Variant ID: 4-55979558-C-T

NM_002253.2(KDR):c.889G>A;(p.Val297Ile)

This variant was identified in 119 publications




Publications:


VEGF-Related Germinal Polymorphisms May Identify a Subgroup of Breast Cancer Patients with Favorable Outcome under Bevacizumab-Based Therapy-A Message from COMET, a French Unicancer Multicentric Study.

Pharmaceuticals (Basel, Switzerland)
J Gal, G Milano, P Brest, N Ebran, J Gilhodes, L Llorca, C Dubot, G Romieu, I Desmoulins, E Brain, A Goncalves, JM Ferrero, PH Cottu, M Debled, O Tredan, E Chamorey, MC Merlano, J Lemonnier, MC Etienne-Grimaldi, JY Pierga
Publication Date: 2020-11-23

Variant appearance in text: rs2305948
PubMed Link: 33238394
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comparing cell-free circulating tumor DNA mutational profiles of disease-free and nonresponders patients with oropharyngeal squamous cell carcinoma.

Laryngoscope Investigative Otolaryngology
AR Khandelwal, AH Greer, M Hamiter, JM Fermin, T McMullen, T Moore-Medlin, G Mills, JM Flores, H Yin, CO Nathan
Publication Date: 2020-10

Variant appearance in text: KDR: V297I
PubMed Link: 33134534
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical outcomes and safety of apatinib monotherapy in the treatment of patients with advanced epithelial ovarian carcinoma who progressed after standard regimens and the analysis of the VEGFR2 polymorphism.

Oncology Letters
Z Yan, YY Gu, XD Hu, Q Zhao, HL Kang, M Wang, W Duan, Y Guan
Publication Date: 2020-09

Variant appearance in text: rs2305948
PubMed Link: 32782621
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics for severe adverse drug reactions induced by molecular-targeted therapy.

Cancer Science
C Udagawa, H Zembutsu
Publication Date: 2020-10

Variant appearance in text: rs2305948
PubMed Link: 32780457
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Pharmacogenomics, Pharmacokinetics and Circulating Proteins as Biomarkers for Bevacizumab Treatment Optimization in Patients with Cancer: A Review.

Journal Of Personalized Medicine
A Papachristos, GB Sivolapenko
Publication Date: 2020-08-04

Variant appearance in text: rs2305948
PubMed Link: 32759686
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Polymorphisms in the Angiogenesis-Related Genes EFNB2, MMP2 and JAG1 Are Associated with Survival of Colorectal Cancer Patients.

International Journal Of Molecular Sciences
D Scherer, H Deutelmoser, Y Balavarca, R Toth, N Habermann, K Buck, EJ Kap, A Botma, P Seibold, L Jansen, J Lorenzo Bermejo, K Weigl, A Benner, M Hoffmeister, A Ulrich, H Brenner, B Burwinkel, J Chang-Claude, CM Ulrich
Publication Date: 2020-07-29

Variant appearance in text: KDR: V297I; rs2305948
PubMed Link: 32751332
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular Bases of Drug Resistance in Hepatocellular Carcinoma.

Cancers
JJG Marin, RIR Macias, MJ Monte, MR Romero, M Asensio, A Sanchez-Martin, C Cives-Losada, AG Temprano, R Espinosa-Escudero, M Reviejo, LH Bohorquez, O Briz
Publication Date: 2020-06-23

Variant appearance in text: rs2305948
PubMed Link: 32585893
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • Supplemental file
View BVdb publication page



Clinical Relevance of +936 C>T VEGFA and c.233C>T bFGF Polymorphisms in Chronic Lymphocytic Leukemia.

Genes
S Ballester, B Pineda, P Rodrigues, E Tormo, MJ Terol, P Eroles
Publication Date: 2020-06-23

Variant appearance in text: rs2305948
PubMed Link: 32585853
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer.

Scientific Reports
A Barat, D Smeets, B Moran, W Zhang, S Cao, S Das, R Klinger, J Betge, V Murphy, O Bacon, EW Kay, NCT Van Grieken, HMW Verheul, T Gaiser, N Schulte, MP Ebert, B Fender, BT Hennessy, DA McNamara, D O'Connor, WM Gallagher, C Cremolini, F Loupakis, A Parikh, C Mancao, B Ylstra, D Lambrechts, HJ Lenz, AT Byrne, JHM Prehn
Publication Date: 2020-06-17

Variant appearance in text: rs2305948
PubMed Link: 32555399
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review.

Genes
MJ Martin, M Estravís, A García-Sánchez, I Dávila, M Isidoro-García, C Sanz
Publication Date: 2020-04-18

Variant appearance in text: rs2305948
PubMed Link: 32325630
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association between Single Nucleotide Polymorphisms in Cardiovascular Developmental Critical Genes and Hypertension: A Propensity Score Matching Analysis.

International Journal Of Hypertension
Z Zhao, C Gong, Y Gao, X Liu, S Wu, H Zhao, X Wang, H Liu, C Xiao, J Liu, J Li, Y He
Publication Date: 2020

Variant appearance in text: rs2305948
PubMed Link: 32257424
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Dual VEGF inhibition with sorafenib and bevacizumab as salvage therapy in metastatic colorectal cancer: results of the phase II North Central Cancer Treatment Group study N054C (Alliance).

Therapeutic Advances In Medical Oncology
H Xie, JM Lafky, BW Morlan, PJ Stella, SR Dakhil, GG Gross, WS Loui, JM Hubbard, SR Alberts, A Grothey
Publication Date: 2020

Variant appearance in text: rs2305948
PubMed Link: 32201506
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Hyperprogression under Immune Checkpoint Inhibitor: a potential role for germinal immunogenetics.

Scientific Reports
S Refae, J Gal, P Brest, D Giacchero, D Borchiellini, N Ebran, F Peyrade, J Guigay, G Milano, E Saada-Bouzid
Publication Date: 2020-02-27

Variant appearance in text: rs2305948
PubMed Link: 32107407
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration.

Bmj Open Ophthalmology
I Balikova, L Postelmans, B Pasteels, P Coquelet, J Catherine, A Efendic, Y Hosoda, M Miyake, K Yamashiro, , B Thienpont, D Lambrechts
Publication Date: 2019

Variant appearance in text: rs2305948
PubMed Link: 31909188
PubMed Central Link
Variant Present in the following documents:
  • bmjophth-2019-000273supp001.pdf
View BVdb publication page



Association between vascular endothelial growth factor receptor 2 rs11941492 C/T polymorphism and Chinese Han patients in rheumatoid arthritis.

Medicine
Z Yang, M Wang, T Yan, Z Hu, H Zhang, R Liu
Publication Date: 2019-12

Variant appearance in text: rs2305948
PubMed Link: 31876763
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Predictive and Prognostic Factors in HCC Patients Treated with Sorafenib.

Medicina (Kaunas, Lithuania)
O Brunetti, A Gnoni, A Licchetta, V Longo, A Calabrese, A Argentiero, S Delcuratolo, AG Solimando, A Casadei-Gardini, N Silvestris
Publication Date: 2019-10-21

Variant appearance in text: rs2305948
PubMed Link: 31640191
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • medicina-55-00707.pdf
View BVdb publication page



NRP-1 and KDR polymorphisms are associated with survival time in patients with advanced gastric cancer.

Oncology Letters
YJ Zhuo, Y Shi, T Wu
Publication Date: 2019-11

Variant appearance in text: rs2305948
PubMed Link: 31611971
PubMed Central Link
Variant Present in the following documents:
  • Supplementary_Data.pdf
  • Main text
  • ol-18-05-4629.pdf
View BVdb publication page



An update on biomarkers of potential benefit with bevacizumab for breast cancer treatment: Do we make progress?

Chinese Journal Of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu
X Liang, H Li, F Coussy, C Callens, F Lerebours
Publication Date: 2019-08

Variant appearance in text: rs2305948
PubMed Link: 31564802
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas.

Journal Of The American Heart Association
O Calvete, P Garcia-Pavia, F Domínguez, L Mosteiro, L Pérez-Cabornero, D Cantalapiedra, E Zorio, T Ramón Y Cajal, MG Crespo-Leiro, Á Teulé, C Lázaro, MM Morente, M Urioste, J Benitez
Publication Date: 2019-09-17

Variant appearance in text: KDR: V297I; rs2305948
PubMed Link: 31510873
PubMed Central Link
Variant Present in the following documents:
  • JAH3-8-e012875.pdf
View BVdb publication page



The association of Q472H variant in the KDR gene with recurrent pregnancy loss in Southern Iran: A case-control study.

International Journal Of Reproductive Biomedicine
L Keshavarz, M Yavarian
Publication Date: 2019-07

Variant appearance in text: KDR: Val297Ile; rs2305948
PubMed Link: 31508572
PubMed Central Link
Variant Present in the following documents:
  • ijrb-17-473.pdf
  • Main text
View BVdb publication page



Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT.

Acta Neuropathologica Communications
G Jungwirth, R Warta, C Beynon, F Sahm, A von Deimling, A Unterberg, C Herold-Mende, C Jungk
Publication Date: 2019-08-30

Variant appearance in text: rs2305948
PubMed Link: 31470906
PubMed Central Link
Variant Present in the following documents:
  • 40478_2019_793_MOESM1_ESM.xlsx
View BVdb publication page



Impact of single nucleotide polymorphisms in the VEGFR2 gene on endothelial cell activation under non‑uniform shear stress.

International Journal Of Molecular Medicine
NM Schacher, D Raaz-Schrauder, F Pasutto, FM Stumpfe, M Tauchi, B Dietel, S Achenbach, K Urschel
Publication Date: 2019-10

Variant appearance in text: rs2305948
PubMed Link: 31432097
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma.

World Journal Of Gastroenterology
E De Mattia, E Cecchin, M Guardascione, L Foltran, T Di Raimo, F Angelini, M D'Andrea, G Toffoli
Publication Date: 2019-08-07

Variant appearance in text: VEGFR2: Val297Ile; rs2305948
PubMed Link: 31413525
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



KDR (VEGFR2) Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis.

Biomolecules
A Paradowska-Gorycka, B Stypinska, A Pawlik, D Malinowski, K Romanowska-Prochnicka, M Manczak, M Olesinska
Publication Date: 2019-08-09

Variant appearance in text: KDR: V297I; rs2305948
PubMed Link: 31405022
PubMed Central Link
Variant Present in the following documents:
  • biomolecules-09-00355-s001.pdf
  • Main text
  • biomolecules-09-00355.pdf
View BVdb publication page



A meta-analysis of the relationship between VEGFR2 polymorphisms and atherosclerotic cardiovascular diseases.

Clinical Cardiology
L Wang, H Ge, L Peng, B Wang
Publication Date: 2019-10

Variant appearance in text: rs2305948
PubMed Link: 31339592
PubMed Central Link
Variant Present in the following documents:
  • CLC-42-860-s001.docx
  • Main text
View BVdb publication page



Effect of gene-gene and gene-environment interaction on the risk of first-ever stroke and poststroke death.

Molecular Genetics & Genomic Medicine
C Feng, Y Yang, S Yang, X Tu, Y Wang, Y Song, R Hui, W Zhang
Publication Date: 2019-08

Variant appearance in text: rs2305948
PubMed Link: 31293107
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • MGG3-7-e846-s001.docx
View BVdb publication page



Evaluation of associations between genetically predicted circulating protein biomarkers and breast cancer risk.

International Journal Of Cancer
X Shu, J Bao, L Wu, J Long, XO Shu, X Guo, Y Yang, K Michailidou, MK Bolla, Q Wang, J Dennis, IL Andrulis, JE Castelao, T Dörk, M Gago-Dominguez, M García-Closas, GG Giles, A Lophatananon, K Muir, H Olsson, G Rennert, E Saloustros, RJ Scott, MC Southey, PDP Pharoah, RL Milne, P Kraft, J Simard, DF Easton, W Zheng
Publication Date: 2020-04-15

Variant appearance in text: rs2305948
PubMed Link: 31265136
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



KDR inferred haplotype is associated with upper limb dysfunction in breast cancer survivors of mixed ancestry.

Cancer Management And Research
TS Mafu, AV September, D Shamley
Publication Date: 2019

Variant appearance in text: rs2305948
PubMed Link: 31118800
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Phase III Trial of Adjuvant Sunitinib in Patients with High-Risk Renal Cell Carcinoma: Exploratory Pharmacogenomic Analysis.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
DJ George, JF Martini, M Staehler, RJ Motzer, A Magheli, F Donskov, B Escudier, S Li, M Casey, O Valota, B Laguerre, AJ Pantuck, HS Pandha, A Patel, M Lechuga, A Ravaud
Publication Date: 2019-02-15

Variant appearance in text: rs2305948
PubMed Link: 30401688
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer.

Cancer Biology & Therapy
X Zhu, Y Wang, W Xue, R Wang, L Wang, ML Zhu, L Zheng
Publication Date: 2019

Variant appearance in text: rs2305948
PubMed Link: 30380970
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Surgical therapy and next-generation sequencing-based genetic alteration analysis of malignant solitary fibrous tumor of the pleura.

Oncotargets And Therapy
Z Song, F Yang, Y Zhang, P Fan, G Liu, C Li, W Ding, Y Zhang, X Xu, Y Ye
Publication Date: 2018

Variant appearance in text: KDR: V297I; rs2305948
PubMed Link: 30214228
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes.

Bmc Cardiovascular Disorders
ECA Marks, TM Wilkinson, CM Frampton, L Skelton, AP Pilbrow, TG Yandle, CJ Pemberton, RN Doughty, GA Whalley, CJ Ellis, RW Troughton, MC Owen, NR Pattinson, VA Cameron, AM Richards, SP Gieseg, BR Palmer
Publication Date: 2018-08-15

Variant appearance in text: rs2305948
PubMed Link: 30111293
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes.

Cancer Cell
I Ganly, V Makarov, S Deraje, Y Dong, E Reznik, V Seshan, G Nanjangud, S Eng, P Bose, F Kuo, LGT Morris, I Landa, PB Carrillo Albornoz, N Riaz, YE Nikiforov, K Patel, C Umbricht, M Zeiger, E Kebebew, E Sherman, R Ghossein, JA Fagin, TA Chan
Publication Date: 2018-08-13

Variant appearance in text: rs2305948
PubMed Link: 30107176
PubMed Central Link
Variant Present in the following documents:
  • NIHMS986371-supplement-2.xlsx
View BVdb publication page



Real-Time Ligand Binding of Fluorescent VEGF-A Isoforms that Discriminate between VEGFR2 and NRP1 in Living Cells.

Cell Chemical Biology
CJ Peach, LE Kilpatrick, R Friedman-Ohana, K Zimmerman, MB Robers, KV Wood, J Woolard, SJ Hill
Publication Date: 2018-10-18

Variant appearance in text: VEGFR2: V297I
PubMed Link: 30057299
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • mmc2.pdf
View BVdb publication page



PD-1 is highly expressed by neoplastic B-cells in Richter transformation.

British Journal Of Haematology
A Behdad, B Griffin, YH Chen, S Ma, K Kelemen, X Lu, QC Chen
Publication Date: 2019-04

Variant appearance in text: KDR: 889G>A
PubMed Link: 30028010
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Impact of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) single nucleotide polymorphisms on outcome in gastroenteropancreatic neuroendocrine neoplasms.

Plos One
R Berardi, M Torniai, S Partelli, C Rubini, S Pagliaretta, A Savini, V Polenta, M Santoni, R Giampieri, S Onorati, F Barucca, A Murrone, F Bianchi, M Falconi
Publication Date: 2018

Variant appearance in text: rs2305948
PubMed Link: 29787601
PubMed Central Link
Variant Present in the following documents:
  • pone.0197035.s001.xlsx
  • Main text
View BVdb publication page



Differences in Genetic Variations Between Treatable and Recalcitrant Atopic Dermatitis in Korean.

Allergy, Asthma & Immunology Research
M Jun, HY Wang, S Lee, E Choi, H Lee, EH Choi
Publication Date: 2018-05

Variant appearance in text: KDR: V297I; rs2305948
PubMed Link: 29676071
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic polymorphisms associated with adverse reactions of molecular-targeted therapies in renal cell carcinoma.

Medical Oncology (Northwood, London, England)
K Yamamoto, I Yano
Publication Date: 2018-01-04

Variant appearance in text: rs2305948
PubMed Link: 29302760
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Single nucleotide polymorphisms as prognostic and predictive biomarkers in renal cell carcinoma.

Oncotarget
C Garrigós, M Espinosa, A Salinas, I Osman, R Medina, M Taron, S Molina-Pinelo, I Duran
Publication Date: 2017-12-05

Variant appearance in text: rs2305948
PubMed Link: 29290970
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Characterizing key nucleotide polymorphisms of hepatitis C virus-disease associations via mass-spectrometric genotyping.

International Journal Of Oncology
Y Horiuchi, J Lin, Y Shinojima, K Fujiwara, M Moriyama, H Nagase
Publication Date: 2018-02

Variant appearance in text: rs2305948
PubMed Link: 29207078
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival.

International Journal Of Environmental Research And Public Health
N Sharafeldin, ML Slattery, Q Liu, C Franco-Villalobos, BJ Caan, JD Potter, Y Yasui
Publication Date: 2017-09-28

Variant appearance in text: rs2305948
PubMed Link: 28956832
PubMed Central Link
Variant Present in the following documents:
  • ijerph-14-01146-s001.pdf
View BVdb publication page



Bevacizumab-induced hypertension: Clinical presentation and molecular understanding.

Pharmacology & Therapeutics
M Li, DL Kroetz
Publication Date: 2018-02

Variant appearance in text: KDR: V297I; rs2305948
PubMed Link: 28882537
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



VEGF, VEGFR2 and GSTM1 polymorphisms in outcome of multiple myeloma patients treated with thalidomide-based regimens.

Blood Cancer Journal
L Lopes-Aguiar, MT Delamain, ABC Brito, GJ Lourenço, EFD Costa, GB Oliveira, J Vassallo, CA De Souza, CSP Lima
Publication Date: 2017-06-30

Variant appearance in text: VEGFR2: 889G>A; rs2305948
PubMed Link: 28665417
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • bcj201758x5.doc
View BVdb publication page



Carfilzomib and lenalidomide response related to VEGF and VEGFR2 germline polymorphisms.

Cancer Chemotherapy And Pharmacology
TM Sissung, CJ Peer, N Korde, S Mailankody, D Kazandjian, DJ Venzon, O Landgren, WD Figg
Publication Date: 2017-07

Variant appearance in text: VEGFR2: V297I; rs2305948
PubMed Link: 28488026
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study.

Plos One
M Peng, G Zhao, F Yang, G Cheng, J Huang, X Qin, Y Liu, Q Wang, Y Li, D Qin
Publication Date: 2017

Variant appearance in text: rs2305948
PubMed Link: 28264017
PubMed Central Link
Variant Present in the following documents:
  • pone.0173298.s001.docx
View BVdb publication page



Determination of VEGFR-2 (KDR) 604A>G Polymorphism in Pancreatic Disorders.

International Journal Of Molecular Sciences
V Pădureanu, MV Boldeanu, I Streaţă, MG Cucu, I Siloşi, L Boldeanu, M Bogdan, AŞ Enescu, M Forţofoiu, A Enescu, EM Dumitrescu, D Alexandru, VM Şurlin, MC Forţofoiu, IO Petrescu, F Petrescu, M Ioana, ME Ciurea, A Săftoiu
Publication Date: 2017-02-17

Variant appearance in text: rs2305948
PubMed Link: 28218664
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity.

Scientific Reports
Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, H Li, HS Tan, R Kanesvaran, H Yu, MH Tan
Publication Date: 2017-01-25

Variant appearance in text: rs2305948
PubMed Link: 28120901
PubMed Central Link
Variant Present in the following documents:
  • srep41238-s1.pdf
View BVdb publication page



Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib.

Scientific Reports
A Cebrián, T Gómez Del Pulgar, MJ Méndez-Vidal, ML Gonzálvez, N Lainez, D Castellano, I García-Carbonero, E Esteban, MI Sáez, R Villatoro, C Suárez, A Carrato, J Munárriz-Ferrándiz, L Basterrechea, M García-Alonso, JL González-Larriba, B Perez-Valderrama, J Cruz-Jurado, A González Del Alba, F Moreno, G Reynés, M Rodríguez-Remírez, V Boni, I Mahillo-Fernández, Y Martin, A Viqueira, J García-Foncillas
Publication Date: 2017-01-24

Variant appearance in text: rs2305948
PubMed Link: 28117391
PubMed Central Link
Variant Present in the following documents:
  • srep41371-s1.pdf
View BVdb publication page



Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients.

Plos One
I Makhoul, VK Todorova, ER Siegel, SW Erickson, I Dhakal, VR Raj, JY Lee, MS Orloff, RJ Griffin, RS Henry-Tillman, S Klimberg, LF Hutchins, SA Kadlubar
Publication Date: 2017

Variant appearance in text: rs2305948
PubMed Link: 28045923
PubMed Central Link
Variant Present in the following documents:
  • pone.0168550.s011.xlsx
  • pone.0168550.s006.xlsx
  • pone.0168550.s007.xlsx
  • pone.0168550.s004.xlsx
  • pone.0168550.s009.xlsx
  • pone.0168550.s005.xlsx
  • pone.0168550.s003.xlsx
View BVdb publication page



Preliminary data of VEGF-A and VEGFR-2 polymorphisms as predictive factors of radiological response and clinical outcome in iodine-refractory differentiated thyroid cancer treated with sorafenib.

Endocrine
V Marotta, C Sciammarella, M Capasso, A Testori, C Pivonello, MG Chiofalo, R Pivonello, L Pezzullo, G Botti, A Colao, A Faggiano
Publication Date: 2017-09

Variant appearance in text: rs2305948
PubMed Link: 27981515
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Influence of Tyrosine Kinase Inhibitors on Hypertension and Nephrotoxicity in Metastatic Renal Cell Cancer Patients.

International Journal Of Molecular Sciences
A Semeniuk-Wojtaś, A Lubas, R Stec, C Szczylik, S Niemczyk
Publication Date: 2016-12-09

Variant appearance in text: rs2305948
PubMed Link: 27941701
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Vascular Endothelial Growth Factor Receptor-2 Polymorphisms Have Protective Effect against the Development of Tendinopathy in Volleyball Athletes.

Plos One
JI Salles, ME Duarte, JM Guimarães, LR Lopes, J Vilarinho Cardoso, DP Aguiar, JO Machado Neto, DE Machado, JA Perini
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27930691
PubMed Central Link
Variant Present in the following documents:
  • pone.0167717.s002.xlsx
  • pone.0167717.s001.xlsx
  • Main text
View BVdb publication page



Germline Polymorphisms of the VEGF Pathway Predict Recurrence in Nonadvanced Differentiated Thyroid Cancer.

The Journal Of Clinical Endocrinology And Metabolism
V Marotta, C Sciammarella, M Capasso, A Testori, C Pivonello, MG Chiofalo, C Gambardella, M Grasso, A Antonino, A Annunziata, PE Macchia, R Pivonello, L Santini, G Botti, S Losito, L Pezzullo, A Colao, A Faggiano
Publication Date: 2017-02-01

Variant appearance in text: rs2305948
PubMed Link: 27849428
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients.

Cancer Medicine
LA Dan, S Werdyani, J Xu, K Shestopaloff, A Hyde, E Dicks, B Younghusband, J Green, P Parfrey, W Xu, S Savas
Publication Date: 2016-09

Variant appearance in text: rs2305948
PubMed Link: 27334288
PubMed Central Link
Variant Present in the following documents:
  • CAM4-5-2221-s007.xlsx
  • CAM4-5-2221-s010.xlsx
  • CAM4-5-2221-s004.xlsx
View BVdb publication page



AMD Genetics in India: The Missing Links.

Frontiers In Aging Neuroscience
A Anand, K Sharma, SK Sharma, R Singh, NK Sharma, K Prasad
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27252648
PubMed Central Link
Variant Present in the following documents:
  • Main text
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Development and clinical application of an integrative genomic approach to personalized cancer therapy.

Genome Medicine
AV Uzilov, W Ding, MY Fink, Y Antipin, AS Brohl, C Davis, CY Lau, C Pandya, H Shah, Y Kasai, J Powell, M Micchelli, R Castellanos, Z Zhang, M Linderman, Y Kinoshita, M Zweig, K Raustad, K Cheung, D Castillo, M Wooten, I Bourzgui, LC Newman, G Deikus, B Mathew, J Zhu, BS Glicksberg, AS Moe, J Liao, L Edelmann, JT Dudley, RG Maki, A Kasarskis, RF Holcombe, M Mahajan, K Hao, B Reva, J Longtine, D Starcevic, R Sebra, MJ Donovan, S Li, EE Schadt, R Chen
Publication Date: 2016-06-01

Variant appearance in text: rs2305948
PubMed Link: 27245685
PubMed Central Link
Variant Present in the following documents:
  • 13073_2016_313_MOESM5_ESM.pdf
View BVdb publication page



Genes, environment and gene expression in colon tissue: a pathway approach to determining functionality.

International Journal Of Molecular Epidemiology And Genetics
ML Slattery, DF Pellatt, RK Wolff, A Lundgreen
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27186328
PubMed Central Link
Variant Present in the following documents:
  • ijmeg0007-0045-f1.pdf
  • Main text
View BVdb publication page



Association of Genetic Polymorphisms on VEGFA and VEGFR2 With Risk of Coronary Heart Disease.

Medicine
D Liu, J Song, X Ji, Z Liu, M Cong, B Hu
Publication Date: 2016-05

Variant appearance in text: rs2305948
PubMed Link: 27175642
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Angiogenesis genotyping in the selection of first-line treatment with either sunitinib or pazopanib for advanced renal cell carcinoma.

Oncotarget
M Bianconi, L Faloppi, C Loretelli, A Zizzi, R Giampieri, A Bittoni, K Andrikou, M Del Prete, L Burattini, R Montironi, M Scartozzi, S Cascinu
Publication Date: 2016-06-21

Variant appearance in text: rs2305948
PubMed Link: 27175586
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role of HIF1A, VEGFA and VEGFR2 SNPs in the Susceptibility and Progression of COPD in a Spanish Population.

Plos One
R Baz-Dávila, A Espinoza-Jiménez, Mdel C Rodríguez-Pérez, J Zulueta, N Varo, Á Montejo, D Almeida-González, A Aguirre-Jaime, E Córdoba-Lanús, C Casanova
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27163696
PubMed Central Link
Variant Present in the following documents:
  • Main text
  • pone.0154998.s002.pdf
View BVdb publication page



Association of kinase insert domain-containing receptor (KDR) gene polymorphism/ haplotypes with recurrent spontaneous abortion and genetic structure.

International Journal Of Reproductive Biomedicine
S Shahsavari, Z Noormohammadi, S Zare Karizi
Publication Date: 2015-12

Variant appearance in text: KDR: V297I; rs2305948
PubMed Link: 27141535
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Angiogenesis genotyping and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients.

Scientific Reports
R Giampieri, L Salvatore, M Del Prete, T Prochilo, M D'Anzeo, C Loretelli, F Loupakis, G Aprile, E Maccaroni, K Andrikou, M Bianconi, A Bittoni, L Faloppi, L Demurtas, R Montironi, M Scarpelli, A Falcone, A Zaniboni, M Scartozzi, S Cascinu
Publication Date: 2016-04-27

Variant appearance in text: rs2305948
PubMed Link: 27117754
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Use of dedicated gene panel sequencing using next generation sequencing to improve the personalized care of lung cancer.

Oncotarget
CG Kaderbhai, R Boidot, F Beltjens, S Chevrier, L Arnould, L Favier, A Lagrange, B Coudert, F Ghiringhelli
Publication Date: 2016-04-26

Variant appearance in text: KDR: V297I
PubMed Link: 27027238
PubMed Central Link
Variant Present in the following documents:
  • oncotarget-07-24860-s001.pdf
View BVdb publication page



Genomic Characterization and Comparison of Multi-Regional and Pooled Tumor Biopsy Specimens.

Plos One
JG Joung, JS Bae, SC Kim, H Jung, WY Park, SY Song
Publication Date: 2016

Variant appearance in text: rs2305948
PubMed Link: 27010638
PubMed Central Link
Variant Present in the following documents:
  • pone.0152574.s006.xlsx
View BVdb publication page



The Association between VEGFR Gene Polymorphisms and Stroke: A Meta-Analysis.

Plos One
S Qiu, T Wu, P Wang, J Li, Q Li, J Du
Publication Date: 2016

Variant appearance in text: VEGFR: Val297Ile; rs2305948
PubMed Link: 26981634
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



The influence of genetic variants of sorafenib on clinical outcomes and toxic effects in patients with advanced renal cell carcinoma.

Scientific Reports
C Qin, Q Cao, P Li, S Wang, J Wang, M Wang, H Chu, L Zhou, X Li, D Ye, H Zhang, Y Huang, B Dong, X Sun, Q Zou, H Cai, L Sun, J Zhu, F Liu, J Ji, L Cui, X Wang, H Zhou, H Zhao, B Wu, J Chen, M Jiang, Z Zhang, P Shao, X Ju, C Yin
Publication Date: 2016-02-02

Variant appearance in text: rs2305948
PubMed Link: 26830973
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers.

Fertility And Sterility
A Vodolazkaia, BT Yesilyurt, CM Kyama, A Bokor, D Schols, D Huskens, C Meuleman, K Peeraer, C Tomassetti, X Bossuyt, D Lambrechts, T D'Hooghe, A Fassbender
Publication Date: 2016-04

Variant appearance in text: rs2305948
PubMed Link: 26773192
PubMed Central Link
Variant Present in the following documents:
  • Supplemental file
View BVdb publication page



Association of Genetic Polymorphisms on Vascular Endothelial Growth Factor and its Receptor Genes with Susceptibility to Coronary Heart Disease.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
L Li, Y Pan, L Dai, B Liu, D Zhang
Publication Date: 2016-01-04

Variant appearance in text: rs2305948
PubMed Link: 26726843
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach.

Frontiers In Pharmacology
CB Platania, L Di Paola, GM Leggio, GL Romano, F Drago, S Salomone, C Bucolo
Publication Date: 2015

Variant appearance in text: rs2305948
PubMed Link: 26578958
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients.

Oncotarget
A Solini, V Simeon, L Derosa, P Orlandi, C Rossi, A Fontana, L Galli, T Di Desidero, A Fioravanti, S Lucchesi, L Coltelli, L Ginocchi, G Allegrini, R Danesi, A Falcone, G Bocci
Publication Date: 2015-10-06

Variant appearance in text: rs2305948
PubMed Link: 26337470
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies.

Journal Of Bone And Mineral Research : The Official Journal Of The American Society For Bone And Mineral Research
T Niu, N Liu, X Yu, M Zhao, HJ Choi, PJ Leo, MA Brown, L Zhang, YF Pei, H Shen, H He, X Fu, S Lu, XD Chen, LJ Tan, TL Yang, Y Guo, NH Cho, J Shen, YF Guo, GC Nicholson, RL Prince, JA Eisman, G Jones, PN Sambrook, Q Tian, XZ Zhu, CJ Papasian, EL Duncan, AG Uitterlinden, CS Shin, S Xiang, HW Deng
Publication Date: 2016-02

Variant appearance in text: rs2305948
PubMed Link: 26256109
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Impact of VEGF, VEGFR, PDGFR, HIF and ERCC1 gene polymorphisms on thymic malignancies outcome after thymectomy.

Oncotarget
R Berardi, A Brunelli, S Pagliaretta, V Paolucci, A Conti, G Goteri, M Refai, C Pompili, G Marcantognini, F Morgese, Z Ballatore, A Savini, M De Lisa, M Caramanti, M Santoni, A Zizzi, F Piva, P Mazzanti, A Onofri, A Sabbatini, M Scarpelli, S Cascinu
Publication Date: 2015-08-07

Variant appearance in text: KDR: V297I; rs2305948
PubMed Link: 26254278
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of ABCB1 and FLT3 Polymorphisms with Toxicities and Survival in Asian Patients Receiving Sunitinib for Renal Cell Carcinoma.

Plos One
YH Chu, H Li, HS Tan, V Koh, J Lai, WM Phyo, Y Choudhury, R Kanesvaran, NM Chau, CK Toh, QS Ng, PH Tan, B Chowbay, MH Tan
Publication Date: 2015

Variant appearance in text: VEGFR2: V297I; rs2305948
PubMed Link: 26244574
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



A case of metastatic renal cell carcinoma and bile duct carcinoma treated with a combination of sunitinib and gemcitabine.

Bmc Cancer
K Takayoshi, K Sagara, K Uchino, H Kusaba, N Sakamoto, A Iguchi, E Baba
Publication Date: 2015-05-22

Variant appearance in text: rs2305948
PubMed Link: 26001650
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization.

Bmc Cardiovascular Disorders
J Duran, PS Olavarría, M Mola, V Götzens, J Carballo, EM Pelegrina, M Petit, O Abdul-Jawad, I Otaegui, BG del Blanco, D García-Dorado, J Reig, A Cordero, JM de Anta
Publication Date: 2015-05-12

Variant appearance in text: KDR: Val297Ile; rs2305948
PubMed Link: 25959001
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



IL8 polymorphisms and overall survival in pazopanib- or sunitinib-treated patients with renal cell carcinoma.

British Journal Of Cancer
CF Xu, T Johnson, J Garcia-Donas, TK Choueiri, CN Sternberg, ID Davis, N Bing, KC Deen, Z Xue, L McCann, E Esteban, JC Whittaker, CF Spraggs, C Rodríguez-Antona, LN Pandite, RJ Motzer
Publication Date: 2015-03-31

Variant appearance in text: VEGFR2: V297I; rs2305948
PubMed Link: 25695485
PubMed Central Link
Variant Present in the following documents:
  • Main text
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000263923.4 c.889G>A p.Val297Ile missense_variant 7/30 -
ENST00000512566.1 n.889G>A - non_coding_transcript_exon_variant 7/13 -
NM_002253.3 c.889G>A p.Val297Ile missense_variant 7/30 -