KIT c.2466T>G ;(p.N822K)

Variant ID: 4-55599340-T-G

NM_000222.2(KIT):c.2466T>G;(p.N822K)

This variant was identified in 249 publications

View GRCh38 version.




Publications:


Breaking the Mold: Epigenetics and Genomics Approaches Addressing Novel Treatments and Chemoresponse in TGCT Patients.

International Journal Of Molecular Sciences
Cuevas-Estrada, Berenice B; Montalvo-Casimiro, Michel M; Munguia-Garza, Paulina P; Ríos-Rodríguez, Juan Alberto JA; González-Barrios, Rodrigo R; Herrera, Luis A LA
Publication Date: 2023-04-26

Variant appearance in text: KIT: N822K
PubMed Link: 37175579
Variant Present in the following documents:
  • Main text
  • ijms-24-07873.pdf
View BVdb publication page



Emerging Targeted Therapeutic Strategies to Overcome Imatinib Resistance of Gastrointestinal Stromal Tumors.

International Journal Of Molecular Sciences
Masucci, Maria Teresa MT; Motti, Maria Letizia ML; Minopoli, Michele M; Di Carluccio, Gioconda G; Carriero, Maria Vincenza MV
Publication Date: 2023-03-23

Variant appearance in text: KIT: N822K
PubMed Link: 37046997
Variant Present in the following documents:
  • Main text
  • ijms-24-06026.pdf
View BVdb publication page



Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: KIT: N822K
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 4
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 2
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
View BVdb publication page



Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia.

Communications Biology
Cheng, Chi-Keung CK; Yung, Yuk-Lin YL; Chan, Hoi-Yun HY; Leung, Kam-Tong KT; Chan, Kathy Y Y KYY; Leung, Alex W K AWK; Cheng, Frankie W T FWT; Li, Chi-Kong CK; Wan, Thomas S K TSK; Luo, Xi X; Pitts, Herbert-Augustus HA; Cheung, Joyce S JS; Chan, Natalie P H NPH; Ng, Margaret H L MHL
Publication Date: 2023-03-31

Variant appearance in text: N/A
PubMed Link: 37002311
Variant Present in the following documents:
View BVdb publication page



Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST).

International Journal Of Molecular Sciences
Rassner, Michael M; Waldeck, Silvia S; Follo, Marie M; Jilg, Stefanie S; Philipp, Ulrike U; Jolic, Martina M; Wehrle, Julius J; Jost, Philipp J PJ; Peschel, Christian C; Illert, Anna Lena AL; Duyster, Justus J; Scherer, Florian F; von Bubnoff, Nikolas N
Publication Date: 2023-03-12

Variant appearance in text: KIT: N822K
PubMed Link: 36982486
Variant Present in the following documents:
  • Main text
  • ijms-24-05411.pdf
View BVdb publication page



Preclinical development and evaluation of nanobody-based CD70-specific CAR T cells for the treatment of acute myeloid leukemia.

Cancer Immunology, Immunotherapy : Cii
Cheng, Jiali J; Ge, Tong T; Zhu, Xiaojian X; Wang, Jue J; Zeng, Yuhao Y; Mu, Wei W; Cai, Haodong H; Dai, Zhenyu Z; Jin, Jin J; Yang, Yongkun Y; Hu, Guang G; Mao, Xia X; Zhou, Jianfeng J; Zhu, Li L; Huang, Liang L
Publication Date: 2023-03-17

Variant appearance in text: KIT: N822K
PubMed Link: 36932256
Variant Present in the following documents:
  • 262_2023_3422_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



RNA demethylase ALKBH5 promotes tumorigenesis of t (8;21) acute myeloid leukemia via ITPA m6A modification.

Biomarker Research
Li, Ran R; Wu, Xiaolu X; Xue, Kai K; Feng, Dandan D; Li, Jianyong J; Li, Junmin J
Publication Date: 2023-03-10

Variant appearance in text: KIT: N822K
PubMed Link: 36899424
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinicopathological and mutational characteristics of primary double mutant gastrointestinal stromal tumor: a single center study with review of the literature.

Bmc Cancer
Yan, Jiaqi J; He, Xin X; Shen, Chaoyong C; Zou, Yan Y; Chen, Huijiao H; Tang, Yuan Y
Publication Date: 2023-03-08

Variant appearance in text: KIT: N822K
PubMed Link: 36890498
Variant Present in the following documents:
  • Main text
  • 12885_2023_Article_10684.pdf
View BVdb publication page



A case report of sudden cardiac arrest and torsade de pointes induced by the second-generation tyrosine kinase inhibitor dasatinib combined with fluconazole.

Frontiers In Cardiovascular Medicine
Yuan, Yuting Y; Wang, Chunjian C; Yao, Hongying H
Publication Date: 2023

Variant appearance in text: KIT: N822K
PubMed Link: 36873392
Variant Present in the following documents:
  • Main text
  • fcvm-10-984572.pdf
View BVdb publication page



Activity of Anlotinib in the Second-Line Therapy of Metastatic Gastrointestinal Stromal Tumors: A Prospective, Multicenter, In Vitro Study.

The Oncologist
Zhou, Yongjian Y; Zeng, Chunling C; Sun, Xiaofeng X; Zhang, Jun J; Qu, Hongyan H; Zhang, Xinhua X; Zhou, Ye Y; Liu, Zimin Z; Wu, Xiaojun X; Wu, Xin X; Jiao, Xuelong X; Shen, Lin L; Zhou, Yanbing Y; Wang, Yuexiang Y; Li, Jian J
Publication Date: 2023-02-13

Variant appearance in text: KIT: N822K
PubMed Link: 36779523
Variant Present in the following documents:
  • Main text
  • oyac271.pdf
View BVdb publication page



Chinese Pedigree with Hereditary Gastrointestinal Stromal Tumors: A Case Report and Literature Review.

International Journal Of Molecular Sciences
Ge, Qichao Q; Liu, Yang Y; Yang, Fan F; Sun, Guangwei G; Guo, Jintao J; Sun, Siyu S
Publication Date: 2023-01-03

Variant appearance in text: KIT: N822K
PubMed Link: 36614290
Variant Present in the following documents:
  • Main text
  • ijms-24-00830.pdf
View BVdb publication page



Escalation of radiotherapy dose in large locally advanced drug-resistant gastrointestinal stromal tumors by multi-shell simultaneous integrated boost intensity-modulated technique: a feasibility study.

Radiation Oncology (London, England)
Cui, Haixia H; Li, Ying Y; Huang, Wei W; Lu, Wenli W; Yi, Xin X
Publication Date: 2022-12-28

Variant appearance in text: KIT: N822K
PubMed Link: 36578008
Variant Present in the following documents:
  • Main text
  • 13014_2022_Article_2179.pdf
View BVdb publication page



High efficacy of azacitidine combined with homoharringtonine, idarubicin, and cytarabine in newly diagnosed patients with AML: A single arm, phase 2 trial.

Frontiers In Oncology
Li, Jun J; Huang, Yanqing Y; Hou, Yue Y; Gu, Yan Y; Song, Chunhua C; Ge, Zheng Z
Publication Date: 2022

Variant appearance in text: KIT: 2466T>G
PubMed Link: 36568250
Variant Present in the following documents:
  • Main text
  • fonc-12-1069246.pdf
View BVdb publication page



The First Case of Acute Myeloid Leukemia With a Novel Five-way Variant Translocation of RUNX1-RUNX1T1.

Annals Of Laboratory Medicine
Jo, Yong Hun YH; Han, Eun-Ae EA; Park, Seong Kyu SK; Jeon, Byung Ryul BR; Jang, Mi-Ae MA
Publication Date: 2023-05-01

Variant appearance in text: KIT: Asn822Lys
PubMed Link: 36544347
Variant Present in the following documents:
  • alm-43-3-315.pdf
View BVdb publication page



Targeting the FGF/FGFR axis and its co-alteration allies.

Esmo Open
Uehara, Y Y; Ikeda, S S; Kim, K H KH; Lim, H J HJ; Adashek, J J JJ; Persha, H E HE; Okamura, R R; Lee, S S; Sicklick, J K JK; Kato, S S; Kurzrock, R R
Publication Date: 2022-11-28

Variant appearance in text: KIT: N822K
PubMed Link: 36455506
Variant Present in the following documents:
  • Main text
  • mmc1.pdf
View BVdb publication page



Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Cheng, Wen-Yan WY; Li, Jian-Feng JF; Zhu, Yong-Mei YM; Lin, Xiang-Jie XJ; Wen, Li-Jun LJ; Zhang, Fan F; Zhang, Yu-Liang YL; Zhao, Ming M; Fang, Hai H; Wang, Sheng-Yue SY; Lin, Xiao-Jing XJ; Qiao, Niu N; Yin, Wei W; Zhang, Jia-Nan JN; Dai, Yu-Ting YT; Jiang, Lu L; Sun, Xiao-Jian XJ; Xu, Yi Y; Zhang, Tong-Tong TT; Chen, Su-Ning SN; Zhu, Hong-Hu HH; Chen, Zhu Z; Jin, Jie J; Wu, De-Pei DP; Shen, Yang Y; Chen, Sai-Juan SJ
Publication Date: 2022-12-06

Variant appearance in text: KIT: 2466T>G; Asn822Lys
PubMed Link: 36442087
Variant Present in the following documents:
  • pnas.2211429119.sd02.xlsx, sheet 1
View BVdb publication page



Plasma Sequencing for Patients with GIST-Limitations and Opportunities in an Academic Setting.

Cancers
Falkenhorst, Johanna J; Grunewald, Susanne S; Krzeciesa, Dawid D; Herold, Thomas T; Ketzer, Julia J; Christoff, Miriam M; Hamacher, Rainer R; Kostbade, Karina K; Treckmann, Jürgen J; Köster, Johannes J; Farzaliyev, Farhad F; Fletcher, Benjamin Samulon BS; Dieckmann, Nils N; Kaths, Moritz M; Mühlenberg, Thomas T; Schildhaus, Hans-Ulrich HU; Bauer, Sebastian S
Publication Date: 2022-11-09

Variant appearance in text: KIT: N822K
PubMed Link: 36428589
Variant Present in the following documents:
  • Main text
  • cancers-14-05496.pdf
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: KIT: N822K
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM20_ESM.xlsx, sheet 3
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
  • 41467_2022_Article_34746.pdf
View BVdb publication page



Urethral Melanoma - Clinical, Pathological and Molecular Characteristics.

Bladder Cancer (Amsterdam, Netherlands)
Mano, Roy R; Hoeh, Benedikt B; DiNatale, Renzo G RG; Sanchez, Alejandro A; Benfante, Nicole E NE; Reznik, Ed E; Leitao, Mario M MM; Shoushtari, Alexander N AN; Goh, Alvin A; Donat, S Machele SM; Herr, Harry W HW; Bochner, Bernard H BH; Dalbagni, Guido G; Donahue, Timothy F TF
Publication Date: 2022

Variant appearance in text: KIT: N822K
PubMed Link: 36277327
Variant Present in the following documents:
  • Main text
  • blc-8-blc211633.pdf
View BVdb publication page



Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020.

Frontiers In Oncology
Kooijman, Jeffrey J JJ; van Riel, Wilhelmina E WE; Dylus, Jelle J; Prinsen, Martine B W MBW; Grobben, Yvonne Y; de Bitter, Tessa J J TJJ; van Doornmalen, Antoon M AM; Melis, Janneke J T M JJTM; Uitdehaag, Joost C M JCM; Narumi, Yugo Y; Kawase, Yusuke Y; de Roos, Jeroen A D M JADM; Willemsen-Seegers, Nicole N; Zaman, Guido J R GJR
Publication Date: 2022

Variant appearance in text: KIT: N822K
PubMed Link: 36185300
Variant Present in the following documents:
  • Table_4.xlsx, sheet 1
View BVdb publication page



Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.

Signal Transduction And Targeted Therapy
Yang, Yang Y; Li, Shuo S; Wang, Yujiao Y; Zhao, Yi Y; Li, Qiu Q
Publication Date: 2022-09-17

Variant appearance in text: KIT: N822K
PubMed Link: 36115852
Variant Present in the following documents:
  • Main text
  • 41392_2022_Article_1168.pdf
View BVdb publication page



Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes.

Nature Genetics
Zhou, Xueya X; Feliciano, Pamela P; Shu, Chang C; Wang, Tianyun T; Astrovskaya, Irina I; Hall, Jacob B JB; Obiajulu, Joseph U JU; Wright, Jessica R JR; Murali, Shwetha C SC; Xu, Simon Xuming SX; Brueggeman, Leo L; Thomas, Taylor R TR; Marchenko, Olena O; Fleisch, Christopher C; Barns, Sarah D SD; Snyder, LeeAnne Green LG; Han, Bing B; Chang, Timothy S TS; Turner, Tychele N TN; Harvey, William T WT; Nishida, Andrew A; O'Roak, Brian J BJ; Geschwind, Daniel H DH; , ; Michaelson, Jacob J JJ; Volfovsky, Natalia N; Eichler, Evan E EE; Shen, Yufeng Y; Chung, Wendy K WK
Publication Date: 2022-09

Variant appearance in text: KIT: 2466T>G; N822K
PubMed Link: 35982159
Variant Present in the following documents:
  • 41588_2022_1148_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine.

Blood Cancer Discovery
Wang, Han H; Chan, Kathy Yuen Yee KYY; Cheng, Chi Keung CK; Ng, Margaret H L MHL; Lee, Po Yi PY; Cheng, Frankie Wai Tsoi FWT; Lam, Grace Kee See GKS; Chow, Tin Wai TW; Ha, Shau Yin SY; Chiang, Alan K S AKS; Leung, Wing Hang WH; Leung, Anskar Y H AYH; Wang, Chi Chiu CC; Zhang, Tao T; Zhang, Xiao-Bing XB; So, Chi Chiu CC; Yuen, Yuet Ping YP; Sun, Qiwei Q; Zhang, Chi C; Xu, Yaqun Y; Cheung, John Tak Kit JTK; Ng, Wing Hei WH; Tang, Patrick Ming-Kuen PM; Kang, Wei W; To, Ka-Fai KF; Lee, Wayne Yuk Wai WYW; Wong, Raymond S M RSM; Poon, Ellen Ngar Yun ENY; Zhao, Qi Q; Huang, Junbin J; Chen, Chun C; Yuen, Patrick Man Pan PMP; Li, Chi-Kong CK; Leung, Alex Wing Kwan AWK; Leung, Kam Tong KT
Publication Date: 2022-11-02

Variant appearance in text: KIT: N822K
PubMed Link: 35960210
Variant Present in the following documents:
  • bcd-22-0011_supplementary_tables_suppst1-st15.xlsx, sheet 10
View BVdb publication page



Gastrointestinal Stromal Tumors Mimicking Gynecologic Disease: Clinicopathological Analysis of 20 Cases.

Diagnostics (Basel, Switzerland)
Liu, Ying Y; Shahi, Maryam M; Miller, Karin K; Meyer, Christian F CF; Hung, Chien-Fu CF; Wu, T-C TC; Vang, Russell R; Xing, Deyin D
Publication Date: 2022-06-27

Variant appearance in text: KIT: N822K
PubMed Link: 35885469
Variant Present in the following documents:
  • diagnostics-12-01563.pdf
View BVdb publication page



Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Publication Date: 2022-08

Variant appearance in text: KIT: N822K
PubMed Link: 35835912
Variant Present in the following documents:
  • 41588_2022_1121_MOESM3_ESM.xlsx, sheet 2
View BVdb publication page



AACR Project GENIE: 100,000 Cases and Beyond.

Cancer Discovery
Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,
Publication Date: 2022-09-02

Variant appearance in text: KIT: N822K
PubMed Link: 35819403
Variant Present in the following documents:
  • cd-21-1547_supplementary_table_1_suppst1.xlsx, sheet 1
View BVdb publication page



The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma.

Nature Communications
Vo, Josh N JN; Wu, Yi-Mi YM; Mishler, Jeanmarie J; Hall, Sarah S; Mannan, Rahul R; Wang, Lisha L; Ning, Yu Y; Zhou, Jin J; Hopkins, Alexander C AC; Estill, James C JC; Chan, Wallace K B WKB; Yesil, Jennifer J; Cao, Xuhong X; Rao, Arvind A; Tsodikov, Alexander A; Talpaz, Moshe M; Cole, Craig E CE; Ye, Jing C JC; , ; Bergsagel, P Leif PL; Auclair, Daniel D; Cho, Hearn Jay HJ; Robinson, Dan R DR; Chinnaiyan, Arul M AM
Publication Date: 2022-06-29

Variant appearance in text: KIT: 2466T>G; Asn822Lys
PubMed Link: 35768438
Variant Present in the following documents:
  • 41467_2022_31430_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Immunohistochemical Staining to Identify Concomitant Systemic Mastocytosis in Acute Myeloid Leukemia with RUNX1::RUNX1T1.

Annals Of Laboratory Medicine
Hwang, Sang Mee SM; Kim, Beom Joon BJ; Lee, Jee-Soo JS; Seong, Moon-Woo MW; Seo, Soo Hyun SH; Paik, Jin Ho JH; Kim, Sang-A SA; Lee, Ji Yun JY; Lee, Jeong-Ok JO; Chang, Yoon Hwan YH; Bang, Soo Mee SM
Publication Date: 2022-11-01

Variant appearance in text: KIT: N822K
PubMed Link: 35765876
Variant Present in the following documents:
  • alm-42-6-678.pdf
View BVdb publication page



Efficacy and safety of ripretinib in patients with KIT-altered metastatic melanoma.

Esmo Open
Janku, F F; Bauer, S S; Shoumariyeh, K K; Jones, R L RL; Spreafico, A A; Jennings, J J; Psoinos, C C; Meade, J J; Ruiz-Soto, R R; Chi, P P
Publication Date: 2022-08

Variant appearance in text: KIT: N822K
PubMed Link: 35753087
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Integrated genomic analyses of acral and mucosal melanomas nominate novel driver genes.

Genome Medicine
Wang, Meng M; Banik, Ishani I; Shain, A Hunter AH; Yeh, Iwei I; Bastian, Boris C BC
Publication Date: 2022-06-16

Variant appearance in text: N/A
PubMed Link: 35706047
Variant Present in the following documents:
View BVdb publication page



Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Publication Date: 2022-06-15

Variant appearance in text: N/A
PubMed Link: 35705558
Variant Present in the following documents:
View BVdb publication page



Molecular landscape and therapeutic alterations in Asian soft-tissue sarcoma patients.

Cancer Medicine
Gan, Meifu M; Zhang, Chen C; Qiu, Liqing L; Wang, Yue Y; Bao, Hua H; Yu, Ruoying R; Liu, Rui R; Wu, Xue X; Shao, Yang Y; Hou, Peifeng P; Fei, Zhenglei Z
Publication Date: 2022-11

Variant appearance in text: KIT: 2466T>G; N822K
PubMed Link: 35586877
Variant Present in the following documents:
  • CAM4-11-4070-s004.xlsx, sheet 1
View BVdb publication page



Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia.

International Journal Of Molecular Sciences
Katagiri, Seiichiro S; Chi, SungGi S; Minami, Yosuke Y; Fukushima, Kentaro K; Shibayama, Hirohiko H; Hosono, Naoko N; Yamauchi, Takahiro T; Morishita, Takanobu T; Kondo, Takeshi T; Yanada, Masamitsu M; Yamamoto, Kazuhito K; Kuroda, Junya J; Usuki, Kensuke K; Akahane, Daigo D; Gotoh, Akihiko A
Publication Date: 2022-04-23

Variant appearance in text: KIT: N822K
PubMed Link: 35563085
Variant Present in the following documents:
  • Main text
  • ijms-23-04694.pdf
View BVdb publication page



Molecular Portrait of GISTs Associated With Clinicopathological Features: A Retrospective Study With Molecular Analysis by a Custom 9-Gene Targeted Next-Generation Sequencing Panel.

Frontiers In Genetics
Qian, Haoran H; Yan, Na N; Hu, Xiaotong X; Jiang, Junchang J; Cao, Zhengzheng Z; Shen, Dan D
Publication Date: 2022

Variant appearance in text: KIT: N822K
PubMed Link: 35547262
Variant Present in the following documents:
  • DataSheet1.xlsx, sheet 1
View BVdb publication page



Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification.

Nature Communications
Liu, Ting T; Rao, Jianan J; Hu, Wenting W; Cui, Bowen B; Cai, Jiaoyang J; Liu, Yuhan Y; Sun, Huiying H; Chen, Xiaoxiao X; Tang, Yanjing Y; Chen, Jing J; Wang, Xiang X; Wang, Han H; Qian, Wubin W; Mao, Binchen B; Guo, Sheng S; Wang, Ronghua R; Liu, Yu Y; Shen, Shuhong S
Publication Date: 2022-03-28

Variant appearance in text: KIT: N822K
PubMed Link: 35347147
Variant Present in the following documents:
  • Main text
  • 41467_2022_29336_MOESM8_ESM.xlsx, sheet 1
  • 41467_2022_Article_29336.pdf
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: KIT: Asn822Lys
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib-induced KIT mutations in gastrointestinal stromal tumours.

Molecular Oncology
Liu, Juan J; Gao, Jingjing J; Wang, Aoli A; Jiang, Zongru Z; Qi, Shuang S; Qi, Ziping Z; Liu, Feiyang F; Yu, Kailin K; Cao, Jiangyan J; Chen, Cheng C; Hu, Chen C; Wu, Hong H; Wang, Li L; Wang, Wenchao W; Liu, Qingsong Q; Liu, Jing J
Publication Date: 2022-04

Variant appearance in text: KIT: N822K
PubMed Link: 35194937
Variant Present in the following documents:
  • Main text
  • MOL2-16-1761.pdf
View BVdb publication page



Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.

Blood Cancer Discovery
Umeda, Masayuki M; Ma, Jing J; Huang, Benjamin J BJ; Hagiwara, Kohei K; Westover, Tamara T; Abdelhamed, Sherif S; Barajas, Juan M JM; Thomas, Melvin E ME; Walsh, Michael P MP; Song, Guangchun G; Tian, Liqing L; Liu, Yanling Y; Chen, Xiaolong X; Kolekar, Pandurang P; Tran, Quang Q; Foy, Scott G SG; Maciaszek, Jamie L JL; Kleist, Andrew B AB; Leonti, Amanda R AR; Ju, Bengsheng B; Easton, John J; Wu, Huiyun H; Valentine, Virginia V; Valentine, Marcus B MB; Liu, Yen-Chun YC; Ries, Rhonda E RE; Smith, Jenny L JL; Parganas, Evan E; Iacobucci, Ilaria I; Hiltenbrand, Ryan R; Miller, Jonathan J; Myers, Jason R JR; Rampersaud, Evadnie E; Rahbarinia, Delaram D; Rusch, Michael M; Wu, Gang G; Inaba, Hiroto H; Wang, Yi-Cheng YC; Alonzo, Todd A TA; Downing, James R JR; Mullighan, Charles G CG; Pounds, Stanley S; Babu, M Madan MM; Zhang, Jinghui J; Rubnitz, Jeffrey E JE; Meshinchi, Soheil S; Ma, Xiaotu X; Klco, Jeffery M JM
Publication Date: 2022-05-05

Variant appearance in text: KIT: N822K
PubMed Link: 35176137
Variant Present in the following documents:
  • bcd-21-0160_supplemental_tables_supp1-32.xlsx, sheet 18
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Mutational profiling of melanomas in patients from the southeast coast of China.

Translational Cancer Research
Zheng, Ai-Wen AW; Jia, Dong-Dong DD; Zhou, Cheng-Cheng CC; Li, Tao T
Publication Date: 2020-08

Variant appearance in text: KIT: N822K
PubMed Link: 35117841
Variant Present in the following documents:
  • Main text
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Current treatment strategies and future perspectives for gastrointestinal stromal tumors.

World Journal Of Gastrointestinal Pathophysiology
Sugiyama, Yoichi Y; Sasaki, Masaru M; Kouyama, Mohei M; Tazaki, Tatsuya T; Takahashi, Shinya S; Nakamitsu, Atsushi A
Publication Date: 2022-01-22

Variant appearance in text: KIT: Asn822Lys
PubMed Link: 35116177
Variant Present in the following documents:
  • Main text
  • WJGP-13-15.pdf
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Preclinical model-based evaluation of Imatinib resistance induced by KIT mutations and its overcoming strategies in gastrointestinal stromal tumor (GIST).

American Journal Of Translational Research
Zhao, Qian Q; Zhang, Cheng C; Qi, Changsong C; Yang, Jing J; Chen, Yang Y; Ge, Sai S; Shen, Lin L; Gao, Jing J; Li, Jian J
Publication Date: 2021

Variant appearance in text: KIT: N822K
PubMed Link: 35035701
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Selective Inhibition of HDAC Class I Sensitizes Leukemia and Neuroblastoma Cells to Anticancer Drugs.

Biomedicines
Vagapova, Elmira E; Kozlov, Maxim M; Lebedev, Timofey T; Ivanenko, Karina K; Leonova, Olga O; Popenko, Vladimir V; Spirin, Pavel P; Kochetkov, Sergey S; Prassolov, Vladimir V
Publication Date: 2021-12-06

Variant appearance in text: KIT: N822K
PubMed Link: 34944663
Variant Present in the following documents:
  • Main text
  • biomedicines-09-01846.pdf
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Selective Inhibition of HDAC Class I Sensitizes Leukemia and Neuroblastoma Cells to Anticancer Drugs.

Biomedicines
Vagapova, Elmira E; Kozlov, Maxim M; Lebedev, Timofey T; Ivanenko, Karina K; Leonova, Olga O; Popenko, Vladimir V; Spirin, Pavel P; Kochetkov, Sergey S; Prassolov, Vladimir V
Publication Date: 2021-12-06

Variant appearance in text: KIT: N822K
PubMed Link: 34944663
Variant Present in the following documents:
  • Main text
  • biomedicines-09-01846.pdf
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