Development and validation of a multivariable genotype-informed gestational diabetes prediction algorithm for clinical use in the Mexican population: insights into susceptibility mechanisms.
Bmj Open Diabetes Research & Care
Zulueta, Mirella M; Gallardo-Rincón, Héctor H; Martinez-Juarez, Luis Alberto LA; Lomelin-Gascon, Julieta J; Ortega-Montiel, Janinne J; Montoya, Alejandra A; Mendizabal, Leire L; Arregi, Maddi M; Martinez-Martinez, María de Los Angeles MLA; Camarillo Romero, Eneida Del Socorro EDS; Mendieta Zerón, Hugo H; Garduño García, José de Jesús JJ; Simón, Laureano L; Tapia-Conyer, Roberto R
Genetic variants for prediction of gestational diabetes mellitus and modulation of susceptibility by a nutritional intervention based on a Mediterranean diet.
Frontiers In Endocrinology
Ramos-Levi, Ana A; Barabash, Ana A; Valerio, Johanna J; García de la Torre, Nuria N; Mendizabal, Leire L; Zulueta, Mirella M; de Miguel, Maria Paz MP; Diaz, Angel A; Duran, Alejandra A; Familiar, Cristina C; Jimenez, Inés I; Del Valle, Laura L; Melero, Veronica V; Moraga, Inmaculada I; Herraiz, Miguel A MA; Torrejon, María José MJ; Arregi, Maddi M; Simón, Laureano L; Rubio, Miguel A MA; Calle-Pascual, Alfonso L AL
FAM13A affects body fat distribution and adipocyte function.
Nature Communications
Fathzadeh, Mohsen M; Li, Jiehan J; Rao, Abhiram A; Cook, Naomi N; Chennamsetty, Indumathi I; Seldin, Marcus M; Zhou, Xiang X; Sangwung, Panjamaporn P; Gloudemans, Michael J MJ; Keller, Mark M; Attie, Allan A; Yang, Jing J; Wabitsch, Martin M; Carcamo-Orive, Ivan I; Tada, Yuko Y; Lusis, Aldons J AJ; Shin, Myung Kyun MK; Molony, Cliona M CM; McLaughlin, Tracey T; Reaven, Gerald G; Montgomery, Stephen B SB; Reilly, Dermot D; Quertermous, Thomas T; Ingelsson, Erik E; Knowles, Joshua W JW
Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes.
Circulation Research
Chen, Zhifen Z; Yu, Haojie H; Shi, Xu X; Warren, Curtis R CR; Lotta, Luca A LA; Friesen, Max M; Meissner, Torsten B TB; Langenberg, Claudia C; Wabitsch, Martin M; Wareham, Nick N; Benson, Mark D MD; Gerszten, Rob E RE; Cowan, Chad A CA
A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program.
Journal Of The Endocrine Society
Srinivasan, Shylaja S; Jablonski, Kathleen A KA; Knowler, William C WC; Dagogo-Jack, Samuel S; E Kahn, Steven S; Boyko, Edward J EJ; Bray, George A GA; Horton, Edward S ES; Hivert, Marie-France MF; Goldberg, Ronald R; Chen, Ling L; Mercader, Josep J; Harden, Maegan M; Florez, Jose C JC; ,
An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese.
Diabetologia
Graae, Anne-Sofie AS; Hollensted, Mette M; Kloppenborg, Julie T JT; Mahendran, Yuvaraj Y; Schnurr, Theresia M TM; Appel, Emil Vincent R EVR; Rask, Johanne J; Nielsen, Tenna R H TRH; Johansen, Mia Ø MØ; Linneberg, Allan A; Jørgensen, Marit E ME; Grarup, Niels N; Kadarmideen, Haja N HN; Holst, Birgitte B; Pedersen, Oluf O; Holm, Jens-Christian JC; Hansen, Torben T
Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium.
Diabetologia
Bien, Stephanie A SA; Pankow, James S JS; Haessler, Jeffrey J; Lu, Yinchang Y; Pankratz, Nathan N; Rohde, Rebecca R RR; Tamuno, Alfred A; Carlson, Christopher S CS; Schumacher, Fredrick R FR; Bůžková, Petra P; Daviglus, Martha L ML; Lim, Unhee U; Fornage, Myriam M; Fernandez-Rhodes, Lindsay L; Avilés-Santa, Larissa L; Buyske, Steven S; Gross, Myron D MD; Graff, Mariaelisa M; Isasi, Carmen R CR; Kuller, Lewis H LH; Manson, JoAnn E JE; Matise, Tara C TC; Prentice, Ross L RL; Wilkens, Lynne R LR; Yoneyama, Sachiko S; Loos, Ruth J F RJF; Hindorff, Lucia A LA; Le Marchand, Loic L; North, Kari E KE; Haiman, Christopher A CA; Peters, Ulrike U; Kooperberg, Charles C
Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study.
Scientific Reports
Christie, Shanice S; Robiou-du-Pont, Sébastien S; Anand, Sonia S SS; Morrison, Katherine M KM; McDonald, Sarah D SD; Paré, Guillaume G; Atkinson, Stephanie A SA; Teo, Koon K KK; Meyre, David D
A genome-wide association meta-analysis on apolipoprotein A-IV concentrations.
Human Molecular Genetics
Lamina, Claudia C; Friedel, Salome S; Coassin, Stefan S; Rueedi, Rico R; Yousri, Noha A NA; Seppälä, Ilkka I; Gieger, Christian C; Schönherr, Sebastian S; Forer, Lukas L; Erhart, Gertraud G; Kollerits, Barbara B; Marques-Vidal, Pedro P; Ried, Janina J; Waeber, Gerard G; Bergmann, Sven S; Dähnhardt, Doreen D; Stöckl, Andrea A; Kiechl, Stefan S; Raitakari, Olli T OT; Kähönen, Mika M; Willeit, Johann J; Kedenko, Ludmilla L; Paulweber, Bernhard B; Peters, Annette A; Meitinger, Thomas T; Strauch, Konstantin K; , ; Lehtimäki, Terho T; Hunt, Steven C SC; Vollenweider, Peter P; Kronenberg, Florian F
Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.
American Journal Of Human Genetics
Liu, Ching-Ti CT; Raghavan, Sridharan S; Maruthur, Nisa N; Kabagambe, Edmond Kato EK; Hong, Jaeyoung J; Ng, Maggie C Y MC; Hivert, Marie-France MF; Lu, Yingchang Y; An, Ping P; Bentley, Amy R AR; Drolet, Anne M AM; Gaulton, Kyle J KJ; Guo, Xiuqing X; Armstrong, Loren L LL; Irvin, Marguerite R MR; Li, Man M; Lipovich, Leonard L; Rybin, Denis V DV; Taylor, Kent D KD; Agyemang, Charles C; Palmer, Nicholette D ND; Cade, Brian E BE; Chen, Wei-Min WM; Dauriz, Marco M; Delaney, Joseph A C JA; Edwards, Todd L TL; Evans, Daniel S DS; Evans, Michele K MK; Lange, Leslie A LA; Leong, Aaron A; Liu, Jingmin J; Liu, Yongmei Y; Nayak, Uma U; Patel, Sanjay R SR; Porneala, Bianca C BC; Rasmussen-Torvik, Laura J LJ; Snijder, Marieke B MB; Stallings, Sarah C SC; Tanaka, Toshiko T; Yanek, Lisa R LR; Zhao, Wei W; Becker, Diane M DM; Bielak, Lawrence F LF; Biggs, Mary L ML; Bottinger, Erwin P EP; Bowden, Donald W DW; Chen, Guanjie G; Correa, Adolfo A; Couper, David J DJ; Crawford, Dana C DC; Cushman, Mary M; Eicher, John D JD; Fornage, Myriam M; Franceschini, Nora N; Fu, Yi-Ping YP; Goodarzi, Mark O MO; Gottesman, Omri O; Hara, Kazuo K; Harris, Tamara B TB; Jensen, Richard A RA; Johnson, Andrew D AD; Jhun, Min A MA; Karter, Andrew J AJ; Keller, Margaux F MF; Kho, Abel N AN; Kizer, Jorge R JR; Krauss, Ronald M RM; Langefeld, Carl D CD; Li, Xiaohui X; Liang, Jingling J; Liu, Simin S; Lowe, William L WL; Mosley, Thomas H TH; North, Kari E KE; Pacheco, Jennifer A JA; Peyser, Patricia A PA; Patrick, Alan L AL; Rice, Kenneth M KM; Selvin, Elizabeth E; Sims, Mario M; Smith, Jennifer A JA; Tajuddin, Salman M SM; Vaidya, Dhananjay D; Wren, Mary P MP; Yao, Jie J; Zhu, Xiaofeng X; Ziegler, Julie T JT; Zmuda, Joseph M JM; Zonderman, Alan B AB; Zwinderman, Aeilko H AH; , ; , ; , ; , ; , ; Adeyemo, Adebowale A; Boerwinkle, Eric E; Ferrucci, Luigi L; Hayes, M Geoffrey MG; Kardia, Sharon L R SL; Miljkovic, Iva I; Pankow, James S JS; Rotimi, Charles N CN; Sale, Michele M MM; Wagenknecht, Lynne E LE; Arnett, Donna K DK; Chen, Yii-Der Ida YD; Nalls, Michael A MA; , ; Province, Michael A MA; Kao, W H Linda WH; Siscovick, David S DS; Psaty, Bruce M BM; Wilson, James G JG; Loos, Ruth J F RJ; Dupuis, Josée J; Rich, Stephen S SS; Florez, Jose C JC; Rotter, Jerome I JI; Morris, Andrew P AP; Meigs, James B JB
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.
Nature Communications
Tang, Clara S CS; Zhang, He H; Cheung, Chloe Y Y CY; Xu, Ming M; Ho, Jenny C Y JC; Zhou, Wei W; Cherny, Stacey S SS; Zhang, Yan Y; Holmen, Oddgeir O; Au, Ka-Wing KW; Yu, Haiyi H; Xu, Lin L; Jia, Jia J; Porsch, Robert M RM; Sun, Lijie L; Xu, Weixian W; Zheng, Huiping H; Wong, Lai-Yung LY; Mu, Yiming Y; Dou, Jingtao J; Fong, Carol H Y CH; Wang, Shuyu S; Hong, Xueyu X; Dong, Liguang L; Liao, Yanhua Y; Wang, Jiansong J; Lam, Levina S M LS; Su, Xi X; Yan, Hua H; Yang, Min-Lee ML; Chen, Jin J; Siu, Chung-Wah CW; Xie, Gaoqiang G; Woo, Yu-Cho YC; Wu, Yangfeng Y; Tan, Kathryn C B KC; Hveem, Kristian K; Cheung, Bernard M Y BM; Zöllner, Sebastian S; Xu, Aimin A; Eugene Chen, Y Y; Jiang, Chao Qiang CQ; Zhang, Youyi Y; Lam, Tai-Hing TH; Ganesh, Santhi K SK; Huo, Yong Y; Sham, Pak C PC; Lam, Karen S L KS; Willer, Cristen J CJ; Tse, Hung-Fat HF; Gao, Wei W
Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.
Diabetes
Hivert, Marie-France MF; Christophi, Costas A CA; Franks, Paul W PW; Jablonski, Kathleen A KA; Ehrmann, David A DA; Kahn, Steven E SE; Horton, Edward S ES; Pollin, Toni I TI; Mather, Kieren J KJ; Perreault, Leigh L; Barrett-Connor, Elizabeth E; Knowler, William C WC; Florez, Jose C JC; ,
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
Nature Communications
Benyamin, Beben B; Esko, Tonu T; Ried, Janina S JS; Radhakrishnan, Aparna A; Vermeulen, Sita H SH; Traglia, Michela M; Gögele, Martin M; Anderson, Denise D; Broer, Linda L; Podmore, Clara C; Luan, Jian'an J; Kutalik, Zoltan Z; Sanna, Serena S; van der Meer, Peter P; Tanaka, Toshiko T; Wang, Fudi F; Westra, Harm-Jan HJ; Franke, Lude L; Mihailov, Evelin E; Milani, Lili L; Hälldin, Jonas J; Häldin, Jonas J; Winkelmann, Juliane J; Meitinger, Thomas T; Thiery, Joachim J; Peters, Annette A; Waldenberger, Melanie M; Rendon, Augusto A; Jolley, Jennifer J; Sambrook, Jennifer J; Kiemeney, Lambertus A LA; Sweep, Fred C FC; Sala, Cinzia F CF; Schwienbacher, Christine C; Pichler, Irene I; Hui, Jennie J; Demirkan, Ayse A; Isaacs, Aaron A; Amin, Najaf N; Steri, Maristella M; Waeber, Gérard G; Verweij, Niek N; Powell, Joseph E JE; Nyholt, Dale R DR; Heath, Andrew C AC; Madden, Pamela A F PA; Visscher, Peter M PM; Wright, Margaret J MJ; Montgomery, Grant W GW; Martin, Nicholas G NG; Hernandez, Dena D; Bandinelli, Stefania S; van der Harst, Pim P; Uda, Manuela M; Vollenweider, Peter P; Scott, Robert A RA; Langenberg, Claudia C; Wareham, Nicholas J NJ; , ; van Duijn, Cornelia C; Beilby, John J; Pramstaller, Peter P PP; Hicks, Andrew A AA; Ouwehand, Willem H WH; Oexle, Konrad K; Gieger, Christian C; Metspalu, Andres A; Camaschella, Clara C; Toniolo, Daniela D; Swinkels, Dorine W DW; Whitfield, John B JB
Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes.
Diabetes
Yaghootkar, Hanieh H; Scott, Robert A RA; White, Charles C CC; Zhang, Weihua W; Speliotes, Elizabeth E; Munroe, Patricia B PB; Ehret, Georg B GB; Bis, Joshua C JC; Fox, Caroline S CS; Walker, Mark M; Borecki, Ingrid B IB; Knowles, Joshua W JW; Yerges-Armstrong, Laura L; Ohlsson, Claes C; Perry, John R B JR; Chambers, John C JC; Kooner, Jaspal S JS; Franceschini, Nora N; Langenberg, Claudia C; Hivert, Marie-France MF; Dastani, Zari Z; Richards, J Brent JB; Semple, Robert K RK; Frayling, Timothy M TM
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
Nature Genetics
Scott, Robert A RA; Lagou, Vasiliki V; Welch, Ryan P RP; Wheeler, Eleanor E; Montasser, May E ME; Luan, Jian'an J; Mägi, Reedik R; Strawbridge, Rona J RJ; Rehnberg, Emil E; Gustafsson, Stefan S; Kanoni, Stavroula S; Rasmussen-Torvik, Laura J LJ; Yengo, Loïc L; Lecoeur, Cecile C; Shungin, Dmitry D; Sanna, Serena S; Sidore, Carlo C; Johnson, Paul C D PC; Jukema, J Wouter JW; Johnson, Toby T; Mahajan, Anubha A; Verweij, Niek N; Thorleifsson, Gudmar G; Hottenga, Jouke-Jan JJ; Shah, Sonia S; Smith, Albert V AV; Sennblad, Bengt B; Gieger, Christian C; Salo, Perttu P; Perola, Markus M; Timpson, Nicholas J NJ; Evans, David M DM; Pourcain, Beate St BS; Wu, Ying Y; Andrews, Jeanette S JS; Hui, Jennie J; Bielak, Lawrence F LF; Zhao, Wei W; Horikoshi, Momoko M; Navarro, Pau P; Isaacs, Aaron A; O'Connell, Jeffrey R JR; Stirrups, Kathleen K; Vitart, Veronique V; Hayward, Caroline C; Esko, Tõnu T; Mihailov, Evelin E; Fraser, Ross M RM; Fall, Tove T; Voight, Benjamin F BF; Raychaudhuri, Soumya S; Chen, Han H; Lindgren, Cecilia M CM; Morris, Andrew P AP; Rayner, Nigel W NW; Robertson, Neil N; Rybin, Denis D; Liu, Ching-Ti CT; Beckmann, Jacques S JS; Willems, Sara M SM; Chines, Peter S PS; Jackson, Anne U AU; Kang, Hyun Min HM; Stringham, Heather M HM; Song, Kijoung K; Tanaka, Toshiko T; Peden, John F JF; Goel, Anuj A; Hicks, Andrew A AA; An, Ping P; Müller-Nurasyid, Martina M; Franco-Cereceda, Anders A; Folkersen, Lasse L; Marullo, Letizia L; Jansen, Hanneke H; Oldehinkel, Albertine J AJ; Bruinenberg, Marcel M; Pankow, James S JS; North, Kari E KE; Forouhi, Nita G NG; Loos, Ruth J F RJ; Edkins, Sarah S; Varga, Tibor V TV; Hallmans, Göran G; Oksa, Heikki H; Antonella, Mulas M; Nagaraja, Ramaiah R; Trompet, Stella S; Ford, Ian I; Bakker, Stephan J L SJ; Kong, Augustine A; Kumari, Meena M; Gigante, Bruna B; Herder, Christian C; Munroe, Patricia B PB; Caulfield, Mark M; Antti, Jula J; Mangino, Massimo M; Small, Kerrin K; Miljkovic, Iva I; Liu, Yongmei Y; Atalay, Mustafa M; Kiess, Wieland W; James, Alan L AL; Rivadeneira, Fernando F; Uitterlinden, Andre G AG; Palmer, Colin N A CN; Doney, Alex S F AS; Willemsen, Gonneke G; Smit, Johannes H JH; Campbell, Susan S; Polasek, Ozren O; Bonnycastle, Lori L LL; Hercberg, Serge S; Dimitriou, Maria M; Bolton, Jennifer L JL; Fowkes, Gerard R GR; Kovacs, Peter P; Lindström, Jaana J; Zemunik, Tatijana T; Bandinelli, Stefania S; Wild, Sarah H SH; Basart, Hanneke V HV; Rathmann, Wolfgang W; Grallert, Harald H; , ; Maerz, Winfried W; Kleber, Marcus E ME; Boehm, Bernhard O BO; Peters, Annette A; Pramstaller, Peter P PP; Province, Michael A MA; Borecki, Ingrid B IB; Hastie, Nicholas D ND; Rudan, Igor I; Campbell, Harry H; Watkins, Hugh H; Farrall, Martin M; Stumvoll, Michael M; Ferrucci, Luigi L; Waterworth, Dawn M DM; Bergman, Richard N RN; Collins, Francis S FS; Tuomilehto, Jaakko J; Watanabe, Richard M RM; de Geus, Eco J C EJ; Penninx, Brenda W BW; Hofman, Albert A; Oostra, Ben A BA; Psaty, Bruce M BM; Vollenweider, Peter P; Wilson, James F JF; Wright, Alan F AF; Hovingh, G Kees GK; Metspalu, Andres A; Uusitupa, Matti M; Magnusson, Patrik K E PK; Kyvik, Kirsten O KO; Kaprio, Jaakko J; Price, Jackie F JF; Dedoussis, George V GV; Deloukas, Panos P; Meneton, Pierre P; Lind, Lars L; Boehnke, Michael M; Shuldiner, Alan R AR; van Duijn, Cornelia M CM; Morris, Andrew D AD; Toenjes, Anke A; Peyser, Patricia A PA; Beilby, John P JP; Körner, Antje A; Kuusisto, Johanna J; Laakso, Markku M; Bornstein, Stefan R SR; Schwarz, Peter E H PE; Lakka, Timo A TA; Rauramaa, Rainer R; Adair, Linda S LS; Smith, George Davey GD; Spector, Tim D TD; Illig, Thomas T; de Faire, Ulf U; Hamsten, Anders A; Gudnason, Vilmundur V; Kivimaki, Mika M; Hingorani, Aroon A; Keinanen-Kiukaanniemi, Sirkka M SM; Saaristo, Timo E TE; Boomsma, Dorret I DI; Stefansson, Kari K; van der Harst, Pim P; Dupuis, Josée J; Pedersen, Nancy L NL; Sattar, Naveed N; Harris, Tamara B TB; Cucca, Francesco F; Ripatti, Samuli S; Salomaa, Veikko V; Mohlke, Karen L KL; Balkau, Beverley B; Froguel, Philippe P; Pouta, Anneli A; Jarvelin, Marjo-Riitta MR; Wareham, Nicholas J NJ; Bouatia-Naji, Nabila N; McCarthy, Mark I MI; Franks, Paul W PW; Meigs, James B JB; Teslovich, Tanya M TM; Florez, Jose C JC; Langenberg, Claudia C; Ingelsson, Erik E; Prokopenko, Inga I; Barroso, Inês I