SNCA c.385T>G ;(p.S129A)

Variant ID: 4-90650350-A-C

NM_000345.3(SNCA):c.385T>G;(p.S129A)

This variant was identified in 52 publications

View GRCh38 version.




Publications:


Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation.

Science Advances
Zenko, Dmitry D; Marsh, Jade J; Castle, Andrew R AR; Lewin, Rahel R; Fischer, Roman R; Tofaris, George K GK
Publication Date: 2023-06-16

Variant appearance in text: SNCA: S129A
PubMed Link: 37315142
Variant Present in the following documents:
  • Main text
  • sciadv.add8910.pdf
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The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology.

Npj Parkinson'S Disease
Obergasteiger, Julia J; Castonguay, Anne-Marie AM; Pizzi, Sara S; Magnabosco, Stefano S; Frapporti, Giulia G; Lobbestael, Evy E; Baekelandt, Veerle V; Hicks, Andrew A AA; Pramstaller, Peter P PP; Gravel, Claude C; Corti, Corrado C; Lévesque, Martin M; Volta, Mattia M
Publication Date: 2023-03-27

Variant appearance in text: SNCA: S129A
PubMed Link: 36973269
Variant Present in the following documents:
  • Main text
  • 41531_2023_Article_484.pdf
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Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.

Npj Parkinson'S Disease
Ramalingam, Nagendran N; Jin, Shan-Xue SX; Moors, Tim E TE; Fonseca-Ornelas, Luis L; Shimanaka, Kazuma K; Lei, Shi S; Cam, Hugh P HP; Watson, Aurelia Hays AH; Brontesi, Lisa L; Ding, Lai L; Hacibaloglu, Dinc Yasat DY; Jiang, Haiyang H; Choi, Se Joon SJ; Kanter, Ellen E; Liu, Lei L; Bartels, Tim T; Nuber, Silke S; Sulzer, David D; Mosharov, Eugene V EV; Chen, Weisheng V WV; Li, Shaomin S; Selkoe, Dennis J DJ; Dettmer, Ulf U
Publication Date: 2023-01-16

Variant appearance in text: SNCA: S129A
PubMed Link: 36646701
Variant Present in the following documents:
  • Main text
  • 41531_2023_Article_444.pdf
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Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective.

International Journal Of Molecular Sciences
Yi, Shuanglong S; Wang, Linfang L; Wang, Honglei H; Ho, Margaret S MS; Zhang, Shiping S
Publication Date: 2022-11-25

Variant appearance in text: SNCA: S129A
PubMed Link: 36499080
Variant Present in the following documents:
  • Main text
  • ijms-23-14753.pdf
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Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson's disease.

Bmb Reports
Yoo, Hajung H; Lee, Jeongmin J; Kim, Bokwang B; Moon, Heechang H; Jeong, Huisu H; Lee, Kyungmi K; Song, Woo Jeung WJ; Hur, Junho K JK; Oh, Yohan Y
Publication Date: 2022-07

Variant appearance in text: SNCA: S129A
PubMed Link: 35733294
Variant Present in the following documents:
  • Main text
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α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Ghanem, Simona S SS; Majbour, Nour K NK; Vaikath, Nishant N NN; Ardah, Mustafa T MT; Erskine, Daniel D; Jensen, Nanna Møller NM; Fayyad, Muneera M; Sudhakaran, Indulekha P IP; Vasili, Eftychia E; Melachroinou, Katerina K; Abdi, Ilham Y IY; Poggiolini, Ilaria I; Santos, Patricia P; Dorn, Anton A; Carloni, Paolo P; Vekrellis, Kostas K; Attems, Johannes J; McKeith, Ian I; Outeiro, Tiago F TF; Jensen, Poul Henning PH; El-Agnaf, Omar M A OMA
Publication Date: 2022-04-12

Variant appearance in text: SNCA: S129A
PubMed Link: 35353605
Variant Present in the following documents:
  • pnas.202109617.pdf
  • pnas.2109617119.sapp.pdf
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Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein.

Plos One
Elfarrash, Sara S; Jensen, Nanna Møller NM; Ferreira, Nelson N; Schmidt, Sissel Ida SI; Gregersen, Emil E; Vestergaard, Marie Vibeke MV; Nabavi, Sadegh S; Meyer, Morten M; Jensen, Poul Henning PH
Publication Date: 2021

Variant appearance in text: SNCA: S129A
PubMed Link: 34613964
Variant Present in the following documents:
  • Main text
  • pone.0252635.pdf
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α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast.

Cells
Popova, Blagovesta B; Galka, Dajana D; Häffner, Nicola N; Wang, Dan D; Schmitt, Kerstin K; Valerius, Oliver O; Knop, Michael M; Braus, Gerhard H GH
Publication Date: 2021-08-28

Variant appearance in text: SNCA: S129A
PubMed Link: 34571878
Variant Present in the following documents:
  • Main text
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SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures.

Eneuro
Nicholatos, Justin W JW; Groot, Joost J; Dhokai, Shekhar S; Tran, David D; Hrdlicka, Lori L; Carlile, Thomas M TM; Bennion, Melissa M; Dalkilic-Liddle, Isin I; Hirst, Warren D WD; Weihofen, Andreas A
Publication Date: 2021

Variant appearance in text: SNCA: S129A
PubMed Link: 34301719
Variant Present in the following documents:
  • Main text
  • ENEURO.0166-21.2021.pdf
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Adeno-Associated Virus Expression of α-Synuclein as a Tool to Model Parkinson's Disease: Current Understanding and Knowledge Gaps.

Aging And Disease
Huntington, Taylor E TE; Srinivasan, Rahul R
Publication Date: 2021-07

Variant appearance in text: SNCA: S129A
PubMed Link: 34221553
Variant Present in the following documents:
  • Main text
  • ad-12-4-1120.pdf
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Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.

Nature Communications
Tanudjojo, Benedict B; Shaikh, Samiha S SS; Fenyi, Alexis A; Bousset, Luc L; Agarwal, Devika D; Marsh, Jade J; Zois, Christos C; Heman-Ackah, Sabrina S; Fischer, Roman R; Sims, David D; Melki, Ronald R; Tofaris, George K GK
Publication Date: 2021-06-21

Variant appearance in text: SNCA: S129A
PubMed Link: 34155194
Variant Present in the following documents:
  • Main text
  • 41467_2021_23682_MOESM2_ESM.pdf
  • 41467_2021_23682_MOESM1_ESM.pdf
  • 41467_2021_Article_23682.pdf
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Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.

Acta Neuropathologica
Ferreira, Nelson N; Gram, Hjalte H; Sorrentino, Zachary A ZA; Gregersen, Emil E; Schmidt, Sissel Ida SI; Reimer, Lasse L; Betzer, Cristine C; Perez-Gozalbo, Clara C; Beltoja, Marjo M; Nagaraj, Madhu M; Wang, Jie J; Nowak, Jan S JS; Dong, Mingdong M; Willén, Katarina K; Cholak, Ersoy E; Bjerregaard-Andersen, Kaare K; Mendez, Nicolas N; Rabadia, Prakruti P; Shahnawaz, Mohammad M; Soto, Claudio C; Otzen, Daniel E DE; Akbey, Ümit Ü; Meyer, Morten M; Giasson, Benoit I BI; Romero-Ramos, Marina M; Jensen, Poul Henning PH
Publication Date: 2021-07

Variant appearance in text: SNCA: S129A
PubMed Link: 33978813
Variant Present in the following documents:
  • Main text
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Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage.

International Journal Of Molecular Sciences
Franco, Rafael R; Rivas-Santisteban, Rafael R; Navarro, Gemma G; Pinna, Annalisa A; Reyes-Resina, Irene I
Publication Date: 2021-04-28

Variant appearance in text: SNCA: S129A
PubMed Link: 33924963
Variant Present in the following documents:
  • Main text
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Fibrillar α-synuclein toxicity depends on functional lysosomes.

The Journal Of Biological Chemistry
Guiney, Stephanie J SJ; Adlard, Paul A PA; Lei, Peng P; Mawal, Celeste H CH; Bush, Ashley I AI; Finkelstein, David I DI; Ayton, Scott S
Publication Date: 2020-12-18

Variant appearance in text: SNCA: S129A
PubMed Link: 33453994
Variant Present in the following documents:
  • Main text
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Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts.

Biomolecules
Teil, Margaux M; Arotcarena, Marie-Laure ML; Faggiani, Emilie E; Laferriere, Florent F; Bezard, Erwan E; Dehay, Benjamin B
Publication Date: 2020-03-03

Variant appearance in text: SNCA: S129A
PubMed Link: 32138193
Variant Present in the following documents:
  • Main text
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Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles.

Frontiers In Neuroscience
Bernal-Conde, Luis D LD; Ramos-Acevedo, Rodrigo R; Reyes-Hernández, Mario A MA; Balbuena-Olvera, Andrea J AJ; Morales-Moreno, Ishbelt D ID; Argüero-Sánchez, Rubén R; Schüle, Birgitt B; Guerra-Crespo, Magdalena M
Publication Date: 2019

Variant appearance in text: SNCA: S129A
PubMed Link: 32038126
Variant Present in the following documents:
  • Main text
  • fnins-13-01399.pdf
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Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates.

Acta Neuropathologica Communications
Elfarrash, Sara S; Jensen, Nanna Møller NM; Ferreira, Nelson N; Betzer, Cristine C; Thevathasan, Jervis Vermal JV; Diekmann, Robin R; Adel, Mohamed M; Omar, Nisreen Mansour NM; Boraie, Mohamed Z MZ; Gad, Sabry S; Ries, Jonas J; Kirik, Deniz D; Nabavi, Sadegh S; Jensen, Poul Henning PH
Publication Date: 2019-12-19

Variant appearance in text: SNCA: S129A
PubMed Link: 31856920
Variant Present in the following documents:
  • Main text
  • 40478_2019_Article_865.pdf
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Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay.

Frontiers In Neuroscience
Cariulo, Cristina C; Martufi, Paola P; Verani, Margherita M; Azzollini, Lucia L; Bruni, Giordana G; Weiss, Andreas A; Deguire, Sean M SM; Lashuel, Hilal A HA; Scaricamazza, Eugenia E; Sancesario, Giulia Maria GM; Schirinzi, Tommaso T; Mercuri, Nicola Biagio NB; Sancesario, Giuseppe G; Caricasole, Andrea A; Petricca, Lara L
Publication Date: 2019

Variant appearance in text: SNCA: S129A
PubMed Link: 31507364
Variant Present in the following documents:
  • Main text
  • fnins-13-00889.pdf
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Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders.

Scientific Reports
Schaser, Allison J AJ; Osterberg, Valerie R VR; Dent, Sydney E SE; Stackhouse, Teresa L TL; Wakeham, Colin M CM; Boutros, Sydney W SW; Weston, Leah J LJ; Owen, Nichole N; Weissman, Tamily A TA; Luna, Esteban E; Raber, Jacob J; Luk, Kelvin C KC; McCullough, Amanda K AK; Woltjer, Randall L RL; Unni, Vivek K VK
Publication Date: 2019-07-29

Variant appearance in text: SNCA: S129A
PubMed Link: 31358782
Variant Present in the following documents:
  • Main text
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Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats.

Acta Neuropathologica
Van Den Berge, Nathalie N; Ferreira, Nelson N; Gram, Hjalte H; Mikkelsen, Trine Werenberg TW; Alstrup, Aage Kristian Olsen AKO; Casadei, Nicolas N; Tsung-Pin, Pai P; Riess, Olaf O; Nyengaard, Jens Randel JR; Tamgüney, Gültekin G; Jensen, Poul Henning PH; Borghammer, Per P
Publication Date: 2019-10

Variant appearance in text: SNCA: S129A
PubMed Link: 31254094
Variant Present in the following documents:
  • Main text
  • 401_2019_Article_2040.pdf
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The role of lipids in α-synuclein misfolding and neurotoxicity.

The Journal Of Biological Chemistry
Ugalde, Cathryn L CL; Lawson, Victoria A VA; Finkelstein, David I DI; Hill, Andrew F AF
Publication Date: 2019-06-07

Variant appearance in text: SNCA: S129A
PubMed Link: 31064841
Variant Present in the following documents:
  • Main text
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α-Synuclein Trafficking in Parkinson's Disease: Insights From Fly and Mouse Models.

Asn Neuro
Cheng, Jingjing J; Lu, Qingqing Q; Song, Li L; Ho, Margaret S MS
Publication Date: 2018

Variant appearance in text: SNCA: S129A
PubMed Link: 30482039
Variant Present in the following documents:
  • Main text
  • 10.1177_1759091418812587.pdf
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α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.

The Embo Journal
Kang, Seong Su SS; Ahn, Eun Hee EH; Zhang, Zhentao Z; Liu, Xia X; Manfredsson, Fredric P FP; Sandoval, Ivette M IM; Dhakal, Susov S; Iuvone, P Michael PM; Cao, Xuebing X; Ye, Keqiang K
Publication Date: 2018-06-15

Variant appearance in text: SNCA: S129A
PubMed Link: 29769405
Variant Present in the following documents:
  • Main text
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Modeling Parkinson's Disease in Drosophila: What Have We Learned for Dominant Traits?

Frontiers In Neurology
Xiong, Yulan Y; Yu, Jianzhong J
Publication Date: 2018

Variant appearance in text: SNCA: S129A
PubMed Link: 29686647
Variant Present in the following documents:
  • Main text
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Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson's Disease.

Frontiers In Neurology
Jewett, Michael M; Dickson, Elna E; Brolin, Kajsa K; Negrini, Matilde M; Jimenez-Ferrer, Itzia I; Swanberg, Maria M
Publication Date: 2018

Variant appearance in text: SNCA: S129A
PubMed Link: 29681884
Variant Present in the following documents:
  • fneur-09-00222.pdf
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In vitro models of multiple system atrophy from primary cells to induced pluripotent stem cells.

Journal Of Cellular And Molecular Medicine
Abati, Elena E; Di Fonzo, Alessio A; Corti, Stefania S
Publication Date: 2018-05

Variant appearance in text: SNCA: S129A
PubMed Link: 29502349
Variant Present in the following documents:
  • Main text
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E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Íñigo-Marco, Ignacio I; Valencia, Miguel M; Larrea, Laura L; Bugallo, Ricardo R; Martínez-Goikoetxea, Mikel M; Zuriguel, Iker I; Arrasate, Montserrat M
Publication Date: 2017-09-26

Variant appearance in text: SNCA: S129A
PubMed Link: 28900007
Variant Present in the following documents:
  • Main text
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α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Kang, Seong Su SS; Zhang, Zhentao Z; Liu, Xia X; Manfredsson, Fredric P FP; He, Li L; Iuvone, P Michael PM; Cao, Xuebing X; Sun, Yi E YE; Jin, Lingjing L; Ye, Keqiang K
Publication Date: 2017-01-31

Variant appearance in text: SNCA: S129A
PubMed Link: 28096359
Variant Present in the following documents:
  • Main text
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Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology.

Journal Of Neurochemistry
Sacino, Amanda N AN; Brooks, Mieu M MM; Chakrabarty, Paramita P; Saha, Kaustuv K; Khoshbouei, Habibeh H; Golde, Todd E TE; Giasson, Benoit I BI
Publication Date: 2017-02

Variant appearance in text: SNCA: Ser129Ala
PubMed Link: 27424880
Variant Present in the following documents:
  • Main text
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How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?

Journal Of Neurochemistry
Volpicelli-Daley, Laura A LA; Kirik, Deniz D; Stoyka, Lindsay E LE; Standaert, David G DG; Harms, Ashley S AS
Publication Date: 2016-10

Variant appearance in text: SNCA: S129A
PubMed Link: 27018978
Variant Present in the following documents:
  • Main text
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Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes.

Bmc Neuroscience
Rannikko, Emmy H EH; Weber, Stephanie S SS; Kahle, Philipp J PJ
Publication Date: 2015-09-07

Variant appearance in text: SNCA: S129A
PubMed Link: 26346361
Variant Present in the following documents:
  • Main text
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α-Synuclein and nonhuman primate models of Parkinson's disease.

Journal Of Neuroscience Methods
Vermilyea, Scott C SC; Emborg, Marina E ME
Publication Date: 2015-11-30

Variant appearance in text: SNCA: S129A
PubMed Link: 26247888
Variant Present in the following documents:
  • Main text
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Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational Modifications.

Biomolecules
Pratt, Matthew R MR; Abeywardana, Tharindumala T; Marotta, Nicholas P NP
Publication Date: 2015-06-25

Variant appearance in text: SNCA: S129A
PubMed Link: 26120904
Variant Present in the following documents:
  • Main text
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Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.

Molecular Neurodegeneration
Van Rompuy, Anne-Sophie AS; Oliveras-Salvá, Marusela M; Van der Perren, Anke A; Corti, Olga O; Van den Haute, Chris C; Baekelandt, Veerle V
Publication Date: 2015-06-23

Variant appearance in text: SNCA: S129A
PubMed Link: 26099628
Variant Present in the following documents:
  • Main text
  • 13024_2015_Article_17.pdf
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Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast.

Biomolecules
Popova, Blagovesta B; Kleinknecht, Alexandra A; Braus, Gerhard H GH
Publication Date: 2015-04-23

Variant appearance in text: SNCA: S129A
PubMed Link: 25915624
Variant Present in the following documents:
  • Main text
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Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.

The Journal Of Biological Chemistry
Mbefo, Martial Kamdem MK; Fares, Mohamed-Bilal MB; Paleologou, Katerina K; Oueslati, Abid A; Yin, Guowei G; Tenreiro, Sandra S; Pinto, Madalena M; Outeiro, Tiago T; Zweckstetter, Markus M; Masliah, Eliezer E; Lashuel, Hilal A HA
Publication Date: 2015-04-10

Variant appearance in text: SNCA: S129A
PubMed Link: 25657004
Variant Present in the following documents:
  • Main text
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Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

Plos Genetics
Lázaro, Diana F DF; Rodrigues, Eva F EF; Langohr, Ramona R; Shahpasandzadeh, Hedieh H; Ribeiro, Thales T; Guerreiro, Patrícia P; Gerhardt, Ellen E; Kröhnert, Katharina K; Klucken, Jochen J; Pereira, Marcos D MD; Popova, Blagovesta B; Kruse, Niels N; Mollenhauer, Brit B; Rizzoli, Silvio O SO; Braus, Gerhard H GH; Danzer, Karin M KM; Outeiro, Tiago F TF
Publication Date: 2014-11

Variant appearance in text: SNCA: S129A
PubMed Link: 25393002
Variant Present in the following documents:
  • Main text
  • pgen.1004741.pdf
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DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.

Cell Death & Disease
Zondler, L L; Miller-Fleming, L L; Repici, M M; Gonçalves, S S; Tenreiro, S S; Rosado-Ramos, R R; Betzer, C C; Straatman, K R KR; Jensen, P H PH; Giorgini, F F; Outeiro, T F TF
Publication Date: 2014-07-24

Variant appearance in text: SNCA: S129A
PubMed Link: 25058424
Variant Present in the following documents:
  • Main text
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Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease.

Plos Genetics
Tenreiro, Sandra S; Reimão-Pinto, Madalena M MM; Antas, Pedro P; Rino, José J; Wawrzycka, Donata D; Macedo, Diana D; Rosado-Ramos, Rita R; Amen, Triana T; Waiss, Meytal M; Magalhães, Filipa F; Gomes, Andreia A; Santos, Cláudia N CN; Kaganovich, Daniel D; Outeiro, Tiago Fleming TF
Publication Date: 2014-05

Variant appearance in text: SNCA: S129A
PubMed Link: 24810576
Variant Present in the following documents:
  • Main text
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The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.

Human Molecular Genetics
Fares, Mohamed-Bilal MB; Ait-Bouziad, Nadine N; Dikiy, Igor I; Mbefo, Martial K MK; Jovičić, Ana A; Kiely, Aoife A; Holton, Janice L JL; Lee, Seung-Jae SJ; Gitler, Aaron D AD; Eliezer, David D; Lashuel, Hilal A HA
Publication Date: 2014-09-01

Variant appearance in text: SNCA: S129A
PubMed Link: 24728187
Variant Present in the following documents:
  • Main text
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MicroRNAs and Molecular Mechanisms of Neurodegeneration.

Genes
Bicchi, Ilaria I; Morena, Francesco F; Montesano, Simona S; Polidoro, Mario M; Martino, Sabata S
Publication Date: 2013-05-29

Variant appearance in text: SNCA: S129A
PubMed Link: 24705162
Variant Present in the following documents:
  • genes-04-00244.pdf
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Transgenic mice expressing S129 phosphorylation mutations in α-synuclein.

Neuroscience Letters
Escobar, Valerie Drews VD; Kuo, Yien-Ming YM; Orrison, Bonnie M BM; Giasson, Benoit I BI; Nussbaum, Robert L RL
Publication Date: 2014-03-20

Variant appearance in text: SNCA: S129A
PubMed Link: 24486885
Variant Present in the following documents:
  • Main text
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Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner.

Molecular Biology Of The Cell
Hara, Susumu S; Arawaka, Shigeki S; Sato, Hiroyasu H; Machiya, Youhei Y; Cui, Can C; Sasaki, Asuka A; Koyama, Shingo S; Kato, Takeo T
Publication Date: 2013-06

Variant appearance in text: SNCA: S129A
PubMed Link: 23576548
Variant Present in the following documents:
  • Main text
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Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein.

Plos One
Nakaso, Kazuhiro K; Tajima, Naoko N; Ito, Satoru S; Teraoka, Mari M; Yamashita, Atsushi A; Horikoshi, Yosuke Y; Kikuchi, Daisuke D; Mochida, Shinsuke S; Nakashima, Kenji K; Matsura, Tatsuya T
Publication Date: 2013

Variant appearance in text: PARK4: S129A
PubMed Link: 23457458
Variant Present in the following documents:
  • Main text
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The many faces of α-synuclein: from structure and toxicity to therapeutic target.

Nature Reviews. Neuroscience
Lashuel, Hilal A HA; Overk, Cassia R CR; Oueslati, Abid A; Masliah, Eliezer E
Publication Date: 2013-01

Variant appearance in text: SNCA: S129A
PubMed Link: 23254192
Variant Present in the following documents:
  • Main text
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α-Synuclein and neuronal cell death.

Molecular Neurobiology
Yasuda, Toru T; Nakata, Yasuto Y; Mochizuki, Hideki H
Publication Date: 2013-04

Variant appearance in text: SNCA: S129A
PubMed Link: 22936307
Variant Present in the following documents:
  • Main text
  • 12035_2012_Article_8327.pdf
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Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.

Human Molecular Genetics
Sancenon, Vicente V; Lee, Sue-Ann SA; Patrick, Christina C; Griffith, Janice J; Paulino, Amy A; Outeiro, Tiago F TF; Reggiori, Fulvio F; Masliah, Eliezer E; Muchowski, Paul J PJ
Publication Date: 2012-06-01

Variant appearance in text: SNCA: S129A
PubMed Link: 22357655
Variant Present in the following documents:
  • Main text
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Drosophila models of proteinopathies: the little fly that could.

Current Pharmaceutical Design
Rincon-Limas, Diego E DE; Jensen, Kurt K; Fernandez-Funez, Pedro P
Publication Date: 2012

Variant appearance in text: SNCA: S129A
PubMed Link: 22288402
Variant Present in the following documents:
  • Main text
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Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra.

Developmental Neurobiology
Khodr, Christina E CE; Pedapati, Jyothi J; Han, Ye Y; Bohn, Martha C MC
Publication Date: 2012-06

Variant appearance in text: SNCA: S129A
PubMed Link: 22021082
Variant Present in the following documents:
  • Main text
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Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.

International Journal Of Molecular Sciences
Olivares, David D; Huang, Xudong X; Branden, Lars L; Greig, Nigel H NH; Rogers, Jack T JT
Publication Date: 2009-03

Variant appearance in text: SNCA: S129A
PubMed Link: 19399246
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alpha-Synuclein and neuronal cell death.

Molecular Neurodegeneration
Cookson, Mark R MR
Publication Date: 2009-02-04

Variant appearance in text: SNCA: S129A
PubMed Link: 19193223
Variant Present in the following documents:
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  • 1750-1326-4-9.pdf
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Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

The Journal Of Biological Chemistry
Paleologou, Katerina E KE; Schmid, Adrian W AW; Rospigliosi, Carla C CC; Kim, Hai-Young HY; Lamberto, Gonzalo R GR; Fredenburg, Ross A RA; Lansbury, Peter T PT; Fernandez, Claudio O CO; Eliezer, David D; Zweckstetter, Markus M; Lashuel, Hilal A HA
Publication Date: 2008-06-13

Variant appearance in text: SNCA: S129A
PubMed Link: 18343814
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