Variant ID: 4-55979558-C-A

NM_002253.2(KDR):c.889G>T;(p.Val297Leu)

This variant was identified in 93 publications




Publications:


VEGF-Related Germinal Polymorphisms May Identify a Subgroup of Breast Cancer Patients with Favorable Outcome under Bevacizumab-Based Therapy-A Message from COMET, a French Unicancer Multicentric Study.

Pharmaceuticals (Basel, Switzerland)
J Gal, G Milano, P Brest, N Ebran, J Gilhodes, L Llorca, C Dubot, G Romieu, I Desmoulins, E Brain, A Goncalves, JM Ferrero, PH Cottu, M Debled, O Tredan, E Chamorey, MC Merlano, J Lemonnier, MC Etienne-Grimaldi, JY Pierga
Publication Date: 2020-11-23

Variant appearance in text: rs2305948
PubMed Link: 33238394
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical outcomes and safety of apatinib monotherapy in the treatment of patients with advanced epithelial ovarian carcinoma who progressed after standard regimens and the analysis of the VEGFR2 polymorphism.

Oncology Letters
Z Yan, YY Gu, XD Hu, Q Zhao, HL Kang, M Wang, W Duan, Y Guan
Publication Date: 2020-09

Variant appearance in text: rs2305948
PubMed Link: 32782621
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics for severe adverse drug reactions induced by molecular-targeted therapy.

Cancer Science
C Udagawa, H Zembutsu
Publication Date: 2020-10

Variant appearance in text: rs2305948
PubMed Link: 32780457
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Pharmacogenomics, Pharmacokinetics and Circulating Proteins as Biomarkers for Bevacizumab Treatment Optimization in Patients with Cancer: A Review.

Journal Of Personalized Medicine
A Papachristos, GB Sivolapenko
Publication Date: 2020-08-04

Variant appearance in text: rs2305948
PubMed Link: 32759686
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular Bases of Drug Resistance in Hepatocellular Carcinoma.

Cancers
JJG Marin, RIR Macias, MJ Monte, MR Romero, M Asensio, A Sanchez-Martin, C Cives-Losada, AG Temprano, R Espinosa-Escudero, M Reviejo, LH Bohorquez, O Briz
Publication Date: 2020-06-23

Variant appearance in text: rs2305948
PubMed Link: 32585893
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • Supplemental file
View BVdb publication page



Clinical Relevance of +936 C>T VEGFA and c.233C>T bFGF Polymorphisms in Chronic Lymphocytic Leukemia.

Genes
S Ballester, B Pineda, P Rodrigues, E Tormo, MJ Terol, P Eroles
Publication Date: 2020-06-23

Variant appearance in text: rs2305948
PubMed Link: 32585853
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer.

Scientific Reports
A Barat, D Smeets, B Moran, W Zhang, S Cao, S Das, R Klinger, J Betge, V Murphy, O Bacon, EW Kay, NCT Van Grieken, HMW Verheul, T Gaiser, N Schulte, MP Ebert, B Fender, BT Hennessy, DA McNamara, D O'Connor, WM Gallagher, C Cremolini, F Loupakis, A Parikh, C Mancao, B Ylstra, D Lambrechts, HJ Lenz, AT Byrne, JHM Prehn
Publication Date: 2020-06-17

Variant appearance in text: rs2305948
PubMed Link: 32555399
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review.

Genes
MJ Martin, M Estravís, A García-Sánchez, I Dávila, M Isidoro-García, C Sanz
Publication Date: 2020-04-18

Variant appearance in text: rs2305948
PubMed Link: 32325630
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis.

International Journal Of Hypertension
Z Zhao, C Gong, Y Gao, X Liu, S Wu, H Zhao, X Wang, H Liu, C Xiao, J Liu, J Li, Y He
Publication Date: 2020

Variant appearance in text: rs2305948
PubMed Link: 32257424
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Dual VEGF inhibition with sorafenib and bevacizumab as salvage therapy in metastatic colorectal cancer: results of the phase II North Central Cancer Treatment Group study N054C (Alliance).

Therapeutic Advances In Medical Oncology
H Xie, JM Lafky, BW Morlan, PJ Stella, SR Dakhil, GG Gross, WS Loui, JM Hubbard, SR Alberts, A Grothey
Publication Date: 2020

Variant appearance in text: rs2305948
PubMed Link: 32201506
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Hyperprogression under Immune Checkpoint Inhibitor: a potential role for germinal immunogenetics.

Scientific Reports
S Refae, J Gal, P Brest, D Giacchero, D Borchiellini, N Ebran, F Peyrade, J Guigay, G Milano, E Saada-Bouzid
Publication Date: 2020-02-27

Variant appearance in text: rs2305948
PubMed Link: 32107407
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration.

Bmj Open Ophthalmology
I Balikova, L Postelmans, B Pasteels, P Coquelet, J Catherine, A Efendic, Y Hosoda, M Miyake, K Yamashiro, , B Thienpont, D Lambrechts
Publication Date: 2019

Variant appearance in text: rs2305948
PubMed Link: 31909188
PubMed Central Link
Variant Present in the following documents:
  • bmjophth-2019-000273supp001.pdf
View BVdb publication page



Association between vascular endothelial growth factor receptor 2 rs11941492 C/T polymorphism and Chinese Han patients in rheumatoid arthritis.

Medicine
Z Yang, M Wang, T Yan, Z Hu, H Zhang, R Liu
Publication Date: 2019-12

Variant appearance in text: rs2305948
PubMed Link: 31876763
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Predictive and Prognostic Factors in HCC Patients Treated with Sorafenib.

Medicina (Kaunas, Lithuania)
O Brunetti, A Gnoni, A Licchetta, V Longo, A Calabrese, A Argentiero, S Delcuratolo, AG Solimando, A Casadei-Gardini, N Silvestris
Publication Date: 2019-10-21

Variant appearance in text: rs2305948
PubMed Link: 31640191
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • medicina-55-00707.pdf
View BVdb publication page



NRP-1 and KDR polymorphisms are associated with survival time in patients with advanced gastric cancer.

Oncology Letters
YJ Zhuo, Y Shi, T Wu
Publication Date: 2019-11

Variant appearance in text: rs2305948
PubMed Link: 31611971
PubMed Central Link
Variant Present in the following documents:
  • Supplementary_Data.pdf
  • Main text
  • ol-18-05-4629.pdf
View BVdb publication page



An update on biomarkers of potential benefit with bevacizumab for breast cancer treatment: Do we make progress?

Chinese Journal Of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu
X Liang, H Li, F Coussy, C Callens, F Lerebours
Publication Date: 2019-08

Variant appearance in text: rs2305948
PubMed Link: 31564802
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT.

Acta Neuropathologica Communications
G Jungwirth, R Warta, C Beynon, F Sahm, A von Deimling, A Unterberg, C Herold-Mende, C Jungk
Publication Date: 2019-08-30

Variant appearance in text: rs2305948
PubMed Link: 31470906
PubMed Central Link
Variant Present in the following documents:
  • 40478_2019_793_MOESM1_ESM.xlsx
View BVdb publication page



Impact of single nucleotide polymorphisms in the VEGFR2 gene on endothelial cell activation under non‑uniform shear stress.

International Journal Of Molecular Medicine
NM Schacher, D Raaz-Schrauder, F Pasutto, FM Stumpfe, M Tauchi, B Dietel, S Achenbach, K Urschel
Publication Date: 2019-10

Variant appearance in text: rs2305948
PubMed Link: 31432097
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



A meta-analysis of the relationship between VEGFR2 polymorphisms and atherosclerotic cardiovascular diseases.

Clinical Cardiology
L Wang, H Ge, L Peng, B Wang
Publication Date: 2019-10

Variant appearance in text: rs2305948
PubMed Link: 31339592
PubMed Central Link
Variant Present in the following documents:
  • CLC-42-860-s001.docx
  • Main text
View BVdb publication page



Effect of gene-gene and gene-environment interaction on the risk of first-ever stroke and poststroke death.

Molecular Genetics & Genomic Medicine
C Feng, Y Yang, S Yang, X Tu, Y Wang, Y Song, R Hui, W Zhang
Publication Date: 2019-08

Variant appearance in text: rs2305948
PubMed Link: 31293107
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • MGG3-7-e846-s001.docx
View BVdb publication page



Evaluation of associations between genetically predicted circulating protein biomarkers and breast cancer risk.

International Journal Of Cancer
X Shu, J Bao, L Wu, J Long, XO Shu, X Guo, Y Yang, K Michailidou, MK Bolla, Q Wang, J Dennis, IL Andrulis, JE Castelao, T Dörk, M Gago-Dominguez, M García-Closas, GG Giles, A Lophatananon, K Muir, H Olsson, G Rennert, E Saloustros, RJ Scott, MC Southey, PDP Pharoah, RL Milne, P Kraft, J Simard, DF Easton, W Zheng
Publication Date: 2020-04-15

Variant appearance in text: rs2305948
PubMed Link: 31265136
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



KDR inferred haplotype is associated with upper limb dysfunction in breast cancer survivors of mixed ancestry.

Cancer Management And Research
TS Mafu, AV September, D Shamley
Publication Date: 2019

Variant appearance in text: rs2305948
PubMed Link: 31118800
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Phase III Trial of Adjuvant Sunitinib in Patients with High-Risk Renal Cell Carcinoma: Exploratory Pharmacogenomic Analysis.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
DJ George, JF Martini, M Staehler, RJ Motzer, A Magheli, F Donskov, B Escudier, S Li, M Casey, O Valota, B Laguerre, AJ Pantuck, HS Pandha, A Patel, M Lechuga, A Ravaud
Publication Date: 2019-02-15

Variant appearance in text: rs2305948
PubMed Link: 30401688
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer.

Cancer Biology & Therapy
X Zhu, Y Wang, W Xue, R Wang, L Wang, ML Zhu, L Zheng
Publication Date: 2019

Variant appearance in text: rs2305948
PubMed Link: 30380970
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes.

Bmc Cardiovascular Disorders
ECA Marks, TM Wilkinson, CM Frampton, L Skelton, AP Pilbrow, TG Yandle, CJ Pemberton, RN Doughty, GA Whalley, CJ Ellis, RW Troughton, MC Owen, NR Pattinson, VA Cameron, AM Richards, SP Gieseg, BR Palmer
Publication Date: 2018-08-15

Variant appearance in text: rs2305948
PubMed Link: 30111293
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes.

Cancer Cell
I Ganly, V Makarov, S Deraje, Y Dong, E Reznik, V Seshan, G Nanjangud, S Eng, P Bose, F Kuo, LGT Morris, I Landa, PB Carrillo Albornoz, N Riaz, YE Nikiforov, K Patel, C Umbricht, M Zeiger, E Kebebew, E Sherman, R Ghossein, JA Fagin, TA Chan
Publication Date: 2018-08-13

Variant appearance in text: rs2305948
PubMed Link: 30107176
PubMed Central Link
Variant Present in the following documents:
  • NIHMS986371-supplement-2.xlsx
View BVdb publication page



Impact of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) single nucleotide polymorphisms on outcome in gastroenteropancreatic neuroendocrine neoplasms.

Plos One
R Berardi, M Torniai, S Partelli, C Rubini, S Pagliaretta, A Savini, V Polenta, M Santoni, R Giampieri, S Onorati, F Barucca, A Murrone, F Bianchi, M Falconi
Publication Date: 2018

Variant appearance in text: rs2305948
PubMed Link: 29787601
PubMed Central Link
Variant Present in the following documents:
  • pone.0197035.s001.xlsx
  • Main text
View BVdb publication page



Genetic polymorphisms associated with adverse reactions of molecular-targeted therapies in renal cell carcinoma.

Medical Oncology (Northwood, London, England)
K Yamamoto, I Yano
Publication Date: 2018-01-04

Variant appearance in text: rs2305948
PubMed Link: 29302760
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Single nucleotide polymorphisms as prognostic and predictive biomarkers in renal cell carcinoma.

Oncotarget
C Garrigós, M Espinosa, A Salinas, I Osman, R Medina, M Taron, S Molina-Pinelo, I Duran
Publication Date: 2017-12-05

Variant appearance in text: rs2305948
PubMed Link: 29290970
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Characterizing key nucleotide polymorphisms of hepatitis C virus-disease associations via mass-spectrometric genotyping.

International Journal Of Oncology
Y Horiuchi, J Lin, Y Shinojima, K Fujiwara, M Moriyama, H Nagase
Publication Date: 2018-02

Variant appearance in text: rs2305948
PubMed Link: 29207078
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival.

International Journal Of Environmental Research And Public Health
N Sharafeldin, ML Slattery, Q Liu, C Franco-Villalobos, BJ Caan, JD Potter, Y Yasui
Publication Date: 2017-09-28

Variant appearance in text: rs2305948
PubMed Link: 28956832
PubMed Central Link
Variant Present in the following documents:
  • ijerph-14-01146-s001.pdf
View BVdb publication page



NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study.

Plos One
M Peng, G Zhao, F Yang, G Cheng, J Huang, X Qin, Y Liu, Q Wang, Y Li, D Qin
Publication Date: 2017

Variant appearance in text: rs2305948
PubMed Link: 28264017
PubMed Central Link
Variant Present in the following documents:
  • pone.0173298.s001.docx
View BVdb publication page



Determination of VEGFR-2 (KDR) 604A>G Polymorphism in Pancreatic Disorders.

International Journal Of Molecular Sciences
V Pădureanu, MV Boldeanu, I Streaţă, MG Cucu, I Siloşi, L Boldeanu, M Bogdan, AŞ Enescu, M Forţofoiu, A Enescu, EM Dumitrescu, D Alexandru, VM Şurlin, MC Forţofoiu, IO Petrescu, F Petrescu, M Ioana, ME Ciurea, A Săftoiu
Publication Date: 2017-02-17

Variant appearance in text: rs2305948
PubMed Link: 28218664
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity.

Scientific Reports
Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, H Li, HS Tan, R Kanesvaran, H Yu, MH Tan
Publication Date: 2017-01-25

Variant appearance in text: rs2305948
PubMed Link: 28120901
PubMed Central Link
Variant Present in the following documents:
  • srep41238-s1.pdf
View BVdb publication page



Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib.

Scientific Reports
A Cebrián, T Gómez Del Pulgar, MJ Méndez-Vidal, ML Gonzálvez, N Lainez, D Castellano, I García-Carbonero, E Esteban, MI Sáez, R Villatoro, C Suárez, A Carrato, J Munárriz-Ferrándiz, L Basterrechea, M García-Alonso, JL González-Larriba, B Perez-Valderrama, J Cruz-Jurado, A González Del Alba, F Moreno, G Reynés, M Rodríguez-Remírez, V Boni, I Mahillo-Fernández, Y Martin, A Viqueira, J García-Foncillas
Publication Date: 2017-01-24

Variant appearance in text: rs2305948
PubMed Link: 28117391
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • srep41371-s1.pdf
View BVdb publication page



Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients.

Plos One
I Makhoul, VK Todorova, ER Siegel, SW Erickson, I Dhakal, VR Raj, JY Lee, MS Orloff, RJ Griffin, RS Henry-Tillman, S Klimberg, LF Hutchins, SA Kadlubar
Publication Date: 2017

Variant appearance in text: rs2305948
PubMed Link: 28045923
PubMed Central Link
Variant Present in the following documents:
  • pone.0168550.s011.xlsx
  • pone.0168550.s006.xlsx
  • pone.0168550.s007.xlsx
  • pone.0168550.s004.xlsx
  • pone.0168550.s009.xlsx
  • pone.0168550.s005.xlsx
  • pone.0168550.s003.xlsx
View BVdb publication page



Preliminary data of VEGF-A and VEGFR-2 polymorphisms as predictive factors of radiological response and clinical outcome in iodine-refractory differentiated thyroid cancer treated with sorafenib.

Endocrine
V Marotta, C Sciammarella, M Capasso, A Testori, C Pivonello, MG Chiofalo, R Pivonello, L Pezzullo, G Botti, A Colao, A Faggiano
Publication Date: 2017-09

Variant appearance in text: rs2305948
PubMed Link: 27981515
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Influence of Tyrosine Kinase Inhibitors on Hypertension and Nephrotoxicity in Metastatic Renal Cell Cancer Patients.

International Journal Of Molecular Sciences
A Semeniuk-Wojtaś, A Lubas, R Stec, C Szczylik, S Niemczyk
Publication Date: 2016-12-09

Variant appearance in text: rs2305948
PubMed Link: 27941701
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Vascular Endothelial Growth Factor Receptor-2 Polymorphisms Have Protective Effect against the Development of Tendinopathy in Volleyball Athletes.

Plos One
JI Salles, ME Duarte, JM Guimarães, LR Lopes, J Vilarinho Cardoso, DP Aguiar, JO Machado Neto, DE Machado, JA Perini
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27930691
PubMed Central Link
Variant Present in the following documents:
  • pone.0167717.s002.xlsx
  • pone.0167717.s001.xlsx
  • Main text
View BVdb publication page



Germline Polymorphisms of the VEGF Pathway Predict Recurrence in Nonadvanced Differentiated Thyroid Cancer.

The Journal Of Clinical Endocrinology And Metabolism
V Marotta, C Sciammarella, M Capasso, A Testori, C Pivonello, MG Chiofalo, C Gambardella, M Grasso, A Antonino, A Annunziata, PE Macchia, R Pivonello, L Santini, G Botti, S Losito, L Pezzullo, A Colao, A Faggiano
Publication Date: 2017-02-01

Variant appearance in text: rs2305948
PubMed Link: 27849428
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients.

Cancer Medicine
LA Dan, S Werdyani, J Xu, K Shestopaloff, A Hyde, E Dicks, B Younghusband, J Green, P Parfrey, W Xu, S Savas
Publication Date: 2016-09

Variant appearance in text: rs2305948
PubMed Link: 27334288
PubMed Central Link
Variant Present in the following documents:
  • CAM4-5-2221-s007.xlsx
  • CAM4-5-2221-s010.xlsx
  • CAM4-5-2221-s004.xlsx
View BVdb publication page



AMD Genetics in India: The Missing Links.

Frontiers In Aging Neuroscience
A Anand, K Sharma, SK Sharma, R Singh, NK Sharma, K Prasad
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27252648
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Development and clinical application of an integrative genomic approach to personalized cancer therapy.

Genome Medicine
AV Uzilov, W Ding, MY Fink, Y Antipin, AS Brohl, C Davis, CY Lau, C Pandya, H Shah, Y Kasai, J Powell, M Micchelli, R Castellanos, Z Zhang, M Linderman, Y Kinoshita, M Zweig, K Raustad, K Cheung, D Castillo, M Wooten, I Bourzgui, LC Newman, G Deikus, B Mathew, J Zhu, BS Glicksberg, AS Moe, J Liao, L Edelmann, JT Dudley, RG Maki, A Kasarskis, RF Holcombe, M Mahajan, K Hao, B Reva, J Longtine, D Starcevic, R Sebra, MJ Donovan, S Li, EE Schadt, R Chen
Publication Date: 2016-06-01

Variant appearance in text: rs2305948
PubMed Link: 27245685
PubMed Central Link
Variant Present in the following documents:
  • 13073_2016_313_MOESM5_ESM.pdf
View BVdb publication page



Genes, environment and gene expression in colon tissue: a pathway approach to determining functionality.

International Journal Of Molecular Epidemiology And Genetics
ML Slattery, DF Pellatt, RK Wolff, A Lundgreen
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27186328
PubMed Central Link
Variant Present in the following documents:
  • ijmeg0007-0045-f1.pdf
  • Main text
View BVdb publication page



Association of Genetic Polymorphisms on VEGFA and VEGFR2 With Risk of Coronary Heart Disease.

Medicine
D Liu, J Song, X Ji, Z Liu, M Cong, B Hu
Publication Date: 2016-05

Variant appearance in text: rs2305948
PubMed Link: 27175642
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Angiogenesis genotyping in the selection of first-line treatment with either sunitinib or pazopanib for advanced renal cell carcinoma.

Oncotarget
M Bianconi, L Faloppi, C Loretelli, A Zizzi, R Giampieri, A Bittoni, K Andrikou, M Del Prete, L Burattini, R Montironi, M Scartozzi, S Cascinu
Publication Date: 2016-06-21

Variant appearance in text: rs2305948
PubMed Link: 27175586
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role of HIF1A, VEGFA and VEGFR2 SNPs in the Susceptibility and Progression of COPD in a Spanish Population.

Plos One
R Baz-Dávila, A Espinoza-Jiménez, Mdel C Rodríguez-Pérez, J Zulueta, N Varo, Á Montejo, D Almeida-González, A Aguirre-Jaime, E Córdoba-Lanús, C Casanova
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27163696
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • pone.0154998.s002.pdf
View BVdb publication page



Angiogenesis genotyping and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients.

Scientific Reports
R Giampieri, L Salvatore, M Del Prete, T Prochilo, M D'Anzeo, C Loretelli, F Loupakis, G Aprile, E Maccaroni, K Andrikou, M Bianconi, A Bittoni, L Faloppi, L Demurtas, R Montironi, M Scarpelli, A Falcone, A Zaniboni, M Scartozzi, S Cascinu
Publication Date: 2016-04-27

Variant appearance in text: rs2305948
PubMed Link: 27117754
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomic Characterization and Comparison of Multi-Regional and Pooled Tumor Biopsy Specimens.

Plos One
JG Joung, JS Bae, SC Kim, H Jung, WY Park, SY Song
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27010638
PubMed Central Link
Variant Present in the following documents:
  • pone.0152574.s006.xlsx
View BVdb publication page



The influence of genetic variants of sorafenib on clinical outcomes and toxic effects in patients with advanced renal cell carcinoma.

Scientific Reports
C Qin, Q Cao, P Li, S Wang, J Wang, M Wang, H Chu, L Zhou, X Li, D Ye, H Zhang, Y Huang, B Dong, X Sun, Q Zou, H Cai, L Sun, J Zhu, F Liu, J Ji, L Cui, X Wang, H Zhou, H Zhao, B Wu, J Chen, M Jiang, Z Zhang, P Shao, X Ju, C Yin
Publication Date: 2016-02-02

Variant appearance in text: rs2305948
PubMed Link: 26830973
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers.

Fertility And Sterility
A Vodolazkaia, BT Yesilyurt, CM Kyama, A Bokor, D Schols, D Huskens, C Meuleman, K Peeraer, C Tomassetti, X Bossuyt, D Lambrechts, T D'Hooghe, A Fassbender
Publication Date: 2016-04

Variant appearance in text: rs2305948
PubMed Link: 26773192
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Association of Genetic Polymorphisms on Vascular Endothelial Growth Factor and its Receptor Genes with Susceptibility to Coronary Heart Disease.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
L Li, Y Pan, L Dai, B Liu, D Zhang
Publication Date: 2016-01-04

Variant appearance in text: rs2305948
PubMed Link: 26726843
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach.

Frontiers In Pharmacology
CB Platania, L Di Paola, GM Leggio, GL Romano, F Drago, S Salomone, C Bucolo
Publication Date: 2015

Variant appearance in text: rs2305948
PubMed Link: 26578958
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients.

Oncotarget
A Solini, V Simeon, L Derosa, P Orlandi, C Rossi, A Fontana, L Galli, T Di Desidero, A Fioravanti, S Lucchesi, L Coltelli, L Ginocchi, G Allegrini, R Danesi, A Falcone, G Bocci
Publication Date: 2015-10-06

Variant appearance in text: rs2305948
PubMed Link: 26337470
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies.

Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research
T Niu, N Liu, X Yu, M Zhao, HJ Choi, PJ Leo, MA Brown, L Zhang, YF Pei, H Shen, H He, X Fu, S Lu, XD Chen, LJ Tan, TL Yang, Y Guo, NH Cho, J Shen, YF Guo, GC Nicholson, RL Prince, JA Eisman, G Jones, PN Sambrook, Q Tian, XZ Zhu, CJ Papasian, EL Duncan, AG Uitterlinden, CS Shin, S Xiang, HW Deng
Publication Date: 2016-02

Variant appearance in text: rs2305948
PubMed Link: 26256109
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



A case of metastatic renal cell carcinoma and bile duct carcinoma treated with a combination of sunitinib and gemcitabine.

Bmc Cancer
K Takayoshi, K Sagara, K Uchino, H Kusaba, N Sakamoto, A Iguchi, E Baba
Publication Date: 2015-05-22

Variant appearance in text: rs2305948
PubMed Link: 26001650
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Epidermal growth factor receptor pathway polymorphisms and the prognosis of hepatocellular carcinoma.

American Journal Of Cancer Research
W Wang, XP Ma, Z Shi, P Zhang, DL Ding, HX Huang, HG Saiyin, TY Chen, PX Lu, NJ Wang, H Yu, J Sun, SL Zheng, L Yu, J Xu, DK Jiang
Publication Date: 2015

Variant appearance in text: rs2305948
PubMed Link: 25628948
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



NCCTG N0821 (Alliance): a phase II first-line study of pemetrexed, carboplatin, and bevacizumab in elderly patients with advanced nonsquamous non-small-cell lung cancer with good performance status.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer
GK Dy, JR Molina, Y Qi, R Ansari, S Thomas, HJ Ross, G Soori, D Anderson, MC Aubry, J Meyers, AA Adjei, S Mandrekar, AA Adjei
Publication Date: 2014-08

Variant appearance in text: rs2305948
PubMed Link: 25157767
PubMed Central Link
Variant Present in the following documents:
  • NIHMS586371-supplement-Supplemental_Digital_Table.doc
View BVdb publication page



Kinase insert domain receptor/vascular endothelial growth factor receptor 2 (KDR) genetic variation is associated with ovarian hyperstimulation syndrome.

Reproductive Biology And Endocrinology : Rb&E
TJ O'Brien, AF Harralson, T Tran, I Gindoff, FE Orkunoglu-Suer, D Frankfurter, P Gindoff
Publication Date: 2014-05-09

Variant appearance in text: rs2305948
PubMed Link: 24886133
PubMed Central Link
Variant Present in the following documents:
  • 1477-7827-12-36-S5.docx
  • 1477-7827-12-36-S1.docx
  • 1477-7827-12-36-S6.docx
  • 1477-7827-12-36-S4.docx
  • Main text
View BVdb publication page



Polymorphisms of VEGF and VEGF receptors are associated with the occurrence of ovarian hyperstimulation syndrome (OHSS)-a retrospective case-control study.

Journal Of Ovarian Research
K Nouri, P Haslinger, L Szabo, M Sator, M Schreiber, C Schneeberger, D Pietrowski
Publication Date: 2014

Variant appearance in text: rs2305948
PubMed Link: 24851136
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comparative genomic analysis of primary and synchronous metastatic colorectal cancers.

Plos One
SY Lee, F Haq, D Kim, C Jun, HJ Jo, SM Ahn, WS Lee
Publication Date: 2014

Variant appearance in text: rs2305948
PubMed Link: 24599305
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma.

The Journal Of Clinical Investigation
M Imielinski, H Greulich, B Kaplan, L Araujo, J Amann, L Horn, J Schiller, MA Villalona-Calero, M Meyerson, DP Carbone
Publication Date: 2014-04

Variant appearance in text: rs2305948
PubMed Link: 24569458
PubMed Central Link
Variant Present in the following documents:
  • JCI72763sd.pdf
View BVdb publication page



Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab.

Plos One
F Loupakis, C Cremolini, D Yang, L Salvatore, W Zhang, T Wakatsuki, P Bohanes, M Schirripa, L Benhaim, S Lonardi, C Antoniotti, G Aprile, F Graziano, A Ruzzo, S Lucchesi, M Ronzoni, F De Vita, G Tonini, A Falcone, HJ Lenz
Publication Date: 2013

Variant appearance in text: rs2305948
PubMed Link: 23861747
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): a north central cancer treatment group trial.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
E Galanis, SK Anderson, JM Lafky, JH Uhm, C Giannini, SK Kumar, TK Kimlinger, DW Northfelt, PJ Flynn, KA Jaeckle, TJ Kaufmann, JC Buckner
Publication Date: 2013-09-01

Variant appearance in text: rs2305948
PubMed Link: 23833308
PubMed Central Link
Variant Present in the following documents:
  • NIHMS503577-supplement-2.docx
  • Main text
View BVdb publication page



VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib.

British Journal Of Cancer
M Scartozzi, M Bianconi, L Faloppi, C Loretelli, A Bittoni, M Del Prete, R Giampieri, E Maccaroni, S Nicoletti, L Burattini, D Minardi, G Muzzonigro, R Montironi, S Cascinu
Publication Date: 2013-03-19

Variant appearance in text: rs2305948
PubMed Link: 23511629
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Biomarker results from the AVADO phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer.

British Journal Of Cancer
DW Miles, SL de Haas, LY Dirix, G Romieu, A Chan, X Pivot, P Tomczak, L Provencher, J Cortés, PR Delmar, SJ Scherer
Publication Date: 2013-03-19

Variant appearance in text: rs2305948
PubMed Link: 23422754
PubMed Central Link
Variant Present in the following documents:
  • bjc201369x1.doc
View BVdb publication page



A genome-wide association study of variations in maternal cardiometabolic genes and risk of placental abruption.

International Journal Of Molecular Epidemiology And Genetics
A Moore, DA Enquobahrie, SE Sanchez, CV Ananth, PN Pacora, MA Williams
Publication Date: 2012

Variant appearance in text: rs2305948
PubMed Link: 23205182
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



PDGFRα/β and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome.

Bmc Cancer
P Estevez-Garcia, A Castaño, AC Martin, F Lopez-Rios, J Iglesias, S Muñoz-Galván, I Lopez-Calderero, S Molina-Pinelo, MD Pastor, A Carnero, L Paz-Ares, R Garcia-Carbonero
Publication Date: 2012-11-12

Variant appearance in text: rs2305948
PubMed Link: 23146028
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization.

Plos One
YS Park, YJ Jeon, HS Kim, KY Chae, SH Oh, IB Han, HS Kim, WC Kim, OJ Kim, TG Kim, JU Choi, DS Kim, NK Kim
Publication Date: 2012

Variant appearance in text: rs2305948
PubMed Link: 23077562
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetic biomarkers for the prediction of response to antiangiogenic treatment.

The Lancet. Oncology
BP Schneider, F Shen, KD Miller
Publication Date: 2012-10

Variant appearance in text: rs2305948
PubMed Link: 23026828
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



The rs2071559 AA VEGFR-2 genotype frequency is significantly lower in neovascular age-related macular degeneration patients.

Thescientificworldjournal
S Lazzeri, P Orlandi, M Figus, A Fioravanti, E Cascio, T Di Desidero, E Agosta, B Canu, MS Sartini, R Danesi, M Nardi, G Bocci
Publication Date: 2012

Variant appearance in text: rs2305948
PubMed Link: 22919317
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role of vascular endothelial growth factor (VEGF) and VEGF-R genotyping in guiding the metastatic process in pT4a resected gastric cancer patients.

Plos One
M Scartozzi, C Loretelli, E Galizia, A Mandolesi, M Pistelli, A Bittoni, R Giampieri, L Faloppi, M Bianconi, M Del Prete, F Bianchi, L Belvederesi, I Bearzi, S Cascinu
Publication Date: 2012

Variant appearance in text: rs2305948
PubMed Link: 22808003
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma.

Cancer Discovery
J Shi, N Chatterjee, M Rotunno, Y Wang, AC Pesatori, D Consonni, P Li, W Wheeler, P Broderick, M Henrion, T Eisen, Z Wang, W Chen, Q Dong, D Albanes, M Thun, MR Spitz, PA Bertazzi, NE Caporaso, SJ Chanock, CI Amos, RS Houlston, MT Landi
Publication Date: 2012-02

Variant appearance in text: rs2305948
PubMed Link: 22585858
PubMed Central Link
Variant Present in the following documents:
  • NIHMS343818-supplement-1.pdf
View BVdb publication page



Gene variants in the angiogenesis pathway and prostate cancer.

Carcinogenesis
EK Amankwah, TA Sellers, JY Park
Publication Date: 2012-07

Variant appearance in text: rs2305948
PubMed Link: 22523086
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Possible genetic predisposition to lymphedema after breast cancer.

Lymphatic Research And Biology
B Newman, F Lose, MA Kedda, M Francois, K Ferguson, M Janda, P Yates, AB Spurdle, SC Hayes
Publication Date: 2012-03

Variant appearance in text: rs2305948
PubMed Link: 22404826
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000263923.4 c.889G>T p.Val297Leu missense_variant 7/30 -
ENST00000512566.1 n.889G>T - non_coding_transcript_exon_variant 7/13 -
NM_002253.3 c.889G>T p.Val297Leu missense_variant 7/30 -