Variant ID: 4-90749300-C-T

NM_000345.3(SNCA):c.157G>A;(p.Ala53Thr)

This variant was identified in 742 publications




Publications:


The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson's Disease and SNCA Gene Methylation.

Acta Naturae
EV Iakovenko, NY Abramycheva, EY Fedotova, SN Illarioshkin
Publication Date: 2020

Variant appearance in text: SNCA: Ala53Thr
PMID: 32742734
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Personalized TMS: role of RNA genotyping.

Mental Illness
S Chan, R Bota
Publication Date: 2019

Variant appearance in text: SNCA: Ala53Thr
PMID: 32742620
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LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models.

Frontiers In Neuroscience
DJ Dues, DJ Moore
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32733200
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Insights into the Effects of Mesenchymal Stem Cell-Derived Secretome in Parkinson's Disease.

International Journal Of Molecular Sciences
M d'Angelo, A Cimini, V Castelli
Publication Date: 2020-07-23

Variant appearance in text: SNCA: A53T
PMID: 32718092
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Association Between Glucocerebrosidase Mutations and Parkinson's Disease in Ireland.

Frontiers In Neurology
DA Olszewska, A McCarthy, AI Soto-Beasley, RL Walton, B Magennis, RL McLaughlin, O Hardiman, OA Ross, T Lynch
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32714263
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Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core.

International Journal Of Molecular Sciences
E Vacchi, A Kaelin-Lang, G Melli
Publication Date: 2020-07-16

Variant appearance in text: SNCA: A53T
PMID: 32708732
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Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression.

Aging
Y Wang, Q Wang, R Yu, Q Zhang, Z Zhang, H Li, C Ren, R Yang, H Niu
Publication Date: 2020-07-24

Variant appearance in text: SNCA: A53T
PMID: 32706757
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The hot sites of α-synuclein in amyloid fibril formation.

Scientific Reports
A Khammari, SS Arab, MR Ejtehadi
Publication Date: 2020-07-22

Variant appearance in text: SNCA: A53T
PMID: 32699326
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α-Synuclein strains that cause distinct pathologies differentially inhibit proteasome.

Elife
G Suzuki, S Imura, M Hosokawa, R Katsumata, T Nonaka, SI Hisanaga, Y Saeki, M Hasegawa
Publication Date: 2020-07-22

Variant appearance in text: SNCA: A53T
PMID: 32697196
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Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson's Disease.

International Journal Of Molecular Sciences
S Blumenreich, OB Barav, BJ Jenkins, AH Futerman
Publication Date: 2020-07-14

Variant appearance in text: SNCA: A53T
PMID: 32674335
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SUMOylation in α-Synuclein Homeostasis and Pathology.

Frontiers In Aging Neuroscience
M Savyon, S Engelender
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32670048
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The role of lipids in autophagy and its implication in neurodegeneration.

Cell Stress
S Hernandez-Diaz, SF Soukup
Publication Date: 2020-05-19

Variant appearance in text: SNCA: A53T
PMID: 32656499
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Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis.

Acta Neuropathologica Communications
L Sheng, T Stewart, D Yang, E Thorland, D Soltys, P Aro, T Khrisat, Z Xie, N Li, Z Liu, C Tian, M Bercow, J Matsumoto, CP Zabetian, E Peskind, JF Quinn, M Shi, J Zhang
Publication Date: 2020-07-08

Variant appearance in text: SNCA: A53T
PMID: 32641150
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Caffeine: An Overview of Its Beneficial Effects in Experimental Models and Clinical Trials of Parkinson's Disease.

International Journal Of Molecular Sciences
G Schepici, S Silvestro, P Bramanti, E Mazzon
Publication Date: 2020-07-04

Variant appearance in text: SNCA: A53T
PMID: 32635541
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Epigenetics in Lewy Body Diseases: Impact on Gene Expression, Utility as a Biomarker, and Possibilities for Therapy.

International Journal Of Molecular Sciences
A Urbizu, K Beyer
Publication Date: 2020-07-02

Variant appearance in text: SNCA: A53T
PMID: 32630630
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Parkinson's Disease and the Gut: Future Perspectives for Early Diagnosis.

Frontiers In Neuroscience
J Harsanyiova, T Buday, A Kralova Trancikova
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32625058
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LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson's Disease?

Frontiers In Neuroscience
DM O'Hara, G Pawar, SK Kalia, LV Kalia
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32625052
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Role of Long Noncoding RNAs in Parkinson's Disease: Putative Biomarkers and Therapeutic Targets.

Parkinson'S Disease
Q Lv, Z Wang, Z Zhong, W Huang
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32617144
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Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein.

Frontiers In Cellular Neuroscience
Y Guan, X Zhao, F Liu, S Yan, Y Wang, C Du, X Cui, R Li, CX Zhang
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32595456
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Maackiain Ameliorates 6-Hydroxydopamine and SNCA Pathologies by Modulating the PINK1/Parkin Pathway in Models of Parkinson's Disease in Caenorhabditis elegans and the SH-SY5Y Cell Line.

International Journal Of Molecular Sciences
RT Tsai, CW Tsai, SP Liu, JX Gao, YH Kuo, PM Chao, HS Hung, WC Shyu, SZ Lin, RH Fu
Publication Date: 2020-06-23

Variant appearance in text: SNCA: A53T
PMID: 32585871
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Translation Imaging in Parkinson's Disease: Focus on Neuroinflammation.

Frontiers In Aging Neuroscience
S Belloli, M Morari, V Murtaj, S Valtorta, RM Moresco, MC Gilardi
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32581765
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Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction.

Plos Genetics
CY Kao, M Xu, L Wang, SC Lin, HJ Lee, L Duraine, HJ Bellen, DS Goldstein, SY Tsai, MJ Tsai
Publication Date: 2020-06-24

Variant appearance in text: SNCA: A53T
PMID: 32579581
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The Future of Targeted Gene-Based Treatment Strategies and Biomarkers in Parkinson's Disease.

Biomolecules
A Polissidis, L Petropoulou-Vathi, M Nakos-Bimpos, HJ Rideout
Publication Date: 2020-06-16

Variant appearance in text: SNCA: A53T
PMID: 32560161
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Neuroprotection or Neurotoxicity of Illicit Drugs on Parkinson's Disease.

Life (Basel, Switzerland)
C Ferreira, C Almeida, S Tenreiro, A Quintas
Publication Date: 2020-06-11

Variant appearance in text: SNCA: A53T
PMID: 32545328
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"LRRK2: Autophagy and Lysosomal Activity".

Frontiers In Neuroscience
M Madureira, N Connor-Robson, R Wade-Martins
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32523507
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Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk.

Journal Of Parkinson'S Disease
R Kayed, U Dettmer, SE Lesné
Publication Date: 2020-05-30

Variant appearance in text: SNCA: A53T
PMID: 32508330
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Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity.

Nature Communications
AD Stephens, M Zacharopoulou, R Moons, G Fusco, N Seetaloo, A Chiki, PJ Woodhams, I Mela, HA Lashuel, JJ Phillips, A De Simone, F Sobott, GSK Schierle
Publication Date: 2020-06-04

Variant appearance in text: SNCA: A53T
PMID: 32499486
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Long-Term Outcomes of Genetic Parkinson's Disease.

Journal Of Movement Disorders
JO Aasly
Publication Date: 2020-05

Variant appearance in text: SNCA: A53T
PMID: 32498494
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Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection via Activation of Immunoproteasome.

Aging And Disease
H Zhou, S Li, C Li, X Yang, H Li, H Zhong, JH Lu, SM Lee
Publication Date: 2020-05

Variant appearance in text: SNCA: A53T
PMID: 32489702
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Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.

Aging Cell
K Mao, J Chen, H Yu, H Li, Y Ren, X Wu, Y Wen, F Zou, W Li
Publication Date: 2020-05-31

Variant appearance in text: SNCA: A53T
PMID: 32475059
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Nanomedicine-based immunotherapy for central nervous system disorders.

Acta Pharmacologica Sinica
S Hanif, P Muhammad, R Chesworth, FU Rehman, RJ Qian, M Zheng, BY Shi
Publication Date: 2020-05-28

Variant appearance in text: SNCA: A53T
PMID: 32467570
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Decreased Vacuolar Ca2+ Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca2+ Dysregulation in S. cerevisiae.

Frontiers In Genetics
G Callewaert, P D'hooge, TY Ma, M Del Vecchio, V Van Eyck, V Franssens, J Winderickx
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32457789
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Parkinson's disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure.

Nature Communications
K Zhao, Y Li, Z Liu, H Long, C Zhao, F Luo, Y Sun, Y Tao, XD Su, D Li, X Li, C Liu
Publication Date: 2020-05-26

Variant appearance in text: SNCA: A53T
PMID: 32457390
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Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.

Cells
CM Chen, CH Lin, YR Wu, CY Yen, YT Huang, JL Lin, CY Lin, WL Chen, CY Chao, GJ Lee-Chen, MT Su, KH Chang
Publication Date: 2020-05-16

Variant appearance in text: SNCA: A53T
PMID: 32429337
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The emerging role of α-synuclein truncation in aggregation and disease.

The Journal Of Biological Chemistry
ZA Sorrentino, BI Giasson
Publication Date: 2020-05-18

Variant appearance in text: SNCA: A53T
PMID: 32424039
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Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases.

Frontiers In Physiology
S Momtaz, Z Memariani, FF El-Senduny, N Sanadgol, F Golab, M Katebi, AH Abdolghaffari, MH Farzaei, M Abdollahi
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32411012
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The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases.

Translational Neurodegeneration
Q Song, B Meng, H Xu, Z Mao
Publication Date: 2020-05-11

Variant appearance in text: SNCA: A53T
PMID: 32393395
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Modeling Parkinson's Disease With the Alpha-Synuclein Protein.

Frontiers In Pharmacology
M Gómez-Benito, N Granado, P García-Sanz, A Michel, M Dumoulin, R Moratalla
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32390826
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Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson's disease pathogenesis.

Acta Neuropathologica Communications
S Smolders, C Van Broeckhoven
Publication Date: 2020-05-06

Variant appearance in text: SNCA: Ala53Thr
PMID: 32375870
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Glucocerebrosidase Defects as a Major Risk Factor for Parkinson's Disease.

Frontiers In Aging Neuroscience
M Avenali, F Blandini, S Cerri
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32372943
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Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells.

Npj Parkinson'S Disease
J Tran, H Anastacio, C Bardy
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32352027
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Identification of biomarkers associated with Parkinson's disease by gene expression profiling studies and bioinformatics analysis.

Aims Neuroscience
MG Krokidis
Publication Date: 2019

Variant appearance in text: SNCA: Ala53Thr
PMID: 32341987
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Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.

Brain Communications
JB Sanderson, S De, H Jiang, M Rovere, M Jin, L Zaccagnini, A Hays Watson, L De Boni, VN Lagomarsino, TL Young-Pearse, X Liu, TC Pochapsky, BT Hyman, DW Dickson, D Klenerman, DJ Selkoe, T Bartels
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32280944
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Noncanonical Roles of hα-syn (A53T) in the Pathogenesis of Parkinson's Disease: Synaptic Pathology and Neuronal Aging.

Neural Plasticity
QJ Wang, AD Chen, HC Chen, DX Wang, YT Cai, J Yin, YH Jing, LP Gao
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32273890
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Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson's Disease.

Frontiers In Aging Neuroscience
A Bellucci, L Bubacco, F Longhena, E Parrella, G Faustini, V Porrini, F Bono, C Missale, M Pizzi
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32265684
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Modeling Parkinson's Disease Using Induced Pluripotent Stem Cells.

Stem Cells International
X Hu, C Mao, L Fan, H Luo, Z Hu, S Zhang, Z Yang, H Zheng, H Sun, Y Fan, J Yang, C Shi, Y Xu
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32256606
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Protein-Protein Interactions in Alpha-Synuclein Biogenesis: New Potential Targets in Parkinson's Disease.

Frontiers In Aging Neuroscience
SM Hernandez, EB Tikhonova, AL Karamyshev
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32256340
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Historical Perspective: Models of Parkinson's Disease.

International Journal Of Molecular Sciences
SJ Chia, EK Tan, YX Chao
Publication Date: 2020-04-02

Variant appearance in text: SNCA: A53T
PMID: 32252301
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Clinicopathologic and genetic features of multiple system atrophy with Lewy body disease.

Brain Pathology (Zurich, Switzerland)
S Koga, F Li, N Zhao, SF Roemer, TJ Ferman, AI Wernick, RL Walton, AH Faroqi, NR Graff-Radford, WP Cheshire, OA Ross, DW Dickson
Publication Date: 2020-03-30

Variant appearance in text: SNCA: A53T
PMID: 32232888
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α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species.

The Journal Of Biological Chemistry
SA Morgan, I Lavenir, J Fan, M Masuda-Suzukake, D Passarella, MA DeTure, DW Dickson, B Ghetti, M Goedert
Publication Date: 2020-03-24

Variant appearance in text: SNCA: A53T
PMID: 32209651
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Immunotherapies in Huntington's disease and α-Synucleinopathies.

Frontiers In Immunology
O Fatoba, Y Ohtake, T Itokazu, T Yamashita
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32161599
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Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation.

Frontiers In Bioengineering And Biotechnology
N Zhao, X Yang, HR Calvelli, Y Cao, NL Francis, RA Chmielowski, LB Joseph, ZP Pang, KE Uhrich, J Baum, PV Moghe
Publication Date: 2020

Variant appearance in text: SNCA: A53T
PMID: 32154238
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Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts.

Biomolecules
M Teil, ML Arotcarena, E Faggiani, F Laferriere, E Bezard, B Dehay
Publication Date: 2020-03-03

Variant appearance in text: SNCA: A53T
PMID: 32138193
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Overexpression of alpha-synuclein promotes both cell proliferation and cell toxicity in human SH-SY5Y neuroblastoma cells.

Journal Of Advanced Research
N Rodríguez-Losada, J de la Rosa, M Larriva, R Wendelbo, JA Aguirre, JS Castresana, SJ Ballaz
Publication Date: 2020-05

Variant appearance in text: SNCA: A53T
PMID: 32071790
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RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.

Prion
JY Han, HS Jang, AJE Green, YP Choi
Publication Date: 2020-12

Variant appearance in text: SNCA: A53T
PMID: 32041499
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Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles.

Frontiers In Neuroscience
LD Bernal-Conde, R Ramos-Acevedo, MA Reyes-Hernández, AJ Balbuena-Olvera, ID Morales-Moreno, R Argüero-Sánchez, B Schüle, M Guerra-Crespo
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 32038126
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Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.

Plos Pathogens
AL Woerman, S Patel, SA Kazmi, A Oehler, J Lee, DA Mordes, SH Olson, SB Prusiner
Publication Date: 2020-02

Variant appearance in text: SNCA: A53T
PMID: 32017806
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Is serotonin pathology a good biomarker in vivo for early Parkinson's disease?

Annals Of Translational Medicine
C Painous, A Perissinotti, MJ Martí
Publication Date: 2019-12

Variant appearance in text: SNCA: A53T
PMID: 32016069
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Modeling Cell-Cell Interactions in Parkinson's Disease Using Human Stem Cell-Based Models.

Frontiers In Cellular Neuroscience
K Simmnacher, J Lanfer, T Rizo, J Kaindl, B Winner
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 32009903
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Protein Quality Control Pathways at the Crossroad of Synucleinopathies.

Journal Of Parkinson'S Disease
EP De Mattos, A Wentink, C Nussbaum-Krammer, C Hansen, S Bergink, R Melki, HH Kampinga
Publication Date: 2020-01-24

Variant appearance in text: SNCA: A53T
PMID: 31985474
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Vesicular Dysfunction and the Pathogenesis of Parkinson's Disease: Clues From Genetic Studies.

Frontiers In Neuroscience
K Ebanks, PA Lewis, R Bandopadhyay
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31969802
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Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease.

Cells
L Sironi, LM Restelli, M Tolnay, A Neutzner, S Frank
Publication Date: 2020-01-17

Variant appearance in text: SNCA: A53T
PMID: 31963435
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Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess α-Synuclein at Synapses.

Eneuro
SML Banks, AT Medeiros, M McQuillan, DJ Busch, AS Ibarraran-Viniegra, R Sousa, EM Lafer, JR Morgan
Publication Date: 2020-01-14

Variant appearance in text: SNCA: A53T
PMID: 31941659
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A compendious summary of Parkinson's disease patient-derived iPSCs in the first decade.

Annals Of Translational Medicine
C Ren, F Wang, LN Guan, XY Cheng, CY Zhang, DQ Geng, CF Liu
Publication Date: 2019-11

Variant appearance in text: SNCA: A53T
PMID: 31930086
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ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway.

Nature Communications
N Moskal, V Riccio, M Bashkurov, R Taddese, A Datti, PN Lewis, G Angus McQuibban
Publication Date: 2020-01-03

Variant appearance in text: PARK1: A53T
PMID: 31900402
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Targeting Alpha-Synuclein as a Therapy for Parkinson's Disease.

Frontiers In Molecular Neuroscience
CR Fields, N Bengoa-Vergniory, R Wade-Martins
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31866823
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Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells.

Disease Models & Mechanisms
CL Ugalde, SJ Annesley, S Gordon, K Mroczek, MA Perugini, VA Lawson, PR Fisher, DI Finkelstein, AF Hill
Publication Date: 2019-12-17

Variant appearance in text: SNCA: A53T
PMID: 31848207
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Immunotherapy Targeting Neurodegenerative Proteinopathies: α-Synucleinopathies and Tauopathies.

Journal Of Movement Disorders
J Shin, HJ Kim, B Jeon
Publication Date: 2019-12-19

Variant appearance in text: SNCA: A53T
PMID: 31847513
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Reducing effect of insulin resistance on alpha-synuclein gene expression in skeletal muscle.

Diabetology & Metabolic Syndrome
A Khoshi, G Goodarzi, R Mohammadi, R Arezumand, M Moghbeli, M Najariyan
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31827624
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The Drosophila Model: Exploring Novel Therapeutic Compounds against Neurodegenerative Diseases.

Antioxidants (Basel, Switzerland)
SJ Cha, HA Do, HJ Choi, M Lee, K Kim
Publication Date: 2019-12-06

Variant appearance in text: SNCA: A53T
PMID: 31817611
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Human Periapical Cyst-Derived Stem Cells Can Be A Smart "Lab-on-A-Cell" to Investigate Neurodegenerative Diseases and the Related Alteration of the Exosomes' Content.

Brain Sciences
M Tatullo, B Codispoti, G Spagnuolo, B Zavan
Publication Date: 2019-12-05

Variant appearance in text: SNCA: Ala53Thr
PMID: 31817546
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Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.

Elife
R Guerrero-Ferreira, NM Taylor, AA Arteni, P Kumari, D Mona, P Ringler, M Britschgi, ME Lauer, A Makky, J Verasdonck, R Riek, R Melki, BH Meier, A Böckmann, L Bousset, H Stahlberg
Publication Date: 2019-12-09

Variant appearance in text: SNCA: A53T
PMID: 31815671
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Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity.

Scientific Reports
A Sharma, N Osato, H Liu, S Asthana, TC Dakal, G Ambrosini, P Bucher, I Schmitt, U Wüllner
Publication Date: 2019-12-05

Variant appearance in text: SNCA: A53T
PMID: 31804560
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Editorial: Mitochondria and Endoplasmic Reticulum Dysfunction in Parkinson's Disease.

Frontiers In Neuroscience
SK Barodia, K Prabhakaran, S Karunakaran, V Mishra, V Tapias
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31780882
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Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.

Scientific Reports
T Kilpeläinen, UH Julku, R Svarcbahs, TT Myöhänen
Publication Date: 2019-11-22

Variant appearance in text: SNCA: A53T
PMID: 31758049
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Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition.

Acta Neuropathologica Communications
RZ Fan, M Guo, S Luo, M Cui, K Tieu
Publication Date: 2019-11-19

Variant appearance in text: SNCA: A53T
PMID: 31744532
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Models of multiple system atrophy.

Experimental & Molecular Medicine
HJ Lee, D Ricarte, D Ortiz, SJ Lee
Publication Date: 2019-11-18

Variant appearance in text: SNCA: A53T
PMID: 31740682
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Autophagic- and Lysosomal-Related Biomarkers for Parkinson's Disease: Lights and Shadows.

Cells
H Xicoy, N Peñuelas, M Vila, A Laguna
Publication Date: 2019-10-25

Variant appearance in text: SNCA: A53T
PMID: 31731485
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The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson's Disease.

International Journal Of Molecular Sciences
KJ Lin, KL Lin, SD Chen, CW Liou, YC Chuang, HY Lin, TK Lin
Publication Date: 2019-10-25

Variant appearance in text: SNCA: A53T
PMID: 31731450
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Endogenous alpha-synuclein monomers, oligomers and resulting pathology: let's talk about the lipids in the room.

Npj Parkinson'S Disease
BA Killinger, R Melki, P Brundin, JH Kordower
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31728405
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A split-GFP tool reveals differences in the sub-mitochondrial distribution of wt and mutant alpha-synuclein.

Cell Death & Disease
M Vicario, D Cieri, F Vallese, C Catoni, L Barazzuol, P Berto, A Grinzato, L Barbieri, M Brini, T Calì
Publication Date: 2019-11-12

Variant appearance in text: SNCA: A53T
PMID: 31719530
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Can infections trigger alpha-synucleinopathies?

Progress In Molecular Biology And Translational Science
CT Tulisiak, G Mercado, W Peelaerts, L Brundin, P Brundin
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31699323
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Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs.

Nature Structural & Molecular Biology
DR Boyer, B Li, C Sun, W Fan, MR Sawaya, L Jiang, DS Eisenberg
Publication Date: 2019-11

Variant appearance in text: SNCA: A53T
PMID: 31695184
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Alpha synuclein in hematopoiesis and immunity.

Heliyon
Y Pei, RW Maitta
Publication Date: 2019-10

Variant appearance in text: SNCA: A53T
PMID: 31692680
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Iron Redox Chemistry and Implications in the Parkinson's Disease Brain.

Oxidative Medicine And Cellular Longevity
DL Abeyawardhane, HR Lucas
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31687080
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Hsp110 mitigates α-synuclein pathology in vivo.

Proceedings Of The National Academy Of Sciences Of The United States Of America
YV Taguchi, EL Gorenberg, M Nagy, D Thrasher, WA Fenton, L Volpicelli-Daley, AL Horwich, SS Chandra
Publication Date: 2019-11-26

Variant appearance in text: SNCA: A53T
PMID: 31685606
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Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease.

Frontiers In Pharmacology
JM Webster, AL Darling, VN Uversky, LJ Blair
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31619995
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Using induced pluripotent stem cells for modeling Parkinson's disease.

World Journal Of Stem Cells
M Ke, CM Chong, H Su
Publication Date: 2019-09-26

Variant appearance in text: SNCA: A53T
PMID: 31616540
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Inflammatory Bowel Diseases and Parkinson's Disease.

Journal Of Parkinson'S Disease
T Brudek
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31609699
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Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein.

Acta Pharmacologica Sinica
MM Xu, P Ryan, S Rudrawar, RJ Quinn, HY Zhang, GD Mellick
Publication Date: 2019-10-04

Variant appearance in text: SNCA: A53T
PMID: 31586134
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Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling.

Frontiers In Cell And Developmental Biology
M Mazzocchi, SL Wyatt, D Mercatelli, M Morari, N Morales-Prieto, LM Collins, AM Sullivan, GW O'Keeffe
Publication Date: 2019

Variant appearance in text: SNCA: A53T
PMID: 31572723
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Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.

Proceedings Of The National Academy Of Sciences Of The United States Of America
T Imberdis, J Negri, N Ramalingam, E Terry-Kantor, GPH Ho, S Fanning, G Stirtz, TE Kim, OA Levy, TL Young-Pearse, D Selkoe, U Dettmer
Publication Date: 2019-10-08

Variant appearance in text: SNCA: A53T
PMID: 31548371
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000336904.3 c.157G>A p.Ala53Thr missense_variant 3/6 -
ENST00000345009.4 c.157G>A p.Ala53Thr missense_variant 2/4 -
ENST00000394986.1 c.157G>A p.Ala53Thr missense_variant 3/6 -
ENST00000394989.2 c.122-5761G>A - intron_variant - 2/4
ENST00000394991.3 c.157G>A p.Ala53Thr missense_variant 3/6 -
ENST00000420646.2 c.157G>A p.Ala53Thr missense_variant 3/5 -
ENST00000502987.1 c.157G>A p.Ala53Thr missense_variant 2/3 -
ENST00000505199.1 c.122-5761G>A - intron_variant - 1/3
ENST00000506244.1 c.157G>A p.Ala53Thr missense_variant 3/6 -
ENST00000506691.1 c.157G>A p.Ala53Thr missense_variant 4/5 -
ENST00000508895.1 c.157G>A p.Ala53Thr missense_variant 3/6 -
NM_000345.4 c.157G>A p.Ala53Thr missense_variant 3/6 -
NM_001146054.2 c.157G>A p.Ala53Thr missense_variant 3/6 -
NM_001146055.2 c.157G>A p.Ala53Thr missense_variant 3/6 -
NM_007308.2 c.157G>A p.Ala53Thr missense_variant 3/5 -