Publications:

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Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.

Nature Communications

González, Lorena L; Díaz, Lucía L; Pous, Joan J; Baginski, Blazej B; Duran-Corbera, Anna A; Scarpa, Margherita M; Brun-Heath, Isabelle I; Igea, Ana A; Martin-Malpartida, Pau P; Ruiz, Lidia L; Pallara, Chiara C; Esguerra, Mauricio M; Colizzi, Francesco F; Mayor-Ruiz, Cristina C; Biondi, Ricardo M RM; Soliva, Robert R; Macias, Maria J MJ; Orozco, Modesto M; Nebreda, Angel R AR

Publication Date: 2023-06-12

Variant appearance in text: KIT: A829P

PubMed Link: 37308482

Variant Present in the following documents:

• 41467_2023_39051_MOESM3_ESM.xlsx, sheet 5

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Emerging Targeted Therapeutic Strategies to Overcome Imatinib Resistance of Gastrointestinal Stromal Tumors.

International Journal Of Molecular Sciences

Masucci, Maria Teresa MT; Motti, Maria Letizia ML; Minopoli, Michele M; Di Carluccio, Gioconda G; Carriero, Maria Vincenza MV

Publication Date: 2023-03-23

Variant appearance in text: KIT: A829P

PubMed Link: 37046997

Variant Present in the following documents:

• Main text
• ijms-24-06026.pdf

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Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Journal Of Medicinal Chemistry

Harnden, Alice C AC; Davis, Owen A OA; Box, Gary M GM; Hayes, Angela A; Johnson, Louise D LD; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Valenti, Melanie M; Cheung, Kwai-Ming J KJ; Brennan, Alfie A; Huckvale, Rosemary R; Pierrat, Olivier A OA; Talbot, Rachel R; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; de Klerk, Selby S; McAndrew, Peter Craig PC; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S

Publication Date: 2023-04-07

Variant appearance in text: KIT: A829P

PubMed Link: 37026591

Variant Present in the following documents:

• jm3c00155_si_002.xlsx, sheet 2

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Somatic mutation detection and KRAS amplification in testicular germ cell tumors.

Frontiers In Oncology

Cabral, Eduardo R M ERM; Pacanhella, Marilia F MF; Lengert, Andre V H AVH; Dos Reis, Mariana B MB; Leal, Leticia F LF; de Lima, Marcos A MA; da Silva, Aline L V ALV; Pinto, Icaro A IA; Reis, Rui M RM; Pinto, Mariana T MT; Cárcano, Flavio M FM

Publication Date: 2023

Variant appearance in text: KIT: A829P

PubMed Link: 37007070

Variant Present in the following documents:

• Main text
• fonc-13-1133363.pdf

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Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.

Acs Chemical Biology

Tredup, Claudia C; Ndreshkjana, Benardina B; Schneider, Natalie S NS; Tjaden, Amelie A; Kemas, Aurino M AM; Youhanna, Sonia S; Lauschke, Volker M VM; Berger, Benedict-Tilman BT; Krämer, Andreas A; Berger, Lena M LM; Röhm, Sandra S; Knapp, Stefan S; Farin, Henner F HF; Müller, Susanne S

Publication Date: 2023-03-21

Variant appearance in text: KIT: A829P

PubMed Link: 36944371

Variant Present in the following documents:

• cb2c00877_si_004.xlsx, sheet 1

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Genomics-Driven Precision Medicine in Pediatric Solid Tumors.

Cancers

Suthapot, Praewa P; Chiangjong, Wararat W; Chaiyawat, Parunya P; Choochuen, Pongsakorn P; Pruksakorn, Dumnoensun D; Sangkhathat, Surasak S; Hongeng, Suradej S; Anurathapan, Usanarat U; Chutipongtanate, Somchai S

Publication Date: 2023-02-23

Variant appearance in text: KIT: A829P

PubMed Link: 36900212

Variant Present in the following documents:

• Main text

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Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics.

Plos One

Kozaki, Ryohei R; Yasuhiro, Tomoko T; Kato, Hikaru H; Murai, Jun J; Hotta, Shingo S; Ariza, Yuko Y; Sakai, Shunsuke S; Fujikawa, Ryu R; Yoshida, Takao T

Publication Date: 2023

Variant appearance in text: KIT: A829P

PubMed Link: 36897912

Variant Present in the following documents:

• pone.0282166.s009.xlsx, sheet 1

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Activity of Anlotinib in the Second-Line Therapy of Metastatic Gastrointestinal Stromal Tumors: A Prospective, Multicenter, In Vitro Study.

The Oncologist

Zhou, Yongjian Y; Zeng, Chunling C; Sun, Xiaofeng X; Zhang, Jun J; Qu, Hongyan H; Zhang, Xinhua X; Zhou, Ye Y; Liu, Zimin Z; Wu, Xiaojun X; Wu, Xin X; Jiao, Xuelong X; Shen, Lin L; Zhou, Yanbing Y; Wang, Yuexiang Y; Li, Jian J

Publication Date: 2023-02-13

Variant appearance in text: KIT: A829P

PubMed Link: 36779523

Variant Present in the following documents:

• Main text
• oyac271.pdf

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Chinese Pedigree with Hereditary Gastrointestinal Stromal Tumors: A Case Report and Literature Review.

International Journal Of Molecular Sciences

Ge, Qichao Q; Liu, Yang Y; Yang, Fan F; Sun, Guangwei G; Guo, Jintao J; Sun, Siyu S

Publication Date: 2023-01-03

Variant appearance in text: KIT: A829P

PubMed Link: 36614290

Variant Present in the following documents:

• Main text
• ijms-24-00830.pdf

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VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia.

Leukemia

Sher, Steven S; Whipp, Ethan E; Walker, Janek J; Zhang, Pu P; Beaver, Larry L; Williams, Katie K; Orwick, Shelley S; Ravikrishnan, Janani J; Walker, Brandi B; Perry, Elizabeth E; Gregory, Charles C; Purcell, Matthew M; Pan, Alexander A; Yan, Pearlly P; Alinari, Lapo L; Johnson, Amy J AJ; Frigault, Melanie M MM; Greer, Joy M JM; Hamdy, Ahmed A; Izumi, Raquel R; Mo, Xiaokui X; Sampath, Deepa D; Woyach, Jennifer J; Blachly, James J; Byrd, John C JC; Lapalombella, Rosa R

Publication Date: 2022-11-14

Variant appearance in text: KIT: A829P

PubMed Link: 36376377

Variant Present in the following documents:

• 41375_2022_1758_MOESM2_ESM.xlsx, sheet 1

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Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.

Signal Transduction And Targeted Therapy

Yang, Yang Y; Li, Shuo S; Wang, Yujiao Y; Zhao, Yi Y; Li, Qiu Q

Publication Date: 2022-09-17

Variant appearance in text: KIT: A829P

PubMed Link: 36115852

Variant Present in the following documents:

• Main text
• 41392_2022_Article_1168.pdf

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Designing Novel BCR-ABL Inhibitors for Chronic Myeloid Leukemia with Improved Cardiac Safety.

Journal Of Medicinal Chemistry

Pandrala, Mallesh M; Bruyneel, Arne Antoon N AAN; Hnatiuk, Anna P AP; Mercola, Mark M; Malhotra, Sanjay V SV

Publication Date: 2022-08-25

Variant appearance in text: KIT: A829P

PubMed Link: 35944901

Variant Present in the following documents:

• jm1c01853_si_003.xlsx, sheet 1

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AACR Project GENIE: 100,000 Cases and Beyond.

Cancer Discovery

Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,

Publication Date: 2022-09-02

Variant appearance in text: KIT: A829P

PubMed Link: 35819403

Variant Present in the following documents:

• cd-21-1547_supplementary_table_1_suppst1.xlsx, sheet 1

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Reengineering Ponatinib to Minimize Cardiovascular Toxicity.

Cancer Research

Hnatiuk, Anna P AP; Bruyneel, Arne A N AAN; Tailor, Dhanir D; Pandrala, Mallesh M; Dheeraj, Arpit A; Li, Wenqi W; Serrano, Ricardo R; Feyen, Dries A M DAM; Vu, Michelle M MM; Amatya, Prashila P; Gupta, Saloni S; Nakauchi, Yusuke Y; Morgado, Isabel I; Wiebking, Volker V; Liao, Ronglih R; Porteus, Matthew H MH; Majeti, Ravindra R; Malhotra, Sanjay V SV; Mercola, Mark M

Publication Date: 2022-08-03

Variant appearance in text: KIT: A829P

PubMed Link: 35763671

Variant Present in the following documents:

• can-21-3652_supplementary_table_s1_suppst1.xls, sheet 2

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Efficacy and safety of ripretinib in patients with KIT-altered metastatic melanoma.

Esmo Open

Janku, F F; Bauer, S S; Shoumariyeh, K K; Jones, R L RL; Spreafico, A A; Jennings, J J; Psoinos, C C; Meade, J J; Ruiz-Soto, R R; Chi, P P

Publication Date: 2022-08

Variant appearance in text: KIT: A829P

PubMed Link: 35753087

Variant Present in the following documents:

• Main text
• main.pdf

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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications

Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX

Publication Date: 2022-06-15

Variant appearance in text: KIT: A829P

PubMed Link: 35705558

Variant Present in the following documents:

• 41467_2022_30496_MOESM2_ESM.xls, sheet 1

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Design and biological evaluation of substituted 5,7-dihydro-6H-indolo[2,3-c]quinolin-6-one as novel selective Haspin inhibitors.

Journal Of Enzyme Inhibition And Medicinal Chemistry

Avula, Sreenivas S; Peng, Xudan X; Lang, Xingfen X; Tortorella, Micky M; Josselin, Béatrice B; Bach, Stéphane S; Bourg, Stephane S; Bonnet, Pascal P; Buron, Frédéric F; Ruchaud, Sandrine S; Routier, Sylvain S; Neagoie, Cleopatra C

Publication Date: 2022-12

Variant appearance in text: KIT: A829P

PubMed Link: 35670091

Variant Present in the following documents:

• IENZ_A_2082419_SM0502.pdf

View BVdb publication page

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Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.

Journal Of Medicinal Chemistry

Huckvale, Rosemary R; Harnden, Alice C AC; Cheung, Kwai-Ming J KJ; Pierrat, Olivier A OA; Talbot, Rachel R; Box, Gary M GM; Henley, Alan T AT; de Haven Brandon, Alexis K AK; Hallsworth, Albert E AE; Bright, Michael D MD; Akpinar, Hafize Aysin HA; Miller, Daniel S J DSJ; Tarantino, Dalia D; Gowan, Sharon S; Hayes, Angela A; Gunnell, Emma A EA; Brennan, Alfie A; Davis, Owen A OA; Johnson, Louise D LD; de Klerk, Selby S; McAndrew, Craig C; Le Bihan, Yann-Vaï YV; Meniconi, Mirco M; Burke, Rosemary R; Kirkin, Vladimir V; van Montfort, Rob L M RLM; Raynaud, Florence I FI; Rossanese, Olivia W OW; Bellenie, Benjamin R BR; Hoelder, Swen S

Publication Date: 2022-06-23

Variant appearance in text: KIT: A829P

PubMed Link: 35653645

Variant Present in the following documents:

• jm1c02175_si_002.xlsx, sheet 2

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Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.

Acs Infectious Diseases

Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S

Publication Date: 2022-06-10

Variant appearance in text: KIT: A829P

PubMed Link: 35609344

Variant Present in the following documents:

• id2c00091_si_001.pdf

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CancerVar: An artificial intelligence-empowered platform for clinical interpretation of somatic mutations in cancer.

Science Advances

Li, Quan Q; Ren, Zilin Z; Cao, Kajia K; Li, Marilyn M MM; Wang, Kai K; Zhou, Yunyun Y

Publication Date: 2022-05-06

Variant appearance in text: KIT: A829P

PubMed Link: 35544644

Variant Present in the following documents:

• Main text

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Circulating Tumor DNA Mutations in Progressive Gastrointestinal Stromal Tumors Identify Biomarkers of Treatment Resistance and Uncover Potential Therapeutic Strategies.

Frontiers In Oncology

Ko, Tun Kiat TK; Lee, Elizabeth E; Ng, Cedric Chuan-Young CC; Yang, Valerie Shiwen VS; Farid, Mohamad M; Teh, Bin Tean BT; Chan, Jason Yongsheng JY; Somasundaram, Nagavalli N

Publication Date: 2022

Variant appearance in text: KIT: 2485G>C

PubMed Link: 35273917

Variant Present in the following documents:

• Main text
• fonc-12-840843.pdf

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: KIT: A829P

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12
• PCMR-35-369-s002.pdf

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: KIT: Ala829Pro

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib-induced KIT mutations in gastrointestinal stromal tumours.

Molecular Oncology

Liu, Juan J; Gao, Jingjing J; Wang, Aoli A; Jiang, Zongru Z; Qi, Shuang S; Qi, Ziping Z; Liu, Feiyang F; Yu, Kailin K; Cao, Jiangyan J; Chen, Cheng C; Hu, Chen C; Wu, Hong H; Wang, Li L; Wang, Wenchao W; Liu, Qingsong Q; Liu, Jing J

Publication Date: 2022-04

Variant appearance in text: KIT: A829P

PubMed Link: 35194937

Variant Present in the following documents:

• Main text
• MOL2-16-1761.pdf

View BVdb publication page

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Anorectal and Genital Mucosal Melanoma: Diagnostic Challenges, Current Knowledge and Therapeutic Opportunities of Rare Melanomas.

Biomedicines

Ottaviano, Margaret M; Giunta, Emilio Francesco EF; Marandino, Laura L; Tortora, Marianna M; Attademo, Laura L; Bosso, Davide D; Cardalesi, Cinzia C; Fabbrocini, Antonietta A; Rosanova, Mario M; Silvestri, Antonia A; Montella, Liliana L; Tammaro, Pasquale P; Marra, Ester E; Trojaniello, Claudia C; Vitale, Maria Grazia MG; Simeone, Ester E; Troiani, Teresa T; Daniele, Bruno B; Ascierto, Paolo Antonio PA

Publication Date: 2022-01-11

Variant appearance in text: KIT: A829P

PubMed Link: 35052829

Variant Present in the following documents:

• Main text
• biomedicines-10-00150.pdf

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Anorectal and Genital Mucosal Melanoma: Diagnostic Challenges, Current Knowledge and Therapeutic Opportunities of Rare Melanomas.

Biomedicines

Ottaviano, Margaret M; Giunta, Emilio Francesco EF; Marandino, Laura L; Tortora, Marianna M; Attademo, Laura L; Bosso, Davide D; Cardalesi, Cinzia C; Fabbrocini, Antonietta A; Rosanova, Mario M; Silvestri, Antonia A; Montella, Liliana L; Tammaro, Pasquale P; Marra, Ester E; Trojaniello, Claudia C; Vitale, Maria Grazia MG; Simeone, Ester E; Troiani, Teresa T; Daniele, Bruno B; Ascierto, Paolo Antonio PA

Publication Date: 2022-01-11

Variant appearance in text: KIT: A829P

PubMed Link: 35052829

Variant Present in the following documents:

• Main text
• biomedicines-10-00150.pdf

View BVdb publication page

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Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms.

Nature Cancer

Lehtiö, Janne J; Arslan, Taner T; Siavelis, Ioannis I; Pan, Yanbo Y; Socciarelli, Fabio F; Berkovska, Olena O; Umer, Husen M HM; Mermelekas, Georgios G; Pirmoradian, Mohammad M; Jönsson, Mats M; Brunnström, Hans H; Brustugun, Odd Terje OT; Purohit, Krishna Pinganksha KP; Cunningham, Richard R; Foroughi Asl, Hassan H; Isaksson, Sofi S; Arbajian, Elsa E; Aine, Mattias M; Karlsson, Anna A; Kotevska, Marija M; Gram Hansen, Carsten C; Drageset Haakensen, Vilde V; Helland, Åslaug Å; Tamborero, David D; Johansson, Henrik J HJ; Branca, Rui M RM; Planck, Maria M; Staaf, Johan J; Orre, Lukas M LM

Publication Date: 2021-11

Variant appearance in text: KIT: 2485G>C; Ala829Pro

PubMed Link: 34870237

Variant Present in the following documents:

• EMS133264-supplement-Supplementary_Tables.xlsx, sheet 9

View BVdb publication page

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Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells.

Cell Death & Disease

Meng, Ya Y; Song, Chengcheng C; Ren, Zhili Z; Li, Xiaohong X; Yang, Xiangyu X; Ai, Nana N; Yang, Yang Y; Wang, Dongjin D; Zhan, Meixiao M; Wang, Jiaxian J; Lei, Chon Lok CL; Liu, Weiwei W; Ge, Wei W; Lu, Ligong L; Chen, Guokai G

Publication Date: 2021-11-29

Variant appearance in text: KIT: A829P

PubMed Link: 34845199

Variant Present in the following documents:

• 41419_2021_4395_MOESM9_ESM.xlsx, sheet 1

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: KIT: A829P

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor.

Cancers

Kozinova, Marya M; Joshi, Shalina S; Ye, Shuai S; Belinsky, Martin G MG; Sharipova, Dinara D; Farma, Jeffrey M JM; Reddy, Sanjay S SS; Litwin, Samuel S; Devarajan, Karthik K; Campos, Alex Rosa AR; Yu, Yi Y; Schwartz, Brian B; von Mehren, Margaret M; Rink, Lori L

Publication Date: 2021-07-23

Variant appearance in text: KIT: A829P

PubMed Link: 34359600

Variant Present in the following documents:

• Main text
• cancers-13-03699.pdf

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Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy.

Frontiers In Oncology

Ma, Yanni Y; Xia, Ronghui R; Ma, Xuhui X; Judson-Torres, Robert L RL; Zeng, Hanlin H

Publication Date: 2021

Variant appearance in text: KIT: A829P

PubMed Link: 34350118

Variant Present in the following documents:

• Main text
• fonc-11-702287.pdf

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Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.

Journal Of Medicinal Chemistry

Henderson, Scott H SH; Sorrell, Fiona F; Bennett, James J; Fedorov, Oleg O; Hanley, Marcus T MT; Godoi, Paulo H PH; Ruela de Sousa, Roberta R; Robinson, Sean S; Ashall-Kelly, Alexander A; Hopkins Navratilova, Iva I; Walter, Daryl S DS; Elkins, Jonathan M JM; Ward, Simon E SE

Publication Date: 2021-08-12

Variant appearance in text: KIT: A829P

PubMed Link: 34342227

Variant Present in the following documents:

• jm1c01115_si_002.xlsx, sheet 5
• jm1c01115_si_002.xlsx, sheet 7
• jm1c01115_si_002.xlsx, sheet 3
• jm1c01115_si_002.xlsx, sheet 13
• jm1c01115_si_002.xlsx, sheet 6
• jm1c01115_si_002.xlsx, sheet 8
• jm1c01115_si_002.xlsx, sheet 14
• jm1c01115_si_002.xlsx, sheet 4
• jm1c01115_si_002.xlsx, sheet 9
• jm1c01115_si_002.xlsx, sheet 11
• jm1c01115_si_002.xlsx, sheet 2
• jm1c01115_si_002.xlsx, sheet 12
• jm1c01115_si_002.xlsx, sheet 1

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Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function.

Cell Reports

Schiapparelli, Paula P; Pirman, Natasha L NL; Mohler, Kyle K; Miranda-Herrera, Pierre A PA; Zarco, Natanael N; Kilic, Onur O; Miller, Chad C; Shah, Sagar R SR; Rogulina, Svetlana S; Hungerford, William W; Abriola, Laura L; Hoyer, Denton D; Turk, Benjamin E BE; Guerrero-Cázares, Hugo H; Isaacs, Farren J FJ; Quiñones-Hinojosa, Alfredo A; Levchenko, Andre A; Rinehart, Jesse J

Publication Date: 2021-07-20

Variant appearance in text: KIT: A829P

PubMed Link: 34289367

Variant Present in the following documents:

• NIHMS1726840-supplement-2.xlsx, sheet 1

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Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.

Journal Of Medicinal Chemistry

Eduful, Benjamin J BJ; O'Byrne, Sean N SN; Temme, Louisa L; Asquith, Christopher R M CRM; Liang, Yi Y; Picado, Alfredo A; Pilotte, Joseph R JR; Hossain, Mohammad Anwar MA; Wells, Carrow I CI; Zuercher, William J WJ; Catta-Preta, Carolina M C CMC; Zonzini Ramos, Priscila P; Santiago, André de S AS; Couñago, Rafael M RM; Langendorf, Christopher G CG; Nay, Kévin K; Oakhill, Jonathan S JS; Pulliam, Thomas L TL; Lin, Chenchu C; Awad, Dominik D; Willson, Timothy M TM; Frigo, Daniel E DE; Scott, John W JW; Drewry, David H DH

Publication Date: 2021-08-12

Variant appearance in text: KIT: A829P

PubMed Link: 34264658

Variant Present in the following documents:

• jm0c02274_si_003.xlsx, sheet 1

View BVdb publication page

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Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions.

Investigative Ophthalmology & Visual Science

Wen, Yao-Tseng YT; Huang, Ching-Wen CW; Liu, Chih-Peng CP; Chen, Chih-Hung CH; Tu, Chia-Mu CM; Hwang, Chrong-Shiong CS; Chen, Yi-Hsun YH; Chen, Wan-Ru WR; Lin, Keh-Liang KL; Ho, Yu-Chieh YC; Chen, Ta-Ching TC; Tsai, Rong-Kung RK

Publication Date: 2021-05-03

Variant appearance in text: KIT: A829P

PubMed Link: 34015079

Variant Present in the following documents:

• iovs-62-6-21_s002.pdf

View BVdb publication page

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RTK Inhibitors in Melanoma: From Bench to Bedside.

Cancers

Sabbah, Malak M; Najem, Ahmad A; Krayem, Mohammad M; Awada, Ahmad A; Journe, Fabrice F; Ghanem, Ghanem E GE

Publication Date: 2021-04-02

Variant appearance in text: KIT: A829P

PubMed Link: 33918490

Variant Present in the following documents:

• Main text

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Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications

Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L

Publication Date: 2021-04-19

Variant appearance in text: KIT: A829P

PubMed Link: 33875650

Variant Present in the following documents:

• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1
• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 5
• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 6

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Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors.

Jama Oncology

Cobain, Erin F EF; Wu, Yi-Mi YM; Vats, Pankaj P; Chugh, Rashmi R; Worden, Francis F; Smith, David C DC; Schuetze, Scott M SM; Zalupski, Mark M MM; Sahai, Vaibhav V; Alva, Ajjai A; Schott, Anne F AF; Caram, Megan E V MEV; Hayes, Daniel F DF; Stoffel, Elena M EM; Jacobs, Michelle F MF; Kumar-Sinha, Chandan C; Cao, Xuhong X; Wang, Rui R; Lucas, David D; Ning, Yu Y; Rabban, Erica E; Bell, Janice J; Camelo-Piragua, Sandra S; Udager, Aaron M AM; Cieslik, Marcin M; Lonigro, Robert J RJ; Kunju, Lakshmi P LP; Robinson, Dan R DR; Talpaz, Moshe M; Chinnaiyan, Arul M AM

Publication Date: 2021-04-01

Variant appearance in text: KIT: A829P

PubMed Link: 33630025

Variant Present in the following documents:

• jamaoncol-e207987-s004.xlsx, sheet 2

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A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement.

Nature Communications

Zhang, Yiqun Y; Chen, Fengju F; Donehower, Lawrence A LA; Scheurer, Michael E ME; Creighton, Chad J CJ

Publication Date: 2021-02-10

Variant appearance in text: KIT: 2485G>C; Ala829Pro; rs1057519713

PubMed Link: 33568653

Variant Present in the following documents:

• 41467_2021_21081_MOESM8_ESM.xlsx, sheet 3

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: KIT: 2485G>C; A829P

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

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Sunitinib-Containing Carborane Pharmacophore with the Ability to Inhibit Tyrosine Kinases Receptors FLT3, KIT and PDGFR-β, Exhibits Powerful In Vivo Anti-Glioblastoma Activity.

Cancers

Alamón, Catalina C; Dávila, Belén B; García, María Fernanda MF; Sánchez, Carina C; Kovacs, Mariángeles M; Trias, Emiliano E; Barbeito, Luis L; Gabay, Martín M; Zeineh, Nidal N; Gavish, Moshe M; Teixidor, Francesc F; Viñas, Clara C; Couto, Marcos M; Cerecetto, Hugo H

Publication Date: 2020-11-18

Variant appearance in text: KIT: A829P

PubMed Link: 33218150

Variant Present in the following documents:

• cancers-12-03423-s001.pdf

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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology

Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S

Publication Date: 2020

Variant appearance in text: KIT: A829P

PubMed Link: 33133066

Variant Present in the following documents:

• Table_1.xlsx, sheet 8
• Table_2.xlsx, sheet 1
• Table_6.xlsx, sheet 9
• Table_1.xlsx, sheet 4
• Table_2.xlsx, sheet 7
• Table_6.xlsx, sheet 4
• Table_2.xlsx, sheet 2

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Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types.

Genome Medicine

Bao, Riyue R; Stapor, Daniel D; Luke, Jason J JJ

Publication Date: 2020-10-27

Variant appearance in text: KIT: A829P

PubMed Link: 33106165

Variant Present in the following documents:

• 13073_2020_787_MOESM1_ESM.xlsx, sheet 9

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Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies.

Peerj

Prieto-Potin, Iván I; Carvajal, Nerea N; Plaza-Sánchez, Jenifer J; Manso, Rebeca R; Aúz-Alexandre, Carmen Laura CL; Chamizo, Cristina C; Zazo, Sandra S; López-Sánchez, Almudena A; Rodríguez-Pinilla, Socorro María SM; Camacho, Laura L; Longarón, Raquel R; Bellosillo, Beatriz B; Somoza, Rosa R; Hernández-Losa, Javier J; Fernández-Soria, Víctor Manuel VM; Ramos-Ruiz, Ricardo R; Cristóbal, Ion I; García-Foncillas, Jesús J; Rojo, Federico F

Publication Date: 2020

Variant appearance in text: KIT: 2485G>C; Ala829Pro

PubMed Link: 33083132

Variant Present in the following documents:

• peerj-08-10069-s009.xlsx, sheet 1
• peerj-08-10069-s013.xlsx, sheet 1
• peerj-08-10069-s012.xlsx, sheet 1
• peerj-08-10069-s010.xlsx, sheet 1

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Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports

Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O

Publication Date: 2020-10-13

Variant appearance in text: rs1057519713

PubMed Link: 33051506

Variant Present in the following documents:

• 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: KIT: A829P

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

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Discovery of a highly potent and selective Bruton's tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma.

Signal Transduction And Targeted Therapy

Liu, Juan J; Liang, Qianmao Q; Wang, Aoli A; Zou, Fengming F; Qi, Ziping Z; Yu, Kailin K; Liu, Qingwang Q; Chen, Cheng C; Liu, Jing J; Liu, Qingsong Q

Publication Date: 2020-09-14

Variant appearance in text: KIT: A829P

PubMed Link: 32929063

Variant Present in the following documents:

• 41392_2020_309_MOESM2_ESM.xlsx, sheet 1

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Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy.

Iscience

Singh, Vibha V; Bhoir, Siddhant S; Chikhale, Rupesh V RV; Hussain, Javeena J; Dwyer, Donard D; Bryce, Richard A RA; Kirubakaran, Sivapriya S; De Benedetti, Arrigo A

Publication Date: 2020-08-20

Variant appearance in text: KIT: A829P

PubMed Link: 32905878

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

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