Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia.
Oncotarget
Kampa-Schittenhelm, Kerstin Maria KM; Frey, Julia J; Haeusser, Lara A LA; Illing, Barbara B; Pavlovsky, Ashly A AA; Blumenstock, Gunnar G; Schittenhelm, Marcus Matthias MM
Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.
Cell Death & Disease
Di Siena, S S; Gimmelli, R R; Nori, S L SL; Barbagallo, F F; Campolo, F F; Dolci, S S; Rossi, P P; Venneri, M A MA; Giannetta, E E; Gianfrilli, D D; Feigenbaum, L L; Lenzi, A A; Naro, F F; Cianflone, E E; Mancuso, T T; Torella, D D; Isidori, A M AM; Pellegrini, M M