655K
PubMed Link: 30053901
Variant Present in the following documents:
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 3
View BVdb publication page



Precision Medicine in Children and Young Adults with Hematologic Malignancies and Blood Disorders: The Columbia University Experience.

Frontiers In Pediatrics
Marks, Lianna J LJ; Oberg, Jennifer A JA; Pendrick, Danielle D; Sireci, Anthony N AN; Glasser, Chana C; Coval, Carrie C; Zylber, Rebecca J RJ; Chung, Wendy K WK; Pang, Jiuhong J; Turk, Andrew T AT; Hsiao, Susan J SJ; Mansukhani, Mahesh M MM; Glade Bender, Julia L JL; Kung, Andrew L AL; Sulis, Maria Luisa ML
Publication Date: 2017

Variant appearance in text: KIT: 1965T>G; Asn655Lys
PubMed Link: 29312904
Variant Present in the following documents:
  • Main text
  • Table_2.xlsx, sheet 1
View BVdb publication page



A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG-ACRIN Cancer Research Group (E2607).

Cancer
Kalinsky, Kevin K; Lee, Sandra S; Rubin, Krista M KM; Lawrence, Donald P DP; Iafrarte, Anthony J AJ; Borger, Darell R DR; Margolin, Kim A KA; Leitao, Mario M MM; Tarhini, Ahmad A AA; Koon, Henry B HB; Pecora, Andrew L AL; Jaslowski, Anthony J AJ; Cohen, Gary I GI; Kuzel, Timothy M TM; Lao, Christopher D CD; Kirkwood, John M JM
Publication Date: 2017-07-15

Variant appearance in text: KIT: N655K
PubMed Link: 28334439
Variant Present in the following documents:
  • Main text
View BVdb publication page



Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.

Elife
Chen, Huaibin H; Marsiglia, William M WM; Cho, Min-Kyu MK; Huang, Zhifeng Z; Deng, Jingjing J; Blais, Steven P SP; Gai, Weiming W; Bhattacharya, Shibani S; Neubert, Thomas A TA; Traaseth, Nathaniel J NJ; Mohammadi, Moosa M
Publication Date: 2017-02-06

Variant appearance in text: KIT: Asn655Lys
PubMed Link: 28166054
Variant Present in the following documents:
  • Main text
View BVdb publication page



Surgical resection of recurrent gastrointestinal stromal tumor after interruption of long-term nilotinib therapy.

Surgical Case Reports
Sugase, Takahito T; Takahashi, Tsuyoshi T; Ishikawa, Takashi T; Ichikawa, Hiroshi H; Kanda, Tatsuo T; Hirota, Seiichi S; Nakajima, Kiyokazu K; Tanaka, Koji K; Miyazaki, Yasuhiro Y; Makino, Tomoki T; Kurokawa, Yukinori Y; Yamasaki, Makoto M; Takiguchi, Shuji S; Wakai, Toshifumi T; Mori, Masaki M; Doki, Yuichiro Y
Publication Date: 2016-12

Variant appearance in text: KIT: Asn655Lys
PubMed Link: 27864817
Variant Present in the following documents:
  • Main text
  • 40792_2016_Article_266.pdf
View BVdb publication page



Comprehensive mutational profiling of core binding factor acute myeloid leukemia.

Blood
Duployez, Nicolas N; Marceau-Renaut, Alice A; Boissel, Nicolas N; Petit, Arnaud A; Bucci, Maxime M; Geffroy, Sandrine S; Lapillonne, Hélène H; Renneville, Aline A; Ragu, Christine C; Figeac, Martin M; Celli-Lebras, Karine K; Lacombe, Catherine C; Micol, Jean-Baptiste JB; Abdel-Wahab, Omar O; Cornillet, Pascale P; Ifrah, Norbert N; Dombret, Hervé H; Leverger, Guy G; Jourdan, Eric E; Preudhomme, Claude C
Publication Date: 2016-05-19

Variant appearance in text: KIT: N655K
PubMed Link: 26980726
Variant Present in the following documents:
  • Main text
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: KIT: N655K
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Garner, Andrew P AP; Gozgit, Joseph M JM; Anjum, Rana R; Vodala, Sadanand S; Schrock, Alexa A; Zhou, Tianjun T; Serrano, Cesar C; Eilers, Grant G; Zhu, Meijun M; Ketzer, Julia J; Wardwell, Scott S; Ning, Yaoyu Y; Song, Youngchul Y; Kohlmann, Anna A; Wang, Frank F; Clackson, Tim T; Heinrich, Michael C MC; Fletcher, Jonathan A JA; Bauer, Sebastian S; Rivera, Victor M VM
Publication Date: 2014-11-15

Variant appearance in text: N/A
PubMed Link: 25239608
Variant Present in the following documents:
View BVdb publication page



Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities.

Annals Of Surgical Oncology
Pommier, Suellen J SJ; Hernandez, Ariel A; Han, Esther E; Massimino, Kristen K; Muller, Patrick P; Diggs, Brian B; Chamberlain, Erin E; Murphy, Jennifer J; Hansen, Juliana J; Naik, Arpana A; Vetto, John J; Pommier, Rodney F RF
Publication Date: 2012-02

Variant appearance in text: KIT: N655K
PubMed Link: 21748247
Variant Present in the following documents:
  • 10434_2011_1892_MOESM2_ESM.pdf
View BVdb publication page



Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: an in vitro mutagenesis screen for drug resistance.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Guo, Tianhua T; Hajdu, Mihai M; Agaram, Narasimhan P NP; Shinoda, Hiroko H; Veach, Darren D; Clarkson, Bayard D BD; Maki, Robert G RG; Singer, Samuel S; Dematteo, Ronald P RP; Besmer, Peter P; Antonescu, Cristina R CR
Publication Date: 2009-11-15

Variant appearance in text: N/A
PubMed Link: 19861442
Variant Present in the following documents:
View BVdb publication page



Correlation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
Torres-Cabala, Carlos A CA; Wang, Wei-Lien WL; Trent, Jonathan J; Yang, Dan D; Chen, Su S; Galbincea, John J; Kim, Kevin B KB; Woodman, Scott S; Davies, Michael M; Plaza, Jose A JA; Nash, J W JW; Prieto, Victor G VG; Lazar, Alexander J AJ; Ivan, Doina D
Publication Date: 2009-11

Variant appearance in text: N/A
PubMed Link: 19718013
Variant Present in the following documents:
View BVdb publication page