KDR c.3176A>T ;(p.Y1059F)

Variant ID: 4-55956139-T-A

NM_002253.2(KDR):c.3176A>T;(p.Y1059F)

This variant was identified in 6 publications

View GRCh38 version.




Publications:


Comparison of the ligand-binding properties of fluorescent VEGF-A isoforms to VEGF receptor 2 in living cells and membrane preparations using NanoBRET.

British Journal Of Pharmacology
Peach, Chloe J CJ; Kilpatrick, Laura E LE; Woolard, Jeanette J; Hill, Stephen J SJ
Publication Date: 2019-09

Variant appearance in text: VEGFR2: Y1059F
PubMed Link: 31162634
Variant Present in the following documents:
  • Main text
  • BPH-176-3220.pdf
View BVdb publication page



Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells.

Genes & Development
Pfister, Neil T NT; Fomin, Vitalay V; Regunath, Kausik K; Zhou, Jeffrey Y JY; Zhou, Wen W; Silwal-Pandit, Laxmi L; Freed-Pastor, William A WA; Laptenko, Oleg O; Neo, Suat Peng SP; Bargonetti, Jill J; Hoque, Mainul M; Tian, Bin B; Gunaratne, Jayantha J; Engebraaten, Olav O; Manley, James L JL; Børresen-Dale, Anne-Lise AL; Neilsen, Paul M PM; Prives, Carol C
Publication Date: 2015-06-15

Variant appearance in text: VEGFR2: Y1059F
PubMed Link: 26080815
Variant Present in the following documents:
  • Main text
  • 1298.pdf
View BVdb publication page



VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.

The Journal Of Experimental Medicine
Sun, Zuyue Z; Li, Xiujuan X; Massena, Sara S; Kutschera, Simone S; Padhan, Narendra N; Gualandi, Laura L; Sundvold-Gjerstad, Vibeke V; Gustafsson, Karin K; Choy, Wing Wen WW; Zang, Guangxiang G; Quach, My M; Jansson, Leif L; Phillipson, Mia M; Abid, Md Ruhul MR; Spurkland, Anne A; Claesson-Welsh, Lena L
Publication Date: 2012-07-02

Variant appearance in text: VEGFR2: Y1059F
PubMed Link: 22689825
Variant Present in the following documents:
  • Main text
View BVdb publication page



VEGFR2 translocates to the nucleus to regulate its own transcription.

Plos One
Domingues, Inês I; Rino, José J; Demmers, Jeroen A A JA; de Lanerolle, Primal P; Santos, Susana Constantino Rosa SC
Publication Date: 2011

Variant appearance in text: VEGFR2: Y1059F
PubMed Link: 21980525
Variant Present in the following documents:
  • pone.0025668.pdf
View BVdb publication page



New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.

Molecular And Cellular Biology
Chabot, Catherine C; Spring, Kathleen K; Gratton, Jean-Philippe JP; Elchebly, Mounib M; Royal, Isabelle I
Publication Date: 2009-01

Variant appearance in text: VEGFR2: Y1059F
PubMed Link: 18936167
Variant Present in the following documents:
  • Main text
View BVdb publication page



Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Sakurai, Yoshiko Y; Ohgimoto, Kaori K; Kataoka, Yuki Y; Yoshida, Nobuaki N; Shibuya, Masabumi M
Publication Date: 2005-01-25

Variant appearance in text: KDR: Y1059F
PubMed Link: 15644447
Variant Present in the following documents:
  • Main text
View BVdb publication page