KDR c.3641A>T ;(p.Y1214F)

Variant ID: 4-55953795-T-A

NM_002253.2(KDR):c.3641A>T;(p.Y1214F)

This variant was identified in 10 publications

View GRCh38 version.




Publications:


Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB.

Cells
Pietilä, Ilkka I; Van Mourik, Djenolan D; Tamelander, Andreas A; Kriz, Vitezslav V; Claesson-Welsh, Lena L; Tengholm, Anders A; Welsh, Michael M
Publication Date: 2019-12-15

Variant appearance in text: VEGFR2: Y1214F
PubMed Link: 31847469
Variant Present in the following documents:
  • Main text
  • cells-08-01645.pdf
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Comparison of the ligand-binding properties of fluorescent VEGF-A isoforms to VEGF receptor 2 in living cells and membrane preparations using NanoBRET.

British Journal Of Pharmacology
Peach, Chloe J CJ; Kilpatrick, Laura E LE; Woolard, Jeanette J; Hill, Stephen J SJ
Publication Date: 2019-09

Variant appearance in text: VEGFR2: Y1214F
PubMed Link: 31162634
Variant Present in the following documents:
  • Main text
  • BPH-176-3220.pdf
View BVdb publication page



VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis.

Biology Open
Fearnley, Gareth W GW; Smith, Gina A GA; Abdul-Zani, Izma I; Yuldasheva, Nadira N; Mughal, Nadeem A NA; Homer-Vanniasinkam, Shervanthi S; Kearney, Mark T MT; Zachary, Ian C IC; Tomlinson, Darren C DC; Harrison, Michael A MA; Wheatcroft, Stephen B SB; Ponnambalam, Sreenivasan S
Publication Date: 2016-05-15

Variant appearance in text: VEGFR2: Y1214F
PubMed Link: 27044325
Variant Present in the following documents:
  • Main text
  • biolopen-5-017434.pdf
View BVdb publication page



Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model.

Plos Computational Biology
Clegg, Lindsay Wendel LW; Mac Gabhann, Feilim F
Publication Date: 2015-06

Variant appearance in text: VEGFR2: Y1214F
PubMed Link: 26067165
Variant Present in the following documents:
  • Main text
  • pcbi.1004158.pdf
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VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.

The Journal Of Experimental Medicine
Sun, Zuyue Z; Li, Xiujuan X; Massena, Sara S; Kutschera, Simone S; Padhan, Narendra N; Gualandi, Laura L; Sundvold-Gjerstad, Vibeke V; Gustafsson, Karin K; Choy, Wing Wen WW; Zang, Guangxiang G; Quach, My M; Jansson, Leif L; Phillipson, Mia M; Abid, Md Ruhul MR; Spurkland, Anne A; Claesson-Welsh, Lena L
Publication Date: 2012-07-02

Variant appearance in text: VEGFR2: Y1214F
PubMed Link: 22689825
Variant Present in the following documents:
  • Main text
  • JEM_20111343.pdf
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Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells.

The Journal Of Biological Chemistry
Daher, Zeinab Z; Boulay, Pierre-Luc PL; Desjardins, Fanny F; Gratton, Jean-Philippe JP; Claing, Audrey A
Publication Date: 2010-08-06

Variant appearance in text: VEGFR: Y1214F
PubMed Link: 20529868
Variant Present in the following documents:
  • Main text
View BVdb publication page



Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells.

The Journal Of Cell Biology
Chen, Tom T TT; Luque, Alfonso A; Lee, Sunyoung S; Anderson, Sean M SM; Segura, Tatiana T; Iruela-Arispe, M Luisa ML
Publication Date: 2010-02-22

Variant appearance in text: VEGFR2: Y1214F
PubMed Link: 20176926
Variant Present in the following documents:
  • Main text
  • JCB_200906044.pdf
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Vascular endothelial growth factor (VEGF) receptor-2 tyrosine 1175 signaling controls VEGF-induced von Willebrand factor release from endothelial cells via phospholipase C-gamma 1- and protein kinase A-dependent pathways.

The Journal Of Biological Chemistry
Xiong, Yan Y; Huo, Yingqing Y; Chen, Chao C; Zeng, Huiyan H; Lu, Xiaofan X; Wei, Chaoliang C; Ruan, Changgeng C; Zhang, Xiaoyu X; Hu, Zhenqian Z; Shibuya, Masabumi M; Luo, Jincai J
Publication Date: 2009-08-28

Variant appearance in text: VEGFR2: Y1214F
PubMed Link: 19570985
Variant Present in the following documents:
  • Main text
View BVdb publication page



New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.

Molecular And Cellular Biology
Chabot, Catherine C; Spring, Kathleen K; Gratton, Jean-Philippe JP; Elchebly, Mounib M; Royal, Isabelle I
Publication Date: 2009-01

Variant appearance in text: VEGFR2: Y1214F
PubMed Link: 18936167
Variant Present in the following documents:
  • Main text
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A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.

The Embo Journal
Takahashi, T T; Yamaguchi, S S; Chida, K K; Shibuya, M M
Publication Date: 2001-06-01

Variant appearance in text: KDR: Y1214F
PubMed Link: 11387210
Variant Present in the following documents:
  • Main text
View BVdb publication page